HLA-E

General Information

Gene Name       : HLA-E
Gene ID             : ENSG00000204592.8
Essential Gene : No

Functions

Localization

Domains (AlphaFold: HLA-E)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878HLA-EENSG00000204592.899.05174.31136.68ENCSR000AEF
HepG2HLA-EENSG00000204592.837.2223.2430.23ENCSR985KAT
K562HLA-EENSG00000204592.827.0718.0422.55ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for HLA-E is not avaliable on ENCORE database.



Proteins bound to RNA
  • HLA-E RNA is bound by 15 proteins.  







eCLIP assay for HLA-E is not avaliable on ENCORE database.





15 proteins are bound to HLA-E RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr63046128030461341+3'-UTR3.282045.50363HepG2AKAP1
chr63046064930460708+3'-UTR4.2557411.77596HepG2UPF1
chr63046101230461063+3'-UTR3.995007.42080HepG2AKAP1
chr63046156630461646+3'-UTR3.9998212.46490K562FAM120A
chr63046112730461145+3'-UTR3.386334.26759HepG2AKAP1
chr63046114030461194+3'-UTR3.738227.33071HepG2UPF1
chr63046145730461504+3'-UTR4.9341812.56575K562UPF1
chr63046055330460612+3'-UTR4.956936.39485HepG2LARP4
chr63046154330461720+3'-UTR5.672068.12128K562AKAP1
chr63046179230461815+3'-UTR3.678586.40324K562UPF1
chr63046186430461930+3'-UTR4.6439215.51277K562UPF1
chr63046112430461265+3'-UTR6.2905336.75818K562UPF1
chr63046150430461574+3'-UTR5.1065726.70406K562UPF1
chr63046099030461062+3'-UTR5.9862313.92550HepG2UPF1
chr63046058530460624+3'-UTR4.621075.04923HepG2AKAP1
chr63046174230461810+3'-UTR4.2523410.37090HepG2UPF1
chr63046153130461569+3'-UTR3.896355.82440HepG2AKAP1
chr63046063930460685+3'-UTR3.936407.50442K562UPF1
chr63046071030460766+3'-UTR4.0438010.09137HepG2UPF1
chr63046071230460765+3'-UTR3.032004.31006HepG2AKAP1
chr63046128430461395+3'-UTR4.604937.76684K562FAM120A
chr63046077130460824+3'-UTR5.9191112.73103HepG2UPF1
chr63046165430461720+3'-UTR4.8935316.69583K562UPF1
chr63046121330461246+3'-UTR5.044775.85041HepG2AKAP1
chr63046092330460961+3'-UTR4.334236.19596HepG2UPF1
chr63046178230461822+3'-UTR4.645254.78280HepG2AKAP1
chr63046156930461627+3'-UTR5.8932313.90466HepG2AKAP1
chr63046157430461654+3'-UTR5.2726129.87390K562UPF1
chr63046152030461644+3'-UTR4.7551522.53290HepG2UPF1
chr63046101930461066+3'-UTR4.8786610.99442K562UPF1
chr63046186530461921+3'-UTR4.314109.77766HepG2AKAP1
chr63046112630461191+3'-UTR4.271793.74511K562IGF2BP1
chr63046063430460691+3'-UTR5.312368.32932HepG2AKAP1
chr63046031130460402+3'-UTR,CDS,intron-Proximal4.8022312.91190HepG2PRPF8
chr63046148330461566+3'-UTR4.7965310.96075K562FAM120A
chr63046145430461518+3'-UTR4.980669.87725HepG2UPF1
chr63045732130457370+CDS3.8661611.56026HepG2RPS3
chr63045811330458176+CDS4.5814715.97940HepG2SND1
chr63045801830458084+CDS4.698685.22159K562SND1
chr63045797130458034+CDS,intron-Proximal4.060563.82050HepG2SF3B4
chr63045828830458342+CDS,intron-Proximal3.874884.98250K562AQR
chr63045899930459045+CDS3.228456.77216HepG2SND1
chr63045796230458078+CDS,intron-Proximal3.675556.13900HepG2RBFOX2
chr63045801530458079+CDS,intron-Proximal4.3392715.05174HepG2SND1
chr63045819030458231+CDS4.086493.60906K562SND1
chr63045775030457773+CDS,intron-Proximal3.484407.52610HepG2SND1
chr63046016930460257+CDS,intron-Proximal3.171235.76569HepG2PRPF8
chr63045913630459190+CDS,intron-Proximal6.0633813.95300HepG2SND1
chr63045937230459406+CDS3.206264.76748HepG2SND1
chr63045818930458236+CDS4.2505812.11021HepG2SND1
chr63046018230460206+CDS4.223774.03377HepG2LARP4
chr63045763630457665+CDS4.096944.95361HepG2SND1
chr63045731830457376+CDS,intron-Proximal3.752648.43072HepG2DDX3X
chr63045797230458046+CDS,intron-Proximal4.518404.10323HepG2PRPF4
chr63045751730457612+CDS5.1598012.21524HepG2RPS3
chr63045766530457723+CDS3.291228.41665HepG2SND1
chr63045911730459186+CDS4.162269.23000K562LIN28B
chr63045765930457714+CDS3.440974.08796K562SND1
chr63045931330459332+CDS,intron-Proximal4.211875.51172HepG2SND1
chr63046044830460500+intron-Proximal3.834436.22597HepG2EFTUD2
chr63046038130460421+intron-Proximal4.738114.34633HepG2EFTUD2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for HLA-E is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for HLA-E is not available on ENCORE database.

  • 142 RBPs can affect the levels of HLA-E.  








The Knockdown/knockout RNA-Seq assay for HLA-E is not available on ENCORE database.





142 RBPs can affect the gene expression of HLA-E :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
HLA-EENSG00000204592.51676.100002021.17380-0.270103.796303.10530HepG2ACO1
HLA-EENSG00000204592.54762.274703660.415300.379503.297202.43920HepG2ASCC1
HLA-EENSG00000204592.53994.958602921.252400.4515010.668609.46650HepG2AUH
HLA-EENSG00000204592.51176.55230781.052500.591006.234305.37810HepG2BOP1
HLA-EENSG00000204592.52916.972702129.880800.453603.168102.12010HepG2CCAR1
HLA-EENSG00000204592.51949.456303317.34400-0.767002.122201.45800HepG2CNOT7
HLA-EENSG00000204592.52806.345002155.831500.380308.564007.36990HepG2DAZAP1
HLA-EENSG00000204592.51556.507501869.31220-0.264203.668402.72660HepG2DDX19B
HLA-EENSG00000204592.51081.421501320.44810-0.288102.773701.61250HepG2DDX1
HLA-EENSG00000204592.5906.067401559.66390-0.7835012.0089010.71310HepG2DDX21
HLA-EENSG00000204592.55014.930703640.901700.461803.935203.20830HepG2DDX6
HLA-EENSG00000204592.51546.859101248.808200.308702.439301.51820HepG2DHX30
HLA-EENSG00000204592.51752.593801294.780400.436706.453905.41540HepG2DNAJC21
HLA-EENSG00000204592.51572.677801283.319100.293204.243103.46790HepG2DNAJC2
HLA-EENSG00000204592.51136.818801697.95450-0.578808.026206.16050HepG2EIF2S2
HLA-EENSG00000204592.51008.106601472.86310-0.547007.205705.60270HepG2EIF3G
HLA-EENSG00000204592.51922.841303866.93200-1.0079015.6524014.14950HepG2EIF4A3
HLA-EENSG00000204592.51111.881203765.62610-1.7599033.5456031.35030HepG2EIF4B
HLA-EENSG00000204592.52823.714302037.333800.470804.464203.44560HepG2EIF4G2
HLA-EENSG00000204592.52550.412703354.03070-0.395208.232607.29060HepG2ETF1
HLA-EENSG00000204592.51687.224201235.652100.449305.605803.90270HepG2FAM120A
HLA-EENSG00000204592.52262.237803902.56340-0.7867011.8055010.47710HepG2FXR1
HLA-EENSG00000204592.51643.204003619.67850-1.1393020.8107019.06520HepG2G3BP1
HLA-EENSG00000204592.52658.362103843.43390-0.531906.080004.75060HepG2G3BP2
HLA-EENSG00000204592.52224.910901929.663500.205302.254201.36690HepG2HDGF
HLA-EENSG00000204592.51584.436801981.22630-0.322404.532503.38610HepG2HNRNPA2B1
HLA-EENSG00000204592.52574.873001528.365700.7524022.6973020.91950HepG2HNRNPF
HLA-EENSG00000204592.52900.706603666.46950-0.338003.091002.35450HepG2HNRNPK
HLA-EENSG00000204592.52873.593101963.825500.5491017.1963015.64740HepG2HNRNPL
HLA-EENSG00000204592.51235.849301559.39360-0.335503.285902.25720HepG2HNRNPM
HLA-EENSG00000204592.52541.222901505.006800.7557015.9482014.36490HepG2IGF2BP1
HLA-EENSG00000204592.52622.537103679.13860-0.488404.997704.11460HepG2IGF2BP2
HLA-EENSG00000204592.51607.827503453.45970-1.102905.209103.87970HepG2IGF2BP3
HLA-EENSG00000204592.52512.024801847.628000.443107.002505.42860HepG2KIF1C
HLA-EENSG00000204592.54884.459103388.314200.527503.937602.43960HepG2KRR1
HLA-EENSG00000204592.51679.087502249.36960-0.421802.660301.84560HepG2LARP4
HLA-EENSG00000204592.52215.592803903.93030-0.8172012.1434010.80470HepG2MAGOH
HLA-EENSG00000204592.51689.087203925.61890-1.2167022.6045020.94220HepG2MATR3
HLA-EENSG00000204592.51418.146401829.04070-0.367103.997003.02900HepG2MSI2
HLA-EENSG00000204592.51140.05790791.171700.526902.987401.97620HepG2MTPAP
HLA-EENSG00000204592.52454.304904017.95820-0.711109.176608.06290HepG2NCBP2
HLA-EENSG00000204592.52307.116603213.28870-0.478002.866601.40770HepG2NKRF
HLA-EENSG00000204592.51708.408301033.573800.724903.822602.52190HepG2NONO
HLA-EENSG00000204592.5993.89780687.780100.531104.633403.67340HepG2NSUN2
HLA-EENSG00000204592.52093.940903577.65170-0.7728010.788809.38570HepG2PABPC4
HLA-EENSG00000204592.52476.930503813.42860-0.6225019.4781018.10220HepG2PCBP1
HLA-EENSG00000204592.51069.866701499.69710-0.487202.273801.33010HepG2PCBP2
HLA-EENSG00000204592.51838.417401288.272700.512906.239905.16700HepG2PPIL4
HLA-EENSG00000204592.51205.422401430.18350-0.246702.411901.68410HepG2PRPF4
HLA-EENSG00000204592.52053.474403880.20440-0.9181033.2156031.74460HepG2PTBP1
HLA-EENSG00000204592.52846.431102040.608600.480106.142905.30120HepG2PUF60
HLA-EENSG00000204592.53807.106002164.602400.8145020.8359019.10300HepG2PUM2
HLA-EENSG00000204592.52957.440904202.57420-0.5069010.030908.94590HepG2QKI
HLA-EENSG00000204592.52549.689602025.647000.331803.830502.84050HepG2RBM15
HLA-EENSG00000204592.51683.251602803.34030-0.7359019.0472017.93700HepG2RBM22
HLA-EENSG00000204592.52922.379003814.02420-0.384204.865603.99370HepG2RBM25
HLA-EENSG00000204592.52495.099904318.37960-0.7914027.1605025.82260HepG2NELFE
HLA-EENSG00000204592.53297.926204021.83020-0.286305.000004.20180HepG2RECQL
HLA-EENSG00000204592.52473.164201646.381500.587007.522306.47830HepG2RPLP0
HLA-EENSG00000204592.5940.835401345.18120-0.515805.940405.07990HepG2RPS19
HLA-EENSG00000204592.51402.540501790.01950-0.351902.746301.94800HepG2RPS2
HLA-EENSG00000204592.5662.44940858.40010-0.373802.302001.57800HepG2RRP9
HLA-EENSG00000204592.51964.590301286.289300.6109015.9650014.61010HepG2SAFB2
HLA-EENSG00000204592.51027.631901349.95720-0.393603.156702.14990HepG2SERBP1
HLA-EENSG00000204592.51001.44870767.669200.383402.709202.01010HepG2SF3B1
HLA-EENSG00000204592.52350.793804039.97620-0.7812029.7328028.15640HepG2SF3B4
HLA-EENSG00000204592.52328.675601956.563600.251103.725402.93170HepG2SLBP
HLA-EENSG00000204592.51272.328701500.03990-0.237503.015502.34740HepG2SMN1
HLA-EENSG00000204592.52085.961201477.917200.497002.912201.92780HepG2SMNDC1
HLA-EENSG00000204592.52100.103201410.511500.574104.534002.44640HepG2SND1
HLA-EENSG00000204592.52152.30330854.180201.333209.515008.07580HepG2SNRNP70
HLA-EENSG00000204592.54257.616303166.254200.4272010.801209.98760HepG2SRFBP1
HLA-EENSG00000204592.51514.947604216.78600-1.47690102.83170100.94750HepG2SRSF1
HLA-EENSG00000204592.52732.237101501.558900.8635030.2175028.41150HepG2SRSF7
HLA-EENSG00000204592.52909.449403430.51580-0.237703.754203.13320HepG2SRSF9
HLA-EENSG00000204592.52244.838602749.03120-0.292304.628303.99840HepG2SSB
HLA-EENSG00000204592.52823.222603790.00490-0.424907.659006.80270HepG2TAF15
HLA-EENSG00000204592.51165.30720756.160200.623806.645005.58780HepG2TARDBP
HLA-EENSG00000204592.51811.428801416.028500.355205.411404.67350HepG2TRIM56
HLA-EENSG00000204592.52454.147601993.538900.299802.811601.93250HepG2TUFM
HLA-EENSG00000204592.51360.793501933.52620-0.506805.386504.52590HepG2U2AF1
HLA-EENSG00000204592.52568.497301767.230300.5393011.676109.72210HepG2UTP18
HLA-EENSG00000204592.51999.228001659.986300.268202.947702.33260HepG2UTP3
HLA-EENSG00000204592.51591.969201102.648300.529704.273303.37820HepG2XRN2
HLA-EENSG00000204592.51311.178201890.98280-0.528304.482503.82990HepG2ZNF622
HLA-EENSG00000204592.51992.218801446.328700.461903.046401.68030HepG2ZRANB2
HLA-EENSG00000204592.5978.84670613.262700.674505.533403.79460K562ABCF1
HLA-EENSG00000204592.52349.053701145.027101.0366027.3626025.68980K562AGGF1
HLA-EENSG00000204592.51938.079701258.283400.623108.927606.87790K562AKAP8
HLA-EENSG00000204592.52321.848501191.470200.9624020.0627017.98060K562AKAP8L
HLA-EENSG00000204592.51656.943301201.868700.463104.764504.03200K562AQR
HLA-EENSG00000204592.51844.607801250.172400.5611010.174308.29030K562ATP5C1
HLA-EENSG00000204592.5978.05830594.154700.7190012.4741010.40840K562BCLAF1
HLA-EENSG00000204592.5613.09210362.571900.757704.889603.71610K562BOP1
HLA-EENSG00000204592.5664.39440427.239300.636904.978302.99430K562BUD13
HLA-EENSG00000204592.51768.176301368.312900.369803.775002.36900K562CCDC124
HLA-EENSG00000204592.51022.36390722.980700.499803.581001.90440K562CKAP4
HLA-EENSG00000204592.51260.26030875.019800.526207.737805.86460K562CPEB4
HLA-EENSG00000204592.5797.50690385.504601.0486015.7802013.87090K562CPSF6
HLA-EENSG00000204592.5672.44480450.754800.577005.867304.24840K562CSTF2
HLA-EENSG00000204592.51752.683301013.021600.7908014.5840012.06600K562DDX3X
HLA-EENSG00000204592.5694.79770905.19280-0.381602.890002.22410K562DDX47
HLA-EENSG00000204592.51247.273301027.097300.280102.692401.41100K562DDX6
HLA-EENSG00000204592.51362.777401112.834600.292202.764001.55680K562EIF2S1
HLA-EENSG00000204592.51230.27470693.062900.8278011.7732010.44190K562EIF2S2
HLA-EENSG00000204592.5222.62570428.70030-0.945305.323803.88830K562EIF3A
HLA-EENSG00000204592.5312.64540635.07130-1.022406.095904.92990K562EIF3G
HLA-EENSG00000204592.5904.299501385.04380-0.615102.559501.65170K562EIF4G2
HLA-EENSG00000204592.5679.59620440.942400.624003.361102.41950K562FIP1L1
HLA-EENSG00000204592.5866.20150392.267701.142808.448806.91210K562FMR1
HLA-EENSG00000204592.5602.43560332.493500.857407.940706.30540K562FTO
HLA-EENSG00000204592.5635.581501100.70050-0.7923010.094909.02320K562FXR1
HLA-EENSG00000204592.5829.72270491.064400.756606.770904.55990K562GEMIN5
HLA-EENSG00000204592.5543.14920368.051300.561304.111403.14790K562GPKOW
HLA-EENSG00000204592.51252.35520923.467800.439403.898303.00510K562GRSF1
HLA-EENSG00000204592.5844.041901053.73160-0.320102.518401.49260K562HNRNPA1
HLA-EENSG00000204592.51676.670201059.262100.662403.158801.82920K562HNRNPA2B1
HLA-EENSG00000204592.5941.31900597.741500.655105.362004.27080K562HSPD1
HLA-EENSG00000204592.51394.37260910.787300.614303.869702.57360K562IGF2BP2
HLA-EENSG00000204592.51358.91670926.210400.552905.515603.72760K562IGF2BP3
HLA-EENSG00000204592.5310.25300440.28700-0.505002.962701.41650K562ILF3
HLA-EENSG00000204592.51978.693201264.385900.646008.070306.47430K562KIF1C
HLA-EENSG00000204592.5573.82630314.298000.868402.470701.59310K562KRR1
HLA-EENSG00000204592.5846.84250613.615000.464703.769901.90310K562LSM11
HLA-EENSG00000204592.51986.619301210.378600.714805.439003.75620K562MAK16
HLA-EENSG00000204592.5572.45130954.73740-0.738009.918208.06620K562MATR3
HLA-EENSG00000204592.52234.424301416.440200.657509.114207.27620K562MBNL1
HLA-EENSG00000204592.5819.01820359.263701.1888018.6522016.30900K562METAP2
HLA-EENSG00000204592.51880.65900992.827500.9215010.424408.30360K562NAA15
HLA-EENSG00000204592.51298.918301056.817500.297502.633801.43340K562NCBP2
HLA-EENSG00000204592.5854.05360483.156200.821705.889503.85170K562NONO
HLA-EENSG00000204592.51149.21610866.584200.407106.351505.28300K562NSUN2
HLA-EENSG00000204592.51463.81220926.871600.659203.098402.03710K562PABPN1
HLA-EENSG00000204592.5531.73810841.74060-0.662705.654704.45920K562PCBP3
HLA-EENSG00000204592.5426.75890645.63100-0.597305.368104.25470K562POLR2G
HLA-EENSG00000204592.5869.31570500.642000.796008.393706.77460K562PPIG
HLA-EENSG00000204592.51727.086501102.259100.647802.836501.37070K562PPP1R8
HLA-EENSG00000204592.5959.87190616.642900.638306.681405.17150K562PSIP1
HLA-EENSG00000204592.5700.16290929.57400-0.408903.712902.95480K562PTBP1
HLA-EENSG00000204592.53118.775001181.485601.4003025.4047023.76390K562PUS1
HLA-EENSG00000204592.51992.843001151.284100.7915010.750809.60530K562RBM15
HLA-EENSG00000204592.5741.44610562.842500.397502.996401.96280K562RCC2
HLA-EENSG00000204592.5359.75710748.33810-1.056708.161105.29910K562RPS3A
HLA-EENSG00000204592.5563.08290834.58840-0.567704.338003.04980K562RPS3
HLA-EENSG00000204592.5323.81990575.31280-0.829208.278806.45360K562SAFB
HLA-EENSG00000204592.5310.21470594.78890-0.9391010.148307.56530K562SDAD1
HLA-EENSG00000204592.51822.05280847.830501.103606.188704.15980K562SF1
HLA-EENSG00000204592.51658.21590855.141600.9553025.6571023.45430K562SF3A3
HLA-EENSG00000204592.5628.96200350.068900.845203.461102.36970K562SF3B1
HLA-EENSG00000204592.5924.21650655.996100.494402.334701.55050K562SF3B4
HLA-EENSG00000204592.51206.41800860.821400.486804.580803.17210K562SRSF5
HLA-EENSG00000204592.5508.50270734.86910-0.531205.214703.06920K562SRSF9
HLA-EENSG00000204592.5706.16430461.176000.614602.211801.30950K562SUPV3L1
HLA-EENSG00000204592.5417.13920647.60230-0.634606.463205.19940K562SYNCRIP
HLA-EENSG00000204592.5665.92190420.571700.662905.161402.90300K562TFIP11
HLA-EENSG00000204592.51084.67170889.623000.285902.079201.37690K562TIA1
HLA-EENSG00000204592.51218.38680873.244900.480403.753002.45150K562TRA2A
HLA-EENSG00000204592.5845.36940630.332600.423403.161302.13610K562TRIM56
HLA-EENSG00000204592.5385.90830611.96070-0.665204.550502.26130K562TRNAU1AP
HLA-EENSG00000204592.51317.48900989.764200.412505.502503.69320K562TROVE2
HLA-EENSG00000204592.5709.63180488.246500.539402.612801.62560K562UCHL5
HLA-EENSG00000204592.52008.66820918.860001.1282033.2971031.12740K562UPF1
HLA-EENSG00000204592.52265.430901198.030700.919006.371604.21540K562UTP18
HLA-EENSG00000204592.5977.23100656.767300.573204.800703.21560K562UTP3
HLA-EENSG00000204592.5434.81770817.62010-0.9110018.2298016.33570K562WDR43
HLA-EENSG00000204592.5828.41960497.405700.735805.256903.38760K562XRN2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for HLA-E is not available on ENCORE database.





3 RBPs can affect the splicing of HLA-E :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
RIHLA-EENSG00000204592.5chr6+3045750230458142304575023045777230458090304581420.113000.012060.08980includedK562AKAP8L
RIHLA-EENSG00000204592.5chr6+3046016230460360304601623046021330460317304603600.071000.009720.07465includedHepG2RBM22
RIHLA-EENSG00000204592.5chr6+3046011230460360304601123046021330460317304603600.132000.000760.00526includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for HLA-E is not avaliable on ENCORE database.