PPARGC1A

General Information

Gene Name       : PPARGC1A
Gene ID             : ENSG00000109819.8
Essential Gene : No

Functions

Localization

Domains (AlphaFold: PPARGC1A)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PPARGC1AENSG00000109819.80.000.000.00ENCSR000AEF
HepG2PPARGC1AENSG00000109819.87.077.147.11ENCSR985KAT
K562PPARGC1AENSG00000109819.80.000.000.00ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
PPARGC1AENCAB400DQWPA5-72948TL2688208Released, ENCODE4


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
PPARGC1AK562CRISPRBGKcLV15-45,BGKcLV15-46BGKcLV15-1,BGKcLV15-20.0,0.0NotSatisfiedENCODE4
PPARGC1AK562CRISPRBGKcLV19-33,BGKcLV19-34BGKcLV19-1,BGKcLV19-20.0,0.0NotSatisfiedENCODE4
PPARGC1AHepG2CRISPRBGHcLV16-39,BGHcLV16-40BGHcLV16-1,BGHcLV16-20.0,0.0NotSatisfiedENCODE4
PPARGC1AHepG2CRISPRBGHcLV16-41,BGHcLV16-42BGHcLV16-1,BGHcLV16-20.0,0.0NotSatisfiedENCODE4


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
PPARGC1AProduct_ID: PA5-72948
Lot_ID: TL2688208
Source: Thermo Fisher
Target Name: PPARGC1A-human		 ThermoFisher_PA5-72948_TL2688208_PPARGC1A.png<br>Caption: IP-WB analysis of K562 whole cell lysate using the PPARGC1A specific antibody, PA5-72948. Lane 1 is 2.5% of five million whole cell lysate input. Lanes 2 and 3 are 50% of IP enrichment from five million whole cell lysate using normal IgG antibody and the PPARGC1A-specific antibody, PA5-72948. The same antibody was used to detect protein levels via Western blot. This antibody passes preliminary validation and will be further pursued for secondary validation. *NOTE* Protein sizes are taken from Genecards.org and are only estimates based on sequence. Actual protein size may differ based on protein characteristics and electrophoresis method used.








RNA Targets

  • eCLIP assay for PPARGC1A is not avaliable on ENCORE database.



Proteins bound to RNA
  • PPARGC1A RNA is bound by 13 proteins.  







eCLIP assay for PPARGC1A is not avaliable on ENCORE database.





13 proteins are bound to PPARGC1A RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr42381618223816240-3'-UTR,CDS,intron-Distal,intron-Proximal4.871866.65517HepG2U2AF2
chr42381604323816106-3'-UTR,CDS,intron-Distal3.045146.80151HepG2BCLAF1
chr42381556023815615-3'-UTR,CDS,intron-Distal3.363147.66871HepG2BCLAF1
chr42388631023886418-3'-UTR,CDS,intron-Distal,intron-Proximal4.096166.23016HepG2PRPF8
chr42379702023797085-3'-UTR,intron-Distal3.751836.36219HepG2SRSF7
chr42379708523797152-3'-UTR,intron-Distal4.709064.36861HepG2SRSF7
chr42379700623797128-3'-UTR,intron-Distal4.0849916.03836HepG2IGF2BP1
chr42381550223815560-3'-UTR,CDS,intron-Distal3.585956.60490HepG2BCLAF1
chr42388575123885815-3'-UTR,intron-Distal4.566614.79708HepG2U2AF2
chr42381528423815350-3'-UTR,CDS,intron-Distal,intron-Proximal3.992045.90868HepG2PRPF8
chr42380340523803467-3'-UTR,CDS,intron-Distal3.176664.61799HepG2BCLAF1
chr42381609323816168-3'-UTR,CDS,intron-Distal3.934843.73296HepG2IGF2BP1
chr42379730423797360-3'-UTR,intron-Distal,intron-Proximal3.819364.51739HepG2BCLAF1
chr42379636923796463-3'-UTR,intron-Distal5.037038.88779HepG2LIN28B
chr42389156223891592-5'-UTR,CDS,intron-Distal3.969143.02457HepG2BCLAF1
chr42389153223891603-5'-UTR,CDS,intron-Distal3.267213.41665HepG2GRWD1
chr42382609023826137-CDS,intron-Distal,intron-Proximal4.093473.62357HepG2U2AF2
chr42383116223831242-CDS,intron-Distal,intron-Proximal5.329514.45977HepG2U2AF2
chr42383314723833248-CDS,intron-Distal,intron-Proximal4.730264.68690HepG2PRPF8
chr42382998323830027-CDS,intron-Distal,intron-Proximal4.927655.60100HepG2PRPF8
chr42380713123807208-intron-Distal4.074273.39864HepG2SUGP2
chr42387512523875198-intron-Distal3.037334.89395HepG2SUGP2
chr42380364123803707-intron-Distal3.192384.57751HepG2U2AF2
chr42380291523803049-intron-Distal3.497823.12167HepG2FUBP3
chr42387767023877765-intron-Distal3.385094.09242HepG2QKI
chr42382940723829532-intron-Distal4.8542319.36431HepG2PTBP1
chr42385578823855933-intron-Distal5.6763911.90344HepG2QKI
chr42380933923809411-intron-Distal3.797846.22518HepG2HNRNPL
chr42387109923871142-intron-Distal3.914773.54208HepG2SUGP2
chr42383704123837164-intron-Distal4.8463913.97732HepG2HNRNPL
chr42387389623873972-intron-Distal4.0149511.48892HepG2SUGP2
chr42387380623873870-intron-Distal3.137166.34497HepG2SUGP2
chr42387362123873711-intron-Distal3.212083.57598HepG2MATR3
chr42377862823778736-intron-Distal4.246725.82272HepG2HNRNPL
chr42378833723788448-intron-Distal4.375787.02083HepG2PTBP1
chr42382367723823770-intron-Distal3.261503.02891HepG2HNRNPL
chr42382796723828044-intron-Distal3.074454.38902HepG2HNRNPL
chr42377640223776499-intron-Distal4.556883.79000HepG2U2AF2
chr42387478023874810-intron-Distal4.111274.03915HepG2SUGP2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PPARGC1A is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PPARGC1A is not available on ENCORE database.

  • 134 RBPs can affect the levels of PPARGC1A.  








The Knockdown/knockout RNA-Seq assay for PPARGC1A is not available on ENCORE database.





134 RBPs can affect the gene expression of PPARGC1A :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PPARGC1AENSG00000109819.4699.21120953.89400-0.448103.755402.51670HepG2AATF
PPARGC1AENSG00000109819.4697.196601690.28960-1.2776022.2794020.11710HepG2ABCF1
PPARGC1AENSG00000109819.4339.762101204.72680-1.8261075.2211073.17360HepG2ACO1
PPARGC1AENSG00000109819.4331.657502131.47960-2.6841075.0415072.89800HepG2AKAP1
PPARGC1AENSG00000109819.4649.541401668.16070-1.360808.939107.18230HepG2AKAP8
PPARGC1AENSG00000109819.4456.196001210.33050-1.4077045.4142042.96890HepG2AKAP8L
PPARGC1AENSG00000109819.4674.577901263.19890-0.905004.460402.28020HepG2APOBEC3C
PPARGC1AENSG00000109819.42049.552901525.298600.426104.427602.68270HepG2ATP5C1
PPARGC1AENSG00000109819.41161.995601447.42700-0.316903.666902.89660HepG2AUH
PPARGC1AENSG00000109819.4234.09390685.06040-1.549108.724007.02210HepG2BCCIP
PPARGC1AENSG00000109819.4126.84600918.54990-2.8563016.5679015.28080HepG2BOP1
PPARGC1AENSG00000109819.4769.955401497.59490-0.9598019.6080017.90160HepG2CALR
PPARGC1AENSG00000109819.4665.022302096.76150-1.6567029.6902026.78600HepG2CCAR1
PPARGC1AENSG00000109819.41121.255201675.56310-0.579506.020604.91060HepG2CIRBP
PPARGC1AENSG00000109819.4686.200801204.39710-0.8116020.4769019.03640HepG2CKAP4
PPARGC1AENSG00000109819.4572.165801352.70370-1.2413012.6573011.06660HepG2CNOT7
PPARGC1AENSG00000109819.4306.81950843.22870-1.458507.154106.09020HepG2CPSF6
PPARGC1AENSG00000109819.41729.437601391.973600.313102.648101.56650HepG2CPSF7
PPARGC1AENSG00000109819.4858.607501301.17100-0.599709.980208.90470HepG2CELF1
PPARGC1AENSG00000109819.4758.962101114.16850-0.5539010.061708.66450HepG2DDX19B
PPARGC1AENSG00000109819.4277.561201052.49190-1.9229047.8963045.59200HepG2DDX21
PPARGC1AENSG00000109819.4816.417601029.89660-0.335102.651801.75920HepG2DDX24
PPARGC1AENSG00000109819.4339.39650630.31330-0.893102.688301.41670HepG2DDX27
PPARGC1AENSG00000109819.4537.319502041.80400-1.9260049.2657046.93960HepG2DDX3X
PPARGC1AENSG00000109819.4684.675801131.49200-0.724709.379907.17720HepG2DDX52
PPARGC1AENSG00000109819.4314.36770673.50250-1.099205.450604.41030HepG2DDX55
PPARGC1AENSG00000109819.4813.252201428.67420-0.8129011.068909.20770HepG2DDX5
PPARGC1AENSG00000109819.4629.865501152.57950-0.8718018.6613017.26010HepG2DKC1
PPARGC1AENSG00000109819.4375.703401013.13440-1.4312033.6499031.50460HepG2DNAJC21
PPARGC1AENSG00000109819.4776.778201004.31020-0.370603.989803.23550HepG2DNAJC2
PPARGC1AENSG00000109819.4481.228501350.12990-1.4883022.9447020.76560HepG2EEF2
PPARGC1AENSG00000109819.4474.826401125.64980-1.2453018.2356015.52740HepG2EFTUD2
PPARGC1AENSG00000109819.4604.554501686.11710-1.4798029.8383028.02690HepG2EIF2S1
PPARGC1AENSG00000109819.4612.541001096.07380-0.839509.302107.74100HepG2EIF3D
PPARGC1AENSG00000109819.4654.32100993.87680-0.603107.208305.60460HepG2EIF3G
PPARGC1AENSG00000109819.4581.722001863.36630-1.6795033.7043031.51680HepG2EIF4A3
PPARGC1AENSG00000109819.41054.013201814.23190-0.783506.960705.90000HepG2EIF4B
PPARGC1AENSG00000109819.41025.874901464.20720-0.513305.089703.65370HepG2ESF1
PPARGC1AENSG00000109819.41253.338101661.78880-0.407003.015202.39180HepG2ETF1
PPARGC1AENSG00000109819.4505.106101177.17310-1.2207025.6376023.36600HepG2EWSR1
PPARGC1AENSG00000109819.4569.440001706.78260-1.5837030.5605028.52580HepG2FIP1L1
PPARGC1AENSG00000109819.4898.94960560.656200.681005.671303.91550HepG2FKBP4
PPARGC1AENSG00000109819.4730.745901199.95040-0.715509.822908.38890HepG2FUBP3
PPARGC1AENSG00000109819.4687.933401409.61640-1.035004.078602.73390HepG2FUS
PPARGC1AENSG00000109819.4849.882801880.03200-1.1454019.9514018.27390HepG2FXR1
PPARGC1AENSG00000109819.4674.218701744.01930-1.3711024.9660023.04550HepG2G3BP1
PPARGC1AENSG00000109819.41012.994001851.48180-0.8701012.5402010.64220HepG2G3BP2
PPARGC1AENSG00000109819.4223.11870975.93270-2.1290037.6581034.97820HepG2GEMIN5
PPARGC1AENSG00000109819.4406.810701130.24530-1.474209.277407.37490HepG2GNB2L1
PPARGC1AENSG00000109819.4665.14130955.72800-0.522901.844501.31440HepG2GPKOW
PPARGC1AENSG00000109819.4685.364801252.14640-0.869507.480305.66840HepG2GRSF1
PPARGC1AENSG00000109819.4609.906201150.12800-0.9151022.0389019.73090HepG2HDGF
PPARGC1AENSG00000109819.4358.143901022.84180-1.5140030.5063028.79000HepG2HNRNPA1
PPARGC1AENSG00000109819.41766.547601285.791500.458207.739106.31690HepG2HNRNPA2B1
PPARGC1AENSG00000109819.4270.241701137.76300-2.0739050.6345048.15930HepG2HNRNPC
PPARGC1AENSG00000109819.4969.59210588.671200.7198011.7459010.40770HepG2HNRNPF
PPARGC1AENSG00000109819.4968.055601765.94490-0.8673013.3766011.95150HepG2HNRNPK
PPARGC1AENSG00000109819.4536.695101177.59510-1.1337022.4010020.20280HepG2HNRNPM
PPARGC1AENSG00000109819.4706.509001130.23780-0.677807.153006.21410HepG2HNRNPU
PPARGC1AENSG00000109819.41165.915001817.18020-0.640202.946801.67420HepG2HSPD1
PPARGC1AENSG00000109819.4975.30910579.666500.750507.412206.28040HepG2IGF2BP1
PPARGC1AENSG00000109819.4461.568601772.76250-1.9414049.8924047.46570HepG2IGF2BP2
PPARGC1AENSG00000109819.4381.745401663.64100-2.1237017.7551015.54210HepG2IGF2BP3
PPARGC1AENSG00000109819.4815.523301318.67570-0.693305.086803.27220HepG2ILF3
PPARGC1AENSG00000109819.41174.424101783.08680-0.602404.672203.33630HepG2KHSRP
PPARGC1AENSG00000109819.41285.731101101.229100.223402.396601.44640HepG2KIF1C
PPARGC1AENSG00000109819.41336.150702213.98360-0.728607.140805.79370HepG2LARP4
PPARGC1AENSG00000109819.4543.836501106.93310-1.025305.744204.12640HepG2LARP7
PPARGC1AENSG00000109819.4529.368301162.79540-1.135306.490804.67680HepG2LIN28B
PPARGC1AENSG00000109819.4591.240501880.68820-1.6694037.5812035.41750HepG2MAGOH
PPARGC1AENSG00000109819.4440.73680937.79940-1.089406.090303.77330HepG2MARK2
PPARGC1AENSG00000109819.4667.209801891.21850-1.5031028.1839026.35510HepG2MATR3
PPARGC1AENSG00000109819.4552.404701147.18920-1.054309.355307.54740HepG2METAP2
PPARGC1AENSG00000109819.4374.604401381.33980-1.8826055.6989052.95020HepG2MSI2
PPARGC1AENSG00000109819.4601.063001935.77080-1.6873037.3567035.23520HepG2NCBP2
PPARGC1AENSG00000109819.4825.360101387.31980-0.7492013.5885011.95700HepG2NOL12
PPARGC1AENSG00000109819.41521.11570808.834300.9111011.5987010.16520HepG2NSUN2
PPARGC1AENSG00000109819.4477.62770819.49130-0.778803.689301.84500HepG2PA2G4
PPARGC1AENSG00000109819.4676.632901236.26470-0.869506.004504.66030HepG2PABPC1
PPARGC1AENSG00000109819.4780.636101723.94630-1.1430018.7659016.93790HepG2PABPC4
PPARGC1AENSG00000109819.4808.207101118.69110-0.469003.823502.84570HepG2PARN
PPARGC1AENSG00000109819.4895.143401691.11900-0.9178026.2930024.74580HepG2PCBP1
PPARGC1AENSG00000109819.4684.37460906.41320-0.405402.889601.63090HepG2PKM
PPARGC1AENSG00000109819.4648.749501403.05220-1.112804.102302.63260HepG2PRPF6
PPARGC1AENSG00000109819.4267.03800519.84600-0.961004.532003.52550HepG2PRPF8
PPARGC1AENSG00000109819.4881.364501720.84260-0.9653028.0234026.63530HepG2PTBP1
PPARGC1AENSG00000109819.4650.358501324.31910-1.0259018.7517017.38300HepG2PUF60
PPARGC1AENSG00000109819.41099.300501405.82430-0.354805.519804.74230HepG2PUM1
PPARGC1AENSG00000109819.4595.143701404.79680-1.2391030.6721028.61200HepG2PUM2
PPARGC1AENSG00000109819.4708.384801227.08250-0.7926018.8919017.54120HepG2PUS1
PPARGC1AENSG00000109819.4976.847001863.57480-0.9319022.1842020.66410HepG2QKI
PPARGC1AENSG00000109819.41149.915301981.67790-0.7852015.7277013.95630HepG2RBM15
PPARGC1AENSG00000109819.4160.800401388.95860-3.11070140.67450138.15200HepG2RBM22
PPARGC1AENSG00000109819.4658.914501334.71630-1.018404.638703.33340HepG2RBM27
PPARGC1AENSG00000109819.4404.807201083.84230-1.420808.721306.84740HepG2RCC2
PPARGC1AENSG00000109819.4346.817201915.07790-2.46520137.23480134.95570HepG2NELFE
PPARGC1AENSG00000109819.4861.644501783.73400-1.0497024.9625023.43670HepG2RECQL
PPARGC1AENSG00000109819.4280.336301066.46470-1.9276032.6084030.89540HepG2RPS19
PPARGC1AENSG00000109819.4289.630801231.07660-2.0876015.5920013.80950HepG2RPS2
PPARGC1AENSG00000109819.4995.213701357.99240-0.448402.678101.89060HepG2RPS3A
PPARGC1AENSG00000109819.4773.204601256.53880-0.700503.246002.07650HepG2RPS5
PPARGC1AENSG00000109819.4575.227401070.46380-0.8960011.092809.26370HepG2SERBP1
PPARGC1AENSG00000109819.4278.714101643.21370-2.5597056.1105053.00090HepG2SF3A3
PPARGC1AENSG00000109819.41232.316701791.50130-0.5398010.139109.11270HepG2SF3B4
PPARGC1AENSG00000109819.41749.941901269.817800.462604.255803.41240HepG2SLBP
PPARGC1AENSG00000109819.4422.024201173.71210-1.4757034.6639032.82100HepG2SMN1
PPARGC1AENSG00000109819.4556.098101311.45780-1.237805.923904.48160HepG2SMNDC1
PPARGC1AENSG00000109819.4689.918101568.79650-1.1852041.3023039.96290HepG2SRFBP1
PPARGC1AENSG00000109819.4967.40650641.575900.592405.580403.41280HepG2SRP68
PPARGC1AENSG00000109819.4445.835701869.98760-2.06840109.38250107.46430HepG2SRSF1
PPARGC1AENSG00000109819.4736.834901307.57350-0.8275018.6480017.22460HepG2SRSF5
PPARGC1AENSG00000109819.4989.39590578.372800.7744013.6432012.29930HepG2SRSF7
PPARGC1AENSG00000109819.41067.852001521.37600-0.510709.361908.45190HepG2SRSF9
PPARGC1AENSG00000109819.4881.285801362.11960-0.6282012.2960011.36600HepG2SSB
PPARGC1AENSG00000109819.4471.712901140.00050-1.2731013.7132011.25140HepG2STAU1
PPARGC1AENSG00000109819.4719.014101181.19200-0.716206.125804.43410HepG2STIP1
PPARGC1AENSG00000109819.41715.518701203.790800.511002.429201.30600HepG2SUB1
PPARGC1AENSG00000109819.4542.037001487.07020-1.4560059.0493056.87910HepG2SUCLG1
PPARGC1AENSG00000109819.4619.719001152.48560-0.8951014.6652012.63250HepG2SUPT6H
PPARGC1AENSG00000109819.4221.11220670.54640-1.600608.849307.75130HepG2SUPV3L1
PPARGC1AENSG00000109819.4422.076601098.08500-1.3794025.4593024.23000HepG2TIAL1
PPARGC1AENSG00000109819.4751.778701108.06440-0.559708.095707.21030HepG2TRIM56
PPARGC1AENSG00000109819.4619.76870871.00310-0.490903.051401.41680HepG2TROVE2
PPARGC1AENSG00000109819.4917.076301460.03110-0.670908.092607.02000HepG2U2AF1
PPARGC1AENSG00000109819.4699.849502074.54980-1.567703.578802.45340HepG2U2AF2
PPARGC1AENSG00000109819.4880.036001369.47380-0.638005.748504.51270HepG2UBE2L3
PPARGC1AENSG00000109819.4384.965001457.28340-1.9205059.1996056.91460HepG2UPF1
PPARGC1AENSG00000109819.4270.98910614.23930-1.180604.584603.27460HepG2UPF2
PPARGC1AENSG00000109819.4247.136101406.94360-2.5092099.8831097.15040HepG2UTP3
PPARGC1AENSG00000109819.4565.546601216.33890-1.1048012.195509.97020HepG2XPO5
PPARGC1AENSG00000109819.4327.913101416.35450-2.110809.470107.63920HepG2XRCC6
PPARGC1AENSG00000109819.4287.55910660.07680-1.198806.223505.15090HepG2XRN2
PPARGC1AENSG00000109819.4480.293301174.00130-1.2894042.6550040.67540HepG2ZC3H8
PPARGC1AENSG00000109819.4575.896501602.72700-1.4766052.1552050.55200HepG2ZNF622
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PPARGC1A is not available on ENCORE database.





1 RBPs can affect the splicing of PPARGC1A :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
MXEPPARGC1AENSG00000109819.4chr4-2381436923814490238146432381474823803846238039682381531223816228-0.198000.000100.015302includedHepG2PCBP2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PPARGC1A is not avaliable on ENCORE database.