ALAS2

General Information

Gene Name       : ALAS2
Gene ID             : ENSG00000158578.20
Essential Gene : No

Functions

Localization

Domains (AlphaFold: ALAS2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878ALAS2ENSG00000158578.200.000.000.00ENCSR000AEF
HepG2ALAS2ENSG00000158578.200.000.000.00ENCSR985KAT
K562ALAS2ENSG00000158578.2030.2632.3931.33ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for ALAS2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • ALAS2 RNA is bound by 30 proteins.  







eCLIP assay for ALAS2 is not avaliable on ENCORE database.





30 proteins are bound to ALAS2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chrX5503550755035568-3'-UTR,intron-Distal,intron-Proximal4.1571311.31612HepG2SUB1
chrX5503557855035624-3'-UTR,CDS,intron-Distal4.3621817.54162K562PABPC4
chrX5503549855035627-3'-UTR,CDS,intron-Distal,intron-Proximal5.0283011.17846K562LARP4
chrX5503552055035578-3'-UTR,intron-Distal,intron-Proximal5.2112360.07463K562PABPC4
chrX5505235455052449-5'-UTR,CDS,intron-Distal,intron-Proximal4.0174519.21794K562DDX3X
chrX5505737455057404-5'-UTR,CDS,intron-Distal4.437636.82597K562DDX3X
chrX5505237755052438-5'-UTR,CDS,intron-Distal3.422388.58776HepG2SUB1
chrX5505238255052449-5'-UTR,CDS,intron-Distal,intron-Proximal3.538624.19293K562EIF3G
chrX5505118355051213-CDS,intron-Distal3.020124.58085K562LIN28B
chrX5504133955041353-CDS,intron-Distal3.738618.46525K562IGF2BP2
chrX5505112755051159-CDS,intron-Distal,intron-Proximal4.368744.08666K562NCBP2
chrX5504755055047571-CDS,intron-Distal4.127109.97366K562LIN28B
chrX5504117855041233-CDS,intron-Distal,intron-Proximal3.8392710.10327K562PCBP1
chrX5505115855051203-CDS,intron-Distal3.343633.63681K562RBM15
chrX5504688255046963-CDS,intron-Distal,intron-Proximal3.7257848.11751K562BUD13
chrX5504687155046953-CDS,intron-Distal,intron-Proximal4.7813471.22148K562U2AF2
chrX5504407355044087-CDS,intron-Distal,intron-Proximal3.8841012.91403K562YBX3
chrX5504126355041311-CDS,intron-Distal4.069295.92795K562METAP2
chrX5503574255035758-CDS,intron-Distal3.592754.14151K562PCBP1
chrX5504405155044063-CDS,intron-Distal,intron-Proximal4.1109112.31603K562YBX3
chrX5504689155046981-CDS,intron-Distal,intron-Proximal3.3531238.99392K562AQR
chrX5503570355035777-CDS,intron-Distal4.276179.97386K562ZC3H11A
chrX5504757155047597-CDS,intron-Distal3.450644.98497K562LIN28B
chrX5504141155041445-CDS,intron-Distal4.570734.67299K562DDX24
chrX5504762355047689-CDS,intron-Distal4.2715410.21930K562GRWD1
chrX5504406355044073-CDS,intron-Distal,intron-Proximal4.1588113.91952K562YBX3
chrX5503563655035676-CDS,intron-Distal4.156179.96973K562PABPC4
chrX5503572355035769-CDS,intron-Distal3.712338.04296K562RPS3
chrX5504119155041233-CDS,intron-Distal3.178006.82148K562IGF2BP2
chrX5503995955040004-CDS,intron-Distal3.890557.57637K562PCBP1
chrX5503993955040006-CDS,intron-Distal3.4892610.83767K562IGF2BP2
chrX5503566055035691-CDS,intron-Distal3.363194.63699HepG2SUB1
chrX5504754755047589-CDS,intron-Distal3.058205.23626K562SND1
chrX5504201555042043-CDS,intron-Distal3.882693.69113K562LIN28B
chrX5505237955052431-CDS,intron-Distal4.371426.14606K562GEMIN5
chrX5504142155041452-CDS,intron-Distal,intron-Proximal3.211236.69205K562BUD13
chrX5504750255047550-CDS,intron-Distal3.445107.87887K562LIN28B
chrX5505110855051205-CDS,intron-Distal,intron-Proximal3.8327722.54981K562BUD13
chrX5504688155046962-CDS,intron-Distal,intron-Proximal3.9369835.94100K562U2AF1
chrX5504645955046540-intron-Distal4.264686.87274K562HNRNPL
chrX5505104155051142-intron-Distal,intron-Proximal4.3230047.98598K562AQR
chrX5504498955045090-intron-Distal4.208456.68143K562HNRNPL
chrX5505313155053217-intron-Distal4.862384.40618K562PTBP1
chrX5504410455044146-intron-Distal,intron-Proximal4.621374.69223K562SF3B4
chrX5505105555051124-intron-Distal,intron-Proximal4.7935710.72439K562RBM22
chrX5504782255047860-intron-Distal4.0708910.73645K562TARDBP
chrX5504561855045667-intron-Distal3.693543.62418K562PTBP1
chrX5504631755046437-intron-Distal3.610068.58842K562HNRNPL
chrX5504828455048350-intron-Distal3.499784.35650K562KHSRP
chrX5504576355045807-intron-Distal4.475334.27660K562HNRNPL
chrX5504704055047170-intron-Distal3.8561410.05966K562HNRNPK
chrX5504695355046967-intron-Distal,intron-Proximal5.6587614.32814K562U2AF2
chrX5504788055047933-intron-Distal6.0238017.27478K562TARDBP
chrX5505106255051108-intron-Distal,intron-Proximal3.044079.60107K562BUD13
chrX5504199355042008-intron-Distal,intron-Proximal4.929354.65563K562AQR
chrX5504698155047023-intron-Distal,intron-Proximal3.427465.64745K562U2AF2
chrX5504197255041993-intron-Distal,intron-Proximal5.145825.17615K562AQR
chrX5504219555042327-intron-Distal,intron-Proximal4.7825010.68378K562HNRNPL
chrX5504608555046198-intron-Distal3.711385.34559K562HNRNPK
chrX5504586055045945-intron-Distal3.232623.71976K562HNRNPL
chrX5505114255051151-intron-Distal,intron-Proximal5.4850330.82809K562AQR
chrX5504786055047880-intron-Distal4.1381610.99259K562TARDBP
chrX5504697355047009-intron-Distal,intron-Proximal3.197505.09479K562SF3B4
chrX5505095755051004-intron-Distal3.095197.24123K562HNRNPL
chrX5504242755042517-intron-Distal4.167808.86029K562AGGF1
chrX5504981255049892-intron-Distal3.045776.87887K562HNRNPL
chrX5503987555039918-intron-Distal,intron-Proximal5.469217.28294K562AQR
chrX5504654055046598-intron-Distal3.699064.92145K562HNRNPL
chrX5504611555046209-intron-Distal3.684806.65670K562HNRNPL
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for ALAS2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for ALAS2 is not available on ENCORE database.

  • 128 RBPs can affect the levels of ALAS2.  








The Knockdown/knockout RNA-Seq assay for ALAS2 is not available on ENCORE database.





128 RBPs can affect the gene expression of ALAS2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
ALAS2ENSG00000158578.1418.268200.0000099999.999905.677804.86860HepG2ACO1
ALAS2ENSG00000158578.1416.855000.0000099999.999904.360603.37030HepG2PRPF8
ALAS2ENSG00000158578.14396.127201746.81720-2.140709.121606.97260K562AARS
ALAS2ENSG00000158578.146102.423002933.019301.0569025.4411022.18000K562ABCF1
ALAS2ENSG00000158578.144179.854601162.463601.8462011.868808.62690K562ADAR
ALAS2ENSG00000158578.143978.541601514.755401.3931043.4687041.26080K562AGGF1
ALAS2ENSG00000158578.143915.772401664.587701.2340035.2067031.58670K562AKAP8
ALAS2ENSG00000158578.145572.693201576.196401.821808.273407.08400K562AKAP8L
ALAS2ENSG00000158578.141817.963202570.71750-0.499806.430904.42300K562APOBEC3C
ALAS2ENSG00000158578.1413721.841902602.774602.39830131.48720128.13080K562AQR
ALAS2ENSG00000158578.142445.390101653.856100.5641011.480409.44110K562ATP5C1
ALAS2ENSG00000158578.143955.563302043.124300.9530010.445707.74880K562BUD13
ALAS2ENSG00000158578.142357.261501138.520501.049903.193802.04410K562CCAR1
ALAS2ENSG00000158578.142653.824601810.135600.551903.700002.30860K562CCDC124
ALAS2ENSG00000158578.145426.748303501.738800.631903.387501.70040K562CEBPZ
ALAS2ENSG00000158578.141729.965501180.072600.551806.440404.53770K562CIRBP
ALAS2ENSG00000158578.145667.330103151.148000.846704.774802.79230K562CKAP4
ALAS2ENSG00000158578.148142.340201723.923802.2396021.3234018.59100K562CNOT7
ALAS2ENSG00000158578.144066.218202348.778700.791702.902302.10040K562CPSF6
ALAS2ENSG00000158578.143839.460001216.866901.657604.843902.35070K562CPSF7
ALAS2ENSG00000158578.143310.671401243.298301.4129010.688907.51450K562YBX3
ALAS2ENSG00000158578.1413936.056203582.753901.95960129.55090125.42410K562CELF1
ALAS2ENSG00000158578.142824.594501777.224700.668306.290204.06240K562DDX19B
ALAS2ENSG00000158578.147504.313004025.141500.8986011.775709.27910K562DDX21
ALAS2ENSG00000158578.142600.795401433.015300.859803.807402.55920K562DDX3X
ALAS2ENSG00000158578.145218.836602096.004101.3160079.4688076.57130K562DDX47
ALAS2ENSG00000158578.143652.300401274.842801.5184012.047709.08550K562DHX30
ALAS2ENSG00000158578.142265.733101224.185200.888103.705502.13690K562DNAJC21
ALAS2ENSG00000158578.142977.773901297.585401.198304.473502.21500K562DNAJC2
ALAS2ENSG00000158578.143315.233802043.523200.698004.794903.06760K562EEF2
ALAS2ENSG00000158578.142723.695201574.538600.790504.441402.88420K562EIF2S1
ALAS2ENSG00000158578.141203.079502327.34040-0.9520015.7076014.20360K562EIF2S2
ALAS2ENSG00000158578.145056.580301157.962802.126509.468107.57980K562EIF3A
ALAS2ENSG00000158578.142335.97010975.951201.2590026.4376023.94500K562EIF3G
ALAS2ENSG00000158578.142546.737001497.332000.766204.893503.79820K562EIF4A3
ALAS2ENSG00000158578.142157.408001348.605100.677703.677202.31260K562EIF4B
ALAS2ENSG00000158578.146544.945702913.459801.1675057.8767054.36430K562EIF4G2
ALAS2ENSG00000158578.144175.497202242.164300.8970011.085307.68940K562ESF1
ALAS2ENSG00000158578.144312.701505914.91270-0.455806.894404.85480K562EXOSC5
ALAS2ENSG00000158578.147175.022202108.563801.7666070.0801066.40250K562FIP1L1
ALAS2ENSG00000158578.144380.045902026.813401.111604.445903.26380K562FTO
ALAS2ENSG00000158578.141819.002801052.682400.789008.557905.94850K562G3BP1
ALAS2ENSG00000158578.146523.995401615.129902.01400141.98040137.88880K562GLRX3
ALAS2ENSG00000158578.147368.335502242.112401.7164019.0067016.84210K562GPKOW
ALAS2ENSG00000158578.148275.612203101.074201.4160056.4694053.18560K562GRSF1
ALAS2ENSG00000158578.142604.203301660.785400.648903.813101.38530K562GRWD1
ALAS2ENSG00000158578.142398.14370961.461501.3185011.099907.39200K562HLTF
ALAS2ENSG00000158578.143946.224901548.718601.349304.767402.42720K562HNRNPA0
ALAS2ENSG00000158578.148251.937202514.477401.7144083.8514079.76530K562HNRNPA1
ALAS2ENSG00000158578.143276.683001284.173601.351309.026306.39950K562HNRNPA2B1
ALAS2ENSG00000158578.144634.378001909.304901.2792023.7401022.06350K562HNRNPC
ALAS2ENSG00000158578.142601.376601705.920900.608603.773402.42060K562HNRNPF
ALAS2ENSG00000158578.143216.646201894.173500.763902.775201.71880K562HNRNPL
ALAS2ENSG00000158578.141063.726101734.43780-0.705306.427904.91910K562HNRNPM
ALAS2ENSG00000158578.143643.613502784.315900.387903.667602.63890K562HNRNPU
ALAS2ENSG00000158578.143477.411002858.604900.282602.295001.56550K562HSPD1
ALAS2ENSG00000158578.142412.988101101.141901.1317011.616209.06590K562IGF2BP2
ALAS2ENSG00000158578.144529.892101578.009301.521305.428603.39530K562ILF2
ALAS2ENSG00000158578.143546.616701189.736501.5757018.6176015.31070K562ILF3
ALAS2ENSG00000158578.142901.580001149.056601.336307.723805.28940K562KHDRBS1
ALAS2ENSG00000158578.143453.999301672.651701.0460027.9664024.41210K562KIF1C
ALAS2ENSG00000158578.143775.800901915.515200.979004.156802.99070K562KRR1
ALAS2ENSG00000158578.142227.132201601.209500.475906.020804.20920K562MAK16
ALAS2ENSG00000158578.142375.710901154.810001.0406025.5862022.73930K562MATR3
ALAS2ENSG00000158578.145539.970102188.717901.3397012.7663010.81400K562METAP2
ALAS2ENSG00000158578.146699.859603105.387201.1093028.0448025.02080K562MSI2
ALAS2ENSG00000158578.146959.054301698.051002.03490209.72600205.92260K562MTPAP
ALAS2ENSG00000158578.142679.042101313.408901.0283012.7338010.33910K562NAA15
ALAS2ENSG00000158578.147432.557801886.953601.97770225.89480221.78780K562NSUN2
ALAS2ENSG00000158578.145290.194501656.219801.675306.864004.93470K562PABPC1
ALAS2ENSG00000158578.144170.668501122.518901.8934019.9442016.46960K562PABPN1
ALAS2ENSG00000158578.142750.286101141.712001.268304.765502.03010K562PARN
ALAS2ENSG00000158578.1416945.633607523.730001.1713026.8743024.46600K562PCBP3
ALAS2ENSG00000158578.1410624.397905770.804700.880405.218704.11800K562POLR2G
ALAS2ENSG00000158578.144502.258002393.801400.9112018.2266015.48310K562PPIG
ALAS2ENSG00000158578.144318.132301535.989801.491106.286003.55450K562PPIL4
ALAS2ENSG00000158578.143000.627901333.794101.169604.989702.85660K562PPP1R8
ALAS2ENSG00000158578.14411.687801124.27020-1.4494035.7660033.48520K562PTBP1
ALAS2ENSG00000158578.143890.755903178.747200.291502.449801.68380K562PUF60
ALAS2ENSG00000158578.144618.725803381.503300.449707.145605.36850K562PUM1
ALAS2ENSG00000158578.145595.763003312.788400.7562024.0195021.42420K562PUM2
ALAS2ENSG00000158578.144945.044101562.977801.6616012.3912011.28920K562PUS1
ALAS2ENSG00000158578.142980.185601215.058301.294304.778402.21490K562RBFOX2
ALAS2ENSG00000158578.144843.563501523.032701.6690094.8228091.46800K562RBM15
ALAS2ENSG00000158578.141643.782401077.993700.608607.611706.12940K562RBM22
ALAS2ENSG00000158578.142589.284901380.903300.906803.021801.39600K562RBM39
ALAS2ENSG00000158578.14774.247701134.42700-0.551105.239103.66980K562NELFE
ALAS2ENSG00000158578.143386.823401537.624301.139105.446102.52600K562DROSHA
ALAS2ENSG00000158578.143655.845001955.886600.9023010.065108.49370K562RPS19
ALAS2ENSG00000158578.146156.834601540.158001.999007.622904.86280K562RPS3A
ALAS2ENSG00000158578.144644.419001963.213101.2422018.6180015.48660K562RRP9
ALAS2ENSG00000158578.143710.583701504.315601.302405.917003.29460K562SAFB2
ALAS2ENSG00000158578.147220.319905142.405800.489505.402903.88720K562SAFB
ALAS2ENSG00000158578.145964.711301571.015601.924706.059003.69770K562SBDS
ALAS2ENSG00000158578.148641.922905316.437600.700809.875907.35180K562SDAD1
ALAS2ENSG00000158578.145875.785001861.545401.65820105.21240101.84690K562SF3A3
ALAS2ENSG00000158578.143780.158802133.760800.824902.988901.97740K562SF3B1
ALAS2ENSG00000158578.144920.980401250.318701.976508.492605.77140K562SFPQ
ALAS2ENSG00000158578.143674.646101253.479201.5516014.4510011.87960K562SLBP
ALAS2ENSG00000158578.142810.997401179.135701.253307.060904.77620K562SNRNP200
ALAS2ENSG00000158578.142684.962101481.867900.857406.986205.14140K562SRFBP1
ALAS2ENSG00000158578.145590.889001907.157701.5516042.8889040.08940K562SRPK2
ALAS2ENSG00000158578.14655.178401102.16930-0.7504010.687209.30870K562SRSF1
ALAS2ENSG00000158578.141591.142501040.939800.612107.379805.56230K562SRSF5
ALAS2ENSG00000158578.146799.447903592.646000.9203016.8113013.94950K562SRSF7
ALAS2ENSG00000158578.141957.357901006.770300.9591012.414109.76830K562SSB
ALAS2ENSG00000158578.145204.000302530.124001.0403020.7319017.48200K562STAU1
ALAS2ENSG00000158578.145577.039002773.459601.0077034.1714030.71430K562SUCLG1
ALAS2ENSG00000158578.144550.047801445.454901.6543010.228006.13960K562SUGP2
ALAS2ENSG00000158578.145056.376401409.957601.8424013.227109.68180K562SUPT6H
ALAS2ENSG00000158578.143905.356201858.534301.0712017.1284014.59500K562SUPV3L1
ALAS2ENSG00000158578.142131.512105788.47860-1.4413064.1412061.19950K562SYNCRIP
ALAS2ENSG00000158578.141458.852601115.446300.387103.100302.35040K562TARDBP
ALAS2ENSG00000158578.145471.927201646.649101.7324043.5002039.83290K562TIAL1
ALAS2ENSG00000158578.141322.790901055.905200.325002.537401.50120K562TRA2A
ALAS2ENSG00000158578.143644.231401750.711701.057603.822902.67600K562TRIM56
ALAS2ENSG00000158578.145017.138902465.964001.0246021.7448017.95110K562TRIP6
ALAS2ENSG00000158578.143441.086002070.948900.732508.572605.76760K562TUFM
ALAS2ENSG00000158578.141883.254001081.906800.799603.124102.27080K562U2AF2
ALAS2ENSG00000158578.144942.340303584.306100.463406.773504.67170K562UBE2L3
ALAS2ENSG00000158578.145008.818501967.653401.3479011.993809.81090K562UCHL5
ALAS2ENSG00000158578.143492.543402000.755800.8036010.740409.44160K562UPF1
ALAS2ENSG00000158578.143878.508801584.875201.291002.963201.60980K562UTP18
ALAS2ENSG00000158578.145343.549902130.116501.3268029.1217026.04560K562UTP3
ALAS2ENSG00000158578.147439.466501712.017902.119409.096607.47120K562WDR3
ALAS2ENSG00000158578.144867.160701780.063601.4511071.4119068.56350K562WDR43
ALAS2ENSG00000158578.149043.737603086.237201.5510017.0398014.30190K562WRN
ALAS2ENSG00000158578.1413742.342602930.917002.2291051.2164047.75230K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for ALAS2 is not available on ENCORE database.





13 RBPs can affect the splicing of ALAS2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEALAS2ENSG00000158578.14chrX-550501895505030055047484550477075505115055051273-0.299000.000000.00000excludedK562SRSF1
SEALAS2ENSG00000158578.14chrX-550501895505030055047484550477075505115055051273-0.130000.001900.03520excludedK562SF3B4
SEALAS2ENSG00000158578.14chrX-5505018955050300550474845504770755051150550512730.140000.000020.00889includedK562HNRNPA1
SEALAS2ENSG00000158578.14chrX-550541835505429055052252550524485505737455057410-0.081000.000170.01882excludedK562SUPV3L1
SEALAS2ENSG00000158578.14chrX-5505418355054290550522525505244855057374550574100.055000.001280.02101includedK562PUS1
SEALAS2ENSG00000158578.14chrX-550501895505030055047484550477075505115055051273-0.223000.000000.00000excludedK562EFTUD2
SEALAS2ENSG00000158578.14chrX-550541835505429055051150550512735505737455057410-0.365000.000870.04641excludedK562EFTUD2
SEALAS2ENSG00000158578.14chrX-550541835505429055052252550524485505737455057410-0.106000.000120.07596excludedK562SSB
SEALAS2ENSG00000158578.14chrX-5505418355054290550522525505244855057374550574100.055000.001910.04465includedK562RBM15
SEALAS2ENSG00000158578.14chrX-550541835505429055052252550524485505737455057410-0.099000.000010.00580excludedK562SERBP1
MXEALAS2ENSG00000158578.14chrX-5504117955041448550420105504217555039918550400815504391855044098-0.178000.000000.000022includedK562UCHL5
MXEALAS2ENSG00000158578.14chrX-5504117955041448550420105504217555039918550400815504391855044098-0.188000.000000.000022includedK562XRN2
MXEALAS2ENSG00000158578.14chrX-5505115055051273550522525505244855047484550477075505737455057410-0.173000.000040.001202includedK562U2AF2
MXEALAS2ENSG00000158578.14chrX-5504117955041448550420105504217555039918550400815504391855044098-0.154000.000020.001292includedK562EFTUD2
MXEALAS2ENSG00000158578.14chrX-5504117955041448550420105504217555039918550400815504391855044098-0.066000.000500.086462includedK562EXOSC5
MXEALAS2ENSG00000158578.14chrX-5504117955041325550420105504217555039918550400815504391855044098-0.193000.000000.000002includedK562SUPV3L1
MXEALAS2ENSG00000158578.14chrX-5504117955041370550420105504217555039918550400815504391855044098-0.192000.000000.000002includedK562SUPV3L1
MXEALAS2ENSG00000158578.14chrX-5504117955041448550420105504217555039918550400815504391855044098-0.191000.000000.000002includedK562SUPV3L1
MXEALAS2ENSG00000158578.14chrX-5504117955041448550420105504217555039918550400815504391855044098-0.138000.000200.021782includedK562SERBP1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for ALAS2 is not avaliable on ENCORE database.