DARS2

General Information

Gene Name       : DARS2
Gene ID             : ENSG00000117593.10
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: DARS2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878DARS2ENSG00000117593.1038.1034.2736.19ENCSR000AEF
HepG2DARS2ENSG00000117593.1019.1133.3126.21ENCSR985KAT
K562DARS2ENSG00000117593.1056.1765.0260.59ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for DARS2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • DARS2 RNA is bound by 8 proteins.  







eCLIP assay for DARS2 is not avaliable on ENCORE database.





8 proteins are bound to DARS2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr1173793856173793915+5'-UTR3.422413.15824K562FTO
chr1173797513173797537+5'-UTR,CDS4.138084.55095K562YBX3
chr1173795893173795904+5'-UTR,CDS4.038303.46958K562YBX3
chr1173793819173793901+5'-UTR4.558716.05264HepG2DDX3X
chr1173802560173802622+5'-UTR,CDS4.430563.71570HepG2BCLAF1
chr1173795904173795924+5'-UTR,CDS4.437815.43239K562YBX3
chr1173794371173794441+5'-UTR,CDS4.4240613.81544K562PUM2
chr1173793809173793936+5'-UTR4.4197022.62814K562DDX3X
chr1173797470173797505+5'-UTR,CDS,intron-Proximal4.650636.26929K562YBX3
chr1173793936173793993+5'-UTR3.262307.86233K562DDX3X
chr1173799798173799865+5'-UTR,CDS3.727945.24452HepG2PPIG
chr1173799918173799992+intron-Proximal4.660705.33214K562PRPF8
chr1173799899173799957+intron-Proximal4.916114.13847K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for DARS2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for DARS2 is not available on ENCORE database.

  • 134 RBPs can affect the levels of DARS2.  








The Knockdown/knockout RNA-Seq assay for DARS2 is not available on ENCORE database.





134 RBPs can affect the gene expression of DARS2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
DARS2ENSG00000117593.8656.18510977.73050-0.575303.375501.47450HepG2AARS
DARS2ENSG00000117593.8766.13260995.53930-0.377904.015203.30760HepG2ACO1
DARS2ENSG00000117593.8718.032401000.30380-0.478306.283905.17180HepG2AKAP8L
DARS2ENSG00000117593.8438.58650752.61200-0.779003.773602.86090HepG2ASCC1
DARS2ENSG00000117593.8736.963301526.14960-1.0502031.0864029.22830HepG2AUH
DARS2ENSG00000117593.8617.30300997.55010-0.692405.842204.45620HepG2BCCIP
DARS2ENSG00000117593.8437.99230866.77380-0.9848011.075309.43450HepG2BCLAF1
DARS2ENSG00000117593.8416.01550982.32930-1.2396021.0580019.64430HepG2BOP1
DARS2ENSG00000117593.8564.23600854.67960-0.599103.736802.31480HepG2BUD13
DARS2ENSG00000117593.8718.315501171.05620-0.7051010.246208.90280HepG2CALR
DARS2ENSG00000117593.8620.445101394.45080-1.1683014.5190012.42670HepG2CCAR1
DARS2ENSG00000117593.8470.58250995.42770-1.0809029.1576027.51380HepG2CKAP4
DARS2ENSG00000117593.8485.65350901.81360-0.8929010.826009.56000HepG2CPSF6
DARS2ENSG00000117593.8353.58780616.15220-0.801207.887806.22500HepG2CSTF2
DARS2ENSG00000117593.8878.032301426.57140-0.7002017.8596016.27560HepG2DAZAP1
DARS2ENSG00000117593.8588.31160778.43770-0.404002.982002.28060HepG2DDX21
DARS2ENSG00000117593.8678.16070980.80890-0.532303.743902.86000HepG2DDX55
DARS2ENSG00000117593.8420.550101024.08170-1.2840010.882509.03160HepG2DDX59
DARS2ENSG00000117593.8446.99060748.31300-0.743403.453502.77110HepG2DDX6
DARS2ENSG00000117593.8561.37130952.48840-0.7627013.0153011.76740HepG2DKC1
DARS2ENSG00000117593.8651.68060950.10960-0.543906.919105.84660HepG2DNAJC21
DARS2ENSG00000117593.8647.15380941.74200-0.541208.774307.69100HepG2DNAJC2
DARS2ENSG00000117593.8382.93260716.53850-0.904007.924506.10740HepG2AGO1
DARS2ENSG00000117593.8355.09300719.57450-1.018906.528905.64120HepG2EIF2S1
DARS2ENSG00000117593.8581.11750734.88060-0.338702.409701.40060HepG2EIF3G
DARS2ENSG00000117593.8586.04470795.31260-0.440502.005601.45860HepG2EIF4A3
DARS2ENSG00000117593.81015.513701407.33580-0.470807.445506.19270HepG2EIF4G1
DARS2ENSG00000117593.8687.262601348.14920-0.9720015.5218013.71020HepG2EIF4G2
DARS2ENSG00000117593.8663.766001752.25600-1.4005053.7916051.76220HepG2ETF1
DARS2ENSG00000117593.8609.04690816.36490-0.422702.595401.36210HepG2FKBP4
DARS2ENSG00000117593.8549.07380903.39720-0.718402.789701.76880HepG2FTO
DARS2ENSG00000117593.8326.89140426.14980-0.382502.068401.38070HepG2FUBP3
DARS2ENSG00000117593.81044.73190802.139900.381102.513301.85230HepG2FXR1
DARS2ENSG00000117593.8352.563701022.22620-1.5358024.6427022.94310HepG2GPKOW
DARS2ENSG00000117593.8619.74660950.51860-0.617009.931508.23290HepG2HDGF
DARS2ENSG00000117593.8551.50290959.21220-0.7985010.078208.96010HepG2HNRNPA1
DARS2ENSG00000117593.8566.323901066.95360-0.9138012.8158011.42200HepG2HNRNPC
DARS2ENSG00000117593.8659.130301083.78580-0.7174012.8306011.43770HepG2HNRNPF
DARS2ENSG00000117593.8834.885501299.52010-0.6383014.1887012.77390HepG2HNRNPL
DARS2ENSG00000117593.8610.03740975.53380-0.677306.617405.69030HepG2HNRNPLL
DARS2ENSG00000117593.8709.477501059.89900-0.579109.537508.46540HepG2HNRNPU
DARS2ENSG00000117593.8727.353101067.22440-0.553106.421005.36070HepG2IGF2BP1
DARS2ENSG00000117593.8458.72540756.57830-0.721904.028503.22750HepG2IGF2BP2
DARS2ENSG00000117593.8798.339101082.65050-0.439507.106105.98960HepG2ILF2
DARS2ENSG00000117593.8706.34330910.11290-0.365704.374603.10420HepG2KIF1C
DARS2ENSG00000117593.8832.166801471.89970-0.822708.131706.69940HepG2LARP4
DARS2ENSG00000117593.8583.40180995.02660-0.770205.326803.95740HepG2MTPAP
DARS2ENSG00000117593.8488.72270782.80760-0.679603.801302.37540HepG2NAA15
DARS2ENSG00000117593.8535.51780806.94150-0.591505.403903.41690HepG2NIP7
DARS2ENSG00000117593.8377.70220900.68820-1.2538010.357808.18330HepG2NONO
DARS2ENSG00000117593.8579.32360865.03350-0.578404.955403.96440HepG2NSUN2
DARS2ENSG00000117593.8248.15570400.05870-0.689002.804901.90980HepG2PABPC1
DARS2ENSG00000117593.8866.785901049.10930-0.275402.530101.71640HepG2PARN
DARS2ENSG00000117593.8534.34150699.84540-0.389303.616502.94220HepG2PCBP1
DARS2ENSG00000117593.8398.27260901.86230-1.1792011.677709.76230HepG2PCBP2
DARS2ENSG00000117593.8505.96370945.34390-0.9018016.6324014.92010HepG2PPIL4
DARS2ENSG00000117593.8695.21490994.54050-0.516607.268906.08560HepG2PRPF4
DARS2ENSG00000117593.8344.38010756.56260-1.1355013.7523012.14790HepG2PRPF8
DARS2ENSG00000117593.8893.80600712.071800.327802.832702.27990HepG2PTBP1
DARS2ENSG00000117593.8584.594401350.32080-1.2078025.4595023.89430HepG2PUF60
DARS2ENSG00000117593.81101.028901433.40080-0.380606.348605.52710HepG2PUM1
DARS2ENSG00000117593.8972.810301432.36890-0.558207.806306.70550HepG2PUM2
DARS2ENSG00000117593.8746.695001014.03670-0.441506.017305.17150HepG2PUS1
DARS2ENSG00000117593.8572.82300771.29160-0.429202.821402.19160HepG2QKI
DARS2ENSG00000117593.8401.87400870.31040-1.114808.177307.00580HepG2RAVER1
DARS2ENSG00000117593.8721.039101094.36330-0.601907.961606.61220HepG2RBM15
DARS2ENSG00000117593.8753.824901464.55510-0.9582022.7414021.54570HepG2RBM22
DARS2ENSG00000117593.8946.33320792.506600.255801.801901.34490HepG2NELFE
DARS2ENSG00000117593.8971.43070738.041300.396304.057003.32950HepG2RECQL
DARS2ENSG00000117593.8557.455101167.43180-1.0664017.9030016.46120HepG2RPLP0
DARS2ENSG00000117593.8341.69750854.92410-1.3231013.5293011.61580HepG2RPS10
DARS2ENSG00000117593.8311.27330605.93910-0.9610011.5927010.43930HepG2RPS19
DARS2ENSG00000117593.8616.46070992.47640-0.687007.045505.80780HepG2RPS2
DARS2ENSG00000117593.8273.29960748.39190-1.4533019.1044017.38850HepG2RRP9
DARS2ENSG00000117593.8808.40780943.88260-0.223501.885701.33700HepG2SAFB2
DARS2ENSG00000117593.8613.99090907.68890-0.564003.501702.73960HepG2SF3A3
DARS2ENSG00000117593.8517.33540965.55700-0.9003011.6238010.27030HepG2SF3B1
DARS2ENSG00000117593.8619.95510741.44300-0.258201.946501.43620HepG2SF3B4
DARS2ENSG00000117593.8953.673801294.69710-0.441007.288706.23420HepG2SLBP
DARS2ENSG00000117593.8847.462301100.71930-0.377205.262304.42390HepG2SMN1
DARS2ENSG00000117593.8605.03240887.42810-0.552603.480502.39090HepG2SMNDC1
DARS2ENSG00000117593.8788.398901654.14920-1.0691036.3901035.11410HepG2SRFBP1
DARS2ENSG00000117593.8698.854901039.02450-0.572203.984502.75970HepG2SRSF3
DARS2ENSG00000117593.8706.369601333.21590-0.9164023.0120021.45030HepG2SRSF5
DARS2ENSG00000117593.8540.472301064.76740-0.9782022.0097020.39840HepG2SRSF7
DARS2ENSG00000117593.8854.726201436.17250-0.7487017.8816016.81790HepG2SSB
DARS2ENSG00000117593.8506.84920813.32800-0.682303.842202.41560HepG2SUB1
DARS2ENSG00000117593.81290.171101516.25880-0.233002.821202.19480HepG2SUCLG1
DARS2ENSG00000117593.8356.74590976.36500-1.4525021.6074020.03860HepG2SUPV3L1
DARS2ENSG00000117593.8469.72100950.97560-1.0176014.2570012.81480HepG2TARDBP
DARS2ENSG00000117593.8395.88610654.41400-0.725105.714404.35680HepG2TFIP11
DARS2ENSG00000117593.8322.569001029.86230-1.6748044.3730042.81670HepG2TIAL1
DARS2ENSG00000117593.8526.741001039.09820-0.9802023.0500021.62140HepG2TRIM56
DARS2ENSG00000117593.81031.239001319.16640-0.355203.186502.24300HepG2TUFM
DARS2ENSG00000117593.8450.82780985.27250-1.127909.575208.39150HepG2U2AF1
DARS2ENSG00000117593.8277.178801181.26310-2.0914010.647808.61180HepG2U2AF2
DARS2ENSG00000117593.8387.19550576.75850-0.574904.139003.21040HepG2UCHL5
DARS2ENSG00000117593.8485.10800804.98070-0.7306011.7958010.53590HepG2UPF1
DARS2ENSG00000117593.8293.44940894.01150-1.6072019.9491017.29810HepG2UPF2
DARS2ENSG00000117593.8471.61290777.17820-0.7206010.167309.13360HepG2UTP3
DARS2ENSG00000117593.8585.19500961.12480-0.715806.950105.81310HepG2XRN2
DARS2ENSG00000117593.8617.17570885.32560-0.520507.903307.10150HepG2ZNF622
DARS2ENSG00000117593.8604.72010869.52790-0.524003.217001.80910HepG2ZRANB2
DARS2ENSG00000117593.81536.422001758.43840-0.194701.925801.43590K562AGGF1
DARS2ENSG00000117593.84973.750304157.524200.258502.592001.39200K562APOBEC3C
DARS2ENSG00000117593.81575.882303945.27020-1.3240021.7415020.27400K562AQR
DARS2ENSG00000117593.82079.214102416.81330-0.217102.635701.70120K562BCLAF1
DARS2ENSG00000117593.81464.453802148.74440-0.553106.189304.87260K562BOP1
DARS2ENSG00000117593.81975.460602731.95480-0.467704.275802.45340K562BUD13
DARS2ENSG00000117593.8877.465701311.51750-0.579806.087804.35650K562CCAR1
DARS2ENSG00000117593.82474.906003496.27140-0.498402.591301.57020K562CNOT7
DARS2ENSG00000117593.81659.894502284.75510-0.460906.154504.98810K562CPSF6
DARS2ENSG00000117593.81361.104001833.51300-0.429805.720004.12240K562CSTF2
DARS2ENSG00000117593.81990.131002536.94330-0.350205.226903.52250K562DDX21
DARS2ENSG00000117593.82486.958403474.00120-0.4822011.115409.90620K562DDX47
DARS2ENSG00000117593.81071.297002037.93780-0.9278015.3103012.97320K562EFTUD2
DARS2ENSG00000117593.82269.971902899.19000-0.353004.490903.60090K562EIF2S2
DARS2ENSG00000117593.81315.736702182.29800-0.730007.713205.83870K562EIF3D
DARS2ENSG00000117593.81187.279001428.32000-0.266702.562101.46530K562EIF4B
DARS2ENSG00000117593.83531.794404711.56750-0.415806.950305.47820K562EIF4G2
DARS2ENSG00000117593.81541.671002324.63900-0.592507.516406.07130K562FMR1
DARS2ENSG00000117593.81441.302301970.32170-0.451103.931102.82500K562FTO
DARS2ENSG00000117593.81135.558202181.39740-0.9419018.7285016.57900K562GPKOW
DARS2ENSG00000117593.82618.975903863.75780-0.561005.771704.67580K562GRSF1
DARS2ENSG00000117593.82164.520102683.11550-0.309903.174502.02330K562HNRNPA1
DARS2ENSG00000117593.81198.248702195.25800-0.873504.928103.15440K562HNRNPA2B1
DARS2ENSG00000117593.81352.014902191.26830-0.6967011.6372010.48660K562HNRNPC
DARS2ENSG00000117593.82536.431003139.38720-0.307703.082601.96220K562HNRNPL
DARS2ENSG00000117593.82170.797802971.31260-0.452907.667606.18720K562HNRNPU
DARS2ENSG00000117593.81831.212602288.19080-0.321402.795401.59680K562IGF2BP3
DARS2ENSG00000117593.81448.312401941.89890-0.423104.403703.33030K562KIF1C
DARS2ENSG00000117593.81335.512401862.59260-0.479903.269702.24650K562KRR1
DARS2ENSG00000117593.81685.148602121.34360-0.332102.868601.45330K562LARP7
DARS2ENSG00000117593.81394.577301858.76700-0.414504.821203.28090K562MAK16
DARS2ENSG00000117593.81505.248402129.27940-0.500406.501905.13130K562METAP2
DARS2ENSG00000117593.82231.130402633.17410-0.239003.300302.42050K562MTPAP
DARS2ENSG00000117593.81076.849901524.78520-0.501803.386102.39060K562NAA15
DARS2ENSG00000117593.81460.372802007.33750-0.458903.895302.29920K562NONO
DARS2ENSG00000117593.82120.331302925.70130-0.4645014.9338013.39270K562NSUN2
DARS2ENSG00000117593.8769.719501920.83410-1.3193010.211407.89070K562PABPN1
DARS2ENSG00000117593.81763.265202311.08550-0.390304.623002.83850K562PCBP1
DARS2ENSG00000117593.81444.834802103.65250-0.542007.014005.43170K562PCBP2
DARS2ENSG00000117593.81425.004202284.25280-0.680802.945601.43350K562PPP1R8
DARS2ENSG00000117593.81294.355301983.14080-0.615607.096005.89660K562PRPF8
DARS2ENSG00000117593.81320.228401964.64390-0.573507.706006.04700K562PSIP1
DARS2ENSG00000117593.83088.661102297.068200.427105.712004.78670K562PTBP1
DARS2ENSG00000117593.83768.310305140.78420-0.448105.414904.27590K562PUF60
DARS2ENSG00000117593.84563.158105357.61880-0.231602.314501.43510K562PUM2
DARS2ENSG00000117593.81395.565401768.05230-0.341303.305102.66590K562RBM15
DARS2ENSG00000117593.81481.081902202.63280-0.572607.326105.87540K562RBM22
DARS2ENSG00000117593.81228.837502363.22540-0.943504.961802.74820K562RBM39
DARS2ENSG00000117593.81306.921602020.25820-0.628405.452504.30330K562RPS19
DARS2ENSG00000117593.81055.127301757.00020-0.735703.162801.85270K562SF1
DARS2ENSG00000117593.82387.424102886.90800-0.274103.678102.74580K562SF3A3
DARS2ENSG00000117593.81410.167302074.51860-0.556905.228603.86630K562SF3B1
DARS2ENSG00000117593.81232.097801840.11580-0.578709.056307.46090K562SF3B4
DARS2ENSG00000117593.8808.120202017.26550-1.319809.137106.48450K562SNRNP200
DARS2ENSG00000117593.81356.809101698.99120-0.324502.607501.62150K562SRFBP1
DARS2ENSG00000117593.82282.609302957.69850-0.373808.351706.82230K562SRPK2
DARS2ENSG00000117593.8889.651802251.88880-1.3398039.8528037.25960K562SRSF1
DARS2ENSG00000117593.81569.785502126.72990-0.438104.444503.06220K562SRSF5
DARS2ENSG00000117593.81602.098602263.99200-0.498909.381607.20660K562SRSF7
DARS2ENSG00000117593.81508.923902413.33580-0.677502.947601.46090K562SUPT6H
DARS2ENSG00000117593.81379.906801920.47730-0.476903.832202.61970K562SUPV3L1
DARS2ENSG00000117593.81569.144802279.06670-0.538506.010404.93870K562TARDBP
DARS2ENSG00000117593.81589.673802198.41500-0.467706.073704.79040K562TIA1
DARS2ENSG00000117593.81143.967701889.69250-0.724108.718406.98460K562TIAL1
DARS2ENSG00000117593.81606.173802157.27940-0.425604.178402.78930K562TRA2A
DARS2ENSG00000117593.81627.694702007.24370-0.302402.442201.56300K562TRIM56
DARS2ENSG00000117593.81240.259301771.45030-0.514307.160205.87580K562U2AF2
DARS2ENSG00000117593.82025.803502848.00740-0.491506.858604.29330K562UPF2
DARS2ENSG00000117593.81719.901802654.44070-0.6261010.451208.70850K562WDR3
DARS2ENSG00000117593.81940.296202760.30280-0.5085013.4936011.79930K562WDR43
DARS2ENSG00000117593.83330.821704444.89140-0.416304.599003.44430K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for DARS2 is not available on ENCORE database.





7 RBPs can affect the splicing of DARS2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEDARS2ENSG00000117593.8chr1+1737974251737975371737958241737959241737997971737998990.085000.003420.09766includedK562FXR1
MXEDARS2ENSG00000117593.8chr1+1737997971737998991738006721738007681737974701737975371738025131738026370.224000.000190.010901includedK562AGGF1
MXEDARS2ENSG00000117593.8chr1+173814366173814429173819464173819617173810003173810111173822486173822705-0.111000.001430.050272includedK562LIN28B
MXEDARS2ENSG00000117593.8chr1+173814366173814429173819464173819617173810003173810111173822486173822705-0.098000.014720.086352includedK562AQR
MXEDARS2ENSG00000117593.8chr1+1738100031738101111738143661738144291738085041738086841738194641738196170.183000.001130.017561includedK562U2AF2
MXEDARS2ENSG00000117593.8chr1+173810003173810111173814366173814429173808504173808684173819464173819617-0.146000.000000.000712includedK562SBDS
MXEDARS2ENSG00000117593.8chr1+173810003173810111173814366173814429173808504173808684173819464173819617-0.092000.005750.068392includedK562HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for DARS2 is not avaliable on ENCORE database.