APAF1

General Information

Gene Name       : APAF1
Gene ID             : ENSG00000120868.13
Essential Gene : No

Functions

Localization

Domains (AlphaFold: APAF1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878APAF1ENSG00000120868.1316.9011.0913.99ENCSR000AEF
HepG2APAF1ENSG00000120868.134.898.096.49ENCSR985KAT
K562APAF1ENSG00000120868.135.906.656.28ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for APAF1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • APAF1 RNA is bound by 18 proteins.  







eCLIP assay for APAF1 is not avaliable on ENCORE database.





18 proteins are bound to APAF1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr129904265899042716+3'-UTR,intron-Distal,intron-Proximal4.140955.35459K562KHSRP
chr129912831399128400+3'-UTR5.8416613.40947K562UPF1
chr129912655499126673+3'-UTR3.007755.23331K562KHSRP
chr129912773999127816+3'-UTR3.155986.65594K562UPF1
chr129912796899128053+3'-UTR4.1042011.97167K562PTBP1
chr129912908699129157+3'-UTR3.751677.06274K562PUM2
chr129912882099128865+3'-UTR3.100464.14964K562UPF1
chr129912798399128068+3'-UTR3.983296.90077HepG2PTBP1
chr129904261399042658+3'-UTR,CDS,intron-Proximal4.818504.72162K562KHSRP
chr129903908299039202+5'-UTR3.098706.73886K562ZNF622
chr129903915599039253+5'-UTR3.365345.76403K562UCHL5
chr129903942899039489+5'-UTR5.058713.85934HepG2DDX3X
chr129909318599093190+CDS,intron-Distal,intron-Proximal8.4155380.91672K562NSUN2
chr129907127399071323+CDS,intron-Distal5.9121416.18483K562LIN28B
chr129904325799043317+CDS,intron-Proximal3.064893.40045K562U2AF2
chr129904318399043274+CDS,intron-Proximal3.554154.10408K562KHSRP
chr129906131099061394+CDS,intron-Distal4.557414.69889HepG2GRWD1
chr129908064499080648+CDS,intron-Distal8.4598483.48876K562NSUN2
chr129906537699065441+CDS,intron-Distal3.086453.13705K562BUD13
chr129908064899080651+CDS,intron-Distal8.4598483.48876K562NSUN2
chr129909327699093336+CDS,intron-Distal3.463303.17151K562UCHL5
chr129904245099042546+CDS4.025643.89948K562YBX3
chr129908063399080644+CDS,intron-Distal7.4598481.64177K562NSUN2
chr129904215799042215+CDS3.008143.55800HepG2BCLAF1
chr129906133399061396+CDS,intron-Distal3.526883.87469HepG2BCLAF1
chr129907332999073368+intron-Distal4.275723.01321K562LSM11
chr129907322899073312+intron-Distal6.6396814.52138K562LSM11
chr129906362399063746+intron-Distal5.385609.42242HepG2PCBP2
chr129904304199043118+intron-Distal3.557523.68839K562KHSRP
chr129906031199060368+intron-Distal4.698363.18052K562QKI
chr129907324699073317+intron-Distal4.444505.03266HepG2LSM11
chr129904689399046969+intron-Distal3.922395.24353K562UPF1
chr129906025699060311+intron-Distal4.029844.93238K562QKI
chr129904606499046120+intron-Distal4.450684.46422K562UPF1
chr129904520399045233+intron-Distal4.423784.54401K562KHSRP
chr129905659499056674+intron-Proximal3.995623.12843K562PRPF8
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for APAF1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for APAF1 is not available on ENCORE database.

  • 115 RBPs can affect the levels of APAF1.  








The Knockdown/knockout RNA-Seq assay for APAF1 is not available on ENCORE database.





115 RBPs can affect the gene expression of APAF1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
APAF1ENSG00000120868.9489.13470725.74000-0.569204.163803.20880HepG2ASCC1
APAF1ENSG00000120868.91248.18110990.711200.333203.742202.96570HepG2AUH
APAF1ENSG00000120868.9319.65800781.40590-1.289509.995708.15860HepG2BCCIP
APAF1ENSG00000120868.9494.92570646.54490-0.385502.403801.84140HepG2BOP1
APAF1ENSG00000120868.9978.73050729.708500.423502.666101.90840HepG2CALR
APAF1ENSG00000120868.9648.20430894.74390-0.465006.313705.38270HepG2CKAP4
APAF1ENSG00000120868.9466.12050593.55740-0.348701.923401.33910HepG2CPSF6
APAF1ENSG00000120868.9644.52200859.08630-0.414604.131902.88200HepG2YBX3
APAF1ENSG00000120868.9943.045801189.40340-0.334804.235103.34840HepG2DAZAP1
APAF1ENSG00000120868.9613.60410827.63810-0.431704.373803.35540HepG2DDX19B
APAF1ENSG00000120868.9371.14780718.93350-0.953906.824504.89240HepG2DDX27
APAF1ENSG00000120868.9589.75060813.59260-0.464203.802502.66290HepG2DHX30
APAF1ENSG00000120868.9692.98660856.13590-0.305002.587001.92920HepG2DKC1
APAF1ENSG00000120868.9550.95690843.52820-0.614507.990106.84590HepG2DNAJC21
APAF1ENSG00000120868.9496.27640836.12340-0.7526014.2584012.89330HepG2DNAJC2
APAF1ENSG00000120868.9433.73260634.79000-0.549504.519703.04220HepG2EIF2S2
APAF1ENSG00000120868.9364.25910554.28880-0.605704.214503.11550HepG2EIF3D
APAF1ENSG00000120868.9577.63800766.86010-0.408802.171801.60270HepG2EIF4A3
APAF1ENSG00000120868.9911.107301173.47040-0.365104.244503.24970HepG2EIF4G1
APAF1ENSG00000120868.9645.13590844.84510-0.389102.070301.39990HepG2FIP1L1
APAF1ENSG00000120868.9502.50890381.737300.396502.165401.46250HepG2FUBP3
APAF1ENSG00000120868.91037.14970773.560300.422902.953102.23690HepG2FXR1
APAF1ENSG00000120868.9358.88670717.67970-0.9998010.470609.21730HepG2G3BP1
APAF1ENSG00000120868.9353.26500566.32560-0.680903.981102.64520HepG2GRSF1
APAF1ENSG00000120868.9582.15750854.87180-0.554302.994401.35260HepG2GTF2F1
APAF1ENSG00000120868.9617.99940854.37130-0.467305.779904.42610HepG2HDGF
APAF1ENSG00000120868.9591.94570851.60990-0.524704.699303.88650HepG2HNRNPA1
APAF1ENSG00000120868.9364.78560529.93230-0.538802.886201.33430HepG2HNRNPD
APAF1ENSG00000120868.9619.152701083.43750-0.8072018.2961016.70660HepG2HNRNPL
APAF1ENSG00000120868.9477.08940642.09280-0.428502.532501.92600HepG2HNRNPLL
APAF1ENSG00000120868.9317.72280941.00920-1.5664047.2741045.02780HepG2HNRNPU
APAF1ENSG00000120868.9534.51690659.20190-0.302502.024301.39840HepG2IGF2BP1
APAF1ENSG00000120868.9709.17840961.20730-0.438706.455305.38280HepG2ILF2
APAF1ENSG00000120868.9651.61870818.05340-0.328203.400402.27040HepG2KIF1C
APAF1ENSG00000120868.9666.145401294.09990-0.958004.789603.68530HepG2LARP4
APAF1ENSG00000120868.9570.18370778.14920-0.448602.627201.52180HepG2LARP7
APAF1ENSG00000120868.9420.27430817.34420-0.959607.732405.78750HepG2LIN28B
APAF1ENSG00000120868.9424.35300659.18570-0.635403.723301.85900HepG2MARK2
APAF1ENSG00000120868.91196.37630778.188200.620401.988901.44950HepG2MATR3
APAF1ENSG00000120868.9341.93510580.13680-0.762703.768402.54740HepG2METAP2
APAF1ENSG00000120868.9513.75390683.91090-0.412702.664501.87150HepG2MSI2
APAF1ENSG00000120868.9446.02740654.88720-0.554102.720701.76090HepG2MTPAP
APAF1ENSG00000120868.9814.639601179.41310-0.533805.908404.79660HepG2NOL12
APAF1ENSG00000120868.9540.95710790.56810-0.547403.628201.34520HepG2NUSAP1
APAF1ENSG00000120868.9217.20700414.41760-0.932005.426803.25560HepG2PA2G4
APAF1ENSG00000120868.9489.88720709.47490-0.534303.717002.88810HepG2PABPC4
APAF1ENSG00000120868.9586.34340931.41980-0.6677010.530209.05570HepG2PARN
APAF1ENSG00000120868.9298.41550458.37700-0.619204.943503.32190HepG2PKM
APAF1ENSG00000120868.9535.82910839.30250-0.647408.761807.49620HepG2PPIL4
APAF1ENSG00000120868.9430.16210902.79470-1.069509.474307.36740HepG2PRPF6
APAF1ENSG00000120868.9424.90720888.41250-1.064106.144803.54140HepG2PSIP1
APAF1ENSG00000120868.9722.243901125.86940-0.640507.567706.64560HepG2PUF60
APAF1ENSG00000120868.9809.092101195.17920-0.5629010.749609.74210HepG2PUM1
APAF1ENSG00000120868.9604.79360911.45580-0.591709.352108.33090HepG2PUS1
APAF1ENSG00000120868.9753.392801024.53350-0.443504.426903.37180HepG2RBM15
APAF1ENSG00000120868.91529.88450950.713100.6862012.6457011.70000HepG2RBM22
APAF1ENSG00000120868.9401.04480938.28510-1.2263010.448008.50280HepG2RBM27
APAF1ENSG00000120868.9482.98180761.92540-0.657704.338003.00810HepG2RCC2
APAF1ENSG00000120868.91052.83340752.255000.484906.084805.33480HepG2NELFE
APAF1ENSG00000120868.9967.96780700.622700.466205.600804.76180HepG2RECQL
APAF1ENSG00000120868.9589.99040721.22040-0.289701.877901.30300HepG2RPLP0
APAF1ENSG00000120868.9452.74070814.06130-0.846506.174004.80170HepG2RPS10
APAF1ENSG00000120868.9383.18700539.31710-0.493103.516802.83230HepG2RPS19
APAF1ENSG00000120868.9506.40480838.00170-0.7267012.3409011.12800HepG2SAFB2
APAF1ENSG00000120868.9349.44160541.33670-0.631504.498403.31450HepG2SERBP1
APAF1ENSG00000120868.9494.13900635.53550-0.363102.107801.48660HepG2SF3B1
APAF1ENSG00000120868.9706.39380977.23720-0.468207.064706.11030HepG2SMN1
APAF1ENSG00000120868.9543.46500806.42570-0.569403.658501.80190HepG2SND1
APAF1ENSG00000120868.9487.12100707.14810-0.537702.641701.87860HepG2SNRNP70
APAF1ENSG00000120868.91568.122801073.795800.5462011.0258010.20560HepG2SRFBP1
APAF1ENSG00000120868.91068.85160734.551900.541007.625406.93200HepG2SRSF1
APAF1ENSG00000120868.9303.95710683.86540-1.1698011.375509.24940HepG2SRSF3
APAF1ENSG00000120868.9895.351701111.65500-0.312201.909701.37650HepG2SRSF5
APAF1ENSG00000120868.9482.98160657.71820-0.445504.457203.60650HepG2SRSF7
APAF1ENSG00000120868.9753.13590597.596800.333603.082002.50540HepG2SRSF9
APAF1ENSG00000120868.91087.93540932.309600.222601.948201.49850HepG2SSB
APAF1ENSG00000120868.9384.22660564.43640-0.554903.275501.93220HepG2STAU1
APAF1ENSG00000120868.9318.18110512.69060-0.688203.845902.69110HepG2TFIP11
APAF1ENSG00000120868.9692.82000914.31160-0.400203.615003.05950HepG2TIAL1
APAF1ENSG00000120868.9504.85370922.54360-0.8698017.2449015.99620HepG2TRIM56
APAF1ENSG00000120868.9765.974501099.95800-0.522105.441404.16640HepG2TUFM
APAF1ENSG00000120868.9160.17270451.86490-1.4963014.7925013.07030HepG2UCHL5
APAF1ENSG00000120868.9668.78660862.83760-0.367503.536202.36710HepG2UTP18
APAF1ENSG00000120868.9329.09980810.46990-1.3002029.2582027.62740HepG2UTP3
APAF1ENSG00000120868.9444.37600752.90060-0.760705.433104.42780HepG2XRN2
APAF1ENSG00000120868.9673.87620923.25100-0.454206.428005.68460HepG2ZNF622
APAF1ENSG00000120868.9568.80550827.96900-0.541603.339201.90250HepG2ZRANB2
APAF1ENSG00000120868.91118.186701581.47490-0.500102.692001.46860K562APOBEC3C
APAF1ENSG00000120868.9801.42840532.406600.589904.874703.70230K562BOP1
APAF1ENSG00000120868.9856.87810566.110500.597906.446705.25030K562CPSF6
APAF1ENSG00000120868.9717.872401416.39030-0.980409.512708.39070K562DDX47
APAF1ENSG00000120868.9215.26430418.94240-0.960604.974203.58300K562EIF3A
APAF1ENSG00000120868.9451.08860924.51030-1.035308.370906.99250K562EIF3G
APAF1ENSG00000120868.91094.261301390.74310-0.345902.786301.96200K562EIF4A3
APAF1ENSG00000120868.91012.552101252.46370-0.306802.847501.67170K562EIF4B
APAF1ENSG00000120868.9503.71820645.47290-0.357702.094901.35350K562FIP1L1
APAF1ENSG00000120868.9926.18610575.985400.685207.080005.68410K562FMR1
APAF1ENSG00000120868.9777.57890488.191500.671405.831404.45230K562FTO
APAF1ENSG00000120868.9668.697801446.31860-1.1130030.4713028.60450K562FXR1
APAF1ENSG00000120868.91332.484101688.14060-0.341303.103901.56600K562G3BP1
APAF1ENSG00000120868.9820.59390540.503900.602305.677404.54450K562GPKOW
APAF1ENSG00000120868.9512.794901019.92830-0.9920015.7995013.95830K562GRSF1
APAF1ENSG00000120868.91197.54410810.970800.562306.427405.55450K562HNRNPC
APAF1ENSG00000120868.9856.772601280.15080-0.579304.326802.97300K562HNRNPL
APAF1ENSG00000120868.9385.14020530.94800-0.463202.483601.60360K562HNRNPM
APAF1ENSG00000120868.9923.561701269.64140-0.459105.822104.51300K562HNRNPU
APAF1ENSG00000120868.92301.877501876.110400.295002.620201.82010K562KIF1C
APAF1ENSG00000120868.9660.33720461.502800.516802.866301.91310K562KRR1
APAF1ENSG00000120868.9561.03270822.53900-0.552004.304302.39280K562LIN28B
APAF1ENSG00000120868.91170.883601855.72910-0.664407.708706.27940K562MAGOH
APAF1ENSG00000120868.91237.689601852.02120-0.581508.296606.59950K562MATR3
APAF1ENSG00000120868.9634.18040984.66940-0.634707.105105.86150K562MTPAP
APAF1ENSG00000120868.91083.00900780.344200.472803.488102.55420K562PCBP3
APAF1ENSG00000120868.9558.68510740.16830-0.405802.551601.83110K562PRPF8
APAF1ENSG00000120868.91083.157601802.92920-0.7351013.0659011.68030K562PTBP1
APAF1ENSG00000120868.92118.988801753.133200.273301.870901.40720K562PUS1
APAF1ENSG00000120868.91228.626901728.99790-0.492905.310304.10230K562RBM22
APAF1ENSG00000120868.91262.968001819.44600-0.526705.487003.87240K562NELFE
APAF1ENSG00000120868.9496.50260753.89940-0.602604.191203.18270K562RPS19
APAF1ENSG00000120868.9635.677001017.94480-0.679305.397403.93450K562RPS3
APAF1ENSG00000120868.9275.87410533.33220-0.951009.980407.99360K562SAFB
APAF1ENSG00000120868.9721.04710514.010400.488202.976701.96590K562SF3B1
APAF1ENSG00000120868.91066.090901475.37730-0.468805.983304.69160K562SF3B4
APAF1ENSG00000120868.9448.35330628.90770-0.488203.440302.26370K562SRFBP1
APAF1ENSG00000120868.91407.306501106.097900.347404.252203.11780K562SRPK2
APAF1ENSG00000120868.91288.052501767.42970-0.456505.394004.41380K562SRSF1
APAF1ENSG00000120868.9672.18360982.71300-0.547905.529203.94390K562SRSF4
APAF1ENSG00000120868.91344.160201669.10040-0.312402.426501.45270K562SRSF5
APAF1ENSG00000120868.91188.84010846.846400.489304.385702.63810K562SSRP1
APAF1ENSG00000120868.91136.27580774.515400.552804.897603.15490K562STAU1
APAF1ENSG00000120868.9353.30290600.36340-0.764908.477207.03660K562SYNCRIP
APAF1ENSG00000120868.9661.040701788.84460-1.4362032.8867029.78400K562TARDBP
APAF1ENSG00000120868.91231.243601725.51880-0.486906.185504.89040K562TIA1
APAF1ENSG00000120868.91324.153301070.665300.306503.444502.01950K562TROVE2
APAF1ENSG00000120868.91167.671001420.54170-0.282802.479001.71780K562U2AF2
APAF1ENSG00000120868.91567.735501159.942900.434505.536604.56020K562UPF1
APAF1ENSG00000120868.9763.034201032.19540-0.435904.493103.43300K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for APAF1 is not available on ENCORE database.





9 RBPs can affect the splicing of APAF1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEAPAF1ENSG00000120868.9chr12+9909714899097277990931859909334799100262991003880.464000.000000.00000includedK562SRSF1
SEAPAF1ENSG00000120868.9chr12+990971489909727799093185990933479910026299100476-0.247000.000000.00000excludedK562AKAP8L
SEAPAF1ENSG00000120868.9chr12+990971489909727799093185990933479910026299100388-0.264000.000000.00000excludedK562PUS1
SEAPAF1ENSG00000120868.9chr12+990971489909727799093185990933479910026299100388-0.147000.004250.07172excludedK562U2AF1
SEAPAF1ENSG00000120868.9chr12+9909714899097277990932739909334799100262991003880.272000.002340.04970includedHepG2SRSF1
SEAPAF1ENSG00000120868.9chr12+990971489909727799093185990933479910026299100388-0.151000.001650.04948excludedK562UTP18
SEAPAF1ENSG00000120868.9chr12+990971489909727799093185990933479910026299100388-0.172000.002140.03690excludedK562U2AF2
SEAPAF1ENSG00000120868.9chr12+990971489909727799093185990933479910026299100388-0.242000.000000.00000excludedK562RBM15
SEAPAF1ENSG00000120868.9chr12+990971489909727799093185990933479910026299100388-0.263000.000000.00000excludedK562AGGF1
SEAPAF1ENSG00000120868.9chr12+9909714899097277990931859909334799100262991003880.203000.000170.00986includedK562PTBP1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for APAF1 is not avaliable on ENCORE database.