TMEM59L

General Information

Gene Name       : TMEM59L
Gene ID             : ENSG00000105696.8
Essential Gene : No

Functions

Localization

Domains (AlphaFold: TMEM59L)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878TMEM59LENSG00000105696.80.000.010.01ENCSR000AEF
HepG2TMEM59LENSG00000105696.817.483.5910.54ENCSR985KAT
K562TMEM59LENSG00000105696.80.180.030.10ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for TMEM59L is not avaliable on ENCORE database.



Proteins bound to RNA
  • TMEM59L RNA is bound by 14 proteins.  







eCLIP assay for TMEM59L is not avaliable on ENCORE database.





14 proteins are bound to TMEM59L RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr191873164518731703+3'-UTR3.134143.74590HepG2DDX55
chr191873170318731767+3'-UTR4.229777.14815HepG2DDX55
chr191873160818731705+3'-UTR4.617755.94150HepG2UPF1
chr191873146818731556+3'-UTR4.567985.41597HepG2UPF1
chr191873143318731541+3'-UTR5.3740322.38655HepG2PCBP2
chr191873159318731692+3'-UTR3.9673515.38912HepG2PCBP2
chr191873170318731763+3'-UTR4.164457.73571HepG2LARP4
chr191873170718731812+3'-UTR4.428494.68979HepG2UPF1
chr191873158918731700+3'-UTR3.6718612.56625HepG2LARP4
chr191871831018718377+5'-UTR,intron-Proximal3.994527.96122HepG2CSTF2T
chr191871831418718442+5'-UTR,intron-Distal,intron-Proximal3.029276.31659HepG2NKRF
chr191871829618718420+5'-UTR,intron-Distal,intron-Proximal4.792868.08697HepG2DDX59
chr191872911018729189+CDS,intron-Proximal3.252243.90917HepG2PRPF4
chr191872910818729231+CDS,intron-Proximal3.9736117.86547HepG2PRPF8
chr191872492718725000+CDS3.292204.24993HepG2PPIG
chr191873125418731318+CDS3.558425.47933HepG2SND1
chr191872908718729208+CDS,intron-Proximal4.4472412.83855HepG2RBFOX2
chr191872271918722769+intron-Distal4.103314.10564HepG2CSTF2T
chr191872221618722255+intron-Distal3.477544.35339HepG2CSTF2T
chr191872248518722568+intron-Distal3.678003.04847HepG2CSTF2T
chr191871991818719964+intron-Distal4.589164.73643HepG2DDX59
chr191872307618723182+intron-Distal3.571435.59719HepG2CSTF2T
chr191872248118722556+intron-Distal3.629973.52528HepG2FAM120A
chr191872073718720790+intron-Distal4.143684.03786HepG2NKRF
chr191871989518719978+intron-Distal6.2246313.95507HepG2PCBP2
chr191872350118723550+intron-Distal3.043173.23466HepG2CSTF2T
chr191871990118719971+intron-Distal3.964006.33671HepG2HNRNPK
chr191872073318720795+intron-Distal3.590085.16304HepG2CSTF2T
chr191871837718718428+intron-Distal,intron-Proximal4.505876.08348HepG2CSTF2T
chr191872911318729177+intron-Proximal4.054938.98325HepG2PPIG
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for TMEM59L is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for TMEM59L is not available on ENCORE database.

  • 119 RBPs can affect the levels of TMEM59L.  








The Knockdown/knockout RNA-Seq assay for TMEM59L is not available on ENCORE database.





119 RBPs can affect the gene expression of TMEM59L :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
TMEM59LENSG00000105696.4165.88570585.16030-1.818603.134702.13070HepG2ABCF1
TMEM59LENSG00000105696.4899.81370493.849800.8655017.5592016.30780HepG2ACO1
TMEM59LENSG00000105696.42318.47660363.838702.6717032.5395030.97460HepG2AKAP1
TMEM59LENSG00000105696.41325.99890394.217501.7499033.5648030.51430HepG2AKAP8
TMEM59LENSG00000105696.4648.25270496.061400.385903.279902.45330HepG2AKAP8L
TMEM59LENSG00000105696.41567.12790300.980502.3803052.4746049.82160HepG2ASCC1
TMEM59LENSG00000105696.41860.778101198.575500.6345010.439609.24730HepG2AUH
TMEM59LENSG00000105696.4140.33530434.41870-1.6302017.9382016.61130HepG2BOP1
TMEM59LENSG00000105696.4310.81140524.83550-0.755806.987405.83290HepG2CALR
TMEM59LENSG00000105696.41210.09940830.405100.543103.026202.00470HepG2CCAR1
TMEM59LENSG00000105696.4205.61860493.61180-1.2634010.982909.83730HepG2CKAP4
TMEM59LENSG00000105696.43454.40980548.333302.6552055.1006052.09220HepG2CNOT7
TMEM59LENSG00000105696.4934.80880481.316000.957604.527403.13690HepG2CPSF7
TMEM59LENSG00000105696.41415.64220560.822301.3357042.1024040.19940HepG2CELF1
TMEM59LENSG00000105696.4940.60280603.092700.641107.857206.70260HepG2DAZAP1
TMEM59LENSG00000105696.4187.45450456.68030-1.2846011.8673010.38530HepG2DDX19B
TMEM59LENSG00000105696.4118.20970398.25210-1.752306.656705.65470HepG2DDX21
TMEM59LENSG00000105696.4111.45220390.37470-1.808406.322904.94670HepG2DDX24
TMEM59LENSG00000105696.4138.49490552.75310-1.996802.803801.50760HepG2DDX27
TMEM59LENSG00000105696.41577.96150348.389402.1792024.2589022.60040HepG2DDX3X
TMEM59LENSG00000105696.4875.11900425.439801.0404013.9255011.31560HepG2DDX52
TMEM59LENSG00000105696.4142.99660461.46030-1.6902021.9581019.55750HepG2DDX5
TMEM59LENSG00000105696.43019.19460299.604603.3329029.3231027.63140HepG2DDX6
TMEM59LENSG00000105696.479.13290472.44670-2.5778024.9092023.37890HepG2DKC1
TMEM59LENSG00000105696.4914.79680344.302301.4097034.8987032.72350HepG2DNAJC21
TMEM59LENSG00000105696.4628.09520341.286800.8799015.0711013.67100HepG2DNAJC2
TMEM59LENSG00000105696.4572.83580287.688800.993502.613402.03720HepG2EIF2S1
TMEM59LENSG00000105696.4187.73900376.52130-1.004003.221602.06490HepG2EIF3G
TMEM59LENSG00000105696.491.54940317.77110-1.795402.204201.63080HepG2EIF4A3
TMEM59LENSG00000105696.41392.75600309.697902.1689011.6715010.30600HepG2EIF4B
TMEM59LENSG00000105696.4206.41190594.92680-1.5272028.9651026.88390HepG2EIF4G1
TMEM59LENSG00000105696.4766.51370569.912700.427502.853602.02670HepG2EIF4G2
TMEM59LENSG00000105696.4149.31130506.52870-1.762303.959302.67220HepG2ESF1
TMEM59LENSG00000105696.4292.77910482.46350-0.720604.678803.59710HepG2EWSR1
TMEM59LENSG00000105696.4902.67620368.265101.293407.680605.71320HepG2FAM120A
TMEM59LENSG00000105696.42009.33820590.752201.7660017.8626016.20160HepG2FIP1L1
TMEM59LENSG00000105696.4116.91140324.87200-1.474504.448603.46600HepG2FUBP3
TMEM59LENSG00000105696.4746.53440321.098301.217104.023903.19940HepG2FXR1
TMEM59LENSG00000105696.42442.85740297.612903.0370099.0023095.39750HepG2G3BP1
TMEM59LENSG00000105696.494.02330316.28470-1.750102.082201.31740HepG2G3BP2
TMEM59LENSG00000105696.41311.39410390.516501.7475034.7020031.44060HepG2GNB2L1
TMEM59LENSG00000105696.4193.98460452.04030-1.220508.756007.66030HepG2GPKOW
TMEM59LENSG00000105696.41573.55950471.406001.7389078.0098074.48240HepG2HDGF
TMEM59LENSG00000105696.464.23400347.60100-2.4360028.8794027.19850HepG2HNRNPA1
TMEM59LENSG00000105696.4777.49980554.225200.488304.981403.78780HepG2HNRNPA2B1
TMEM59LENSG00000105696.41175.34300453.668801.3733010.789307.97660HepG2HNRNPAB
TMEM59LENSG00000105696.4362.13250773.77500-1.0954015.8592014.33040HepG2HNRNPF
TMEM59LENSG00000105696.4691.51080549.392800.331802.814302.13570HepG2HNRNPL
TMEM59LENSG00000105696.495.22730431.39380-2.1796028.0707026.41170HepG2HNRNPLL
TMEM59LENSG00000105696.41318.20790407.263001.6944017.9452015.87780HepG2HNRNPM
TMEM59LENSG00000105696.41131.78030384.093201.559008.173907.17210HepG2HNRNPU
TMEM59LENSG00000105696.4649.81090429.132300.598503.620502.21160HepG2HSPD1
TMEM59LENSG00000105696.4193.08220761.95750-1.9805035.3092033.16330HepG2IGF2BP1
TMEM59LENSG00000105696.4915.84460284.177101.688202.633001.67560HepG2IGF2BP3
TMEM59LENSG00000105696.41042.57560523.507700.993804.286502.74750HepG2KHDRBS1
TMEM59LENSG00000105696.4552.55840304.358200.860302.347401.43580HepG2KHSRP
TMEM59LENSG00000105696.4568.90420451.359400.333802.571201.58690HepG2KIF1C
TMEM59LENSG00000105696.4931.38500382.702301.2831020.9534018.17920HepG2LARP7
TMEM59LENSG00000105696.4886.02710322.932201.456008.197607.16040HepG2MATR3
TMEM59LENSG00000105696.4853.70080431.003600.985906.976305.38550HepG2METAP2
TMEM59LENSG00000105696.41040.93160330.475501.6552013.6727012.33250HepG2NCBP2
TMEM59LENSG00000105696.41076.14270598.021700.8475014.4643012.78640HepG2NOL12
TMEM59LENSG00000105696.4108.4032021.196202.354409.050306.48120HepG2NOLC1
TMEM59LENSG00000105696.461.60870382.54050-2.6344032.4758030.38420HepG2NSUN2
TMEM59LENSG00000105696.4747.03700388.863200.941803.707601.38720HepG2NUSAP1
TMEM59LENSG00000105696.4742.25020380.176200.965103.051202.16610HepG2PARN
TMEM59LENSG00000105696.4520.95580340.620600.612902.534701.36260HepG2PKM
TMEM59LENSG00000105696.4230.57830615.41700-1.4163028.5289026.56120HepG2PRPF4
TMEM59LENSG00000105696.4574.60330322.143800.834808.616507.76090HepG2PTBP1
TMEM59LENSG00000105696.41273.92940605.953301.0719034.8122033.18650HepG2PUM1
TMEM59LENSG00000105696.4810.63340605.525100.420801.995101.41950HepG2PUM2
TMEM59LENSG00000105696.4138.16340502.99900-1.8642016.1879014.91780HepG2PUS1
TMEM59LENSG00000105696.41644.54690348.813502.2371046.2808044.31980HepG2QKI
TMEM59LENSG00000105696.4102.47400277.48210-1.437102.232501.59390HepG2RAVER1
TMEM59LENSG00000105696.471.4835020.261701.818803.684301.66150HepG2RBM14
TMEM59LENSG00000105696.4906.57220569.647900.670304.855003.75740HepG2RBM15
TMEM59LENSG00000105696.4577.707801150.19890-0.9935020.0252018.89200HepG2RBM22
TMEM59LENSG00000105696.4424.95400333.934200.347602.178801.62340HepG2RECQL
TMEM59LENSG00000105696.4219.47710833.39420-1.9249025.5009023.86380HepG2RPLP0
TMEM59LENSG00000105696.4893.88310400.846101.1569016.9528015.61810HepG2RPS19
TMEM59LENSG00000105696.41039.28710434.469501.2582018.7292016.05620HepG2RPS5
TMEM59LENSG00000105696.489.80550288.15440-1.6820012.4573010.96600HepG2SF3A3
TMEM59LENSG00000105696.432.21650426.97280-3.7283058.5459055.97900HepG2SF3B1
TMEM59LENSG00000105696.4739.61260116.706702.663803.869302.09090HepG2SFPQ
TMEM59LENSG00000105696.4382.98140547.30320-0.515105.247804.33180HepG2SLBP
TMEM59LENSG00000105696.41230.84320398.876601.6255027.4586025.77820HepG2SMN1
TMEM59LENSG00000105696.4341.51260107.537701.667003.064901.66780HepG2SNRNP200
TMEM59LENSG00000105696.41124.46710475.090001.242904.436103.43610HepG2SNRNP70
TMEM59LENSG00000105696.4467.941701299.09970-1.4731053.2423051.76810HepG2SRFBP1
TMEM59LENSG00000105696.4238.14780350.03720-0.555702.894802.41410HepG2SRSF1
TMEM59LENSG00000105696.4192.91930459.48620-1.2520010.267908.23780HepG2SRSF3
TMEM59LENSG00000105696.41595.26280563.597901.5010059.3084056.96410HepG2SRSF5
TMEM59LENSG00000105696.4344.15730760.17350-1.1433018.9390017.41310HepG2SRSF7
TMEM59LENSG00000105696.4914.59560284.796401.6831054.1172052.29150HepG2SRSF9
TMEM59LENSG00000105696.432.461701127.91280-5.11880230.18630227.72440HepG2SSB
TMEM59LENSG00000105696.4716.86730427.680800.745106.151704.33290HepG2SSRP1
TMEM59LENSG00000105696.41999.22930640.989801.6410088.1728085.66070HepG2SUCLG1
TMEM59LENSG00000105696.4860.64200289.089101.573805.549004.37920HepG2TIA1
TMEM59LENSG00000105696.4739.08530278.958001.4056011.629208.89580HepG2TRA2A
TMEM59LENSG00000105696.41287.63410376.556701.7737071.3165069.02320HepG2TRIM56
TMEM59LENSG00000105696.41526.05310557.653001.452307.077105.57150HepG2TUFM
TMEM59LENSG00000105696.4215.73790505.05100-1.227102.423401.83200HepG2U2AF1
TMEM59LENSG00000105696.4864.45740590.242100.550403.694702.72100HepG2UBE2L3
TMEM59LENSG00000105696.4775.87800347.354801.159304.259203.31700HepG2UCHL5
TMEM59LENSG00000105696.4875.74270255.549301.7768011.5136010.26650HepG2UPF1
TMEM59LENSG00000105696.4147.47590246.72220-0.742404.268203.55010HepG2UTP3
TMEM59LENSG00000105696.4939.34480494.117300.926703.391702.16930HepG2XPO5
TMEM59LENSG00000105696.4755.67870305.360801.307205.166803.74430HepG2XRCC6
TMEM59LENSG00000105696.4167.23270579.06260-1.791902.715301.99710HepG2XRN2
TMEM59LENSG00000105696.4168.29090281.05480-0.739904.295903.65360HepG2ZNF622
TMEM59LENSG00000105696.4491.59750277.601600.824403.052701.68430HepG2ZRANB2
TMEM59LENSG00000105696.426.275407.886401.736202.606302.05230K562AGGF1
TMEM59LENSG00000105696.425.339708.207801.626202.435801.82250K562AKAP8L
TMEM59LENSG00000105696.434.270305.815402.558902.754602.16770K562AQR
TMEM59LENSG00000105696.425.303607.619001.731602.278601.33880K562DDX3X
TMEM59LENSG00000105696.425.113004.079202.622003.822902.29850K562EXOSC5
TMEM59LENSG00000105696.414.250601.259503.500002.948301.76980K562GLRX3
TMEM59LENSG00000105696.427.188101.372804.307704.772003.77970K562GRSF1
TMEM59LENSG00000105696.429.513901.511304.287506.005105.15930K562HNRNPC
TMEM59LENSG00000105696.418.244501.473203.630403.503102.67290K562NSUN2
TMEM59LENSG00000105696.423.066608.128501.504601.828601.36860K562PUS1
TMEM59LENSG00000105696.431.799007.929402.003603.701503.03040K562RBM15
TMEM59LENSG00000105696.414.096401.450303.280802.502101.72370K562SF3A3
TMEM59LENSG00000105696.413.785501.386803.313302.136601.32060K562TRIM56
TMEM59LENSG00000105696.414.528501.336703.442002.896002.00030K562WDR3
TMEM59LENSG00000105696.424.270406.543401.891002.668301.82360K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for TMEM59L is not available on ENCORE database.





3 RBPs can affect the splicing of TMEM59L :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SETMEM59LENSG00000105696.4chr19+187278091872791218726784187269371872896418729302-0.073000.000500.05841excludedHepG2SSB
RITMEM59LENSG00000105696.4chr19+187289641872930218728964187290821872918418729302-0.082000.001380.09716excludedHepG2DDX55
RITMEM59LENSG00000105696.4chr19+1872896418729302187289641872908218729184187293020.197000.000000.00000includedHepG2RBM22

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for TMEM59L is not avaliable on ENCORE database.