FEN1

General Information

Gene Name       : FEN1
Gene ID             : ENSG00000168496.3
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: FEN1)


Antibody Validation

 View validation images for all FEN1 antibodies

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878FEN1ENSG00000168496.358.4981.9970.24ENCSR000AEF
HepG2FEN1ENSG00000168496.372.2167.8670.03ENCSR985KAT
K562FEN1ENSG00000168496.3105.5093.1299.31ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
FEN1A300-255A3BGHcLV41-71, Submitted, ENCORE2BGKcLV40-51, Submitted, ENCORE2
FEN1A300-256A2BGHcLV41-71, Submitted, ENCORE2BGKcLV40-51, Submitted, ENCORE2


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
FEN1K562CRISPRFEN1-BGKcLV40-51,FEN1-BGKcLV40-52NT-BGKcLV40-1,NT-BGKcLV40-281.5,82.9SubmittingENCORE2
FEN1HepG2CRISPRFEN1-BGHcLV41-71,FEN1-BGHcLV41-72NT-BGHcLV41-1,NT-BGHcLV41-276.2,81.3SubmittingENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
FEN1Product_ID: A300-255A
Lot_ID: 3
Source: Bethyl Labs
Target Name: FEN1-human		 FEN1-HEPG2-CRISPR-A300-255A.png<br>Caption: Western blot following CRISPR against FEN1 in HepG2 whole cell lysate using FEN1 specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against FEN1. FEN1 protein appears as the green arrow, Tubulin serves as a control and appears in red arrow.
 FEN1-K562-CRISPR-A300-255A.png<br>Caption: Western blot following CRISPR against FEN1 in K562 whole cell lysate using FEN1 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against FEN1. FEN1 protein appears as the green arrow, Tubulin serves as a control and appears in red arrow.
FEN1Product_ID: A300-256A
Lot_ID: 2
Source: Bethyl Labs
Target Name: FEN1-human		 FEN1-K562-CRISPR-A300-256A.png<br>Caption: Western blot following CRISPR against FEN1 in K562 whole cell lysate using FEN1 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against FEN1. FEN1 protein appears as the green arrow, Tubulin serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for FEN1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • FEN1 RNA is bound by 9 proteins.  







eCLIP assay for FEN1 is not avaliable on ENCORE database.





9 proteins are bound to FEN1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr116156434461564413+3'-UTR,CDS,intron-Distal,intron-Proximal3.437233.79156K562LIN28B
chr116156281261562817+3'-UTR,intron-Distal,intron-Proximal3.7439710.05151K562DDX3X
chr116156424861564340+3'-UTR,intron-Distal,intron-Proximal5.2980510.24308K562PUM2
chr116156450261564554+3'-UTR,intron-Distal4.048515.75821HepG2SUB1
chr116156444461564629+3'-UTR,intron-Distal4.577364.89596HepG2LIN28B
chr116156430961564344+3'-UTR,intron-Distal,intron-Proximal3.764414.99353K562LIN28B
chr116156449661564598+3'-UTR,intron-Distal3.667937.13548K562UPF1
chr116156437761564424+3'-UTR,CDS,intron-Distal,intron-Proximal4.972515.25980HepG2SUB1
chr116156281761562858+3'-UTR,CDS,intron-Distal3.1655414.93330K562DDX3X
chr116156281161562827+3'-UTR,intron-Distal,intron-Proximal3.234286.00087K562YBX3
chr116156445661564556+3'-UTR,intron-Distal3.078623.09954K562DDX6
chr116156456461564629+3'-UTR,intron-Distal3.409747.63427HepG2SUB1
chr116156449661564557+3'-UTR,intron-Distal3.382604.94406K562YBX3
chr116156427561564309+3'-UTR,intron-Distal,intron-Proximal3.895663.07411K562LIN28B
chr116156050061560552+5'-UTR,intron-Proximal4.538674.89208K562AQR
chr116156045861560499+5'-UTR4.971496.75419HepG2DDX3X
chr116156038261560461+5'-UTR3.9539120.77353K562DDX3X
chr116156045761560500+5'-UTR3.302217.11210K562YBX3
chr116156046161560502+5'-UTR,intron-Proximal4.8792526.88998K562DDX3X
chr116156326261563336+CDS,intron-Distal4.1477311.47083K562YBX3
chr116156294961563047+CDS,intron-Distal3.026999.97831K562DDX3X
chr116156300061563057+CDS,intron-Distal3.099085.63814K562YBX3
chr116156376461563827+CDS,intron-Distal3.513064.06757K562UCHL5
chr116156344861563503+CDS,intron-Distal3.592986.82132K562YBX3
chr116156285361562912+CDS,intron-Distal3.220277.87234K562YBX3
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for FEN1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for FEN1 is not available on ENCORE database.

  • 133 RBPs can affect the levels of FEN1.  








The Knockdown/knockout RNA-Seq assay for FEN1 is not available on ENCORE database.





133 RBPs can affect the gene expression of FEN1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
FEN1ENSG00000168496.3143.76590215.87790-0.586502.315401.35870HepG2AKAP8
FEN1ENSG00000168496.3256.60520485.54770-0.920107.744006.46210HepG2ASCC1
FEN1ENSG00000168496.3949.584401468.15780-0.6286012.0439010.78850HepG2AUH
FEN1ENSG00000168496.3593.105601128.35340-0.9279011.113109.46740HepG2BCLAF1
FEN1ENSG00000168496.3235.871501119.65310-2.2470055.2456053.26250HepG2BOP1
FEN1ENSG00000168496.3366.15830932.08120-1.3480027.4871025.56570HepG2CALR
FEN1ENSG00000168496.3446.57780970.37720-1.1196030.3129028.64670HepG2CKAP4
FEN1ENSG00000168496.3351.464301027.87340-1.5482029.2379027.32550HepG2CPSF6
FEN1ENSG00000168496.3602.64870848.47740-0.493604.285202.92350HepG2CPSF7
FEN1ENSG00000168496.31151.034201484.50740-0.367104.283503.51500HepG2CELF1
FEN1ENSG00000168496.3647.16040897.67150-0.472106.819305.60050HepG2DDX19B
FEN1ENSG00000168496.3409.83550911.81970-1.1537018.8109017.23590HepG2DDX21
FEN1ENSG00000168496.3438.87980892.37770-1.0238016.4101014.34600HepG2DDX24
FEN1ENSG00000168496.3304.32670562.13000-0.885307.640806.64850HepG2DDX3X
FEN1ENSG00000168496.3720.525901276.87910-0.825508.972407.67110HepG2DDX55
FEN1ENSG00000168496.3455.023301167.23540-1.3591012.4338010.45220HepG2DDX59
FEN1ENSG00000168496.3573.44920813.19730-0.503904.031002.81810HepG2DDX5
FEN1ENSG00000168496.3153.85190482.89720-1.6502017.7501016.36650HepG2DDX6
FEN1ENSG00000168496.3461.89470667.41210-0.531002.282001.39240HepG2DHX30
FEN1ENSG00000168496.3668.11840928.61460-0.475004.817603.96850HepG2DKC1
FEN1ENSG00000168496.3339.01920691.97770-1.0294016.8977015.30210HepG2DNAJC21
FEN1ENSG00000168496.3511.81880685.86790-0.422304.595903.79150HepG2DNAJC2
FEN1ENSG00000168496.3208.16990839.73000-2.0122032.6740029.21350HepG2AGO1
FEN1ENSG00000168496.3145.78070464.20500-1.6710019.3431017.87340HepG2EIF2S1
FEN1ENSG00000168496.3380.53440569.54340-0.581804.058702.97790HepG2EIF3D
FEN1ENSG00000168496.3618.99900861.12780-0.476304.500903.16140HepG2EIF3G
FEN1ENSG00000168496.3979.445701574.73820-0.6851014.4540012.83600HepG2EIF4G1
FEN1ENSG00000168496.31036.402901508.47270-0.541504.434303.41800HepG2EIF4G2
FEN1ENSG00000168496.3764.391101685.56610-1.1409037.1109035.37240HepG2ETF1
FEN1ENSG00000168496.3365.512501029.69590-1.494209.736607.85180HepG2FTO
FEN1ENSG00000168496.31274.61850517.612001.3000021.8660020.11880HepG2FXR1
FEN1ENSG00000168496.3782.96170509.755500.619005.129903.90400HepG2G3BP2
FEN1ENSG00000168496.31123.63150861.451100.383202.322401.39290HepG2GNB2L1
FEN1ENSG00000168496.3528.737301165.09470-1.1398015.6217014.21860HepG2GPKOW
FEN1ENSG00000168496.3538.70920926.64620-0.7825014.9991013.03150HepG2HDGF
FEN1ENSG00000168496.3529.41610899.15320-0.764203.137101.65380HepG2HLTF
FEN1ENSG00000168496.3421.93650698.60700-0.727506.945505.99100HepG2HNRNPA1
FEN1ENSG00000168496.3896.709401466.88990-0.7100014.5423012.74690HepG2HNRNPA2B1
FEN1ENSG00000168496.3580.51120777.07140-0.420702.964202.24980HepG2HNRNPC
FEN1ENSG00000168496.3659.200401402.74870-1.0895031.3827029.40370HepG2HNRNPF
FEN1ENSG00000168496.31225.200401453.82280-0.246802.705102.03870HepG2HNRNPL
FEN1ENSG00000168496.3293.187301111.87850-1.9231031.6859029.93030HepG2HNRNPLL
FEN1ENSG00000168496.31050.53640717.801800.549405.945004.61590HepG2HNRNPM
FEN1ENSG00000168496.3213.79720771.93380-1.8522053.2034050.82360HepG2HNRNPU
FEN1ENSG00000168496.3679.099301381.31110-1.0243021.3634019.57340HepG2IGF2BP1
FEN1ENSG00000168496.3198.07820488.05650-1.3010013.6933012.32000HepG2IGF2BP2
FEN1ENSG00000168496.3598.23920887.24960-0.568609.107407.35420HepG2KIF1C
FEN1ENSG00000168496.3907.881901251.66250-0.463302.490901.70460HepG2LARP4
FEN1ENSG00000168496.31220.09670517.792801.2364019.1267017.48690HepG2MAGOH
FEN1ENSG00000168496.3678.02370841.99630-0.312502.070001.36540HepG2MSI2
FEN1ENSG00000168496.3589.285601134.14630-0.944607.637905.99940HepG2MTPAP
FEN1ENSG00000168496.3520.92790707.02820-0.440702.554301.38780HepG2NAA15
FEN1ENSG00000168496.3696.88540532.949100.386802.132501.57340HepG2NCBP2
FEN1ENSG00000168496.31949.307101582.642200.300503.370302.53060HepG2NOL12
FEN1ENSG00000168496.3503.51560985.95100-0.9695012.9904011.49070HepG2NSUN2
FEN1ENSG00000168496.3667.52520425.696300.648903.516701.71190HepG2PA2G4
FEN1ENSG00000168496.3282.30960474.61190-0.749505.447204.44420HepG2PABPC4
FEN1ENSG00000168496.3699.16900514.764500.441604.159003.44250HepG2PCBP1
FEN1ENSG00000168496.3291.57360886.83310-1.6048016.7138014.50480HepG2PCBP2
FEN1ENSG00000168496.3680.95860923.03140-0.438803.372201.46340HepG2PES1
FEN1ENSG00000168496.3539.03140688.50330-0.353102.835902.09090HepG2PPIL4
FEN1ENSG00000168496.3513.21360764.81140-0.575507.228006.04780HepG2PRPF4
FEN1ENSG00000168496.3270.93250984.81130-1.8619036.6883034.31250HepG2PRPF8
FEN1ENSG00000168496.3784.08280523.750500.582006.949206.16150HepG2PTBP1
FEN1ENSG00000168496.3515.138801510.81670-1.5523023.8759022.35920HepG2PUF60
FEN1ENSG00000168496.31067.051501602.64750-0.586808.482607.33670HepG2PUM2
FEN1ENSG00000168496.3456.78500567.32350-0.312701.906201.37280HepG2QKI
FEN1ENSG00000168496.3791.996101073.33620-0.438504.985503.87690HepG2RBM15
FEN1ENSG00000168496.3558.777901408.83710-1.3342038.5546037.05730HepG2RBM22
FEN1ENSG00000168496.3399.57120514.84900-0.365702.272901.65650HepG2RBM25
FEN1ENSG00000168496.3967.95670582.918700.7315011.1144010.16660HepG2NELFE
FEN1ENSG00000168496.3812.14920542.846700.581106.939506.02810HepG2RECQL
FEN1ENSG00000168496.3205.520401511.04360-2.87820102.1913099.62670HepG2RPLP0
FEN1ENSG00000168496.3334.41670840.90620-1.3303012.0090010.18720HepG2RPS10
FEN1ENSG00000168496.3248.63950554.24880-1.1565014.8816013.61070HepG2RPS19
FEN1ENSG00000168496.3643.39410938.80160-0.545104.229903.24870HepG2RPS2
FEN1ENSG00000168496.3232.57760974.16280-2.0665039.5442037.29680HepG2RRP9
FEN1ENSG00000168496.3317.37620687.44110-1.1150021.7472020.18760HepG2SAFB2
FEN1ENSG00000168496.3467.131001100.49400-1.2363017.4431015.83720HepG2SF3B1
FEN1ENSG00000168496.3998.508801448.74850-0.537007.343206.28450HepG2SLBP
FEN1ENSG00000168496.3388.40910835.23020-1.104605.724803.53590HepG2SLTM
FEN1ENSG00000168496.31024.90490801.672300.354304.505303.71960HepG2SMN1
FEN1ENSG00000168496.3413.20580873.82010-1.080507.536105.90480HepG2SMNDC1
FEN1ENSG00000168496.3607.226501224.50910-1.011908.970507.56920HepG2SNRNP70
FEN1ENSG00000168496.3404.533301591.25750-1.9758084.9000083.12230HepG2SRFBP1
FEN1ENSG00000168496.31371.85290569.214201.2690038.5848037.26790HepG2SRSF1
FEN1ENSG00000168496.3830.191401184.26650-0.512503.475902.34100HepG2SRSF3
FEN1ENSG00000168496.3946.518301491.77610-0.6563013.0807011.85450HepG2SRSF5
FEN1ENSG00000168496.3458.940301378.14030-1.5863058.5157056.25150HepG2SRSF7
FEN1ENSG00000168496.3307.94580463.05980-0.588505.246404.52930HepG2SRSF9
FEN1ENSG00000168496.31108.418701381.63680-0.317903.770403.19240HepG2SSB
FEN1ENSG00000168496.3319.46520694.88860-1.1211012.202609.85060HepG2STAU1
FEN1ENSG00000168496.3371.67740799.59440-1.105209.004506.91950HepG2SUB1
FEN1ENSG00000168496.31289.560101696.50500-0.395706.591905.70420HepG2SUCLG1
FEN1ENSG00000168496.3135.58020237.03760-0.806002.848701.50060HepG2SUGP2
FEN1ENSG00000168496.3237.224801271.05610-2.4217058.9160056.65360HepG2SUPV3L1
FEN1ENSG00000168496.3399.15940511.54730-0.357902.041701.54730HepG2TAF15
FEN1ENSG00000168496.3364.520801083.94920-1.5722026.9127025.10110HepG2TARDBP
FEN1ENSG00000168496.3424.33740851.90940-1.0055011.734409.96860HepG2TFIP11
FEN1ENSG00000168496.3190.59680750.07720-1.9765047.4124045.81200HepG2TIAL1
FEN1ENSG00000168496.3552.36400756.78320-0.454305.201904.47850HepG2TRIM56
FEN1ENSG00000168496.31214.853501476.09210-0.281002.083501.33460HepG2TUFM
FEN1ENSG00000168496.3412.57570892.13380-1.112603.609502.47930HepG2U2AF2
FEN1ENSG00000168496.31170.211901562.47820-0.417102.606501.79420HepG2UBE2L3
FEN1ENSG00000168496.3303.94330750.81280-1.3047018.9713017.03100HepG2UCHL5
FEN1ENSG00000168496.3429.12570943.63500-1.1368027.6735025.93250HepG2UPF1
FEN1ENSG00000168496.3759.91650911.04370-0.261702.304401.74660HepG2UTP3
FEN1ENSG00000168496.3586.37860841.77690-0.521602.639201.41370HepG2XRCC5
FEN1ENSG00000168496.3188.71530754.76400-1.9998059.4637057.23200HepG2ZC3H8
FEN1ENSG00000168496.3247.753801037.81900-2.0666086.5673084.65150HepG2ZNF622
FEN1ENSG00000168496.3561.49620855.25010-0.607103.828302.28250HepG2ZRANB2
FEN1ENSG00000168496.31867.836402518.49540-0.431202.723001.85670K562BOP1
FEN1ENSG00000168496.31256.012301712.32840-0.447104.227702.86550K562CCAR1
FEN1ENSG00000168496.33329.449105031.46950-0.595702.307301.35410K562CNOT7
FEN1ENSG00000168496.31996.208402678.00450-0.423902.452801.71060K562CPSF6
FEN1ENSG00000168496.32036.524102417.97240-0.247702.596101.57670K562CSTF2
FEN1ENSG00000168496.36931.007908287.17580-0.257802.870601.87980K562CELF1
FEN1ENSG00000168496.32841.703103775.16440-0.409807.502105.48260K562DDX21
FEN1ENSG00000168496.32979.827204816.16600-0.6927023.4601021.74680K562DDX47
FEN1ENSG00000168496.33656.891802680.844200.447803.244801.84870K562EEF2
FEN1ENSG00000168496.33802.147204619.41710-0.280904.056303.21040K562EIF2S2
FEN1ENSG00000168496.31046.955001741.73990-0.734305.064303.66570K562EIF3A
FEN1ENSG00000168496.32016.963802773.45140-0.459503.523502.34250K562EIF3D
FEN1ENSG00000168496.35613.276106740.22740-0.264003.783202.68720K562EIF4G2
FEN1ENSG00000168496.32407.233003076.16050-0.353803.467102.02820K562EXOSC5
FEN1ENSG00000168496.31694.117402250.35870-0.409604.582602.47360K562FASTKD2
FEN1ENSG00000168496.31434.937002145.08490-0.580006.023304.24510K562FKBP4
FEN1ENSG00000168496.31981.218202724.57120-0.459602.904702.02840K562FMR1
FEN1ENSG00000168496.31569.944702309.21780-0.556704.996503.72620K562FTO
FEN1ENSG00000168496.33300.261702123.087500.6363016.1022014.74910K562FXR1
FEN1ENSG00000168496.31089.642101564.01670-0.521403.679502.83850K562G3BP2
FEN1ENSG00000168496.32832.737703607.73990-0.348903.516602.23230K562GLRX3
FEN1ENSG00000168496.34729.422206155.89790-0.380304.908603.90390K562GRSF1
FEN1ENSG00000168496.33005.299304033.74340-0.424605.900504.36270K562HNRNPA1
FEN1ENSG00000168496.31407.505002472.03970-0.8126012.4951011.30180K562HNRNPC
FEN1ENSG00000168496.31509.342904467.13500-1.5654081.5793077.48560K562HNRNPU
FEN1ENSG00000168496.33465.996204830.44560-0.478905.909104.76070K562HSPD1
FEN1ENSG00000168496.3962.791402183.04690-1.1810014.6947012.40100K562KRR1
FEN1ENSG00000168496.31799.590102495.81030-0.471803.580802.57710K562METAP2
FEN1ENSG00000168496.35360.758307184.48290-0.422404.653503.18350K562MSI2
FEN1ENSG00000168496.33290.425103793.01860-0.205102.552201.77410K562MTPAP
FEN1ENSG00000168496.32900.475804214.66170-0.5391010.425909.10420K562NSUN2
FEN1ENSG00000168496.33976.259702488.581700.6760013.5929012.17590K562PTBP1
FEN1ENSG00000168496.35879.062907354.15410-0.323003.217602.33910K562PUF60
FEN1ENSG00000168496.36560.618407664.31870-0.224302.778201.81690K562PUM2
FEN1ENSG00000168496.3991.693501492.21420-0.589503.381501.78200K562RAVER1
FEN1ENSG00000168496.32971.361902386.078200.316402.784601.94180K562RBM22
FEN1ENSG00000168496.33316.319102511.006500.401203.784002.48210K562NELFE
FEN1ENSG00000168496.31363.803302567.58400-0.9128012.4897010.72800K562RPS19
FEN1ENSG00000168496.33437.313704158.38300-0.274703.262002.37900K562SF3A3
FEN1ENSG00000168496.31663.140602431.37990-0.547903.263802.20510K562SF3B1
FEN1ENSG00000168496.31471.250301885.98570-0.358302.937001.63370K562SLBP
FEN1ENSG00000168496.31530.141901931.51910-0.336103.058701.37670K562SND1
FEN1ENSG00000168496.33681.513204260.31590-0.210702.705601.77810K562SRPK2
FEN1ENSG00000168496.33009.179002439.675600.302603.041902.30290K562SRSF1
FEN1ENSG00000168496.32692.093503368.74480-0.323504.659603.12410K562SRSF7
FEN1ENSG00000168496.31748.113402169.76850-0.311703.806002.26650K562SSB
FEN1ENSG00000168496.32890.987404275.53640-0.564506.567704.56800K562STAU1
FEN1ENSG00000168496.31803.150702440.59160-0.436703.546502.38220K562SUPV3L1
FEN1ENSG00000168496.33054.688102469.033600.307002.436501.77000K562TARDBP
FEN1ENSG00000168496.31266.846002131.81430-0.750806.572505.07630K562TIAL1
FEN1ENSG00000168496.31486.198402583.02270-0.7974011.977709.79760K562UCHL5
FEN1ENSG00000168496.33296.495504468.87320-0.439007.063305.97470K562UPF1
FEN1ENSG00000168496.32219.640703823.90950-0.7847017.4448015.25470K562WDR3
FEN1ENSG00000168496.32604.793203976.17600-0.610206.740205.47330K562WDR43
FEN1ENSG00000168496.34483.503106028.25470-0.427105.431704.15350K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for FEN1 is not available on ENCORE database.






No RBPs affect the alternative splcing events of FEN1 on ENCORE database.





The Knockdown/knockout RNA-Seq assay for FEN1 is not avaliable on ENCORE database.