CCM2

General Information

Gene Name       : CCM2
Gene ID             : ENSG00000136280.16
Essential Gene : No

Functions

Localization

Domains (AlphaFold: CCM2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878CCM2ENSG00000136280.1612.0424.6118.32ENCSR000AEF
HepG2CCM2ENSG00000136280.1615.925.9710.95ENCSR985KAT
K562CCM2ENSG00000136280.1622.3217.4019.86ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for CCM2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • CCM2 RNA is bound by 17 proteins.  







eCLIP assay for CCM2 is not avaliable on ENCORE database.





17 proteins are bound to CCM2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr74511316645113223+3'-UTR,CDS,intron-Proximal5.9211010.84943K562AQR
chr74511383945113896+3'-UTR,CDS,intron-Proximal5.278566.04760K562AQR
chr74510353845103565+CDS,intron-Distal4.281584.12025K562YBX3
chr74504007345040197+intron-Distal4.178663.80269HepG2DROSHA
chr74504007145040166+intron-Distal4.616644.42691HepG2GTF2F1
chr74504066545040730+intron-Distal5.415289.01569HepG2CSTF2
chr74504066345040742+intron-Distal5.989198.42929K562FMR1
chr74504007145040193+intron-Distal3.281204.64824K562PRPF8
chr74504007345040145+intron-Distal4.3472010.57219K562CSTF2T
chr74505301445053176+intron-Distal3.094003.41538HepG2HNRNPL
chr74507926345079380+intron-Distal4.829957.10262K562SAFB2
chr74511322345113278+intron-Distal,intron-Proximal5.358796.83960K562AQR
chr74504017445040275+intron-Distal4.040353.02324K562XRN2
chr74508727545087379+intron-Distal3.204944.61518K562SLTM
chr74504066645040678+intron-Distal4.941526.76416K562CSTF2T
chr74504007345040154+intron-Distal4.791566.94957HepG2CSTF2T
chr74508336945083441+intron-Distal4.817083.91475K562PTBP1
chr74504006345040133+intron-Distal3.603366.59813HepG2FAM120A
chr74504022445040296+intron-Distal3.352346.83858K562GTF2F1
chr74504020245040285+intron-Distal3.025445.00815HepG2PRPF4
chr74507294845073039+intron-Distal4.483363.49140K562RBFOX2
chr74504007845040167+intron-Distal4.201323.94554K562XRN2
chr74504008545040170+intron-Distal3.982037.18598K562DROSHA
chr74508694145087026+intron-Distal4.210484.72697K562SAFB2
chr74507604145076103+intron-Distal4.486703.59909K562EXOSC5
chr74504005345040187+intron-Distal,intron-Proximal4.289669.49794HepG2PRPF4
chr74508087545080927+intron-Distal3.067223.26524K562SAFB2
chr74504007145040186+intron-Distal4.3559416.34743K562GTF2F1
chr74504022945040316+intron-Distal3.792949.67373K562CSTF2T
chr74504067845040749+intron-Distal4.7656821.64879K562CSTF2T
chr74504022845040298+intron-Distal3.053213.15890HepG2GTF2F1
chr74504016145040179+intron-Distal3.730873.17740K562CSTF2T
chr74504015445040294+intron-Distal4.5980510.75836HepG2CSTF2T
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for CCM2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for CCM2 is not available on ENCORE database.

  • 115 RBPs can affect the levels of CCM2.  








The Knockdown/knockout RNA-Seq assay for CCM2 is not available on ENCORE database.





115 RBPs can affect the gene expression of CCM2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
CCM2ENSG00000136280.11557.65900331.560400.750009.686708.68950HepG2ACO1
CCM2ENSG00000136280.11536.85180377.953700.506202.967001.89360HepG2AKAP8
CCM2ENSG00000136280.11658.97050483.219400.447404.226303.40990HepG2AUH
CCM2ENSG00000136280.11413.27450308.650600.421002.187001.64960HepG2BOP1
CCM2ENSG00000136280.11495.43120366.965800.432902.255001.55280HepG2CIRBP
CCM2ENSG00000136280.11419.42440331.436900.339602.198501.59490HepG2CKAP4
CCM2ENSG00000136280.11462.75080338.860300.449403.395802.69870HepG2CELF1
CCM2ENSG00000136280.11493.75820364.335600.438403.861703.00950HepG2DAZAP1
CCM2ENSG00000136280.11720.96580447.133900.689105.306304.46460HepG2DDX3X
CCM2ENSG00000136280.11448.65610246.105600.866204.886403.89280HepG2DDX55
CCM2ENSG00000136280.11699.24470384.248500.863707.476106.50570HepG2DDX6
CCM2ENSG00000136280.11308.27070227.585800.437702.386701.72770HepG2DNAJC21
CCM2ENSG00000136280.11317.10190225.582700.491203.405602.69540HepG2DNAJC2
CCM2ENSG00000136280.11105.37880197.98560-0.909804.162802.78860HepG2AGO1
CCM2ENSG00000136280.11547.82250369.237300.569103.564102.89530HepG2EIF2S1
CCM2ENSG00000136280.11830.54590407.978001.0255010.822309.58550HepG2EIF4A3
CCM2ENSG00000136280.11221.10580359.45880-0.701105.417304.31190HepG2EIF4G1
CCM2ENSG00000136280.11344.95070554.83240-0.685707.283006.38640HepG2ETF1
CCM2ENSG00000136280.11360.46690255.574600.496002.525101.86000HepG2HNRNPC
CCM2ENSG00000136280.11497.52390339.467400.551405.185504.24150HepG2HNRNPF
CCM2ENSG00000136280.11497.26020334.279900.572804.722203.79900HepG2IGF2BP1
CCM2ENSG00000136280.11635.32730388.190500.710605.788004.84630HepG2IGF2BP2
CCM2ENSG00000136280.11382.48380259.334500.560504.870403.91980HepG2ILF2
CCM2ENSG00000136280.11267.55160411.99720-0.622803.546002.80200HepG2MAGOH
CCM2ENSG00000136280.11470.23700349.950100.426102.171501.45010HepG2MSI2
CCM2ENSG00000136280.11469.47640361.275600.377902.124501.45440HepG2NOL12
CCM2ENSG00000136280.11180.34590271.79950-0.591802.562701.84140HepG2NSUN2
CCM2ENSG00000136280.11468.82700249.964800.907205.098403.86190HepG2PABPC1
CCM2ENSG00000136280.11333.23510226.444500.557303.775302.92670HepG2PPIL4
CCM2ENSG00000136280.11243.09570344.87540-0.504602.673802.08610HepG2PUF60
CCM2ENSG00000136280.11562.24610366.107800.618807.669506.78430HepG2PUM1
CCM2ENSG00000136280.11501.73390365.835800.455603.210502.48760HepG2PUM2
CCM2ENSG00000136280.11558.08610337.708200.724609.112508.10190HepG2PUS1
CCM2ENSG00000136280.11575.06670409.024500.491404.005503.27360HepG2QKI
CCM2ENSG00000136280.11237.08120371.23820-0.647004.233803.41430HepG2RBM25
CCM2ENSG00000136280.11516.92610365.669500.499303.449702.70020HepG2RPLP0
CCM2ENSG00000136280.11289.30800192.023000.591202.400901.52040HepG2RPS10
CCM2ENSG00000136280.11385.42840226.094300.769407.522706.53660HepG2SAFB2
CCM2ENSG00000136280.11376.30810263.662000.513103.899103.15720HepG2SMN1
CCM2ENSG00000136280.11296.08420199.486800.569602.556601.63720HepG2SMNDC1
CCM2ENSG00000136280.11216.64110337.58420-0.639902.573801.82140HepG2SNRNP70
CCM2ENSG00000136280.11198.09540326.46730-0.720703.602602.44630HepG2SRSF3
CCM2ENSG00000136280.11444.24880340.523000.383502.631802.01770HepG2SRSF5
CCM2ENSG00000136280.11590.54470454.722800.377002.152201.68530HepG2SSB
CCM2ENSG00000136280.11593.17030387.261000.615006.648605.75750HepG2SUCLG1
CCM2ENSG00000136280.11409.68030244.959000.741903.383602.64390HepG2SUPV3L1
CCM2ENSG00000136280.11111.38740368.98020-1.7280022.5780021.19550HepG2TAF15
CCM2ENSG00000136280.11529.75700246.688401.1025014.4170013.43290HepG2TIAL1
CCM2ENSG00000136280.11434.11950248.902300.802408.767807.85190HepG2TRIM56
CCM2ENSG00000136280.11417.06180224.214300.895303.686502.51240HepG2UPF2
CCM2ENSG00000136280.11370.81690241.136300.620802.635401.92810HepG2XRN2
CCM2ENSG00000136280.11360.48370283.109500.348501.987001.40380HepG2ZC3H8
CCM2ENSG00000136280.11653.06030406.865800.682609.922509.04750HepG2ZNF622
CCM2ENSG00000136280.11484.60860764.83630-0.658305.984104.18660K562ABCF1
CCM2ENSG00000136280.11516.24600854.29750-0.7267011.012909.97540K562AGGF1
CCM2ENSG00000136280.11578.00060888.92360-0.621006.417805.39210K562AKAP8L
CCM2ENSG00000136280.11251.799701173.88710-2.2209053.9318051.65170K562AQR
CCM2ENSG00000136280.11237.13620412.19250-0.797605.700004.43520K562BOP1
CCM2ENSG00000136280.11362.44870512.29690-0.499203.529201.79490K562CEBPZ
CCM2ENSG00000136280.11515.98280895.40380-0.795204.999003.51830K562CNOT7
CCM2ENSG00000136280.11777.21850964.47570-0.311402.773101.66760K562CPEB4
CCM2ENSG00000136280.11293.13640523.69880-0.837204.326301.94400K562CPSF7
CCM2ENSG00000136280.11280.30280535.11650-0.932906.206603.58030K562YBX3
CCM2ENSG00000136280.11780.078801658.73130-1.0884010.171408.36480K562CELF1
CCM2ENSG00000136280.11416.88360588.78530-0.498103.991802.52000K562DDX21
CCM2ENSG00000136280.11488.01400998.06170-1.0322023.3078021.60330K562DDX47
CCM2ENSG00000136280.11330.52910526.81720-0.672505.543003.63630K562DNAJC21
CCM2ENSG00000136280.11257.69290558.43310-1.115707.462404.74350K562DNAJC2
CCM2ENSG00000136280.111010.32720683.249100.564207.614306.50840K562EIF2S2
CCM2ENSG00000136280.11160.60200498.32230-1.6336013.9236011.71060K562EIF3A
CCM2ENSG00000136280.11163.36980327.58270-1.003709.310007.85330K562EIF3G
CCM2ENSG00000136280.11342.32850491.88050-0.522902.046601.33800K562EIF4A3
CCM2ENSG00000136280.11253.54580534.90160-1.077006.134803.13600K562EIF4G1
CCM2ENSG00000136280.11816.162701348.64620-0.724609.598407.88450K562EIF4G2
CCM2ENSG00000136280.11375.07590584.70490-0.640503.864801.88890K562ESF1
CCM2ENSG00000136280.11243.53160377.99790-0.634303.831202.74130K562FTO
CCM2ENSG00000136280.1172.63560212.85180-1.551109.939408.44130K562G3BP2
CCM2ENSG00000136280.11454.61340832.19700-0.8723013.9675011.71160K562GLRX3
CCM2ENSG00000136280.11273.64670418.42160-0.612604.070503.11180K562GPKOW
CCM2ENSG00000136280.11669.18570910.42860-0.444103.607202.74880K562GRSF1
CCM2ENSG00000136280.11318.63710795.68720-1.3203013.4040011.32640K562HNRNPA1
CCM2ENSG00000136280.11502.97200831.13480-0.724603.139301.81620K562HNRNPA2B1
CCM2ENSG00000136280.11536.39890837.84350-0.643403.669201.83970K562HNRNPAB
CCM2ENSG00000136280.11320.92800549.59860-0.776107.186006.26820K562HNRNPC
CCM2ENSG00000136280.11639.51760901.95820-0.496104.731903.30710K562HNRNPL
CCM2ENSG00000136280.11619.19250881.24980-0.509203.344702.36470K562HNRNPU
CCM2ENSG00000136280.11449.63840816.95960-0.861505.214603.22000K562ILF2
CCM2ENSG00000136280.11350.13440511.78710-0.547603.611601.89490K562ILF3
CCM2ENSG00000136280.11277.14480494.69900-0.835907.503005.09920K562KHDRBS1
CCM2ENSG00000136280.11602.30060943.41110-0.647406.748405.32580K562KIF1C
CCM2ENSG00000136280.11187.56560357.31200-0.929805.589704.20350K562KRR1
CCM2ENSG00000136280.11278.66020408.43140-0.551603.530802.53430K562METAP2
CCM2ENSG00000136280.11995.128001437.44630-0.530606.067304.41100K562MSI2
CCM2ENSG00000136280.11377.51400874.94830-1.2127028.0198025.86960K562MTPAP
CCM2ENSG00000136280.111081.981101475.37060-0.447403.000101.43890K562NOL12
CCM2ENSG00000136280.11439.15150972.13650-1.1464031.9583029.88880K562NSUN2
CCM2ENSG00000136280.11588.81410860.21840-0.546902.453501.31000K562PABPC1
CCM2ENSG00000136280.11447.81700727.24030-0.699502.864701.85180K562PABPN1
CCM2ENSG00000136280.11287.46790396.03010-0.462202.038701.39040K562PRPF8
CCM2ENSG00000136280.11567.99960456.920800.313801.927801.35510K562PTBP1
CCM2ENSG00000136280.11805.371801471.41320-0.8695012.4854010.74300K562PUF60
CCM2ENSG00000136280.111155.104301565.51590-0.438603.860102.57910K562PUM1
CCM2ENSG00000136280.111186.342801533.44940-0.370303.778802.65380K562PUM2
CCM2ENSG00000136280.11475.86900881.65200-0.8896010.671809.65290K562PUS1
CCM2ENSG00000136280.11544.98270858.96770-0.656408.381507.37590K562RBM15
CCM2ENSG00000136280.11115.12010202.05730-0.811604.188502.50090K562RBM25
CCM2ENSG00000136280.11603.47110427.062000.498703.377501.79690K562RBM34
CCM2ENSG00000136280.11516.11600894.73300-0.793803.215501.52660K562RBM39
CCM2ENSG00000136280.11630.44250460.932900.451703.032401.88280K562NELFE
CCM2ENSG00000136280.11269.27420403.28370-0.582702.800501.97860K562RPS19
CCM2ENSG00000136280.11494.34310798.46550-0.691704.086602.13860K562RPS3A
CCM2ENSG00000136280.11293.54240174.054300.753903.596202.43890K562RPS3
CCM2ENSG00000136280.11266.83700404.79650-0.601202.980601.59600K562RRP9
CCM2ENSG00000136280.11540.31500815.55300-0.594002.991601.41140K562SBDS
CCM2ENSG00000136280.11473.81810959.26500-1.0176020.8659018.81120K562SF3A3
CCM2ENSG00000136280.11227.50820397.97850-0.806805.138103.79000K562SF3B1
CCM2ENSG00000136280.11301.20750539.64350-0.841206.478004.53740K562SLBP
CCM2ENSG00000136280.11457.18160763.74900-0.740302.994301.69950K562SNRNP200
CCM2ENSG00000136280.11743.37630982.78900-0.402805.053403.83540K562SRPK2
CCM2ENSG00000136280.11367.39420525.36690-0.516004.261302.78880K562SRSF7
CCM2ENSG00000136280.11190.76130337.89490-0.824807.047104.88380K562SSB
CCM2ENSG00000136280.11437.91250659.77370-0.591302.530901.33750K562STAU1
CCM2ENSG00000136280.11429.29580913.70590-1.089805.817903.52090K562SUPT6H
CCM2ENSG00000136280.11222.69050383.23250-0.783203.824302.61470K562SUPV3L1
CCM2ENSG00000136280.11755.95260453.301500.737707.446806.22250K562TARDBP
CCM2ENSG00000136280.11742.77930437.279200.764308.575907.02250K562TIA1
CCM2ENSG00000136280.11325.44650473.96320-0.542403.199902.18770K562TIAL1
CCM2ENSG00000136280.11616.12410429.269300.521203.915102.58230K562TRA2A
CCM2ENSG00000136280.11115.93410206.49970-0.832803.851502.51840K562U2AF1
CCM2ENSG00000136280.11120.26430213.21130-0.826104.743303.69630K562U2AF2
CCM2ENSG00000136280.11766.803101030.77770-0.426805.464804.49310K562UPF1
CCM2ENSG00000136280.11527.20240795.05930-0.592704.446102.91580K562UTP3
CCM2ENSG00000136280.11412.26020882.00260-1.0972018.6644016.42280K562WDR3
CCM2ENSG00000136280.11518.53590917.18900-0.8228016.5663014.73740K562WDR43
CCM2ENSG00000136280.111033.571201390.83980-0.428304.282202.66610K562WRN
CCM2ENSG00000136280.11624.881101322.42280-1.0815020.3087017.83480K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for CCM2 is not available on ENCORE database.





13 RBPs can affect the splicing of CCM2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SECCM2ENSG00000136280.11chr7+4507785145078025450398474503996245103516451036000.141000.000020.01211includedK562PUM1
SECCM2ENSG00000136280.11chr7+451123244511238245109424451095604511305845113118-0.156000.002390.05407excludedHepG2HNRNPK
SECCM2ENSG00000136280.11chr7+451080414510817845077851450780254510942445109560-0.084000.007490.06459excludedK562AQR
SECCM2ENSG00000136280.11chr7+4511134845111471451094244510956045112324451123850.084000.000200.04769includedK562HNRNPA1
SECCM2ENSG00000136280.11chr7+451035164510360045077851450780254510406145104245-0.063000.001140.01895excludedK562PUS1
SECCM2ENSG00000136280.11chr7+451080414510817845104061451042454510942445109560-0.460000.000620.01539excludedK562U2AF1
SECCM2ENSG00000136280.11chr7+450778514507802545039786450399624510351645103600-0.458000.000030.00103excludedK562U2AF1
SECCM2ENSG00000136280.11chr7+4507785145078025450398474503996245103516451036000.162000.000580.06897includedHepG2HNRNPUL1
SECCM2ENSG00000136280.11chr7+451123244511238245109424451095604511305845113118-0.095000.001400.05809excludedK562HNRNPK
SECCM2ENSG00000136280.11chr7+4511134845111471451094244510956045112324451123850.121000.000000.00002includedK562PTBP1
SECCM2ENSG00000136280.11chr7+451080414510817845104061451042454510942445109560-0.270000.000130.00336excludedK562HNRNPC
MXECCM2ENSG00000136280.11chr7+4507785145078025451035164510360045039786450399624510406145104245-0.192000.001130.082092includedK562HNRNPL
MXECCM2ENSG00000136280.11chr7+45108041451081784510942445109560451040614510424545112324451123820.082000.008730.080011includedK562DROSHA
MXECCM2ENSG00000136280.11chr7+4507785145078025451035164510360045039786450399624510406145104245-0.124000.003550.043022includedK562DROSHA
MXECCM2ENSG00000136280.11chr7+45104061451042454510804145108178450778514507802545109424451095600.422000.001240.023621includedK562U2AF1
MXECCM2ENSG00000136280.11chr7+45109424451095604511232445112382451040614510424545113058451131700.263000.002580.040161includedK562U2AF1
MXECCM2ENSG00000136280.11chr7+45104061451042454510942445109560450778514507802545112324451123820.096000.000740.016201includedK562PUS1
MXECCM2ENSG00000136280.11chr7+45077851450780254510351645103600450672704506739645104061451042450.108000.001310.025271includedK562PUS1
MXECCM2ENSG00000136280.11chr7+4507785145078025451123244511238245039783450399624511305845113170-0.220000.015500.089892includedK562AQR
MXECCM2ENSG00000136280.11chr7+4507785145078025451035164510360045039786450399624510406145104245-0.156000.002960.062652includedK562SBDS
MXECCM2ENSG00000136280.11chr7+45104061451042454510804145108178450778514507802545109424451095600.230000.000160.004751includedK562HNRNPC
MXECCM2ENSG00000136280.11chr7+45109424451095604511232445112382451040614510424545113058451131700.206000.006110.075841includedK562SF3B4
MXECCM2ENSG00000136280.11chr7+45109424451095604511232445112382451040614510424545113058451131700.277000.000030.004511includedK562HNRNPK

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for CCM2 is not avaliable on ENCORE database.