SRM

General Information

Gene Name       : SRM
Gene ID             : ENSG00000116649.9
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: SRM)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SRMENSG00000116649.937.5390.7964.16ENCSR000AEF
HepG2SRMENSG00000116649.9119.9148.8084.35ENCSR985KAT
K562SRMENSG00000116649.9245.99198.99222.49ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SRM is not avaliable on ENCORE database.



Proteins bound to RNA
  • SRM RNA is bound by 13 proteins.  







eCLIP assay for SRM is not avaliable on ENCORE database.





13 proteins are bound to SRM RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr11111676111116770-3'-UTR,CDS,intron-Distal4.0648113.72241K562YBX3
chr11111476911114787-3'-UTR,intron-Distal3.328137.65028K562YBX3
chr11111468111114742-3'-UTR,intron-Distal,intron-Proximal3.4186716.48149K562YBX3
chr11111483611114895-3'-UTR,intron-Distal3.536085.34452K562PCBP1
chr11111676111116791-3'-UTR,CDS,intron-Distal3.268933.25727K562METAP2
chr11111677011116801-3'-UTR,CDS,intron-Distal4.9472424.58527K562YBX3
chr11111488711114910-3'-UTR,intron-Distal3.2099614.30295K562YBX3
chr11111614111116151-3'-UTR,CDS,intron-Distal3.125316.89911K562YBX3
chr11111491011114940-3'-UTR,CDS,intron-Distal,intron-Proximal3.5332512.01139K562YBX3
chr11111675111116761-3'-UTR,CDS,intron-Distal,intron-Proximal3.8035610.18354K562YBX3
chr11111486111114887-3'-UTR,intron-Distal3.567806.07797HepG2LARP4
chr11111680511116808-3'-UTR,CDS,intron-Distal4.3110310.52552K562YBX3
chr11111492311114991-3'-UTR,CDS,intron-Distal,intron-Proximal4.681138.77485HepG2PRPF8
chr11111468211114758-3'-UTR,intron-Distal,intron-Proximal4.418586.31568HepG2LARP4
chr11112000111120070-5'-UTR,intron-Distal5.3815820.22515K562DDX3X
chr11111999511120073-5'-UTR,CDS,intron-Distal5.6810964.32398HepG2DDX3X
chr11111960211119732-5'-UTR,intron-Distal3.619573.76326HepG2RBFOX2
chr11111885611118920-5'-UTR,CDS,intron-Distal,intron-Proximal3.6974815.61647HepG2DDX3X
chr11111994811119995-CDS,intron-Distal4.0748319.37445HepG2DDX3X
chr11111932911119356-CDS,intron-Distal3.3895826.45062K562YBX3
chr11111584311115861-CDS,intron-Distal3.051543.80869K562YBX3
chr11111985611119948-CDS,intron-Distal4.8600537.11014HepG2DDX3X
chr11111939611119438-CDS,intron-Distal,intron-Proximal3.503686.43421HepG2BUD13
chr11111510711115162-CDS,intron-Distal,intron-Proximal3.068014.71929HepG2PRPF8
chr11111995011120001-CDS,intron-Distal4.0359311.86739K562DDX3X
chr11111979011119837-CDS,intron-Distal,intron-Proximal4.022218.16617HepG2PRPF8
chr11111585211115942-CDS,intron-Distal,intron-Proximal3.223776.16969HepG2LARP4
chr11111939611119454-CDS,intron-Distal,intron-Proximal4.376004.62947HepG2AQR
chr11111511711115134-CDS,intron-Distal3.853713.15159HepG2LARP4
chr11111585611115974-CDS,intron-Distal,intron-Proximal4.4305311.07273K562PCBP1
chr11111935611119367-CDS,intron-Distal3.5311622.11094K562YBX3
chr11111585711115944-CDS,intron-Distal,intron-Proximal3.6335910.41528HepG2PCBP2
chr11111513511115140-CDS,intron-Distal3.8915610.62213K562YBX3
chr11111589311115931-CDS,intron-Distal,intron-Proximal3.276265.66231K562PABPC4
chr11111503411115069-CDS,intron-Distal4.2891913.41447K562YBX3
chr11111512211115168-CDS,intron-Distal,intron-Proximal4.632733.95187HepG2AQR
chr11111979511119844-CDS,intron-Distal,intron-Proximal4.632734.28193HepG2AQR
chr11111509711115135-CDS,intron-Distal3.9641220.07395K562YBX3
chr11111881411118856-CDS,intron-Distal,intron-Proximal4.819794.13847K562AQR
chr11111936811119399-CDS,intron-Distal3.478047.54844K562YBX3
chr11111984011119950-CDS,intron-Distal,intron-Proximal3.2695812.00016K562DDX3X
chr11111598511116036-intron-Distal,intron-Proximal4.213156.81564HepG2PRPF8
chr11111977011119824-intron-Distal,intron-Proximal4.215489.80019K562AQR
chr11111982411119834-intron-Distal,intron-Proximal3.899597.53394K562AQR
chr11111658911116658-intron-Distal,intron-Proximal4.364997.08947HepG2PRPF8
chr11111575611115810-intron-Distal,intron-Proximal4.198934.06667K562GTF2F1
chr11111686911116927-intron-Distal,intron-Proximal3.097563.10102HepG2SF3B4
chr11111923811119279-intron-Distal,intron-Proximal5.284526.35567HepG2PRPF8
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SRM is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SRM is not available on ENCORE database.

  • 122 RBPs can affect the levels of SRM.  








The Knockdown/knockout RNA-Seq assay for SRM is not available on ENCORE database.





122 RBPs can affect the gene expression of SRM :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SRMENSG00000116649.51413.737701062.501500.411901.741201.30880HepG2AKAP1
SRMENSG00000116649.5820.110301065.40910-0.377502.368801.65330HepG2AKAP8L
SRMENSG00000116649.5462.489901565.74120-1.7594073.7008071.10980HepG2AUH
SRMENSG00000116649.5470.75680835.17410-0.827102.970402.16980HepG2CIRBP
SRMENSG00000116649.5230.15130410.59250-0.835104.462803.48760HepG2CNOT7
SRMENSG00000116649.5890.73160502.362700.826205.946504.45510HepG2YBX3
SRMENSG00000116649.5338.80510525.41370-0.633003.588901.95920HepG2CSTF2T
SRMENSG00000116649.51163.81540993.169400.228702.276801.59550HepG2DAZAP1
SRMENSG00000116649.5702.78850503.074300.482204.426002.98100HepG2DDX1
SRMENSG00000116649.5410.33910565.53290-0.462803.084302.37090HepG2DDX21
SRMENSG00000116649.5380.16750553.77860-0.542704.199103.06310HepG2DDX24
SRMENSG00000116649.5323.46190475.78010-0.556703.932902.77690HepG2DHX30
SRMENSG00000116649.5668.854201014.67610-0.601304.115503.32180HepG2DKC1
SRMENSG00000116649.5795.71860493.297700.689704.015203.18210HepG2DNAJC21
SRMENSG00000116649.5611.16810488.919700.321902.761302.11060HepG2DNAJC2
SRMENSG00000116649.5561.43670928.40260-0.725602.652602.02590HepG2EIF4A3
SRMENSG00000116649.5945.522401304.49600-0.464304.260602.93180HepG2ESF1
SRMENSG00000116649.5632.329101797.71810-1.5074064.3137062.14320HepG2ETF1
SRMENSG00000116649.5769.25340539.122400.512704.482303.07990HepG2FASTKD2
SRMENSG00000116649.51106.967601520.83180-0.458202.483201.75040HepG2FIP1L1
SRMENSG00000116649.5458.752001088.40570-1.246405.132603.75720HepG2FTO
SRMENSG00000116649.5806.140101231.42890-0.611204.008203.25050HepG2GPKOW
SRMENSG00000116649.5563.612901012.45060-0.845108.315706.73140HepG2HDGF
SRMENSG00000116649.5606.47230347.123500.804905.668803.63560HepG2HNRNPA0
SRMENSG00000116649.5318.79170498.02340-0.643604.649203.84100HepG2HNRNPA1
SRMENSG00000116649.51108.94360904.677400.293603.564602.80660HepG2HNRNPL
SRMENSG00000116649.5810.612601175.18760-0.535802.797302.16500HepG2HNRNPLL
SRMENSG00000116649.5680.47170550.289800.306202.559301.97620HepG2HNRNPU
SRMENSG00000116649.5758.13280562.104000.431505.266404.28050HepG2ILF2
SRMENSG00000116649.5542.41330391.162300.471502.452801.34840HepG2KHDRBS1
SRMENSG00000116649.51739.34060942.893500.883305.148904.31330HepG2MATR3
SRMENSG00000116649.5972.087401230.47360-0.340103.045202.19690HepG2MSI2
SRMENSG00000116649.5599.880701198.83560-0.998904.118802.92570HepG2MTPAP
SRMENSG00000116649.5764.935201033.32610-0.433903.741602.32910HepG2NAA15
SRMENSG00000116649.51345.69780965.009900.479602.402101.80910HepG2NCBP2
SRMENSG00000116649.5851.81300579.680600.555203.044601.52140HepG2NOLC1
SRMENSG00000116649.5613.167501042.12720-0.765204.934803.94590HepG2NSUN2
SRMENSG00000116649.5832.84880544.701800.612508.426207.07560HepG2PARN
SRMENSG00000116649.51298.37590869.811400.5778010.244009.19330HepG2PCBP1
SRMENSG00000116649.5180.87930565.37410-1.644206.059004.56630HepG2PCBP2
SRMENSG00000116649.5662.21030490.815800.432003.869803.01180HepG2PPIL4
SRMENSG00000116649.5857.847801022.92750-0.253902.224001.52280HepG2PRPF4
SRMENSG00000116649.51928.42890998.012300.9502038.9702037.27130HepG2PUM1
SRMENSG00000116649.5662.054701080.28980-0.706405.725004.89750HepG2PUS1
SRMENSG00000116649.5558.88620958.52780-0.7783011.4501010.30710HepG2QKI
SRMENSG00000116649.51194.541101508.21210-0.336403.514302.55770HepG2RBM15
SRMENSG00000116649.51071.73020510.465101.070003.305801.32540HepG2RBM17
SRMENSG00000116649.5661.82640869.94100-0.394503.095402.38640HepG2RBM25
SRMENSG00000116649.5677.020401298.22990-0.9393011.7058010.47080HepG2RPLP0
SRMENSG00000116649.51049.57560490.061701.0987029.6923027.90200HepG2SAFB2
SRMENSG00000116649.5617.92600388.184100.670604.517302.85280HepG2SART3
SRMENSG00000116649.5861.22180571.502000.591508.562107.52940HepG2SMN1
SRMENSG00000116649.5921.66550557.477300.725204.715003.43330HepG2SMNDC1
SRMENSG00000116649.5874.27160441.060200.987003.167701.74480HepG2SNRNP200
SRMENSG00000116649.5967.272101294.20880-0.420102.028501.36410HepG2SNRNP70
SRMENSG00000116649.51124.782101697.06310-0.5934013.0984012.22380HepG2SRFBP1
SRMENSG00000116649.5779.570601251.74970-0.683203.453602.32170HepG2SRSF3
SRMENSG00000116649.51112.72150928.269500.261402.587101.97730HepG2SRSF5
SRMENSG00000116649.51017.889901183.89720-0.218002.119301.50070HepG2SRSF7
SRMENSG00000116649.5542.70830782.49710-0.527906.722405.92990HepG2SRSF9
SRMENSG00000116649.5893.638201473.42820-0.7214016.9405015.89650HepG2SSB
SRMENSG00000116649.51445.630501055.671900.453408.122107.15170HepG2SUCLG1
SRMENSG00000116649.5537.72490864.55280-0.685106.826106.01420HepG2TAF15
SRMENSG00000116649.5338.36500534.73670-0.660206.076905.38800HepG2TIAL1
SRMENSG00000116649.51164.35720539.487501.1098030.8916029.25620HepG2TRIM56
SRMENSG00000116649.51206.11810918.506400.392903.726502.69820HepG2TUFM
SRMENSG00000116649.51072.452101300.75170-0.278401.881501.35220HepG2U2AF1
SRMENSG00000116649.51244.37870972.252100.355902.317701.55710HepG2UBE2L3
SRMENSG00000116649.5795.74620506.861800.650602.043201.39110HepG2UCHL5
SRMENSG00000116649.51100.346701329.79880-0.273202.671101.98250HepG2UPF1
SRMENSG00000116649.51967.243301283.862000.615603.982403.28320HepG2UTP3
SRMENSG00000116649.5598.865001009.48580-0.7533015.3165013.94250HepG2ZC3H8
SRMENSG00000116649.53715.323404600.56680-0.308302.777801.55270K562ABCF1
SRMENSG00000116649.53490.699702420.805400.5279013.3699012.22320K562AGGF1
SRMENSG00000116649.51986.961301575.293600.334804.232802.33280K562AKAP1
SRMENSG00000116649.52199.092602659.97000-0.274502.289701.40760K562AKAP8
SRMENSG00000116649.53621.805402518.926000.523802.913202.24290K562AKAP8L
SRMENSG00000116649.55243.693704302.815000.285202.529201.34540K562APOBEC3C
SRMENSG00000116649.52086.526803756.37750-0.848204.363703.65870K562AQR
SRMENSG00000116649.53550.895202642.899600.426007.078705.52470K562ATP5C1
SRMENSG00000116649.51203.995302155.82220-0.8404013.0564011.10610K562BOP1
SRMENSG00000116649.52284.605603087.74260-0.434603.345101.67210K562CEBPZ
SRMENSG00000116649.51404.969002292.21210-0.7062013.1261011.40680K562CPSF6
SRMENSG00000116649.54513.219705996.76580-0.410007.210105.65960K562CELF1
SRMENSG00000116649.57493.437504183.069500.8410038.1841036.04160K562DDX47
SRMENSG00000116649.53950.376902710.744200.543207.429905.87370K562DKC1
SRMENSG00000116649.52821.046403846.07150-0.447204.619003.71910K562EIF2S2
SRMENSG00000116649.54256.423102208.880000.946208.920307.07580K562EIF3A
SRMENSG00000116649.51867.76370668.646501.4819042.6965039.58930K562EIF3G
SRMENSG00000116649.52468.659203515.90480-0.510203.848401.87730K562ESF1
SRMENSG00000116649.51842.906901455.393300.340503.863602.30240K562EWSR1
SRMENSG00000116649.51126.720302332.35930-1.0497021.3413018.89570K562FMR1
SRMENSG00000116649.5994.816001976.92310-0.9908015.5343013.20310K562FTO
SRMENSG00000116649.53462.888101733.981000.9978037.1480035.06670K562FXR1
SRMENSG00000116649.5175.04520519.68190-1.5699017.0209014.88960K562G3BP2
SRMENSG00000116649.51544.898102188.46210-0.502406.022404.85050K562GPKOW
SRMENSG00000116649.51415.793302781.38910-0.9742015.2548013.93480K562HNRNPC
SRMENSG00000116649.51786.280302484.47500-0.476004.916403.33650K562HNRNPF
SRMENSG00000116649.53480.574702719.821300.355702.639701.73250K562HNRNPM
SRMENSG00000116649.51750.11600992.147500.818703.244902.10120K562IGF2BP2
SRMENSG00000116649.5999.302701868.76890-0.9031010.011508.11780K562KRR1
SRMENSG00000116649.51602.706801042.044500.621008.708607.17570K562MAGOH
SRMENSG00000116649.53343.222702558.936100.385603.904902.55660K562MAK16
SRMENSG00000116649.52218.453101039.829601.0931027.4519024.52070K562MATR3
SRMENSG00000116649.53811.863602994.779800.347903.948802.83100K562MBNL1
SRMENSG00000116649.53887.959305197.73480-0.418905.375003.80490K562MSI2
SRMENSG00000116649.53411.145104168.37110-0.289202.184901.51440K562NSUN2
SRMENSG00000116649.52457.274201693.064400.537302.220101.35360K562PABPN1
SRMENSG00000116649.51417.762801018.908600.476502.997601.59040K562PCBP1
SRMENSG00000116649.5612.60270927.04040-0.597704.047702.85860K562PCBP2
SRMENSG00000116649.52175.279604031.00960-0.889903.964102.96860K562PCBP3
SRMENSG00000116649.51978.064703091.66010-0.644303.111702.26040K562POLR2G
SRMENSG00000116649.54744.445303753.770300.337803.057702.18910K562PPIG
SRMENSG00000116649.52142.557901012.461101.0814027.6267025.62550K562PTBP1
SRMENSG00000116649.54484.594105544.87860-0.306205.218203.88200K562PUM2
SRMENSG00000116649.53490.834202498.311000.482501.962201.49000K562PUS1
SRMENSG00000116649.53398.409002434.039100.481408.571507.55430K562RBM15
SRMENSG00000116649.51391.68910946.297400.556403.623701.96750K562RBM34
SRMENSG00000116649.53500.374101992.702600.812705.701504.52420K562RPS19
SRMENSG00000116649.51771.86440873.842801.019706.307504.71750K562RPS3
SRMENSG00000116649.54233.567002755.565200.619405.728504.17140K562SAFB
SRMENSG00000116649.52982.180004112.59350-0.463703.117302.25210K562SF3A3
SRMENSG00000116649.51092.328702081.43750-0.9302012.8209010.65030K562SF3B1
SRMENSG00000116649.5772.06340540.464400.514405.296204.08900K562SF3B4
SRMENSG00000116649.52985.212202157.848600.468105.599603.99050K562SRFBP1
SRMENSG00000116649.51902.52950992.623900.9385015.2440013.58070K562SRSF1
SRMENSG00000116649.51195.92000843.490600.503605.151203.63910K562SRSF4
SRMENSG00000116649.52898.914504338.95230-0.581808.153805.73910K562SSRP1
SRMENSG00000116649.53128.978503968.63500-0.343002.761601.51330K562STAU1
SRMENSG00000116649.54463.541603101.377300.525202.894602.05380K562SYNCRIP
SRMENSG00000116649.5245.56350510.13650-1.054804.764802.64900K562TAF15
SRMENSG00000116649.51503.953901004.439600.582306.281105.17520K562TARDBP
SRMENSG00000116649.5214.15060541.77230-1.3391017.1254013.91420K562TBRG4
SRMENSG00000116649.51633.64330968.937600.753505.348604.15670K562TIA1
SRMENSG00000116649.51562.949502398.69760-0.618003.559302.49300K562TIAL1
SRMENSG00000116649.51413.92630951.195900.571806.430404.60120K562TRA2A
SRMENSG00000116649.5368.42050503.83800-0.451602.297301.31320K562U2AF1
SRMENSG00000116649.5339.82610520.32320-0.614605.474404.34850K562U2AF2
SRMENSG00000116649.53304.174404419.78420-0.419703.950403.10460K562UPF1
SRMENSG00000116649.52608.433703781.91540-0.535906.071504.74610K562WDR3
SRMENSG00000116649.52683.231004232.49880-0.657503.148602.22100K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SRM is not available on ENCORE database.





19 RBPs can affect the splicing of SRM :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESRMENSG00000116649.5chr1-111158371111598311115018111151411111606711116151-0.065000.000000.00002excludedK562PRPF8
SESRMENSG00000116649.5chr1-111150181111514111114645111149421111606711116151-0.073000.000380.04662excludedK562FMR1
SESRMENSG00000116649.5chr1-111158371111599311115018111151411111606711116151-0.053000.000020.00046excludedK562AQR
SESRMENSG00000116649.5chr1-111158371111599311115018111151411111606711116151-0.092000.000090.00791excludedK562EFTUD2
SESRMENSG00000116649.5chr1-111158371111599311114720111151411111606711116151-0.119000.000010.00029excludedK562HNRNPC
MXESRMENSG00000116649.5chr1-1111501811115141111158371111598311114645111149421111606711116151-0.158000.000000.000002includedK562XRN2
MXESRMENSG00000116649.5chr1-11115018111151411111583711115983111146451111494211116067111161510.111000.000150.040111includedK562WDR43
MXESRMENSG00000116649.5chr1-11115018111151411111583711115983111146451111494211116067111161510.180000.000010.000741includedHepG2TAF15
MXESRMENSG00000116649.5chr1-1111501811115141111158371111598311114645111149421111606711116151-0.154000.000020.001142includedK562TARDBP
MXESRMENSG00000116649.5chr1-1111501811115141111158371111598311114645111149421111606711116151-0.122000.001410.045112includedHepG2PCBP1
MXESRMENSG00000116649.5chr1-1111501811115141111158371111598311114645111149421111606711116151-0.081000.002560.081002includedK562SAFB
MXESRMENSG00000116649.5chr1-11115018111151411111583711115983111146451111494211116067111161510.115000.000000.001321includedK562PUM1
MXESRMENSG00000116649.5chr1-1111501811115141111158371111598311114645111149421111606711116151-0.109000.002290.063312includedHepG2HNRNPC
MXESRMENSG00000116649.5chr1-1111501811115141111158371111598311114645111149421111606711116151-0.142000.000210.023092includedK562RBM22
MXESRMENSG00000116649.5chr1-1111501811115141111158371111598311114645111149421111606711116151-0.094000.000040.014102includedK562EXOSC5
MXESRMENSG00000116649.5chr1-1111501811115141111158371111598311114645111149421111606711116151-0.166000.000000.000152includedHepG2HNRNPU
MXESRMENSG00000116649.5chr1-11115018111151411111583711115983111146451111494211116067111161510.158000.000000.000101includedK562PPIL4
MXESRMENSG00000116649.5chr1-1111501811115141111158371111598311114645111149421111606711116151-0.142000.000070.006252includedK562TIA1
MXESRMENSG00000116649.5chr1-1111501811115141111158371111598311114645111149421111606711116151-0.145000.000310.015022includedHepG2TIAL1
MXESRMENSG00000116649.5chr1-1111501811115141111158371111598311114645111149421111606711116151-0.177000.000000.000002includedK562PRPF8
MXESRMENSG00000116649.5chr1-1111501811115141111158371111598311114645111149421111606711116151-0.094000.000660.092152includedK562GPKOW

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SRM is not avaliable on ENCORE database.