SH2B3

General Information

Gene Name       : SH2B3
Gene ID             : ENSG00000111252.10
Essential Gene : No

Functions

Localization

Domains (AlphaFold: SH2B3)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SH2B3ENSG00000111252.1022.5026.0724.29ENCSR000AEF
HepG2SH2B3ENSG00000111252.104.055.414.73ENCSR985KAT
K562SH2B3ENSG00000111252.1046.5340.3243.42ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SH2B3 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SH2B3 RNA is bound by 19 proteins.  







eCLIP assay for SH2B3 is not avaliable on ENCORE database.





19 proteins are bound to SH2B3 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr12111889187111889230+3'-UTR4.295594.12025K562YBX3
chr12111888712111888792+3'-UTR3.465938.58119HepG2IGF2BP1
chr12111886710111886815+3'-UTR3.4575212.28680K562QKI
chr12111888595111888654+3'-UTR4.492635.82137K562YBX3
chr12111888473111888538+3'-UTR4.024113.98716K562IGF2BP1
chr12111886497111886577+3'-UTR3.264103.64762HepG2QKI
chr12111886808111886904+3'-UTR5.6745314.60304K562IGF2BP1
chr12111886542111886595+3'-UTR3.094335.02143K562IGF2BP2
chr12111886807111886827+3'-UTR4.256423.76295K562IGF2BP2
chr12111888705111888765+3'-UTR3.358163.82829K562IGF2BP2
chr12111888552111888595+3'-UTR4.7467515.90034K562YBX3
chr12111886708111886764+3'-UTR3.707525.49597K562IGF2BP1
chr12111886853111886897+3'-UTR5.144996.33394K562IGF2BP2
chr12111888132111888171+3'-UTR3.802493.31904K562IGF2BP1
chr12111889269111889403+3'-UTR4.271575.19823K562KHSRP
chr12111886808111886881+3'-UTR3.439773.85040HepG2IGF2BP1
chr12111886506111886573+3'-UTR3.621204.11795K562YBX3
chr12111888520111888536+3'-UTR3.7983610.32378K562YBX3
chr12111886843111886906+3'-UTR3.360233.34359K562SND1
chr12111886827111886853+3'-UTR4.592914.51303K562IGF2BP2
chr12111888536111888552+3'-UTR4.6421014.26329K562YBX3
chr12111887385111887458+3'-UTR3.036413.96632K562IGF2BP2
chr12111843777111843903+5'-UTR3.137485.48399K562DDX3X
chr12111843899111843955+5'-UTR4.812793.53084HepG2DDX3X
chr12111843800111843882+5'-UTR5.620146.58500HepG2DDX3X
chr12111856520111856564+CDS3.905713.03355K562METAP2
chr12111885329111885348+CDS4.893064.94552K562TROVE2
chr12111872755111872790+CDS,intron-Distal3.037095.26430K562NONO
chr12111884792111884839+CDS,intron-Proximal4.573674.50440HepG2PPIG
chr12111885456111885518+CDS,intron-Proximal3.447177.74155K562TROVE2
chr12111863157111863274+intron-Distal4.286248.19675HepG2CSTF2T
chr12111873655111873718+intron-Distal4.492754.75718K562EWSR1
chr12111863158111863244+intron-Distal4.180484.34791K562FUS
chr12111875975111876075+intron-Distal3.605933.69530HepG2CSTF2T
chr12111863413111863538+intron-Distal4.516486.86719K562FUS
chr12111863171111863246+intron-Distal4.522204.42197K562EWSR1
chr12111873689111873799+intron-Distal4.751133.86368HepG2HNRNPM
chr12111858340111858413+intron-Distal4.359674.08332K562NONO
chr12111874428111874508+intron-Distal5.355497.20412K562NONO
chr12111873689111873842+intron-Distal4.033136.51671K562HNRNPM
chr12111876203111876260+intron-Distal3.821163.37414K562CSTF2T
chr12111862118111862176+intron-Distal4.079683.04182K562HNRNPM
chr12111863041111863119+intron-Distal3.113845.34585K562CSTF2T
chr12111844580111844706+intron-Distal3.640154.25134HepG2RBFOX2
chr12111874725111874805+intron-Distal3.449594.45679K562NONO
chr12111862200111862274+intron-Distal5.076227.87558HepG2HNRNPM
chr12111868478111868524+intron-Distal4.252163.06347K562NONO
chr12111863165111863262+intron-Distal3.691385.31818K562GTF2F1
chr12111872853111872914+intron-Distal,intron-Proximal3.567193.38183K562NONO
chr12111863165111863268+intron-Distal3.741254.76898K562CSTF2T
chr12111869396111869454+intron-Distal3.107573.63132HepG2HNRNPC
chr12111876024111876102+intron-Distal4.153427.92474K562CSTF2T
chr12111863024111863123+intron-Distal3.228385.09410K562GTF2F1
chr12111874191111874256+intron-Distal3.674355.81451K562CSTF2T
chr12111862119111862200+intron-Distal4.643375.72853HepG2HNRNPM
chr12111874180111874247+intron-Distal3.144764.58795K562EWSR1
chr12111862108111862177+intron-Distal3.067194.56077K562NONO
chr12111876550111876599+intron-Distal3.837573.43867K562CSTF2T
chr12111872560111872636+intron-Distal3.198203.59509K562HNRNPM
chr12111873744111873784+intron-Distal3.430103.38183K562NONO
chr12111874023111874084+intron-Distal3.400244.20405K562EWSR1
chr12111868366111868466+intron-Distal4.045856.92249K562EWSR1
chr12111862182111862273+intron-Distal5.067928.94038K562HNRNPM
chr12111876011111876098+intron-Distal4.210126.36430K562GTF2F1
chr12111862707111862868+intron-Distal3.410417.31938K562CSTF2T
chr12111873784111873819+intron-Distal4.160733.06347K562NONO
chr12111844100111844181+intron-Proximal3.942344.89208K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SH2B3 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SH2B3 is not available on ENCORE database.

  • 129 RBPs can affect the levels of SH2B3.  








The Knockdown/knockout RNA-Seq assay for SH2B3 is not available on ENCORE database.





129 RBPs can affect the gene expression of SH2B3 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SH2B3ENSG00000111252.6380.26780641.03020-0.753402.447201.56120HepG2ABCF1
SH2B3ENSG00000111252.6505.16390379.379200.413003.361402.70150HepG2ACO1
SH2B3ENSG00000111252.6285.48030493.67210-0.790203.079301.31470HepG2APOBEC3C
SH2B3ENSG00000111252.6226.18250583.00830-1.3660016.3858014.65030HepG2ASCC1
SH2B3ENSG00000111252.6360.98640553.89260-0.617704.305703.35350HepG2CIRBP
SH2B3ENSG00000111252.6302.28030379.34060-0.327601.948001.37720HepG2CKAP4
SH2B3ENSG00000111252.6866.46520528.252800.713804.703703.29100HepG2CPSF7
SH2B3ENSG00000111252.6546.38970424.294300.364802.436401.82540HepG2CELF1
SH2B3ENSG00000111252.6482.25680674.98280-0.485003.004702.35630HepG2DDX3X
SH2B3ENSG00000111252.6477.08980313.316700.606502.092201.41040HepG2DDX55
SH2B3ENSG00000111252.6770.71500480.367400.682003.441702.35330HepG2DDX59
SH2B3ENSG00000111252.61229.21980579.739101.0842013.7623012.51480HepG2DDX6
SH2B3ENSG00000111252.6538.55990338.173600.671207.000105.92270HepG2DNAJC21
SH2B3ENSG00000111252.6190.71380347.11940-0.864005.567004.29550HepG2EEF2
SH2B3ENSG00000111252.6480.72190247.024300.960407.301305.53760HepG2AGO1
SH2B3ENSG00000111252.6308.85780557.40180-0.851807.123306.20370HepG2EIF2S1
SH2B3ENSG00000111252.6831.37570486.537600.772808.533106.62700HepG2EIF2S2
SH2B3ENSG00000111252.6654.73910450.099000.540605.396704.29330HepG2EIF4G1
SH2B3ENSG00000111252.6308.10950431.17780-0.484802.928502.09200HepG2EIF4G2
SH2B3ENSG00000111252.61349.40430953.485500.500907.808206.88550HepG2ETF1
SH2B3ENSG00000111252.6178.57830251.84300-0.496002.409301.32150HepG2FAM120A
SH2B3ENSG00000111252.6894.50350647.358800.466402.773102.00180HepG2FIP1L1
SH2B3ENSG00000111252.6232.00880414.41170-0.836906.843405.64090HepG2FUBP3
SH2B3ENSG00000111252.6355.41500576.53260-0.697905.158704.26240HepG2G3BP1
SH2B3ENSG00000111252.6354.18170479.51460-0.437102.143301.57620HepG2GPKOW
SH2B3ENSG00000111252.6498.54120362.225100.460704.046502.87940HepG2HDGF
SH2B3ENSG00000111252.6696.56910446.917600.640204.031502.35800HepG2HNRNPA0
SH2B3ENSG00000111252.6640.87300436.432500.554203.370901.82370HepG2HNRNPAB
SH2B3ENSG00000111252.6718.34150457.904800.649504.312902.42390HepG2HNRNPD
SH2B3ENSG00000111252.6588.04420481.635000.287902.241501.59120HepG2HNRNPF
SH2B3ENSG00000111252.6423.72700583.63970-0.461902.825202.11850HepG2HNRNPK
SH2B3ENSG00000111252.6186.70500377.25460-1.0148011.5067010.34070HepG2HNRNPU
SH2B3ENSG00000111252.6747.66510586.056000.351302.040801.45180HepG2IGF2BP2
SH2B3ENSG00000111252.6196.37210385.35200-0.9726011.7872010.39370HepG2ILF2
SH2B3ENSG00000111252.6762.72010503.618500.598704.093202.59170HepG2KHDRBS1
SH2B3ENSG00000111252.6394.19780589.42890-0.580403.192902.10560HepG2KHSRP
SH2B3ENSG00000111252.6529.83380346.827400.611206.993405.42100HepG2KIF1C
SH2B3ENSG00000111252.6358.33730621.64660-0.794806.685405.67900HepG2MAGOH
SH2B3ENSG00000111252.6431.92330639.88800-0.567003.779703.04380HepG2NCBP2
SH2B3ENSG00000111252.6927.30240612.465000.598303.851402.17350HepG2NKRF
SH2B3ENSG00000111252.61177.68780483.149901.2853011.790309.92550HepG2PABPC1
SH2B3ENSG00000111252.6955.07470474.056001.010508.089205.61650HepG2PNPT1
SH2B3ENSG00000111252.6553.40140336.479900.717708.133506.91810HepG2PPIL4
SH2B3ENSG00000111252.6428.81610620.17610-0.532305.578304.52030HepG2PRPF4
SH2B3ENSG00000111252.6410.60610613.87720-0.580206.409705.64490HepG2PTBP1
SH2B3ENSG00000111252.6682.85890458.445900.574707.331406.46110HepG2PUM1
SH2B3ENSG00000111252.6261.50800386.42870-0.563302.852502.22970HepG2PUS1
SH2B3ENSG00000111252.6816.70910528.191700.628706.918105.64640HepG2RBM15
SH2B3ENSG00000111252.6804.68510603.413600.415203.191902.47260HepG2RBM25
SH2B3ENSG00000111252.6803.18190510.548400.653604.265502.38110HepG2RBM47
SH2B3ENSG00000111252.6427.73230683.20460-0.675608.281107.43620HepG2NELFE
SH2B3ENSG00000111252.6375.77680636.27920-0.759809.788708.73650HepG2RECQL
SH2B3ENSG00000111252.6821.90740499.785600.717605.523603.67160HepG2SART3
SH2B3ENSG00000111252.6478.47390900.12650-0.9117018.3701017.38090HepG2SRFBP1
SH2B3ENSG00000111252.6407.38550667.13360-0.711609.007508.26360HepG2SRSF1
SH2B3ENSG00000111252.6534.44440426.399100.325702.033001.48630HepG2SRSF5
SH2B3ENSG00000111252.6572.86150473.170700.275702.028901.42240HepG2SRSF7
SH2B3ENSG00000111252.6429.54210781.53890-0.8635014.9417013.94080HepG2SSB
SH2B3ENSG00000111252.6662.83130432.683400.615203.032701.74300HepG2STAU1
SH2B3ENSG00000111252.6683.94270461.648700.567003.580102.31350HepG2STIP1
SH2B3ENSG00000111252.6663.05650283.864901.2238010.122907.93260HepG2SUB1
SH2B3ENSG00000111252.6698.70810484.958600.526705.816904.97500HepG2SUCLG1
SH2B3ENSG00000111252.6363.22280599.60120-0.723108.243407.35980HepG2TAF15
SH2B3ENSG00000111252.6176.58300366.54930-1.0537010.342809.48290HepG2TIAL1
SH2B3ENSG00000111252.6348.14060223.912000.636603.437901.68900HepG2TROVE2
SH2B3ENSG00000111252.6768.11570323.831501.246004.234503.00160HepG2U2AF2
SH2B3ENSG00000111252.6865.47910446.546000.954609.083407.53100HepG2UBE2L3
SH2B3ENSG00000111252.6628.98990425.878600.562506.049105.22150HepG2UTP3
SH2B3ENSG00000111252.6606.09060298.731801.020607.608105.57290HepG2XRCC5
SH2B3ENSG00000111252.6286.65410612.02970-1.0943019.5454018.04830HepG2ZC3H8
SH2B3ENSG00000111252.6786.42400485.142200.696808.132707.32360HepG2ZNF622
SH2B3ENSG00000111252.62704.091303058.00860-0.177402.034001.53300K562AGGF1
SH2B3ENSG00000111252.61359.237401669.49150-0.296602.952401.39420K562AKAP1
SH2B3ENSG00000111252.62254.976803181.95940-0.496806.493805.46050K562AKAP8L
SH2B3ENSG00000111252.61628.382603761.09520-1.2077011.4319010.35810K562AQR
SH2B3ENSG00000111252.61658.057502140.52910-0.368506.187904.72900K562BCLAF1
SH2B3ENSG00000111252.61131.987802206.41680-0.9628012.3719010.48350K562BOP1
SH2B3ENSG00000111252.61733.835202242.58870-0.371204.626902.64630K562CEBPZ
SH2B3ENSG00000111252.61477.627102346.11780-0.6670010.943909.36910K562CPSF6
SH2B3ENSG00000111252.63992.198305143.86740-0.365704.778803.48480K562CELF1
SH2B3ENSG00000111252.61892.466702577.64000-0.445808.309906.20790K562DDX21
SH2B3ENSG00000111252.61718.017203416.52870-0.9918034.2798032.25580K562DDX47
SH2B3ENSG00000111252.61119.723001559.78590-0.478204.697002.92520K562DNAJC21
SH2B3ENSG00000111252.61328.884902034.61330-0.614505.137103.36370K562EEF2
SH2B3ENSG00000111252.61329.900101965.83930-0.563806.388804.95330K562EFTUD2
SH2B3ENSG00000111252.63227.270702723.245300.244902.904402.17060K562EIF2S2
SH2B3ENSG00000111252.6751.348301475.41680-0.973608.097506.34400K562EIF3A
SH2B3ENSG00000111252.61234.419502104.82410-0.769908.386506.41980K562EIF3D
SH2B3ENSG00000111252.61239.941002045.24070-0.7220016.0699014.08580K562EIF3G
SH2B3ENSG00000111252.62728.843204184.01090-0.6166015.3289013.22310K562EIF4G2
SH2B3ENSG00000111252.61971.477802931.35200-0.572309.253706.94870K562EXOSC5
SH2B3ENSG00000111252.61666.157802386.99590-0.518706.002504.73230K562FMR1
SH2B3ENSG00000111252.61029.339202023.14080-0.9749015.6157013.26490K562FTO
SH2B3ENSG00000111252.62271.728801837.646100.305802.427301.85340K562FXR1
SH2B3ENSG00000111252.61936.565801453.941600.413402.603401.92070K562G3BP2
SH2B3ENSG00000111252.62149.615902789.76460-0.376105.462003.89100K562GLRX3
SH2B3ENSG00000111252.61291.056802240.01600-0.7950013.8515012.05450K562GPKOW
SH2B3ENSG00000111252.61745.599403628.79400-1.0558028.4240025.90790K562GRSF1
SH2B3ENSG00000111252.61499.137402509.89160-0.743504.336201.85140K562HLTF
SH2B3ENSG00000111252.61859.253302584.91130-0.475406.482104.88240K562HNRNPA1
SH2B3ENSG00000111252.61420.658702103.52810-0.566307.998907.03200K562HNRNPC
SH2B3ENSG00000111252.62445.132303087.45500-0.336503.549602.33380K562HNRNPL
SH2B3ENSG00000111252.61759.027602862.61990-0.7026016.8099014.72900K562HNRNPU
SH2B3ENSG00000111252.61630.464002683.62530-0.718904.324102.52540K562ILF2
SH2B3ENSG00000111252.61458.404501912.56080-0.391102.226401.39860K562KRR1
SH2B3ENSG00000111252.61494.044302186.48410-0.549403.439702.45800K562METAP2
SH2B3ENSG00000111252.63223.905404459.85090-0.468204.222702.83020K562MSI2
SH2B3ENSG00000111252.61560.537102933.08190-0.9104036.2521033.94010K562MTPAP
SH2B3ENSG00000111252.62179.489203258.87100-0.5804023.3970021.55360K562NSUN2
SH2B3ENSG00000111252.62928.153602301.891900.347103.658502.09880K562PCBP1
SH2B3ENSG00000111252.61372.721203728.66510-1.4416034.1588031.54120K562PCBP3
SH2B3ENSG00000111252.61192.595502859.98460-1.2619041.1098038.46670K562POLR2G
SH2B3ENSG00000111252.61806.296102817.42460-0.641303.395701.31900K562PRPF6
SH2B3ENSG00000111252.61180.951301912.98790-0.695908.983107.63100K562PRPF8
SH2B3ENSG00000111252.62966.359404565.16170-0.622009.572808.03250K562PUF60
SH2B3ENSG00000111252.63559.807104757.71510-0.418507.168205.59830K562PUM2
SH2B3ENSG00000111252.61674.328203155.89700-0.9145018.0024016.65240K562PUS1
SH2B3ENSG00000111252.61989.584003074.72540-0.628005.535604.72230K562RBM15
SH2B3ENSG00000111252.62405.093401720.868800.482904.243503.01270K562RCC2
SH2B3ENSG00000111252.6792.825301948.59760-1.2974022.5831020.27040K562RPS19
SH2B3ENSG00000111252.61357.067101955.95510-0.527403.728902.16500K562RRP9
SH2B3ENSG00000111252.62118.385102548.40550-0.266602.306201.32300K562SAFB
SH2B3ENSG00000111252.61899.086902634.71550-0.472303.468101.82990K562SDAD1
SH2B3ENSG00000111252.62547.142003215.74300-0.336303.968303.00170K562SF3A3
SH2B3ENSG00000111252.62071.345301513.142800.452904.951403.79270K562SF3B4
SH2B3ENSG00000111252.61161.846901597.61160-0.459504.381402.75550K562SLBP
SH2B3ENSG00000111252.61643.626202242.63020-0.448304.101003.24670K562SRSF1
SH2B3ENSG00000111252.61727.746202300.40730-0.413006.902005.04180K562SRSF7
SH2B3ENSG00000111252.62568.101103255.31990-0.342104.018302.18150K562SRSF9
SH2B3ENSG00000111252.62731.711603619.47190-0.406004.116602.42570K562SSRP1
SH2B3ENSG00000111252.63237.328403983.19460-0.299103.262601.63440K562SUCLG1
SH2B3ENSG00000111252.61277.858301852.19310-0.535504.812103.44160K562SUPV3L1
SH2B3ENSG00000111252.62293.423302868.67880-0.322903.674702.72900K562SYNCRIP
SH2B3ENSG00000111252.62176.501801516.721200.521005.821103.49110K562TBRG4
SH2B3ENSG00000111252.62671.371502189.190200.287102.796101.97360K562TIA1
SH2B3ENSG00000111252.6774.734301814.05570-1.2274022.4377019.60290K562TIAL1
SH2B3ENSG00000111252.62528.594603226.84720-0.351802.948401.50930K562TRIP6
SH2B3ENSG00000111252.62417.282901410.803100.776809.791407.55320K562U2AF1
SH2B3ENSG00000111252.62772.484201456.574500.9285022.0338019.74510K562U2AF2
SH2B3ENSG00000111252.61353.458801960.31460-0.534405.479504.00220K562UCHL5
SH2B3ENSG00000111252.62273.817203455.45370-0.603808.943807.74320K562UPF1
SH2B3ENSG00000111252.61631.598002956.71670-0.8577019.0557016.79240K562WDR3
SH2B3ENSG00000111252.61894.396703074.68340-0.6987025.1428023.00570K562WDR43
SH2B3ENSG00000111252.61545.682401996.14240-0.369002.919101.67010K562XRN2
SH2B3ENSG00000111252.63150.206104237.59670-0.427802.154601.40340K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SH2B3 is not available on ENCORE database.





1 RBPs can affect the splicing of SH2B3 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSSH2B3ENSG00000111252.6chr12+1118844631118846581118845561118846581118559221118566810.159000.001510.06662longerK562PUS1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SH2B3 is not avaliable on ENCORE database.