XRN1

General Information

Gene Name : XRN1
Gene ID : ENSG00000114127.10
Essential Gene : No

Functions

RNA stability & decay
Viral RNA regulation

Localization(RBPImage: XRN1)

Cytoplasm
Compartment/Organelle
P bodies
Cytoskeleton
Actin

Domains (AlphaFold: XRN1)

Nuclease

Antibody Validation

Bethyl Labs: A300-443A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	XRN1	ENSG00000114127.10	18.20	11.41	14.80	ENCSR000AEF
HepG2	XRN1	ENSG00000114127.10	3.13	5.48	4.30	ENCSR985KAT
K562	XRN1	ENSG00000114127.10	8.92	7.76	8.34	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	XRN1-BGKLV38-K562	ENCSR949RMX	XRN1	K562	Released		ENCSR260BQC	shRNA	KD% = 91.5,93.8
knockdown followed by RNA-seq	XRN1-BGHLV37-HepG2	ENCSR676SDU	XRN1	HepG2	Released		ENCSR225PRV	shRNA	KD% = 79.8,85.7

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
XRN1	ENCAB231MQI	A300-443A	3				BGHLV37-99, Released, ENCODE3	BGKLV38-129, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
XRN1	K562	shRNA			BGKLV38-125,BGKLV38-126	BGKLV38-1,BGKLV38-2		NotSatisfied	ENCODE3
XRN1	K562	shRNA			BGKLV38-127,BGKLV38-128	BGKLV38-1,BGKLV38-2		NotSatisfied	ENCODE3
XRN1	K562	shRNA	ENCSR949RMX	ENCSR260BQC	XRN1-BGKLV38-129C,XRN1-BGKLV38-130C	NT-BGKLV38-1C,NT-BGKLV38-2C	91.5,93.8	Released	ENCODE4
XRN1	K562	shRNA			BGKLV38-131,BGKLV38-132	BGKLV38-1,BGKLV38-2	91.7,89.3	NotSatisfied	ENCODE3
XRN1	HepG2	shRNA			BGHLV23-59,BGHLV23-60	BGHLV23-1,BGHLV23-2	redo transfection,redo transfection	NotSatisfied	ENCODE3
XRN1	HepG2	shRNA			BGHLV37-97,BGHLV37-98	BGHLV37-1,BGHLV37-2		NotSatisfied	ENCODE3
XRN1	HepG2	shRNA	ENCSR676SDU	ENCSR225PRV	XRN1-BGHLV37-99C,XRN1-BGHLV37-100C	non-target-BGHLV37-1C,non-target-BGHLV37-2C	79.8,85.7	Released	ENCODE4
XRN1	HepG2	shRNA			BGHLV37-101,BGHLV37-102	BGHLV37-1,BGHLV37-2	99.5,99.5	NotSatisfied	ENCODE3
XRN1	HepG2	shRNA			BGHLV37-103,BGHLV37-104	BGHLV37-1,BGHLV37-2		NotSatisfied	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

XRN1: Click to RBP Image Database

Cytoplasm

Compartment/Organelle

P bodies

Cytoskeleton

Actin

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
XRN1	Product_ID: A300-443A Lot_ID: 3 Source: Bethyl Labs Target Name: XRN1-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for XRN1 is not avaliable on ENCORE database.

Proteins bound to RNA

XRN1 RNA is bound by 23 proteins.

eCLIP assay for XRN1 is not avaliable on ENCORE database.

23 proteins are bound to XRN1 RNA:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr3	142137172	142137268	-	3'-UTR,intron-Distal,intron-Proximal	3.85686	5.25185	K562	PRPF8
chr3	142151545	142151594	-	3'-UTR,CDS,intron-Distal	3.55410	7.83567	HepG2	BCLAF1
chr3	142141678	142141729	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.97827	8.94445	HepG2	BCLAF1
chr3	142140316	142140372	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.37164	3.25772	K562	ZNF622
chr3	142139857	142139949	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.53668	8.43531	K562	ZNF622
chr3	142137110	142137229	-	3'-UTR,intron-Distal,intron-Proximal	3.39449	12.08170	K562	KHSRP
chr3	142139889	142139964	-	3'-UTR,CDS,intron-Distal	4.35982	12.43877	HepG2	BCLAF1
chr3	142141528	142141672	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.42135	17.08595	K562	EFTUD2
chr3	142140327	142140365	-	3'-UTR,CDS,intron-Distal	3.33762	6.20035	HepG2	BCLAF1
chr3	142029780	142029861	-	3'-UTR,intron-Distal	3.82965	3.06150	K562	KHSRP
chr3	142026341	142026390	-	3'-UTR,intron-Distal	5.03279	7.11441	K562	PUM2
chr3	142028701	142028735	-	3'-UTR,intron-Distal	4.71999	5.45041	K562	PUM2
chr3	142137135	142137245	-	3'-UTR,intron-Distal,intron-Proximal	5.21066	9.18298	HepG2	KHSRP
chr3	142029764	142029882	-	3'-UTR,intron-Distal	5.32930	8.69807	HepG2	FUBP3
chr3	142137661	142137714	-	3'-UTR,CDS,intron-Distal	3.66958	8.66838	HepG2	BCLAF1
chr3	142137229	142137292	-	3'-UTR,intron-Distal,intron-Proximal	3.12561	5.98045	K562	KHSRP
chr3	142141678	142141715	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.44217	4.77252	K562	ZNF622
chr3	142139968	142139994	-	3'-UTR,CDS,intron-Distal	5.11184	7.49561	HepG2	BCLAF1
chr3	142137396	142137450	-	3'-UTR,CDS,intron-Distal	4.06734	7.65975	HepG2	BCLAF1
chr3	142139949	142139996	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.27085	6.05769	K562	ZNF622
chr3	142151643	142151722	-	3'-UTR,CDS,intron-Distal	5.05410	14.51064	HepG2	BCLAF1
chr3	142141499	142141550	-	3'-UTR,CDS,intron-Distal	3.65376	7.02567	HepG2	BCLAF1
chr3	142137660	142137703	-	3'-UTR,CDS,intron-Distal	4.02240	5.14848	K562	ZNF622
chr3	142145602	142145656	-	5'-UTR,CDS,intron-Distal	4.01593	3.49332	HepG2	PPIG
chr3	142051217	142051255	-	5'-UTR,CDS,intron-Distal	5.13011	6.58593	HepG2	BCLAF1
chr3	142166736	142166871	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.06476	3.36034	K562	SRSF1
chr3	142166713	142166791	-	5'-UTR,CDS,intron-Distal	3.51905	8.77730	K562	UCHL5
chr3	142166718	142166840	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.10392	5.11648	K562	DDX3X
chr3	142089323	142089396	-	CDS,intron-Distal,intron-Proximal	3.25748	5.62120	K562	ZNF622
chr3	142084199	142084208	-	CDS,intron-Distal	3.10288	3.94979	HepG2	BCLAF1
chr3	142102144	142102189	-	CDS,intron-Distal	3.48033	6.74947	HepG2	BCLAF1
chr3	142066081	142066120	-	CDS,intron-Distal	3.60979	6.06436	HepG2	BCLAF1
chr3	142144276	142144320	-	CDS,intron-Distal	4.32626	7.97334	HepG2	BCLAF1
chr3	142098978	142099022	-	CDS,intron-Distal	3.42547	5.65306	K562	ZNF622
chr3	142090079	142090167	-	CDS,intron-Distal,intron-Proximal	3.62805	9.24221	K562	DDX24
chr3	142103365	142103447	-	CDS,intron-Distal	3.17889	4.02508	K562	DDX24
chr3	142094686	142094780	-	CDS,intron-Distal	4.24612	10.36594	HepG2	BCLAF1
chr3	142075924	142075954	-	CDS,intron-Distal	5.07061	7.04013	HepG2	BCLAF1
chr3	142103402	142103436	-	CDS,intron-Distal	3.25556	3.36945	K562	ZNF622
chr3	142103385	142103432	-	CDS,intron-Distal	4.69886	9.47159	HepG2	BCLAF1
chr3	142119291	142119349	-	CDS,intron-Distal	3.96579	6.81385	HepG2	BCLAF1
chr3	142131463	142131505	-	CDS,intron-Distal,intron-Proximal	3.64013	8.20757	HepG2	BCLAF1
chr3	142066149	142066185	-	CDS,intron-Distal,intron-Proximal	3.52713	4.24220	K562	ZNF622
chr3	142089457	142089462	-	CDS,intron-Distal,intron-Proximal	3.80062	4.76554	HepG2	BCLAF1
chr3	142074245	142074305	-	CDS,intron-Distal	3.39906	4.76953	K562	DDX24
chr3	142119367	142119388	-	CDS,intron-Distal	3.71685	7.23562	HepG2	BCLAF1
chr3	142133081	142133132	-	CDS,intron-Distal	3.70566	8.66838	HepG2	BCLAF1
chr3	142051821	142051895	-	CDS,intron-Distal,intron-Proximal	3.56996	9.83905	HepG2	BCLAF1
chr3	142122515	142122549	-	CDS,intron-Distal,intron-Proximal	4.71311	5.59615	K562	ZNF622
chr3	142083987	142084021	-	CDS,intron-Distal	4.41554	8.80935	HepG2	BCLAF1
chr3	142066160	142066184	-	CDS,intron-Distal	4.12407	6.22576	HepG2	BCLAF1
chr3	142094691	142094797	-	CDS,intron-Distal,intron-Proximal	3.26728	5.89932	K562	ZNF622
chr3	142090091	142090151	-	CDS,intron-Distal	4.11679	5.80935	K562	ZNF622
chr3	142094638	142094686	-	CDS,intron-Distal,intron-Proximal	3.82282	9.43524	HepG2	BCLAF1
chr3	142075894	142075923	-	CDS,intron-Distal	3.73458	6.00726	K562	YBX3
chr3	142123792	142123918	-	CDS,intron-Distal,intron-Proximal	3.25989	7.36807	K562	UCHL5
chr3	142089326	142089372	-	CDS,intron-Distal,intron-Proximal	3.93844	8.08603	HepG2	BCLAF1
chr3	142083898	142083965	-	CDS,intron-Distal	3.47988	9.01874	HepG2	BCLAF1
chr3	142131384	142131406	-	CDS,intron-Distal,intron-Proximal	3.63871	10.10467	HepG2	BCLAF1
chr3	142116209	142116297	-	CDS,intron-Distal	4.14126	3.82000	HepG2	GRWD1
chr3	142132975	142133024	-	CDS,intron-Distal,intron-Proximal	4.00621	11.64153	HepG2	BCLAF1
chr3	142116214	142116291	-	CDS,intron-Distal	3.05714	4.61701	K562	ZNF622
chr3	142135980	142136018	-	CDS,intron-Distal,intron-Proximal	4.22039	6.22576	HepG2	BCLAF1
chr3	142051813	142051888	-	CDS,intron-Distal,intron-Proximal	3.48005	9.32936	K562	ZNF622
chr3	142083897	142083957	-	CDS,intron-Distal	3.97429	4.66686	K562	DDX24
chr3	142094749	142094839	-	CDS,intron-Distal,intron-Proximal	5.27685	21.95813	K562	TARDBP
chr3	142084151	142084162	-	CDS,intron-Distal,intron-Proximal	4.96914	6.58593	HepG2	BCLAF1
chr3	142074242	142074296	-	CDS,intron-Distal,intron-Proximal	4.30062	9.98400	HepG2	BCLAF1
chr3	142084155	142084211	-	CDS,intron-Distal,intron-Proximal	3.42994	3.75245	K562	BUD13
chr3	142054316	142054339	-	CDS,intron-Distal	4.96914	6.58593	HepG2	BCLAF1
chr3	142102141	142102189	-	CDS,intron-Distal,intron-Proximal	3.22932	6.36421	K562	ZNF622
chr3	142103411	142103486	-	CDS,intron-Distal	3.84878	3.79347	HepG2	GRWD1
chr3	142074316	142074337	-	CDS,intron-Distal	3.83762	5.06180	HepG2	BCLAF1
chr3	142116176	142116203	-	CDS,intron-Distal	3.83762	5.06180	HepG2	BCLAF1
chr3	142122514	142122560	-	CDS,intron-Distal,intron-Proximal	3.49686	9.28980	HepG2	BCLAF1
chr3	142123751	142123825	-	CDS,intron-Distal	3.90408	11.46750	HepG2	BCLAF1
chr3	142090080	142090146	-	CDS,intron-Distal,intron-Proximal	5.36309	15.86994	HepG2	BCLAF1
chr3	142051811	142051890	-	CDS,intron-Distal,intron-Proximal	3.41653	4.45064	HepG2	GRWD1
chr3	142103432	142103499	-	CDS,intron-Distal	5.37603	15.18966	HepG2	BCLAF1
chr3	142131410	142131463	-	CDS,intron-Distal	4.08874	12.82496	HepG2	BCLAF1
chr3	142102218	142102252	-	CDS,intron-Distal	4.08906	3.01428	K562	UCHL5
chr3	142131414	142131465	-	CDS,intron-Distal	3.16715	4.33023	K562	ZNF622
chr3	142098921	142098945	-	CDS,intron-Distal,intron-Proximal	3.39536	4.74886	HepG2	BCLAF1
chr3	142090146	142090170	-	CDS,intron-Distal	3.89536	7.58784	HepG2	BCLAF1
chr3	142094656	142094731	-	CDS,intron-Distal	4.19802	6.83823	K562	DDX24
chr3	142089328	142089391	-	CDS,intron-Distal	4.08112	3.38114	HepG2	GRWD1
chr3	142051857	142051907	-	CDS,intron-Distal	3.78077	5.07449	K562	DDX24
chr3	142123851	142123919	-	CDS,intron-Distal,intron-Proximal	3.99134	15.00162	HepG2	BCLAF1
chr3	142144271	142144325	-	CDS,intron-Distal,intron-Proximal	3.65738	3.02850	K562	YBX3
chr3	142096099	142096185	-	intron-Distal	4.19486	14.75316	K562	KHSRP
chr3	142055371	142055491	-	intron-Distal	5.83196	8.42544	K562	PTBP1
chr3	142096219	142096285	-	intron-Distal	5.00400	16.87092	K562	KHSRP
chr3	142144912	142145025	-	intron-Distal	5.45966	18.13366	HepG2	QKI
chr3	142095870	142095923	-	intron-Distal	3.53532	4.70224	K562	KHSRP
chr3	142123004	142123057	-	intron-Distal	3.85146	3.45805	K562	KHSRP
chr3	142142539	142142602	-	intron-Distal,intron-Proximal	4.27853	4.07352	K562	KHSRP
chr3	142055376	142055462	-	intron-Distal	5.05773	7.11021	HepG2	PTBP1
chr3	142092166	142092239	-	intron-Distal	4.10555	3.23532	K562	MATR3
chr3	142091821	142091877	-	intron-Distal	4.11818	4.28663	HepG2	SUGP2
chr3	142058587	142058644	-	intron-Distal	3.54598	4.33009	HepG2	SUGP2
chr3	142095191	142095229	-	intron-Distal,intron-Proximal	4.32223	5.25174	K562	KHSRP
chr3	142055243	142055285	-	intron-Distal	4.10060	3.18981	K562	PTBP1
chr3	142096681	142096731	-	intron-Distal	4.31532	4.51299	HepG2	SUGP2
chr3	142141373	142141404	-	intron-Distal,intron-Proximal	4.04539	3.12843	K562	PRPF8
chr3	142092164	142092254	-	intron-Distal	4.32232	3.74583	HepG2	PTBP1
chr3	142142321	142142399	-	intron-Distal,intron-Proximal	3.82433	5.56048	K562	KHSRP
chr3	142097168	142097231	-	intron-Distal	4.82775	7.83570	HepG2	SUGP2
chr3	142091549	142091596	-	intron-Distal	3.80479	3.29248	HepG2	SUGP2
chr3	142091765	142091808	-	intron-Distal	4.06250	3.54208	HepG2	SUGP2
chr3	142097455	142097531	-	intron-Distal	4.87051	7.55950	K562	MATR3
chr3	142096186	142096219	-	intron-Distal	4.18045	13.15655	K562	KHSRP
chr3	142097455	142097537	-	intron-Distal	4.89308	5.39854	K562	PTBP1
chr3	142055357	142055462	-	intron-Distal	5.32336	9.01334	HepG2	PCBP2
chr3	142058297	142058368	-	intron-Distal	4.12229	4.36036	HepG2	SUGP2
chr3	142095611	142095686	-	intron-Distal	3.30932	7.34034	HepG2	U2AF2
chr3	142141601	142141670	-	intron-Distal,intron-Proximal	4.75291	5.82778	K562	PRPF8
chr3	142059978	142060104	-	intron-Distal	4.58113	7.82056	K562	QKI
chr3	142095923	142096052	-	intron-Distal	4.73042	20.33936	K562	KHSRP
chr3	142051447	142051507	-	intron-Distal,intron-Proximal	3.89656	3.45805	K562	KHSRP
chr3	142116481	142116544	-	intron-Distal	3.90256	3.16986	HepG2	QKI
chr3	142141802	142141927	-	intron-Distal,intron-Proximal	3.67973	10.10950	K562	KHSRP
chr3	142144929	142145037	-	intron-Distal	4.38762	7.21090	K562	QKI
chr3	142096285	142096333	-	intron-Distal	3.74716	5.56048	K562	KHSRP
chr3	142060010	142060073	-	intron-Distal	4.24503	4.17759	HepG2	QKI
chr3	142137599	142137649	-	intron-Distal,intron-Proximal	4.74336	4.65563	K562	AQR
chr3	142116011	142116085	-	intron-Distal,intron-Proximal	4.61480	5.20135	HepG2	QKI
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

eCLIP assay for XRN1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for XRN1 is not available on ENCORE database.
111 RBPs can affect the levels of XRN1.

The Knockdown/knockout RNA-Seq assay for XRN1 is not available on ENCORE database.

111 RBPs can affect the gene expression of XRN1 :

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
XRN1	ENSG00000114127.6	867.77550	1146.19640	-0.40150	2.60120	2.00840	HepG2	ACO1
XRN1	ENSG00000114127.6	1225.10950	1549.18220	-0.33860	1.93000	1.47660	HepG2	AKAP1
XRN1	ENSG00000114127.6	760.54660	1281.84000	-0.75310	8.38460	7.06600	HepG2	ASCC1
XRN1	ENSG00000114127.6	1558.38730	1326.05020	0.23280	2.26420	1.63190	HepG2	AUH
XRN1	ENSG00000114127.6	339.78860	728.02980	-1.09940	8.52410	6.83580	HepG2	BCCIP
XRN1	ENSG00000114127.6	849.63960	1217.82920	-0.51940	4.44060	3.47170	HepG2	CIRBP
XRN1	ENSG00000114127.6	282.57270	449.82270	-0.67070	4.17220	2.88240	HepG2	CSTF2
XRN1	ENSG00000114127.6	894.90020	1047.72400	-0.22750	1.91840	1.36430	HepG2	CELF1
XRN1	ENSG00000114127.6	1322.21820	1126.69190	0.23080	2.35830	1.66590	HepG2	DAZAP1
XRN1	ENSG00000114127.6	833.07430	1060.18300	-0.34780	2.18780	1.43970	HepG2	DDX19B
XRN1	ENSG00000114127.6	454.34700	715.75950	-0.65570	3.79400	2.90390	HepG2	DDX55
XRN1	ENSG00000114127.6	649.09460	843.42140	-0.37780	4.47910	3.68500	HepG2	DNAJC2
XRN1	ENSG00000114127.6	703.48040	905.83290	-0.36470	2.15970	1.34450	HepG2	EEF2
XRN1	ENSG00000114127.6	657.92490	851.41050	-0.37190	2.84010	1.65360	HepG2	EIF2S2
XRN1	ENSG00000114127.6	536.99570	735.34980	-0.45350	2.51920	1.65250	HepG2	EIF3D
XRN1	ENSG00000114127.6	1061.08660	623.81640	0.76620	7.14180	5.91650	HepG2	FUBP3
XRN1	ENSG00000114127.6	931.58020	1366.37480	-0.55260	5.01420	4.10360	HepG2	FXR1
XRN1	ENSG00000114127.6	606.57000	859.16850	-0.50230	4.39160	3.60300	HepG2	HNRNPA1
XRN1	ENSG00000114127.6	669.74850	955.63950	-0.51280	4.54770	3.67330	HepG2	HNRNPC
XRN1	ENSG00000114127.6	830.23540	685.09010	0.27710	2.08870	1.45930	HepG2	HNRNPF
XRN1	ENSG00000114127.6	546.23410	781.94120	-0.51750	4.72060	3.51640	HepG2	HNRNPM
XRN1	ENSG00000114127.6	552.71350	949.32330	-0.78040	14.65940	13.35690	HepG2	HNRNPU
XRN1	ENSG00000114127.6	930.51540	674.61290	0.46390	4.22460	3.34630	HepG2	IGF2BP1
XRN1	ENSG00000114127.6	942.43890	1288.51470	-0.45120	3.58470	2.82640	HepG2	IGF2BP2
XRN1	ENSG00000114127.6	916.33620	1528.59110	-0.73830	5.05150	3.91650	HepG2	LARP4
XRN1	ENSG00000114127.6	665.45240	933.61470	-0.48850	3.90600	2.54930	HepG2	LARP7
XRN1	ENSG00000114127.6	1063.15280	1374.52730	-0.37060	2.27270	1.69710	HepG2	MATR3
XRN1	ENSG00000114127.6	874.02670	1117.21830	-0.35420	2.90350	2.12280	HepG2	NOL12
XRN1	ENSG00000114127.6	1086.18610	730.93740	0.57140	5.41160	4.38120	HepG2	NSUN2
XRN1	ENSG00000114127.6	322.58670	549.74920	-0.76910	3.04360	1.37260	HepG2	PA2G4
XRN1	ENSG00000114127.6	728.95060	1112.93440	-0.61050	10.20190	9.15300	HepG2	PCBP1
XRN1	ENSG00000114127.6	460.52540	608.11320	-0.40110	2.94710	1.67450	HepG2	PKM
XRN1	ENSG00000114127.6	556.93760	784.72920	-0.49470	5.71110	4.64240	HepG2	PRPF4
XRN1	ENSG00000114127.6	819.60030	552.39480	0.56910	4.97130	3.92310	HepG2	PRPF8
XRN1	ENSG00000114127.6	656.49240	1066.44620	-0.70000	4.46660	3.73010	HepG2	PUF60
XRN1	ENSG00000114127.6	884.53280	1167.51220	-0.40040	2.60300	2.00010	HepG2	PUS1
XRN1	ENSG00000114127.6	1824.54120	1226.44580	0.57300	9.38240	8.33110	HepG2	QKI
XRN1	ENSG00000114127.6	1511.25770	1113.10000	0.44110	3.41990	2.67660	HepG2	RBM25
XRN1	ENSG00000114127.6	714.40310	1125.75620	-0.65610	6.09790	4.61790	HepG2	RBM27
XRN1	ENSG00000114127.6	507.30870	914.16070	-0.84960	7.91960	6.14710	HepG2	RCC2
XRN1	ENSG00000114127.6	979.74960	1260.31840	-0.36330	4.07590	3.44200	HepG2	NELFE
XRN1	ENSG00000114127.6	449.06010	715.51560	-0.67210	6.67510	5.76690	HepG2	RPS19
XRN1	ENSG00000114127.6	771.54920	1038.30090	-0.42840	2.89030	2.07450	HepG2	RPS2
XRN1	ENSG00000114127.6	762.91260	546.45680	0.48130	3.42360	2.56180	HepG2	RRP9
XRN1	ENSG00000114127.6	1022.08460	815.97660	0.32480	2.17190	1.54200	HepG2	SF3B1
XRN1	ENSG00000114127.6	979.88610	1179.00890	-0.26690	2.40860	1.85110	HepG2	SF3B4
XRN1	ENSG00000114127.6	1367.29310	1022.46790	0.41920	6.56160	5.55540	HepG2	SLBP
XRN1	ENSG00000114127.6	601.74590	985.94080	-0.71230	14.52420	13.23070	HepG2	SMN1
XRN1	ENSG00000114127.6	1299.09900	907.91100	0.51680	2.95750	2.14790	HepG2	SNRNP70
XRN1	ENSG00000114127.6	1835.19090	1437.25220	0.35250	5.65370	5.00820	HepG2	SRFBP1
XRN1	ENSG00000114127.6	1552.58310	1230.64970	0.33520	4.48430	3.91810	HepG2	SRSF1
XRN1	ENSG00000114127.6	1482.99980	1001.21600	0.56670	11.50050	10.51150	HepG2	SRSF9
XRN1	ENSG00000114127.6	917.96360	1246.35690	-0.44120	2.69880	1.61360	HepG2	STIP1
XRN1	ENSG00000114127.6	843.57670	1197.49150	-0.50540	8.73530	7.73390	HepG2	SUCLG1
XRN1	ENSG00000114127.6	587.25040	765.26950	-0.38200	3.11890	2.12630	HepG2	SUPT6H
XRN1	ENSG00000114127.6	1695.90530	1106.21050	0.61630	11.12140	10.11600	HepG2	TAF15
XRN1	ENSG00000114127.6	1423.00220	1016.39890	0.48540	5.99310	4.77070	HepG2	TIA1
XRN1	ENSG00000114127.6	701.20830	922.54480	-0.39580	3.63620	3.07950	HepG2	TIAL1
XRN1	ENSG00000114127.6	616.02830	930.68450	-0.59530	9.19340	8.25780	HepG2	TRIM56
XRN1	ENSG00000114127.6	721.30600	1245.91530	-0.78850	16.83060	15.53770	HepG2	UTP3
XRN1	ENSG00000114127.6	951.76640	1283.31880	-0.43120	2.44690	1.42520	HepG2	XPO5
XRN1	ENSG00000114127.6	309.95590	701.47280	-1.17830	9.56320	8.23280	HepG2	XRN2
XRN1	ENSG00000114127.6	954.20660	774.43980	0.30100	3.08690	2.38510	HepG2	ZC3H8
XRN1	ENSG00000114127.6	2462.89780	1981.09020	0.31400	2.52340	1.36230	K562	ABCF1
XRN1	ENSG00000114127.6	1356.34110	2065.16410	-0.60650	13.41650	12.26830	K562	AGGF1
XRN1	ENSG00000114127.6	1559.58530	2269.35380	-0.54110	6.72420	5.02510	K562	AKAP8
XRN1	ENSG00000114127.6	1497.06240	2148.90930	-0.52150	6.17860	5.17530	K562	AKAP8L
XRN1	ENSG00000114127.6	1894.63420	2439.43900	-0.36460	3.33630	1.97000	K562	APOBEC3C
XRN1	ENSG00000114127.6	3743.68260	2129.09170	0.81410	14.84170	13.63310	K562	AQR
XRN1	ENSG00000114127.6	1917.63330	2254.74670	-0.23360	2.17530	1.37350	K562	ATP5C1
XRN1	ENSG00000114127.6	1852.61030	1234.30240	0.58580	6.54420	5.18840	K562	BOP1
XRN1	ENSG00000114127.6	1799.48700	2467.94400	-0.45570	5.86360	4.11450	K562	CCDC124
XRN1	ENSG00000114127.6	3185.82200	1889.38690	0.75360	5.42450	3.87530	K562	CNOT7
XRN1	ENSG00000114127.6	1269.53900	2184.61340	-0.78310	20.83810	18.08660	K562	CPEB4
XRN1	ENSG00000114127.6	1785.90840	1312.36630	0.44440	5.29580	4.21790	K562	CPSF6
XRN1	ENSG00000114127.6	4919.93430	3399.25250	0.53330	10.23340	8.41830	K562	CELF1
XRN1	ENSG00000114127.6	1097.81380	1380.19780	-0.33020	3.11620	1.70760	K562	DDX6
XRN1	ENSG00000114127.6	1610.65150	2312.30230	-0.52170	9.54890	7.71840	K562	DKC1
XRN1	ENSG00000114127.6	1568.46490	1193.41710	0.39420	2.56350	1.33560	K562	EEF2
XRN1	ENSG00000114127.6	853.28090	1375.73470	-0.68910	12.03560	10.35520	K562	EIF3G
XRN1	ENSG00000114127.6	983.28090	1241.52140	-0.33640	3.04470	1.67330	K562	EWSR1
XRN1	ENSG00000114127.6	962.23390	1424.10930	-0.56560	6.23320	4.92400	K562	FIP1L1
XRN1	ENSG00000114127.6	1231.47760	952.24250	0.37090	2.50510	1.43970	K562	FKBP4
XRN1	ENSG00000114127.6	1527.00360	1131.91570	0.43180	3.39740	2.37640	K562	FTO
XRN1	ENSG00000114127.6	1130.39110	1479.10040	-0.38790	4.32860	3.59600	K562	FXR1
XRN1	ENSG00000114127.6	1321.06250	1828.29600	-0.46880	5.37280	3.29210	K562	G3BP1
XRN1	ENSG00000114127.6	2041.41280	1557.84730	0.38990	2.13760	1.52760	K562	G3BP2
XRN1	ENSG00000114127.6	1980.89250	1473.37800	0.42690	6.11170	4.45870	K562	GLRX3
XRN1	ENSG00000114127.6	1265.93630	1886.00350	-0.57510	3.59230	2.73520	K562	GRSF1
XRN1	ENSG00000114127.6	1812.09880	1482.09820	0.28990	2.28040	1.31030	K562	HNRNPA1
XRN1	ENSG00000114127.6	743.18170	1171.36860	-0.65640	6.07910	4.62720	K562	HNRNPM
XRN1	ENSG00000114127.6	1342.87100	1930.76400	-0.52390	5.84640	4.70300	K562	HSPD1
XRN1	ENSG00000114127.6	848.06010	615.15120	0.46310	3.23490	1.61250	K562	ILF3
XRN1	ENSG00000114127.6	1865.60880	2280.48630	-0.28970	2.71910	1.90190	K562	KIF1C
XRN1	ENSG00000114127.6	1480.28590	1069.96700	0.46820	3.04290	2.05960	K562	KRR1
XRN1	ENSG00000114127.6	1594.82500	2009.80430	-0.33370	3.15840	2.25870	K562	MAGOH
XRN1	ENSG00000114127.6	1631.42980	2183.02190	-0.42020	4.63430	3.13700	K562	MAK16
XRN1	ENSG00000114127.6	1961.00060	2554.72670	-0.38160	4.11990	2.97540	K562	MBNL1
XRN1	ENSG00000114127.6	2156.18740	1721.17160	0.32500	6.38230	5.31190	K562	NSUN2
XRN1	ENSG00000114127.6	791.42800	1079.84100	-0.44830	3.21560	1.63720	K562	NUSAP1
XRN1	ENSG00000114127.6	1396.56170	1964.33070	-0.49220	4.92490	3.06740	K562	PCBP1
XRN1	ENSG00000114127.6	2039.13550	1545.16820	0.40010	3.08990	2.20920	K562	PCBP3
XRN1	ENSG00000114127.6	1429.70630	1185.20580	0.27050	2.24240	1.52110	K562	POLR2G
XRN1	ENSG00000114127.6	1054.25500	1616.67220	-0.61680	7.44090	5.95640	K562	PPIG
XRN1	ENSG00000114127.6	616.01900	983.29830	-0.67470	7.42830	5.80740	K562	PSIP1
XRN1	ENSG00000114127.6	1308.15250	1952.61160	-0.57790	8.69600	7.56040	K562	PTBP1
XRN1	ENSG00000114127.6	1697.65730	2076.45060	-0.29060	2.97710	2.36640	K562	RBM15
XRN1	ENSG00000114127.6	1460.90250	1872.60750	-0.35820	3.13280	2.23250	K562	RBM22
XRN1	ENSG00000114127.6	666.99080	897.18010	-0.42770	3.53240	2.41410	K562	RCC2
XRN1	ENSG00000114127.6	1540.38920	1970.55290	-0.35530	2.85340	1.74170	K562	NELFE
XRN1	ENSG00000114127.6	823.65080	1056.01840	-0.35850	2.83970	1.74300	K562	SAFB
XRN1	ENSG00000114127.6	1079.99800	1619.85200	-0.58480	8.91500	7.33000	K562	SF3B4
XRN1	ENSG00000114127.6	1095.15940	1495.67350	-0.44970	3.66120	2.42570	K562	SRSF4
XRN1	ENSG00000114127.6	1248.44330	1807.62640	-0.53400	6.07800	4.41540	K562	SRSF5
XRN1	ENSG00000114127.6	2420.85540	1708.96250	0.50230	4.90760	3.16100	K562	STAU1
XRN1	ENSG00000114127.6	1501.35280	1086.69590	0.46620	3.63300	2.45280	K562	SUPV3L1
XRN1	ENSG00000114127.6	836.27660	1188.77970	-0.50740	5.94320	4.73160	K562	SYNCRIP
XRN1	ENSG00000114127.6	1305.49350	1937.37290	-0.56950	6.42620	5.30680	K562	TARDBP
XRN1	ENSG00000114127.6	1196.36310	1868.78170	-0.64340	10.26060	8.56400	K562	TIA1
XRN1	ENSG00000114127.6	1410.30130	1833.53070	-0.37860	3.39760	2.16130	K562	TRA2A
XRN1	ENSG00000114127.6	1282.92100	1559.53570	-0.28170	2.50290	1.73830	K562	U2AF2
XRN1	ENSG00000114127.6	1984.39380	1623.85070	0.28920	4.21690	3.18660	K562	WDR43
XRN1	ENSG00000114127.6	858.48920	1170.89570	-0.44770	3.40620	2.01890	K562	XRN2
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for XRN1 is not available on ENCORE database.

10 RBPs can affect the splicing of XRN1 :

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	XRN1	ENSG00000114127.6	chr3	-	142135981	142136071			142132976	142133133	142137345	142137451	-0.18600	0.00670	0.09554	excluded	K562	SRSF1
SE	XRN1	ENSG00000114127.6	chr3	-	142145585	142145683			142142401	142142484	142151502	142151735	-0.30200	0.00471	0.07073	excluded	K562	SF3B4
SE	XRN1	ENSG00000114127.6	chr3	-	142095538	142095637			142095090	142095436	142098923	142099022	0.25700	0.00027	0.00924	included	HepG2	HNRNPK
SE	XRN1	ENSG00000114127.6	chr3	-	142037631	142037745			142037488	142037536	142048275	142048457	-0.33800	0.00036	0.01146	excluded	HepG2	HNRNPK
SE	XRN1	ENSG00000114127.6	chr3	-	142095538	142095637			142095090	142095436	142098923	142099022	0.59900	0.00121	0.01652	included	HepG2	U2AF2
SE	XRN1	ENSG00000114127.6	chr3	-	142066075	142066184			142054289	142054351	142074242	142074338	-0.22000	0.00000	0.00001	excluded	K562	AQR
SE	XRN1	ENSG00000114127.6	chr3	-	142145585	142145683			142142332	142142484	142151502	142151735	-0.47700	0.00000	0.00001	excluded	K562	AQR
SE	XRN1	ENSG00000114127.6	chr3	-	142144063	142144174			142142401	142142484	142145585	142145683	-0.16800	0.00128	0.02092	excluded	K562	PUS1
SE	XRN1	ENSG00000114127.6	chr3	-	142095538	142095637			142095090	142095436	142098923	142099022	0.41500	0.00078	0.01840	included	K562	U2AF1
SE	XRN1	ENSG00000114127.6	chr3	-	142037631	142037745			142037488	142037536	142048275	142048479	0.25300	0.00000	0.01292	included	HepG2	RBM5
SE	XRN1	ENSG00000114127.6	chr3	-	142145585	142145683			142142401	142142484	142151502	142151735	-0.21500	0.00030	0.02841	excluded	K562	HNRNPUL1
SE	XRN1	ENSG00000114127.6	chr3	-	142066075	142066184			142054289	142054351	142074242	142074338	-0.16100	0.00048	0.01555	excluded	K562	AGGF1
A3SS	XRN1	ENSG00000114127.6	chr3	-	142066075	142066199			142066075	142066184	142074242	142074416	0.07900	0.00071	0.00514	longer	K562	AQR
A3SS	XRN1	ENSG00000114127.6	chr3	-	142090080	142090195			142090080	142090170	142094639	142094734	0.10900	0.00012	0.00102	longer	K562	AQR
A3SS	XRN1	ENSG00000114127.6	chr3	-	142131389	142131543			142131389	142131505	142132976	142133168	0.05500	0.01490	0.07436	longer	K562	AQR
A3SS	XRN1	ENSG00000114127.6	chr3	-	142098923	142099166			142098923	142099022	142102141	142102255	0.07100	0.00280	0.01732	longer	K562	AQR
A3SS	XRN1	ENSG00000114127.6	chr3	-	142078703	142078802			142078703	142078773	142083888	142084021	0.25400	0.00000	0.00004	longer	K562	AQR
A3SS	XRN1	ENSG00000114127.6	chr3	-	142132976	142133168			142132976	142133133	142135981	142136214	0.22700	0.00007	0.00062	longer	K562	AQR
A3SS	XRN1	ENSG00000114127.6	chr3	-	142083888	142084036			142083888	142084021	142084151	142084208	0.06200	0.00136	0.00917	longer	K562	AQR
A3SS	XRN1	ENSG00000114127.6	chr3	-	142054289	142054435			142054289	142054351	142066075	142066184	0.08400	0.00834	0.04524	longer	K562	AQR
A3SS	XRN1	ENSG00000114127.6	chr3	-	142074242	142074416			142074242	142074338	142075753	142075946	0.05600	0.00171	0.01123	longer	K562	AQR
MXE	XRN1	ENSG00000114127.6	chr3	-	142095320	142095436	142095503	142095637	142094639	142094786	142098923	142099022	0.22900	0.00143	0.02598	1included	K562	U2AF1
MXE	XRN1	ENSG00000114127.6	chr3	-	142037631	142037745	142048275	142048479	142037433	142037536	142051216	142051266	0.32600	0.00190	0.04341	1included	HepG2	HNRNPK
MXE	XRN1	ENSG00000114127.6	chr3	-	142051216	142051376	142051808	142051931	142048275	142048457	142054289	142054351	-0.28500	0.00087	0.01772	2included	K562	SF3B4

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

XRN1

General Information

Functions

Localization(RBPImage: XRN1)

Domains (AlphaFold: XRN1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for XRN1 is not avaliable on ENCORE database.

23 proteins are bound to XRN1 RNA:

eCLIP assay for XRN1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for XRN1 is not available on ENCORE database.

111 RBPs can affect the gene expression of XRN1 :

The Knockdown/knockout RNA-Seq assay for XRN1 is not available on ENCORE database.

10 RBPs can affect the splicing of XRN1 :

The Knockdown/knockout RNA-Seq assay for XRN1 is not avaliable on ENCORE database.