METTL3

General Information

Gene Name       : METTL3
Gene ID             : ENSG00000165819.11
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: METTL3)


Antibody Validation

 View validation images for all METTL3 antibodies

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878METTL3ENSG00000165819.1143.8348.5946.21ENCSR000AEF
HepG2METTL3ENSG00000165819.1189.82100.6395.22ENCSR985KAT
K562METTL3ENSG00000165819.1149.3750.3249.84ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
knockdown followed by RNA-seq METTL3-BGKcLV23-K562ENCSR335KFNMETTL3K562ReleasedENCSR877JEM   CRISPRKD% = 61.3,66.3
knockdown followed by RNA-seq METTL3-BGHcLV22-HepG2ENCSR884RELMETTL3HepG2ReleasedENCSR704VPL   CRISPRKD% = 71.3,87.0






  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
METTL3ENCAB373NTVA301-568A1BGHcLV22-31, Released, ENCODE4BGKcLV23-53, Released, ENCODE4
METTL386132S1Submitted, ENCORE2BGHcLV22-31, Released, ENCODE4BGKcLV23-53, Submitted, ENCORE2


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
METTL3K562CRISPRBGKcLV21-29,BGKcLV21-30BGKcLV21-1,BGKcLV21-20.0,0.0NotSatisfiedENCODE4
METTL3K562CRISPRENCSR335KFNENCSR877JEMMETTL3-BGKcLV23-53,METTL3-BGKcLV23-54NT-BGKcLV23-1,NT-BGKcLV23-261.3,66.3ReleasedENCODE4
METTL3HepG2CRISPRENCSR884RELENCSR704VPLMETTL3-BGHcLV22-31,METTL3-BGHcLV22-32NT-BGHcLV22-1,NT-BGHcLV22-271.3,87.0ReleasedENCODE4
METTL3HepG2CRISPRBGHcLV22-33,BGHcLV22-34BGHcLV22-1,BGHcLV22-245.9,58.0NotSatisfiedENCODE4


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
METTL3Product_ID: 86132S
Lot_ID: 1
Source: Cell Signaling Technology
Target Name: METTL3-human		 CST_86132S_1_METTL3.png<br>Caption: IP-WB analysis of 86132S whole cell lysate using the METTL3 specific antibody, 86132S. Lanes 1 and 2 are 2.5% of five million whole cell lysate input and 50% of IP enrichment, respectively, using a normal IgG antibody. Lane 3 is 50% of IP enrichment from five million whole cell lysate using the METTL3-specific antibody, 86132S. The same antibody was used to detect protein levels via Western blot. This antibody passes preliminary validation and will be further pursued for secondary validation. *NOTE* Protein sizes are taken from Genecards.org and are only estimates based on sequence. Actual protein size may differ based on protein characteristics and electrophoresis method used.
 METTL3-K562-CRISPR-86132S.png<br>Caption: Western blot following CRISPR against METTL3 in K562 whole cell lysate using METTL3 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against METTL3. METTL3 protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.
METTL3Product_ID: A301-568A
Lot_ID: 1
Source: Bethyl Labs
Target Name: METTL3-human		 METTL3-HEPG2-CRISPR-A301-568A.png<br>Caption: Western blot following CRISPR against METTL3 in HepG2 whole cell lysate using METTL3 specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against METTL3. METTL3 protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.
 METTL3-K562-CRISPR-A301-568A.png<br>Caption: Western blot following CRISPR against METTL3 in K562 whole cell lysate using METTL3 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against METTL3. METTL3 protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for METTL3 is not avaliable on ENCORE database.



Proteins bound to RNA
  • METTL3 RNA is bound by 18 proteins.  







eCLIP assay for METTL3 is not avaliable on ENCORE database.





18 proteins are bound to METTL3 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr142196716721967219-3'-UTR,CDS,intron-Distal,intron-Proximal3.862756.87794HepG2LSM11
chr142196743621967560-3'-UTR,CDS,intron-Distal,intron-Proximal3.414727.22029K562FUS
chr142196986821969956-3'-UTR,CDS,intron-Distal,intron-Proximal3.287868.50351HepG2BCLAF1
chr142196877921968820-3'-UTR,CDS,intron-Distal3.705184.52024HepG2PPIG
chr142196986421969967-3'-UTR,CDS,intron-Distal,intron-Proximal3.140826.54912HepG2GRWD1
chr142196745921967572-3'-UTR,CDS,intron-Distal,intron-Proximal3.484413.78855HepG2RBM5
chr142196866821968769-3'-UTR,CDS,intron-Distal3.468769.03599HepG2GRWD1
chr142196725221967327-3'-UTR,CDS,intron-Distal,intron-Proximal4.4991120.94432K562SF3B4
chr142196716621967228-3'-UTR,CDS,intron-Distal,intron-Proximal4.530155.02622HepG2SRSF1
chr142196790521967947-3'-UTR,CDS,intron-Distal,intron-Proximal3.384417.84823HepG2PPIG
chr142196759721967730-3'-UTR,CDS,intron-Distal,intron-Proximal3.543054.83391K562GRWD1
chr142196760221967715-3'-UTR,CDS,intron-Distal,intron-Proximal3.6417013.18299HepG2PPIG
chr142196904721969077-3'-UTR,CDS,intron-Distal,intron-Proximal3.266593.63043HepG2GRWD1
chr142196983121969903-3'-UTR,CDS,intron-Distal,intron-Proximal5.1628013.47152HepG2PRPF8
chr142196863521968668-3'-UTR,CDS,intron-Distal,intron-Proximal3.652286.15459HepG2GRWD1
chr142196919121969300-3'-UTR,CDS,intron-Distal,intron-Proximal3.328396.51722HepG2U2AF2
chr142197130621971374-3'-UTR,CDS,intron-Distal,intron-Proximal3.170816.02988K562UCHL5
chr142196716621967182-3'-UTR,CDS,intron-Distal,intron-Proximal3.806909.63482HepG2GRWD1
chr142196743621967536-3'-UTR,CDS,intron-Distal,intron-Proximal4.4597616.66938HepG2BCLAF1
chr142196761921967690-3'-UTR,CDS,intron-Distal,intron-Proximal3.5654613.68298HepG2BCLAF1
chr142196919221969235-3'-UTR,CDS,intron-Distal,intron-Proximal4.194724.72880HepG2GRWD1
chr142196735421967402-3'-UTR,intron-Distal,intron-Proximal3.325336.23972K562KHSRP
chr142196722121967295-3'-UTR,CDS,intron-Distal,intron-Proximal4.1465115.90466HepG2U2AF2
chr142196863521968667-3'-UTR,CDS,intron-Distal,intron-Proximal3.530806.00907HepG2PPIG
chr142196862721968648-3'-UTR,CDS,intron-Distal,intron-Proximal4.059623.71613K562UCHL5
chr142196637621966406-3'-UTR,CDS,intron-Distal3.902243.82000HepG2GRWD1
chr142196649021966514-3'-UTR,CDS,intron-Distal3.412704.85880HepG2PPIG
chr142196644021966514-3'-UTR,CDS,intron-Distal4.4120215.61961HepG2GRWD1
chr142196771921967757-3'-UTR,CDS,intron-Distal,intron-Proximal3.828897.37475HepG2U2AF2
chr142196644721966515-3'-UTR,CDS,intron-Distal5.015587.46830HepG2SRSF1
chr142196644521966477-3'-UTR,CDS,intron-Distal3.747103.32039HepG2PPIG
chr142196717921967202-3'-UTR,CDS,intron-Distal3.939938.34074HepG2PPIG
chr142196647821966515-3'-UTR,CDS,intron-Distal4.464515.83017HepG2LSM11
chr142197197321972034-3'-UTR,CDS,intron-Distal,intron-Proximal4.009676.32636HepG2U2AF2
chr142196642621966487-3'-UTR,CDS,intron-Distal3.326264.23325HepG2BCLAF1
chr142196771321967746-3'-UTR,CDS,intron-Distal,intron-Proximal3.481964.70460K562DDX24
chr142196769021967749-3'-UTR,CDS,intron-Distal,intron-Proximal3.226019.90630HepG2BCLAF1
chr142196743121967554-3'-UTR,CDS,intron-Distal,intron-Proximal3.781908.31280HepG2GRWD1
chr142196718221967210-3'-UTR,CDS,intron-Distal3.337609.22245HepG2GRWD1
chr142196634821966408-3'-UTR,CDS,intron-Distal3.990143.28818K562LSM11
chr142196643521966497-3'-UTR,CDS,intron-Distal3.292396.05769K562ZNF622
chr142196649721966514-3'-UTR,CDS,intron-Distal4.205797.93948K562ZNF622
chr142196978421969877-3'-UTR,CDS,intron-Distal,intron-Proximal5.169867.96842K562PRPF8
chr142197927121979399-5'-UTR,CDS,intron-Distal4.2441314.18457HepG2GRWD1
chr142197931821979419-5'-UTR,CDS,intron-Distal,intron-Proximal3.6379011.45752HepG2SRSF1
chr142197939121979450-5'-UTR,intron-Distal,intron-Proximal4.0324013.22798HepG2NCBP2
chr142197933521979391-5'-UTR,CDS,intron-Distal3.386688.23092HepG2NCBP2
chr142197945021979478-5'-UTR,intron-Distal,intron-Proximal3.924375.11373HepG2NCBP2
chr142197930921979371-5'-UTR,CDS,intron-Distal4.246043.62765K562SRSF1
chr142197926721979287-CDS,intron-Distal4.950555.68502HepG2PRPF8
chr142197919021979267-CDS,intron-Distal4.3176210.86325HepG2PRPF8
chr142197925021979322-CDS,intron-Distal3.8087110.97171HepG2BUD13
chr142197925521979318-CDS,intron-Distal3.483605.54148HepG2SRSF1
chr142196665821966704-intron-Distal5.7450312.93612HepG2QKI
chr142197919621979266-intron-Distal3.500685.40420HepG2AQR
chr142197583121975957-intron-Distal,intron-Proximal3.517425.04794HepG2KHSRP
chr142196670421966749-intron-Distal5.042517.68989HepG2QKI
chr142197121321971271-intron-Distal,intron-Proximal5.053616.84553HepG2U2AF2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for METTL3 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for METTL3 is not available on ENCORE database.

  • 118 RBPs can affect the levels of METTL3.  








The Knockdown/knockout RNA-Seq assay for METTL3 is not available on ENCORE database.





118 RBPs can affect the gene expression of METTL3 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
METTL3ENSG00000165819.7831.435701473.57830-0.8256022.7093021.34600HepG2ACO1
METTL3ENSG00000165819.72361.954601527.951700.628305.980605.23340HepG2AKAP1
METTL3ENSG00000165819.71104.783501480.50290-0.422306.290505.17790HepG2AKAP8L
METTL3ENSG00000165819.71111.643701430.48650-0.363803.126601.62950HepG2ATP5C1
METTL3ENSG00000165819.71214.019702427.49220-0.9997035.7794033.80710HepG2AUH
METTL3ENSG00000165819.7858.847301371.04510-0.674806.828805.48700HepG2BCLAF1
METTL3ENSG00000165819.7591.212901199.12330-1.0202016.5035015.22010HepG2BOP1
METTL3ENSG00000165819.7917.931101187.70410-0.371703.139501.82970HepG2BUD13
METTL3ENSG00000165819.7930.342001324.13800-0.509206.295505.19300HepG2CALR
METTL3ENSG00000165819.7902.492001473.25960-0.7070018.4514017.06440HepG2CKAP4
METTL3ENSG00000165819.7825.494201100.84730-0.415303.227702.49070HepG2CPSF6
METTL3ENSG00000165819.71041.455201305.47460-0.326002.661101.57750HepG2CPSF7
METTL3ENSG00000165819.7939.446401393.82560-0.569209.090607.27270HepG2YBX3
METTL3ENSG00000165819.7746.78980974.58750-0.384102.926601.82360HepG2CSTF2
METTL3ENSG00000165819.71855.917602375.57840-0.356105.188704.35830HepG2CELF1
METTL3ENSG00000165819.7749.893301343.49240-0.8412012.8908011.55940HepG2DDX21
METTL3ENSG00000165819.71012.518401314.64490-0.376703.575702.52940HepG2DDX24
METTL3ENSG00000165819.7758.080101463.59820-0.9491012.8922011.63540HepG2DDX3X
METTL3ENSG00000165819.71144.474101551.49120-0.439003.266302.43610HepG2DDX55
METTL3ENSG00000165819.7821.935001250.09730-0.604903.103602.06950HepG2DDX59
METTL3ENSG00000165819.71005.980501320.08650-0.392003.443402.35610HepG2DHX30
METTL3ENSG00000165819.7985.222801409.81550-0.517008.526107.46720HepG2DKC1
METTL3ENSG00000165819.7836.619601368.69900-0.7102013.4924012.03110HepG2DNAJC21
METTL3ENSG00000165819.71191.195501356.51600-0.187501.899701.34080HepG2DNAJC2
METTL3ENSG00000165819.7876.288101245.09980-0.506804.370503.23780HepG2EEF2
METTL3ENSG00000165819.7800.205401037.86860-0.375202.627901.54470HepG2EFTUD2
METTL3ENSG00000165819.7840.295301237.10420-0.558004.062402.70650HepG2AGO1
METTL3ENSG00000165819.7954.498601208.63100-0.340602.109601.58410HepG2EIF2S1
METTL3ENSG00000165819.71002.884601268.66770-0.339203.023101.90020HepG2EIF3G
METTL3ENSG00000165819.71265.182202414.00100-0.9321016.9376015.05240HepG2EIF4G2
METTL3ENSG00000165819.71461.695902787.13240-0.9311034.4705032.77640HepG2ETF1
METTL3ENSG00000165819.7659.50350903.42460-0.454004.513602.98490HepG2FAM120A
METTL3ENSG00000165819.7901.430401291.33980-0.518604.709303.08790HepG2FKBP4
METTL3ENSG00000165819.7663.112001102.76170-0.733802.931601.88510HepG2FTO
METTL3ENSG00000165819.71094.52430894.127100.291702.001901.32450HepG2FUBP3
METTL3ENSG00000165819.71027.128101454.40190-0.501804.624203.30470HepG2GNB2L1
METTL3ENSG00000165819.7455.343001247.85990-1.4544024.3122022.62520HepG2GPKOW
METTL3ENSG00000165819.7833.479001381.81050-0.729309.894108.78330HepG2HNRNPA1
METTL3ENSG00000165819.71691.933802347.50100-0.472508.974207.47150HepG2HNRNPA2B1
METTL3ENSG00000165819.71267.287501536.97650-0.278402.001901.40140HepG2HNRNPC
METTL3ENSG00000165819.71232.740901769.84570-0.5218010.497309.21660HepG2HNRNPF
METTL3ENSG00000165819.7684.123501190.85900-0.799709.551208.46220HepG2HNRNPLL
METTL3ENSG00000165819.71149.872501526.81730-0.409106.409505.51840HepG2HNRNPU
METTL3ENSG00000165819.71194.024601742.77680-0.545608.194307.01010HepG2IGF2BP1
METTL3ENSG00000165819.7752.141801270.71740-0.756608.608907.48910HepG2IGF2BP2
METTL3ENSG00000165819.71270.033301559.59880-0.296304.318703.42320HepG2ILF2
METTL3ENSG00000165819.71137.484101347.03630-0.243902.839001.81010HepG2KIF1C
METTL3ENSG00000165819.71166.022601885.95840-0.693706.346505.07620HepG2LARP4
METTL3ENSG00000165819.71132.211701496.03960-0.402003.790202.36860HepG2LIN28B
METTL3ENSG00000165819.7895.274601206.48630-0.430403.536801.72000HepG2MARK2
METTL3ENSG00000165819.7802.727601214.60060-0.597503.568302.45840HepG2MTPAP
METTL3ENSG00000165819.71086.122301387.67920-0.353502.245801.67200HepG2NCBP2
METTL3ENSG00000165819.7892.922401288.52680-0.529105.697403.65130HepG2NIP7
METTL3ENSG00000165819.72042.589102532.86530-0.310403.623702.75070HepG2NOL12
METTL3ENSG00000165819.7760.314501424.85970-0.906206.505804.80380HepG2NONO
METTL3ENSG00000165819.7782.790801055.95060-0.431803.324302.50370HepG2NSUN2
METTL3ENSG00000165819.7756.023001235.68610-0.708807.388406.22180HepG2PABPC4
METTL3ENSG00000165819.71271.183301511.32800-0.249602.586401.76410HepG2PARN
METTL3ENSG00000165819.71538.026201339.324200.199501.895601.37710HepG2PCBP1
METTL3ENSG00000165819.7744.124901376.54370-0.887407.745906.09770HepG2PCBP2
METTL3ENSG00000165819.7652.49600835.81760-0.357202.946501.67430HepG2PKM
METTL3ENSG00000165819.71073.781201361.80460-0.342803.788302.93800HepG2PPIL4
METTL3ENSG00000165819.7497.273201196.65250-1.2669020.8207018.91300HepG2PRPF8
METTL3ENSG00000165819.71037.483002417.84250-1.2206032.2238030.47220HepG2PUF60
METTL3ENSG00000165819.72086.951202566.64740-0.298505.677904.89130HepG2PUM1
METTL3ENSG00000165819.71871.107802564.77210-0.454906.610805.59040HepG2PUM2
METTL3ENSG00000165819.71134.534901500.93530-0.403806.527205.65220HepG2PUS1
METTL3ENSG00000165819.71097.089402329.51730-1.0863035.8611034.40730HepG2RBM22
METTL3ENSG00000165819.71316.781801718.47370-0.384103.433702.32440HepG2RBM27
METTL3ENSG00000165819.7997.676401906.79730-0.9345017.7683016.32990HepG2RPLP0
METTL3ENSG00000165819.7792.155101305.06850-0.720305.182103.91210HepG2RPS10
METTL3ENSG00000165819.7482.68740983.50210-1.0268017.0292015.69330HepG2RPS19
METTL3ENSG00000165819.71186.651301584.82320-0.417403.873702.93200HepG2RPS2
METTL3ENSG00000165819.7952.902901410.76600-0.566103.988403.02710HepG2RPS3A
METTL3ENSG00000165819.71126.735701359.71730-0.271203.192402.51080HepG2SAFB2
METTL3ENSG00000165819.7697.84280986.99050-0.500104.149403.00320HepG2SERBP1
METTL3ENSG00000165819.7988.567901417.71630-0.520203.383802.63560HepG2SF3A3
METTL3ENSG00000165819.7951.963501178.69420-0.308202.067101.45140HepG2SF3B1
METTL3ENSG00000165819.7871.622601418.84190-0.7029014.2935013.11090HepG2SF3B4
METTL3ENSG00000165819.71677.566702318.33590-0.4667011.160309.90860HepG2SLBP
METTL3ENSG00000165819.71364.679701585.69210-0.216602.654402.02100HepG2SMN1
METTL3ENSG00000165819.72103.031602631.08690-0.323205.962705.30460HepG2SRFBP1
METTL3ENSG00000165819.71744.816901480.984900.236402.615202.15170HepG2SRSF1
METTL3ENSG00000165819.71332.694102387.26830-0.8410026.9705025.29740HepG2SRSF5
METTL3ENSG00000165819.71206.288001738.87030-0.527609.783308.61180HepG2SRSF7
METTL3ENSG00000165819.7900.040101204.87830-0.420805.963605.20860HepG2SRSF9
METTL3ENSG00000165819.71472.930002284.37640-0.6331016.9112015.86840HepG2SSB
METTL3ENSG00000165819.7857.906801241.27870-0.532903.079201.80710HepG2SUB1
METTL3ENSG00000165819.72222.814202714.98080-0.288604.991004.19780HepG2SUCLG1
METTL3ENSG00000165819.7964.538001544.42830-0.679207.061406.05940HepG2SUPV3L1
METTL3ENSG00000165819.7634.615301160.81500-0.8712011.8562010.51440HepG2TARDBP
METTL3ENSG00000165819.7822.809001483.70900-0.8506016.7749015.73090HepG2TIAL1
METTL3ENSG00000165819.71148.798901496.84270-0.381805.557604.81070HepG2TRIM56
METTL3ENSG00000165819.71629.115802362.13120-0.536007.781806.20130HepG2TUFM
METTL3ENSG00000165819.7994.239201369.33280-0.461803.788003.05680HepG2U2AF1
METTL3ENSG00000165819.71547.753102500.27960-0.691907.688406.26990HepG2UBE2L3
METTL3ENSG00000165819.71344.30290912.302200.559205.096904.05860HepG2UCHL5
METTL3ENSG00000165819.7726.243201257.29400-0.7918018.4516016.95610HepG2UPF1
METTL3ENSG00000165819.71452.630901213.873400.259002.951502.33640HepG2UTP3
METTL3ENSG00000165819.7939.336001263.59410-0.427802.455601.43190HepG2XPO5
METTL3ENSG00000165819.71386.839201198.251700.210802.111401.51260HepG2ZC3H8
METTL3ENSG00000165819.7839.214701382.78780-0.7205019.0525017.93400HepG2ZNF622
METTL3ENSG00000165819.71259.919302454.76270-0.9623018.3355016.99310K562AQR
METTL3ENSG00000165819.7746.637301032.43640-0.467603.653302.65120K562BOP1
METTL3ENSG00000165819.71416.595401713.18890-0.274302.490701.38350K562CCDC124
METTL3ENSG00000165819.71129.938501388.49860-0.297303.214501.77340K562DDX27
METTL3ENSG00000165819.7855.998301061.94630-0.311002.258501.32300K562DDX3X
METTL3ENSG00000165819.71396.974701883.42260-0.431107.159606.17950K562DDX47
METTL3ENSG00000165819.7966.551401258.51590-0.380802.813201.89170K562EFTUD2
METTL3ENSG00000165819.71263.600601750.44130-0.470207.365706.27410K562EIF2S2
METTL3ENSG00000165819.7766.136701109.40440-0.534105.614704.44990K562EIF4A3
METTL3ENSG00000165819.72426.468302992.20900-0.302403.858102.75140K562EIF4G2
METTL3ENSG00000165819.7888.159001117.00110-0.330702.238701.46710K562FMR1
METTL3ENSG00000165819.7616.348001048.02990-0.765909.858908.34890K562GPKOW
METTL3ENSG00000165819.7781.537001253.08290-0.681109.066108.03730K562HNRNPC
METTL3ENSG00000165819.72154.145801702.057900.339703.332202.15970K562HNRNPL
METTL3ENSG00000165819.71534.445801863.30710-0.280102.881401.96970K562HNRNPU
METTL3ENSG00000165819.7649.51040894.97790-0.462502.621901.71650K562KRR1
METTL3ENSG00000165819.7776.110301107.89890-0.513504.768103.14980K562NCBP2
METTL3ENSG00000165819.7920.746401239.62420-0.429003.042501.66670K562NONO
METTL3ENSG00000165819.7869.206901080.85070-0.314402.539301.77510K562POLR2G
METTL3ENSG00000165819.7799.141901224.67650-0.615906.053604.94440K562PRPF8
METTL3ENSG00000165819.71969.430003264.75790-0.7292011.675509.99380K562PUF60
METTL3ENSG00000165819.72616.143903402.45240-0.379105.870004.45540K562PUM2
METTL3ENSG00000165819.71807.646701479.416600.289001.891301.42610K562PUS1
METTL3ENSG00000165819.71628.642402212.05300-0.441705.222503.03000K562RBM17
METTL3ENSG00000165819.7890.823401259.53290-0.499704.982303.81490K562RBM22
METTL3ENSG00000165819.7813.260301247.59650-0.617405.359204.21750K562RPS19
METTL3ENSG00000165819.7909.443301252.31740-0.461502.632701.33920K562RRP9
METTL3ENSG00000165819.7710.18340996.84010-0.489203.388402.30990K562SF3B1
METTL3ENSG00000165819.7773.109201129.43830-0.546906.820805.44000K562SF3B4
METTL3ENSG00000165819.7790.833301185.97620-0.584604.850003.47300K562SUPV3L1
METTL3ENSG00000165819.7951.041601303.28570-0.454603.983203.12680K562TARDBP
METTL3ENSG00000165819.71042.284901257.17160-0.270402.028401.33470K562TIA1
METTL3ENSG00000165819.71530.897602010.33110-0.393106.487504.51050K562TROVE2
METTL3ENSG00000165819.7856.419801255.09730-0.551404.933803.53260K562UCHL5
METTL3ENSG00000165819.71384.140101632.12550-0.237802.576801.88270K562UPF1
METTL3ENSG00000165819.71155.676501526.38690-0.401402.807901.59730K562UTP3
METTL3ENSG00000165819.72351.766802908.22640-0.306402.947101.61050K562WRN
METTL3ENSG00000165819.7990.279501277.86260-0.367802.500101.36900K562XRN2
METTL3ENSG00000165819.71978.218102765.47750-0.483306.036804.68130K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for METTL3 is not available on ENCORE database.





28 RBPs can affect the splicing of METTL3 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEMETTL3ENSG00000165819.7chr14-219674492196751521967168219672812196763521967744-0.216000.000300.00783excludedK562SRSF1
SEMETTL3ENSG00000165819.7chr14-219686362196882421967907219679462196905421969271-0.105000.000360.00913excludedK562SRSF1
SEMETTL3ENSG00000165819.7chr14-219686362196882421967907219679462196905421969271-0.113000.003780.05966excludedK562SF3B4
SEMETTL3ENSG00000165819.7chr14-219686362196882421967907219679462196905421969271-0.099000.002500.07325excludedK562PRPF8
SEMETTL3ENSG00000165819.7chr14-219686362196882421967907219679462196905421969271-0.165000.000000.00000excludedHepG2U2AF1
SEMETTL3ENSG00000165819.7chr14-219690542196927121967907219679462197131521971720-0.298000.003280.07671excludedK562AKAP8L
SEMETTL3ENSG00000165819.7chr14-219686362196882421967635219677442196905421969271-0.059000.001450.01671excludedK562AQR
SEMETTL3ENSG00000165819.7chr14-2197897321979122219718062197202421979265219794840.104000.000780.01392includedK562PUS1
SEMETTL3ENSG00000165819.7chr14-219690542196927121967907219679462197131521971720-0.334000.000000.00007excludedK562PUS1
SEMETTL3ENSG00000165819.7chr14-219686362196882421967907219679462196905421969271-0.110000.000050.00634excludedHepG2NCBP2
SEMETTL3ENSG00000165819.7chr14-219674492196751521967168219672812196763521967744-0.077000.000740.08688excludedK562LARP4
SEMETTL3ENSG00000165819.7chr14-219686362196882421967907219679462196905421969271-0.064000.000030.01307excludedK562APOBEC3C
SEMETTL3ENSG00000165819.7chr14-219686362196882421967907219679462196905421969271-0.115000.000270.01871excludedK562EFTUD2
SEMETTL3ENSG00000165819.7chr14-219686362196882421967907219679462196905421969271-0.064000.005810.09864excludedHepG2SRSF1
SEMETTL3ENSG00000165819.7chr14-219686362196882421967907219679462196905421969271-0.075000.001220.03564excludedHepG2SF3A3
SEMETTL3ENSG00000165819.7chr14-219674492196751521967168219672812196763521967744-0.199000.000220.01169excludedK562TARDBP
SEMETTL3ENSG00000165819.7chr14-219690542196927121967907219679462197131521971720-0.294000.004180.07998excludedK562RBM15
SEMETTL3ENSG00000165819.7chr14-2197897321979122219718062197202421979265219794840.204000.000010.00080includedK562AGGF1
SEMETTL3ENSG00000165819.7chr14-219690542196927121967907219679462197131521971720-0.326000.001150.03090excludedK562AGGF1
SEMETTL3ENSG00000165819.7chr14-2196905421969271219679072196794621971315219717200.745000.000110.02590includedK562EIF3G
SEMETTL3ENSG00000165819.7chr14-219686362196882421967907219679462196905421969271-0.177000.000010.00294excludedK562EIF3G
SEMETTL3ENSG00000165819.7chr14-219674492196751521967168219672812196763521967744-0.135000.001410.02554excludedK562HNRNPC
SEMETTL3ENSG00000165819.7chr14-219686362196882421967907219679462196905421969271-0.089000.000410.00900excludedK562HNRNPC
A3SSMETTL3ENSG00000165819.7chr14-219698692197004521969869219699662197131521971720-0.114000.000000.00651shorterK562EIF4G2
A3SSMETTL3ENSG00000165819.7chr14-2196630521966549219663052196651321967168219672990.096000.000000.00000longerK562AQR
A3SSMETTL3ENSG00000165819.7chr14-2196984921970067219698492197004521971315219717200.053000.000160.00135longerK562AQR
A3SSMETTL3ENSG00000165819.7chr14-219698692197004521969869219699662197131521971720-0.063000.016150.07965shorterK562AQR
A3SSMETTL3ENSG00000165819.7chr14-2196716821967295219671682196728121967449219675150.194000.000000.00005longerHepG2HNRNPC
RIMETTL3ENSG00000165819.7chr14-2197131521971972219713152197172021971806219719720.123000.000190.00583includedHepG2PCBP2
RIMETTL3ENSG00000165819.7chr14-2197131521971972219713152197172021971806219719720.262000.000000.00007includedHepG2SF3A3
RIMETTL3ENSG00000165819.7chr14-2197131521971720219713152197143421971648219717200.066000.000470.04799includedK562NSUN2
RIMETTL3ENSG00000165819.7chr14-219713152197197221971315219717202197180621971972-0.058000.000560.05349excludedK562NSUN2
RIMETTL3ENSG00000165819.7chr14-2197131521971972219713152197172021971806219719720.110000.003350.08631includedK562SF3B1
RIMETTL3ENSG00000165819.7chr14-2197131521971972219713152197172021971806219719720.236000.000000.00002includedHepG2U2AF2
RIMETTL3ENSG00000165819.7chr14-219713152197172021971315219714342197164821971720-0.054000.001640.07472excludedK562NPM1
RIMETTL3ENSG00000165819.7chr14-2197131521971972219713152197172021971806219719720.109000.000590.00951includedHepG2PRPF8
RIMETTL3ENSG00000165819.7chr14-219713152197172021971315219714342197164821971720-0.051000.000930.03601excludedK562HNRNPUL1
RIMETTL3ENSG00000165819.7chr14-2197131521971972219713152197172021971806219719720.060000.001190.01665includedK562PRPF8
RIMETTL3ENSG00000165819.7chr14-2197131521971720219713152197143421971648219717200.066000.001580.08863includedK562WDR3
RIMETTL3ENSG00000165819.7chr14-2197131521971972219713152197172021971806219719720.057000.001670.01422includedHepG2SF3B4
RIMETTL3ENSG00000165819.7chr14-2197131521971972219713152197172021971806219719720.069000.000000.00002includedHepG2RBM22
RIMETTL3ENSG00000165819.7chr14-2197131521971972219713152197172021971806219719720.057000.001560.01769includedK562EFTUD2
RIMETTL3ENSG00000165819.7chr14-2197131521971972219713152197172021971806219719720.059000.000040.00035includedK562AQR
RIMETTL3ENSG00000165819.7chr14-219671682196774421967168219672812196763521967744-0.216000.000000.00001excludedK562TARDBP
RIMETTL3ENSG00000165819.7chr14-219671682196774421967168219672812196763521967744-0.151000.000020.00112excludedK562PTBP1
MXEMETTL3ENSG00000165819.7chr14-21967449219675152196763521967744219671682196728121969054219692710.078000.000170.012351includedK562SF3B1
MXEMETTL3ENSG00000165819.7chr14-21967907219679462196863621968824219676352196774421969054219692710.086000.000440.018911includedK562SBDS
MXEMETTL3ENSG00000165819.7chr14-2196905421969271219698492197004521967907219679462197131521971720-0.100000.002610.047322includedK562PRPF8

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for METTL3 is not avaliable on ENCORE database.