ERN1

General Information

Gene Name : ERN1
Gene ID : ENSG00000178607.15
Essential Gene : No

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: ERN1)

Not Available

Antibody Validation

Thermo Fisher: MA5-14991

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	ERN1	ENSG00000178607.15	4.09	4.59	4.34	ENCSR000AEF
HepG2	ERN1	ENSG00000178607.15	4.74	4.90	4.82	ENCSR985KAT
K562	ERN1	ENSG00000178607.15	5.91	4.42	5.17	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	ERN1-BGKcLV17-K562	ENCSR026FEM	ERN1	K562	Released		ENCSR516TLX	CRISPR	KD% = 92.9,96.8
knockdown followed by RNA-seq	ERN1-BGHcLV18-HepG2	ENCSR005UDT	ERN1	HepG2	Released		ENCSR670KAS	CRISPR	KD% = 95.2,98.4

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
ERN1	ENCAB311UNO	MA5-14991	TL2693035			Released, ENCODE4	BGHcLV18-17, Released, ENCODE4	BGKcLV17-17, Released, ENCODE4

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
ERN1	K562	CRISPR	ENCSR026FEM	ENCSR516TLX	ERN1-BGKcLV17-17,ERN1-BGKcLV17-18	NT-BGKcLV17-1,NT-BGKcLV17-2	92.9,96.8	Released	ENCODE4
ERN1	HepG2	CRISPR	ENCSR005UDT	ENCSR670KAS	ERN1-BGHcLV18-17,ERN1-BGHcLV18-18	NT-BGHcLV18-1,NT-BGHcLV18-2	95.2,98.4	Released	ENCODE4

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
ERN1	Product_ID: MA5-14991 Lot_ID: TL2693035 Source: Thermo Fisher Target Name: ERN1-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for ERN1 is not avaliable on ENCORE database.

Proteins bound to RNA

ERN1 RNA is bound by 10 proteins.

CanvasJS.com

eCLIP assay for ERN1 is not avaliable on ENCORE database.

10 proteins are bound to ERN1 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr17	62118837	62118959	-	3'-UTR,intron-Distal	4.11818	15.42976	HepG2	SUGP2
chr17	62117458	62117507	-	3'-UTR,intron-Distal	3.69778	11.65979	HepG2	SUGP2
chr17	62120785	62120885	-	3'-UTR,intron-Distal	5.55391	11.21630	K562	UPF1
chr17	62118762	62118832	-	3'-UTR,intron-Distal	4.25880	8.81208	HepG2	SUGP2
chr17	62117094	62117156	-	3'-UTR,intron-Distal	4.00077	7.87505	K562	UPF1
chr17	62125180	62125252	-	CDS,intron-Distal,intron-Proximal	4.16004	7.87148	HepG2	PRPF8
chr17	62141293	62141358	-	CDS,intron-Distal,intron-Proximal	5.25324	7.59497	HepG2	PRPF8
chr17	62117468	62117504	-	3'-UTR,intron-Distal	5.34538	6.97910	HepG2	PCBP2
chr17	62117451	62117510	-	3'-UTR,intron-Distal	3.83828	6.76837	K562	UPF1
chr17	62120495	62120601	-	3'-UTR,intron-Distal	4.27509	6.74636	K562	UPF1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 22 entries

eCLIP assay for ERN1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for ERN1 is not available on ENCORE database.
126 RBPs can affect the levels of ERN1.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for ERN1 is not available on ENCORE database.

126 RBPs can affect the gene expression of ERN1 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
ERN1	ENSG00000178607.11	3072.49930	607.88210	2.33740	225.92070	223.26740	HepG2	ZNF622
ERN1	ENSG00000178607.11	1376.37740	509.60130	1.43330	45.61770	43.42050	K562	EIF2S2
ERN1	ENSG00000178607.11	1696.77780	758.89480	1.16070	42.04050	40.69150	HepG2	SRFBP1
ERN1	ENSG00000178607.11	353.22780	976.04480	-1.46630	38.16680	36.66420	HepG2	NELFE
ERN1	ENSG00000178607.11	1165.40310	2581.43450	-1.14730	38.01340	35.73450	K562	RBM15
ERN1	ENSG00000178607.11	1462.62210	479.02030	1.61030	36.16560	33.84710	HepG2	U2AF1
ERN1	ENSG00000178607.11	1562.69080	775.37320	1.01100	32.46000	30.97450	HepG2	SRSF9
ERN1	ENSG00000178607.11	1073.23280	505.40570	1.08630	32.07100	30.50200	HepG2	PUM1
ERN1	ENSG00000178607.11	1213.23720	505.03620	1.26430	29.55610	27.52310	HepG2	PUM2
ERN1	ENSG00000178607.11	1103.94690	496.22110	1.15350	29.45000	27.35110	HepG2	EIF4G1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 146 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for ERN1 is not available on ENCORE database.

4 RBPs can affect the splicing of ERN1 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	ERN1	ENSG00000178607.11	chr17	-	62126414	62126562			62125217	62125345	62130139	62130339	-0.43400	0.00002	0.00081	excluded	HepG2	U2AF1
SE	ERN1	ENSG00000178607.11	chr17	-	62145549	62145651			62144030	62144292	62149340	62149463	0.59900	0.00008	0.00164	included	HepG2	U2AF2
SE	ERN1	ENSG00000178607.11	chr17	-	62145549	62145651			62144030	62144292	62149340	62149463	0.56700	0.00094	0.08792	included	HepG2	RBFOX2
SE	ERN1	ENSG00000178607.11	chr17	-	62145549	62145651			62144030	62144292	62149340	62149463	-0.21700	0.00370	0.03629	excluded	K562	AQR
MXE	ERN1	ENSG00000178607.11	chr17	-	62144030	62144292	62145549	62145651	62142568	62142647	62149340	62149463	0.39800	0.01993	0.09236	1included	HepG2	U2AF2

Showing 1 to 5 of 5 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

ERN1

General Information

Functions

Localization

Domains (AlphaFold: ERN1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for ERN1 is not avaliable on ENCORE database.

10 proteins are bound to ERN1 RNA:

eCLIP assay for ERN1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for ERN1 is not available on ENCORE database.

126 RBPs can affect the gene expression of ERN1 :

The Knockdown/knockout RNA-Seq assay for ERN1 is not available on ENCORE database.

4 RBPs can affect the splicing of ERN1 :

The Knockdown/knockout RNA-Seq assay for ERN1 is not avaliable on ENCORE database.