MAP2K1

General Information

Gene Name       : MAP2K1
Gene ID             : ENSG00000169032.9
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: MAP2K1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878MAP2K1ENSG00000169032.926.2332.1429.19ENCSR000AEF
HepG2MAP2K1ENSG00000169032.916.8926.5221.70ENCSR985KAT
K562MAP2K1ENSG00000169032.930.5427.8729.20ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for MAP2K1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • MAP2K1 RNA is bound by 28 proteins.  







eCLIP assay for MAP2K1 is not avaliable on ENCORE database.





28 proteins are bound to MAP2K1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr156678372466783779+3'-UTR4.9732127.36324K562PUM2
chr156678347666783534+3'-UTR4.384355.22498HepG2TIAL1
chr156678378766783861+3'-UTR5.4908422.45467K562QKI
chr156678318466783228+3'-UTR4.409746.41483HepG2SUB1
chr156678313766783216+3'-UTR4.7122412.38199HepG2FUBP3
chr156678370566783782+3'-UTR5.8150413.07555K562IGF2BP1
chr156678356866783595+3'-UTR3.857583.25175K562YBX3
chr156678323866783299+3'-UTR3.143313.50904K562LIN28B
chr156678371666783765+3'-UTR3.770895.55970K562YBX3
chr156678335766783409+3'-UTR3.340254.30970K562IGF2BP2
chr156678360566783655+3'-UTR5.438837.60469HepG2FUBP3
chr156678366366783750+3'-UTR5.343766.87924HepG2FUBP3
chr156667933766679454+5'-UTR4.358187.67648K562GEMIN5
chr156667936866679443+5'-UTR3.8624524.20352HepG2DDX3X
chr156667930166679368+5'-UTR4.4821529.90724HepG2DDX3X
chr156667934566679427+5'-UTR3.0030712.78795K562DDX3X
chr156667954566679634+5'-UTR5.5032019.67840HepG2DDX3X
chr156667934866679430+5'-UTR5.382466.74617K562DDX6
chr156667934366679416+5'-UTR3.837754.12910K562DROSHA
chr156667927266679345+5'-UTR4.1158211.03951K562DDX3X
chr156667936866679450+5'-UTR3.983226.83645K562FTO
chr156677740366777531+CDS,intron-Proximal4.228838.81535HepG2G3BP1
chr156677403566774128+CDS,intron-Proximal4.919425.13952K562SF3B4
chr156672743566727550+CDS3.1533210.93472K562ZNF622
chr156672745066727542+CDS3.235935.29881K562ZNF800
chr156672749666727570+CDS3.587867.91657HepG2PPIG
chr156677410866774196+CDS3.035656.89415K562YBX3
chr156678205466782091+CDS,intron-Proximal4.219997.06234K562PUM2
chr156678161266781660+CDS,intron-Proximal3.492114.98672K562AQR
chr156677412866774191+CDS3.267183.05161HepG2PPIG
chr156673562466735696+CDS,intron-Proximal3.406385.15776HepG2BCLAF1
chr156678156966781615+CDS,intron-Proximal4.005575.38549K562PUM2
chr156678149466781573+CDS,intron-Proximal5.143396.40247K562SF3B4
chr156674183366741903+intron-Distal3.892463.65589K562SAFB2
chr156672063466720722+intron-Distal4.611253.26170K562EIF4G2
chr156674074966740853+intron-Distal4.053994.37667K562SAFB2
chr156674483766744913+intron-Distal3.629995.53469K562SAFB2
chr156675319766753294+intron-Distal3.348653.46130HepG2PRPF4
chr156672525766725395+intron-Distal5.072255.14653K562EIF4G2
chr156675103766751090+intron-Distal3.244153.20171HepG2ILF3
chr156673778566737904+intron-Distal3.393583.84589K562HNRNPL
chr156673117666731333+intron-Distal4.414773.84389HepG2SUGP2
chr156669496366695107+intron-Distal3.678595.35459K562KHSRP
chr156673780366737893+intron-Distal4.088683.19026HepG2HNRNPL
chr156674550866745615+intron-Distal3.150733.73364K562SAFB2
chr156677424066774293+intron-Proximal4.699634.65563K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for MAP2K1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for MAP2K1 is not available on ENCORE database.

  • 116 RBPs can affect the levels of MAP2K1.  








The Knockdown/knockout RNA-Seq assay for MAP2K1 is not available on ENCORE database.





116 RBPs can affect the gene expression of MAP2K1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
MAP2K1ENSG00000169032.5582.23970958.80640-0.719606.425705.05640HepG2ABCF1
MAP2K1ENSG00000169032.51449.161701222.072500.245802.736702.13220HepG2ACO1
MAP2K1ENSG00000169032.5631.23340876.70250-0.473903.663502.53560HepG2ADAR
MAP2K1ENSG00000169032.5995.315401227.82660-0.302903.237602.41450HepG2AKAP8L
MAP2K1ENSG00000169032.52153.331501438.226900.5822013.3396012.03020HepG2AUH
MAP2K1ENSG00000169032.5581.674901015.48820-0.803906.989405.46050HepG2BCCIP
MAP2K1ENSG00000169032.5834.15270503.100600.729407.784606.84360HepG2BOP1
MAP2K1ENSG00000169032.51269.758001597.26080-0.331002.301101.59150HepG2CIRBP
MAP2K1ENSG00000169032.5783.807801221.82190-0.6405013.6967012.44900HepG2CKAP4
MAP2K1ENSG00000169032.51062.22450789.385800.428203.553402.30240HepG2CPSF7
MAP2K1ENSG00000169032.51118.19200899.040900.314602.899601.85680HepG2YBX3
MAP2K1ENSG00000169032.5404.11180627.33480-0.634504.976703.59030HepG2CSTF2
MAP2K1ENSG00000169032.52073.528601481.449900.485008.378207.37490HepG2CELF1
MAP2K1ENSG00000169032.5813.689301130.24890-0.474107.786206.50680HepG2DDX19B
MAP2K1ENSG00000169032.5620.83540948.70560-0.611706.367805.38750HepG2DDX21
MAP2K1ENSG00000169032.5697.54360928.58780-0.412803.516102.47750HepG2DDX24
MAP2K1ENSG00000169032.5808.85910524.484100.624903.061902.03520HepG2DDX59
MAP2K1ENSG00000169032.52925.118701672.156500.806709.750208.66610HepG2DDX6
MAP2K1ENSG00000169032.5496.487101169.19610-1.2357034.3124032.61900HepG2DKC1
MAP2K1ENSG00000169032.5687.93790874.98770-0.347003.983803.22970HepG2DNAJC2
MAP2K1ENSG00000169032.5571.04190787.49010-0.463703.066202.09830HepG2EEF2
MAP2K1ENSG00000169032.51147.875801607.25850-0.485604.120703.40600HepG2EIF2S1
MAP2K1ENSG00000169032.5577.15690727.17740-0.333302.390501.30530HepG2EIF2S2
MAP2K1ENSG00000169032.5655.07560896.03690-0.451904.200402.90230HepG2EIF3G
MAP2K1ENSG00000169032.5596.183501776.10020-1.5749030.1963028.12550HepG2EIF4A3
MAP2K1ENSG00000169032.51325.919001571.53180-0.245202.715701.88510HepG2EIF4G1
MAP2K1ENSG00000169032.5585.81470830.43310-0.503404.254802.92910HepG2ESF1
MAP2K1ENSG00000169032.51058.85080831.059400.349402.545901.32510HepG2FKBP4
MAP2K1ENSG00000169032.51400.330601792.34160-0.356102.591501.92260HepG2FXR1
MAP2K1ENSG00000169032.51223.705901662.48560-0.442103.401502.66710HepG2G3BP1
MAP2K1ENSG00000169032.51142.970301765.16910-0.627006.982305.55310HepG2G3BP2
MAP2K1ENSG00000169032.5409.21680569.20110-0.476103.064702.11790HepG2GEMIN5
MAP2K1ENSG00000169032.5307.48200523.53410-0.767805.587004.69870HepG2GPKOW
MAP2K1ENSG00000169032.5759.538501215.15920-0.678004.822403.36360HepG2GRSF1
MAP2K1ENSG00000169032.5493.49350891.26480-0.8528010.466709.33260HepG2HNRNPA1
MAP2K1ENSG00000169032.5387.36370991.35930-1.3557024.2639022.44780HepG2HNRNPC
MAP2K1ENSG00000169032.5885.34810722.406000.293302.478901.79820HepG2HNRNPF
MAP2K1ENSG00000169032.5502.62670667.83870-0.410003.096002.09160HepG2HNRNPM
MAP2K1ENSG00000169032.5653.82280984.80560-0.590909.102308.05070HepG2HNRNPU
MAP2K1ENSG00000169032.5550.210801023.87850-0.896008.541206.45070HepG2HSPD1
MAP2K1ENSG00000169032.51017.471601586.07100-0.640502.177801.31380HepG2IGF2BP3
MAP2K1ENSG00000169032.5853.760301005.94770-0.236702.330701.65080HepG2ILF2
MAP2K1ENSG00000169032.5857.043301314.38780-0.617004.739703.64370HepG2LARP4
MAP2K1ENSG00000169032.5714.67370947.20290-0.406402.772801.55750HepG2LIN28B
MAP2K1ENSG00000169032.51043.341201792.96890-0.781109.693608.48360HepG2MAGOH
MAP2K1ENSG00000169032.51149.434601802.95010-0.649406.315705.39370HepG2MATR3
MAP2K1ENSG00000169032.5891.216901845.37590-1.0501015.9504014.51420HepG2NCBP2
MAP2K1ENSG00000169032.5601.00530916.66180-0.609002.654801.58520HepG2NONO
MAP2K1ENSG00000169032.52083.865701199.781100.796405.538704.25150HepG2PABPC1
MAP2K1ENSG00000169032.5546.58700974.79900-0.8347015.9383014.19700HepG2PARN
MAP2K1ENSG00000169032.51230.974701622.19440-0.398105.998105.15830HepG2PCBP1
MAP2K1ENSG00000169032.5320.84330528.66670-0.720507.095805.18460HepG2PKM
MAP2K1ENSG00000169032.5636.10800878.36930-0.465603.286602.48910HepG2PPIL4
MAP2K1ENSG00000169032.5206.17270517.11320-1.3266021.9440020.13290HepG2PRPF4
MAP2K1ENSG00000169032.5670.430601112.25080-0.730304.325602.82260HepG2PRPF6
MAP2K1ENSG00000169032.5450.64390770.34020-0.773506.735705.53660HepG2PRPF8
MAP2K1ENSG00000169032.51107.088901650.64430-0.5763011.1911010.23490HepG2PTBP1
MAP2K1ENSG00000169032.51113.521001507.88730-0.437404.625103.87720HepG2PUF60
MAP2K1ENSG00000169032.51177.016001600.64700-0.443509.257708.30590HepG2PUM1
MAP2K1ENSG00000169032.51059.584601599.50390-0.594109.211508.02360HepG2PUM2
MAP2K1ENSG00000169032.5962.777501244.76230-0.370605.050704.26330HepG2PUS1
MAP2K1ENSG00000169032.51402.617401021.066400.457902.067801.45060HepG2RAVER1
MAP2K1ENSG00000169032.51394.557301119.981600.316202.786501.92770HepG2RBM15
MAP2K1ENSG00000169032.5767.731701087.55350-0.502403.812902.63600HepG2RBM27
MAP2K1ENSG00000169032.51001.386101837.00790-0.8754024.0302022.75010HepG2NELFE
MAP2K1ENSG00000169032.5957.120501710.92440-0.8380022.2441020.78610HepG2RECQL
MAP2K1ENSG00000169032.5311.20030622.03690-0.9992012.4837011.29070HepG2RPS19
MAP2K1ENSG00000169032.5608.016901003.05360-0.722207.365206.09830HepG2RPS2
MAP2K1ENSG00000169032.5753.319701318.08090-0.807107.249605.96590HepG2RPS3A
MAP2K1ENSG00000169032.5764.573301023.85580-0.421302.759401.68720HepG2RPS5
MAP2K1ENSG00000169032.5566.36240762.04050-0.428102.232901.51950HepG2RRP9
MAP2K1ENSG00000169032.5408.22340624.32890-0.612904.645103.44140HepG2SERBP1
MAP2K1ENSG00000169032.51282.340301718.53230-0.422406.565705.71700HepG2SF3B4
MAP2K1ENSG00000169032.5683.817301022.75880-0.5808010.644509.51560HepG2SMN1
MAP2K1ENSG00000169032.52611.854701558.807500.7445025.3053024.18790HepG2SRFBP1
MAP2K1ENSG00000169032.5882.063001793.77630-1.0240033.3525032.10890HepG2SRSF1
MAP2K1ENSG00000169032.51200.173101488.76880-0.310903.862903.14470HepG2SRSF5
MAP2K1ENSG00000169032.5886.08310709.749200.320002.854802.14830HepG2SRSF7
MAP2K1ENSG00000169032.52058.496801459.333000.4962010.608509.65180HepG2SRSF9
MAP2K1ENSG00000169032.5683.384301353.47960-0.9859019.5201018.42300HepG2SSB
MAP2K1ENSG00000169032.5758.344001020.17140-0.427902.789101.50270HepG2SSRP1
MAP2K1ENSG00000169032.51268.694201693.18330-0.416407.724106.77140HepG2SUCLG1
MAP2K1ENSG00000169032.5733.88210993.94350-0.437602.390301.75560HepG2SUPV3L1
MAP2K1ENSG00000169032.5980.587401612.31770-0.7174014.3008013.17220HepG2TAF15
MAP2K1ENSG00000169032.5612.468901002.03830-0.710203.217102.06790HepG2TBRG4
MAP2K1ENSG00000169032.5366.57800956.95290-1.3843031.4107030.05570HepG2TIAL1
MAP2K1ENSG00000169032.5638.016201025.15550-0.684204.755902.85710HepG2TRA2A
MAP2K1ENSG00000169032.5810.167401473.07360-0.8625015.5301013.28240HepG2TUFM
MAP2K1ENSG00000169032.5364.04600910.26150-1.3222013.3604011.07260HepG2UPF2
MAP2K1ENSG00000169032.5756.59380974.69300-0.365403.693802.50300HepG2UTP18
MAP2K1ENSG00000169032.5772.699401122.84270-0.539203.346402.17680HepG2XRCC6
MAP2K1ENSG00000169032.5463.89050978.42710-1.0767013.4006011.82570HepG2XRN2
MAP2K1ENSG00000169032.51384.451501042.933000.408607.068406.29940HepG2ZNF622
MAP2K1ENSG00000169032.52226.720001547.734800.524707.540106.66880K562AGGF1
MAP2K1ENSG00000169032.52319.570101610.512800.526206.932205.85880K562AKAP8L
MAP2K1ENSG00000169032.5442.80380646.53050-0.546104.176602.82330K562CCAR1
MAP2K1ENSG00000169032.5541.07640723.74580-0.419702.826301.48240K562DHX30
MAP2K1ENSG00000169032.5382.94070657.65120-0.780204.400503.10420K562EIF3A
MAP2K1ENSG00000169032.51321.786701601.25740-0.276702.043401.33510K562EIF4A3
MAP2K1ENSG00000169032.5808.091001049.46520-0.377103.248101.86200K562EXOSC5
MAP2K1ENSG00000169032.51364.372901665.23930-0.287503.085002.45100K562FXR1
MAP2K1ENSG00000169032.51730.121402212.73810-0.355003.623502.76250K562GRSF1
MAP2K1ENSG00000169032.5531.561001214.83110-1.1924023.7445022.06710K562HNRNPC
MAP2K1ENSG00000169032.51740.976502140.70970-0.298203.371102.38690K562HNRNPU
MAP2K1ENSG00000169032.5998.775501439.61440-0.527504.644503.61900K562HSPD1
MAP2K1ENSG00000169032.5887.962301232.19320-0.472703.808402.02770K562LIN28B
MAP2K1ENSG00000169032.51805.579901342.005300.428002.086801.34290K562NAA15
MAP2K1ENSG00000169032.51427.488901651.44070-0.210202.567901.84510K562NSUN2
MAP2K1ENSG00000169032.5771.215001196.17370-0.633205.614103.31180K562NUSAP1
MAP2K1ENSG00000169032.5932.325801334.91580-0.517804.400803.35260K562PCBP3
MAP2K1ENSG00000169032.5817.466601186.08050-0.537005.546903.44880K562PHF6
MAP2K1ENSG00000169032.51499.380702118.27790-0.498504.677002.55580K562PKM
MAP2K1ENSG00000169032.52189.707602831.27580-0.370703.724602.06690K562PNPT1
MAP2K1ENSG00000169032.5684.374201023.92860-0.581306.757005.51580K562POLR2G
MAP2K1ENSG00000169032.5656.919901089.23350-0.729508.616906.82810K562PSIP1
MAP2K1ENSG00000169032.52602.086303133.03110-0.267903.687002.57810K562PUM2
MAP2K1ENSG00000169032.52447.731101597.011000.616008.250407.36170K562PUS1
MAP2K1ENSG00000169032.52038.930801556.192300.389705.345904.54640K562RBM15
MAP2K1ENSG00000169032.5712.16880993.83360-0.480804.656003.36600K562RCC2
MAP2K1ENSG00000169032.5544.71260912.33670-0.744109.016107.12560K562SAFB
MAP2K1ENSG00000169032.5714.08160943.25410-0.401603.007801.49450K562SDAD1
MAP2K1ENSG00000169032.5618.11760942.12260-0.608005.910704.25130K562SRFBP1
MAP2K1ENSG00000169032.51353.869301669.64460-0.302504.228903.09730K562SRPK2
MAP2K1ENSG00000169032.5899.335101165.48150-0.374003.728701.95470K562SRSF9
MAP2K1ENSG00000169032.5743.759201027.02340-0.465604.930603.82690K562SYNCRIP
MAP2K1ENSG00000169032.51437.670701844.41450-0.359402.898502.17430K562TARDBP
MAP2K1ENSG00000169032.5711.209801047.65450-0.558804.726403.47870K562TIAL1
MAP2K1ENSG00000169032.5775.040601113.05230-0.522204.916403.56820K562TRIM56
MAP2K1ENSG00000169032.5682.63580970.50500-0.507603.340001.37330K562TRNAU1AP
MAP2K1ENSG00000169032.51344.877301751.06410-0.380805.806304.80920K562UPF1
MAP2K1ENSG00000169032.51373.670302051.78830-0.578808.453405.71860K562UPF2
MAP2K1ENSG00000169032.51232.538401558.15090-0.338204.906603.80840K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for MAP2K1 is not available on ENCORE database.





6 RBPs can affect the splicing of MAP2K1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEMAP2K1ENSG00000169032.5chr15+667820556678210166781572667816146678283966784650-0.105000.000000.00017excludedK562SF3B4
SEMAP2K1ENSG00000169032.5chr15+667356176673569566729083667292306673699366737045-0.129000.000110.00217excludedHepG2U2AF2
SEMAP2K1ENSG00000169032.5chr15+667820556678210166781552667816146678283966784650-0.073000.000010.00031excludedK562AQR
SEMAP2K1ENSG00000169032.5chr15+667290836672923066727334667275756673699366737045-0.055000.000800.01012excludedK562AQR
SEMAP2K1ENSG00000169032.5chr15+667740926677421766736993667370456677732766777541-0.077000.000050.00101excludedK562AQR
SEMAP2K1ENSG00000169032.5chr15+667356176673569566729083667292306673699366737045-0.056000.000280.00792excludedK562U2AF1
SEMAP2K1ENSG00000169032.5chr15+667820556678210166781552667816146678283966784650-0.171000.000000.00000excludedK562U2AF2
SEMAP2K1ENSG00000169032.5chr15+667356176673569566729083667292306673699366737045-0.088000.000000.00007excludedK562U2AF2
MXEMAP2K1ENSG00000169032.5chr15+6677409266774217667795656677963066745791667458816678155266781614-0.206000.000020.000692includedHepG2SRSF1
MXEMAP2K1ENSG00000169032.5chr15+66736875667370456677732766777529667356176673569566779565667796300.113000.000000.000001includedK562AQR
MXEMAP2K1ENSG00000169032.5chr15+6678155266781614667820556678210166779565667796306678283966784650-0.084000.000030.002882includedK562SBDS
MXEMAP2K1ENSG00000169032.5chr15+66781572667816146678205566782101667795656677963066782839667836810.132000.000020.000611includedK562SF3B4

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for MAP2K1 is not avaliable on ENCORE database.