GGCX

General Information

Gene Name       : GGCX
Gene ID             : ENSG00000115486.11
Essential Gene : No

Functions

Localization

Domains (AlphaFold: GGCX)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878GGCXENSG00000115486.1114.1912.3113.25ENCSR000AEF
HepG2GGCXENSG00000115486.1165.8656.7861.32ENCSR985KAT
K562GGCXENSG00000115486.1116.4215.7516.09ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for GGCX is not avaliable on ENCORE database.



Proteins bound to RNA
  • GGCX RNA is bound by 24 proteins.  







eCLIP assay for GGCX is not avaliable on ENCORE database.





24 proteins are bound to GGCX RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr28577653485776593-3'-UTR,intron-Distal4.3244913.19163HepG2UPF1
chr28578260385782654-3'-UTR,CDS,intron-Distal,intron-Proximal3.060074.97224HepG2PPIG
chr28578573885785801-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.404534.24670HepG2SF3B4
chr28578206185782166-3'-UTR,intron-Distal3.190894.12870K562PTBP1
chr28577701985777100-3'-UTR,CDS,intron-Distal3.562223.82830HepG2LARP4
chr28577689885776955-3'-UTR,intron-Distal,intron-Proximal3.478723.46148HepG2TIA1
chr28577659385776648-3'-UTR,intron-Distal3.465618.16716HepG2UPF1
chr28577652985776626-3'-UTR,intron-Distal3.534064.90523HepG2AKAP1
chr28578335885783381-3'-UTR,CDS,intron-Distal5.343745.54337HepG2SND1
chr28578563385785697-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.796644.69290HepG2RPS3
chr28578260585782642-3'-UTR,CDS,intron-Distal,intron-Proximal3.368223.93930HepG2SND1
chr28578206785782156-3'-UTR,intron-Distal5.2384417.02345HepG2PTBP1
chr28578549485785564-3'-UTR,CDS,intron-Distal,intron-Proximal3.131586.41278HepG2PRPF8
chr28578260285782634-3'-UTR,CDS,intron-Distal,intron-Proximal4.210354.50960HepG2GRWD1
chr28578330485783328-3'-UTR,CDS,intron-Distal,intron-Proximal4.180444.12428HepG2SND1
chr28578205985782121-3'-UTR,intron-Distal3.453006.57527HepG2U2AF2
chr28578568785785753-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.6461814.04012HepG2U2AF2
chr28578575385785804-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.8453614.03218HepG2U2AF2
chr28577674285776803-3'-UTR,intron-Distal5.0016016.85427HepG2UPF1
chr28578189785781982-3'-UTR,intron-Distal,intron-Proximal3.194655.38424HepG2HNRNPL
chr28578255485782644-3'-UTR,CDS,intron-Distal,intron-Proximal4.9599321.25580HepG2PRPF8
chr28577562785775721-3'-UTR,intron-Distal3.382386.22789HepG2PCBP2
chr28578850685788602-5'-UTR,CDS,intron-Distal,intron-Proximal3.6673322.36087HepG2DDX3X
chr28578850285788594-5'-UTR,CDS,intron-Distal3.070114.71568HepG2NCBP2
chr28578850885788613-5'-UTR,CDS,intron-Distal,intron-Proximal5.306115.82881K562DDX3X
chr28578053185780610-CDS,intron-Distal3.443029.53660HepG2SND1
chr28577959585779637-CDS,intron-Distal,intron-Proximal4.4601510.07222HepG2SND1
chr28578847085788522-CDS,intron-Distal3.913776.34662HepG2PRPF8
chr28577894185779031-CDS,intron-Distal5.2323112.11021HepG2SND1
chr28578001885780081-CDS,intron-Distal,intron-Proximal3.657478.78144HepG2PRPF8
chr28578041785780464-CDS,intron-Distal3.491475.86107HepG2PPIG
chr28578038085780474-CDS,intron-Distal3.081106.75888HepG2SND1
chr28578142885781477-CDS,intron-Distal,intron-Proximal5.0687714.80705HepG2SF3B4
chr28577897385779032-CDS,intron-Distal3.618723.85127HepG2GRWD1
chr28578009385780184-CDS,intron-Distal3.280003.34359K562SND1
chr28577872285778743-CDS,intron-Distal,intron-Proximal3.585673.16095HepG2U2AF2
chr28577808085778139-CDS,intron-Distal6.049518.83160HepG2SND1
chr28577901585779122-CDS,intron-Distal,intron-Proximal4.800453.62536K562AQR
chr28578055485780638-CDS,intron-Distal,intron-Proximal3.097003.29838K562U2AF2
chr28578011485780180-CDS,intron-Distal4.495608.63212HepG2SND1
chr28578038785780480-CDS,intron-Distal5.1705410.51120HepG2RPS3
chr28578135585781426-CDS,intron-Distal5.2913615.63767HepG2SND1
chr28577715785777212-CDS,intron-Distal4.4398312.11021HepG2SND1
chr28577864285778718-CDS,intron-Distal4.3793910.75945HepG2SND1
chr28578599585786045-CDS,intron-Distal,intron-Proximal4.472749.43475HepG2PRPF8
chr28577903085779104-CDS,intron-Distal4.402254.10924HepG2ZNF800
chr28577903185779098-CDS,intron-Distal5.3791415.63767HepG2SND1
chr28577872085778799-CDS,intron-Distal,intron-Proximal4.0027310.14515HepG2SF3B4
chr28578605085786189-CDS,intron-Distal,intron-Proximal3.8704122.89630HepG2RPS3
chr28578047485780521-CDS,intron-Distal3.419393.68108HepG2SND1
chr28578135585781423-CDS,intron-Distal4.1501212.18649HepG2RPS3
chr28577804885778052-CDS,intron-Distal3.652154.12428HepG2SND1
chr28578612385786190-CDS,intron-Distal,intron-Proximal3.384537.07011HepG2SRSF1
chr28577895085779081-CDS,intron-Distal3.659024.98210K562SND1
chr28577780185777874-CDS,intron-Distal,intron-Proximal4.3133211.28448HepG2SND1
chr28577713385777147-CDS,intron-Distal4.511774.35919HepG2SND1
chr28578797285788023-CDS,intron-Distal4.282367.02113HepG2RPS3
chr28578151685781558-intron-Distal,intron-Proximal3.033763.40321HepG2GRWD1
chr28578149285781525-intron-Distal,intron-Proximal3.180393.12708HepG2RBM5
chr28578840185788443-intron-Distal5.392175.99517HepG2EFTUD2
chr28577913985779224-intron-Distal,intron-Proximal3.333804.40834HepG2QKI
chr28578835885788401-intron-Distal4.541955.22198HepG2EFTUD2
chr28577935985779426-intron-Distal3.028894.35585HepG2RBFOX2
chr28578307385783130-intron-Distal3.242265.01844HepG2U2AF2
chr28578001385780043-intron-Distal,intron-Proximal4.027313.52230K562AQR
chr28577912285779178-intron-Distal,intron-Proximal4.8821612.27453HepG2SF3B4
chr28577922485779315-intron-Distal4.4888415.69529HepG2QKI
chr28578543985785527-intron-Distal,intron-Proximal3.342978.01217HepG2EFTUD2
chr28578121985781263-intron-Distal,intron-Proximal4.927655.68502HepG2PRPF8
chr28578143085781471-intron-Distal,intron-Proximal3.702979.14970HepG2SF3A3
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for GGCX is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for GGCX is not available on ENCORE database.

  • 120 RBPs can affect the levels of GGCX.  








The Knockdown/knockout RNA-Seq assay for GGCX is not available on ENCORE database.





120 RBPs can affect the gene expression of GGCX :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
GGCXENSG00000115486.71345.595901703.66590-0.340402.879801.78960HepG2AATF
GGCXENSG00000115486.71153.005402465.97090-1.0968050.0828048.29940HepG2ACO1
GGCXENSG00000115486.71455.366101854.68700-0.349802.729301.73790HepG2ADAR
GGCXENSG00000115486.71564.622504133.53600-1.4016028.0146026.53350HepG2AKAP1
GGCXENSG00000115486.72003.949302477.53350-0.306104.473203.51480HepG2AKAP8L
GGCXENSG00000115486.72007.360103346.53050-0.7374023.5477021.90480HepG2AUH
GGCXENSG00000115486.73687.673301517.015601.2814035.3891033.67390HepG2BOP1
GGCXENSG00000115486.72332.604901846.000000.337403.721102.84540HepG2CALR
GGCXENSG00000115486.71655.607302465.40710-0.5745017.1832015.83220HepG2CKAP4
GGCXENSG00000115486.72860.031001392.661401.0381021.0002019.32900HepG2CPSF6
GGCXENSG00000115486.71364.418901901.98760-0.479207.669705.99330HepG2YBX3
GGCXENSG00000115486.71712.992902702.63500-0.6578015.8928014.60160HepG2CELF1
GGCXENSG00000115486.74210.551802905.685800.5350020.1159018.45960HepG2DAZAP1
GGCXENSG00000115486.71318.504602280.65700-0.7905028.2108026.25450HepG2DDX19B
GGCXENSG00000115486.71571.280501904.58450-0.277502.876001.69640HepG2DDX1
GGCXENSG00000115486.72723.007301879.391000.534807.051906.01990HepG2DDX21
GGCXENSG00000115486.72501.610101839.351800.443605.765604.44780HepG2DDX24
GGCXENSG00000115486.71673.134803959.68820-1.2428026.1670024.44860HepG2DDX3X
GGCXENSG00000115486.71113.342601507.76810-0.437504.781903.05430HepG2DDX52
GGCXENSG00000115486.71082.950901779.39670-0.716407.412306.21790HepG2DDX55
GGCXENSG00000115486.73313.699402251.208800.557606.923005.38470HepG2DDX5
GGCXENSG00000115486.71831.493103401.28110-0.8931012.0599010.87930HepG2DDX6
GGCXENSG00000115486.71328.943801801.25750-0.438704.550103.30710HepG2DHX30
GGCXENSG00000115486.71399.316301851.15500-0.403708.000606.96270HepG2DNAJC2
GGCXENSG00000115486.72758.874701798.830600.616907.664406.21250HepG2EEF2
GGCXENSG00000115486.7892.958501499.47780-0.747809.541307.51020HepG2EFTUD2
GGCXENSG00000115486.72277.962901730.832100.396202.512901.46400HepG2AGO1
GGCXENSG00000115486.71989.745703269.90570-0.716709.506508.44570HepG2EIF2S1
GGCXENSG00000115486.71560.158501932.40290-0.308702.742601.57950HepG2EIF2S2
GGCXENSG00000115486.71143.566101460.17930-0.352602.167301.35790HepG2EIF3D
GGCXENSG00000115486.72185.542703518.29850-0.686906.082605.09190HepG2EIF4B
GGCXENSG00000115486.73614.066502866.904800.334006.317605.14350HepG2EIF4G1
GGCXENSG00000115486.71390.605202409.66940-0.7931015.3505013.47750HepG2EWSR1
GGCXENSG00000115486.7743.271401305.17670-0.8123014.7088012.08360HepG2FAM120A
GGCXENSG00000115486.71302.946102572.09870-0.9812014.0313012.50820HepG2FIP1L1
GGCXENSG00000115486.71632.946902249.10370-0.461902.864401.72970HepG2FUS
GGCXENSG00000115486.72285.545703645.83400-0.673708.862007.68560HepG2FXR1
GGCXENSG00000115486.72031.331101578.576300.363702.470001.86180HepG2GPKOW
GGCXENSG00000115486.72639.839901785.739000.563805.462502.90610HepG2GRWD1
GGCXENSG00000115486.71711.450602354.27940-0.460109.312807.65880HepG2HDGF
GGCXENSG00000115486.72995.513701885.421500.6678011.053409.89400HepG2HNRNPA1
GGCXENSG00000115486.72040.194502670.55820-0.388406.391405.07250HepG2HNRNPA2B1
GGCXENSG00000115486.73512.015001506.474701.2210027.5900025.94620HepG2HNRNPLL
GGCXENSG00000115486.7850.870801774.73760-1.0606023.5473021.31230HepG2HNRNPM
GGCXENSG00000115486.71734.535202083.35330-0.264403.379102.71490HepG2HNRNPU
GGCXENSG00000115486.74071.623202688.824600.598505.557703.82970HepG2HSPD1
GGCXENSG00000115486.72664.753602140.940000.315703.064802.30490HepG2IGF2BP1
GGCXENSG00000115486.71771.295802128.06980-0.264704.132303.25400HepG2ILF2
GGCXENSG00000115486.71581.986802972.10290-0.9097010.987309.32830HepG2LARP4
GGCXENSG00000115486.71519.531001884.50900-0.310602.346001.30710HepG2LARP7
GGCXENSG00000115486.72373.534303667.55890-0.627806.699105.75050HepG2MATR3
GGCXENSG00000115486.7998.855401528.15960-0.613403.509502.32910HepG2METAP2
GGCXENSG00000115486.71270.377102081.84710-0.7126011.7176010.17110HepG2MSI2
GGCXENSG00000115486.72484.174801536.657500.692905.377503.99880HepG2MTPAP
GGCXENSG00000115486.71593.543403753.98370-1.2362024.7522022.99000HepG2NCBP2
GGCXENSG00000115486.71848.346402881.28870-0.6405013.0939011.49030HepG2NOL12
GGCXENSG00000115486.72168.545001335.860700.698909.732108.39210HepG2NSUN2
GGCXENSG00000115486.71120.973301866.52040-0.735604.767203.57980HepG2PABPC1
GGCXENSG00000115486.71582.189502062.11440-0.382206.100804.92120HepG2PARN
GGCXENSG00000115486.72598.498603399.19640-0.387507.935206.99230HepG2PCBP1
GGCXENSG00000115486.71450.958401963.74570-0.436607.327106.14010HepG2PRPF4
GGCXENSG00000115486.71090.002701372.06340-0.332002.307401.56690HepG2PRPF8
GGCXENSG00000115486.71394.247903458.76300-1.3108068.4018066.54400HepG2PTBP1
GGCXENSG00000115486.72140.372902919.90770-0.4481010.665809.66180HepG2PUM1
GGCXENSG00000115486.73522.414102917.712400.271603.180702.46110HepG2PUM2
GGCXENSG00000115486.71558.707803746.02470-1.2650051.2393049.20640HepG2QKI
GGCXENSG00000115486.7864.484702054.66900-1.2490011.8575010.47410HepG2RAVER1
GGCXENSG00000115486.71873.445303211.36960-0.7775022.5052021.31360HepG2RBM22
GGCXENSG00000115486.72066.081503399.72080-0.7185014.3568012.88740HepG2RBM25
GGCXENSG00000115486.72360.927003849.30970-0.7052023.5047022.23550HepG2NELFE
GGCXENSG00000115486.72500.256503585.03890-0.5199013.6333012.42310HepG2RECQL
GGCXENSG00000115486.72881.311002342.483100.298602.224601.60310HepG2RPLP0
GGCXENSG00000115486.72898.888102018.266700.522303.295002.26450HepG2RPS10
GGCXENSG00000115486.7805.735201420.89300-0.8184013.6198012.38870HepG2RPS19
GGCXENSG00000115486.73350.525702050.218100.708506.594805.36700HepG2RPS3A
GGCXENSG00000115486.7760.904401357.19610-0.8348010.105608.74200HepG2RRP9
GGCXENSG00000115486.7849.393601855.29530-1.1271045.0554042.94960HepG2SAFB2
GGCXENSG00000115486.71906.915803176.31730-0.736107.103205.98720HepG2SF3A3
GGCXENSG00000115486.71772.698303601.10200-1.0225046.0587044.21730HepG2SF3B4
GGCXENSG00000115486.73045.984402637.534300.207603.466602.69620HepG2SLBP
GGCXENSG00000115486.71479.879602163.54920-0.5479015.7242014.38480HepG2SMN1
GGCXENSG00000115486.7808.198203627.15480-2.16610187.57440185.15590HepG2SRFBP1
GGCXENSG00000115486.72061.731402715.86650-0.397607.041106.10690HepG2SRSF5
GGCXENSG00000115486.71820.149702136.15480-0.231002.834502.13060HepG2SRSF7
GGCXENSG00000115486.72203.561903057.90340-0.4727011.6526010.65890HepG2SRSF9
GGCXENSG00000115486.7829.334901783.24840-1.1045014.2511011.62240HepG2STIP1
GGCXENSG00000115486.72241.535903088.58520-0.4625011.6764010.54810HepG2SUCLG1
GGCXENSG00000115486.72330.336601771.188800.395702.289701.66670HepG2SUPV3L1
GGCXENSG00000115486.71879.841203378.40490-0.8457026.1264024.63600HepG2TAF15
GGCXENSG00000115486.74484.791601468.648601.6105053.6691051.23450HepG2TARDBP
GGCXENSG00000115486.72482.453803104.39390-0.322503.622802.67210HepG2TIA1
GGCXENSG00000115486.71570.904602024.22110-0.365804.299103.70420HepG2TIAL1
GGCXENSG00000115486.71623.793702042.47280-0.330905.004004.29040HepG2TRIM56
GGCXENSG00000115486.73260.370702687.313900.278802.931102.02940HepG2TUFM
GGCXENSG00000115486.71450.562502200.35360-0.601107.108006.10980HepG2U2AF1
GGCXENSG00000115486.71501.269702844.58740-0.9220013.1689011.29560HepG2UBE2L3
GGCXENSG00000115486.71782.842402719.60890-0.6092011.2773010.19970HepG2UTP3
GGCXENSG00000115486.71401.808802020.41920-0.527403.503302.06020HepG2XRCC5
GGCXENSG00000115486.71641.491102259.56910-0.461002.856301.78240HepG2XRCC6
GGCXENSG00000115486.72578.679201937.910900.412009.537808.41680HepG2ZC3H8
GGCXENSG00000115486.72374.988003098.05670-0.383406.347005.60740HepG2ZNF622
GGCXENSG00000115486.7683.07340871.58700-0.351602.442301.82810K562AKAP8L
GGCXENSG00000115486.71284.50050600.963001.0958017.9606016.63190K562AQR
GGCXENSG00000115486.7654.70110270.616501.2745016.0727013.93590K562BOP1
GGCXENSG00000115486.7637.10230439.667400.535004.189202.60110K562CIRBP
GGCXENSG00000115486.7597.61320456.000600.390102.973801.82360K562CPEB4
GGCXENSG00000115486.7408.18510287.721100.504503.202902.35710K562CPSF6
GGCXENSG00000115486.71000.99780789.879100.341602.387001.48220K562CELF1
GGCXENSG00000115486.7627.67390982.77030-0.646806.819204.52050K562DDX19B
GGCXENSG00000115486.7651.86520937.92940-0.524906.547105.11380K562DKC1
GGCXENSG00000115486.7641.25570450.489600.509305.033704.10440K562EIF2S2
GGCXENSG00000115486.7206.05500287.42610-0.480202.546001.78220K562EIF3G
GGCXENSG00000115486.7428.30060292.791700.548603.316202.37510K562FMR1
GGCXENSG00000115486.7428.83880248.185700.788905.775404.40150K562FTO
GGCXENSG00000115486.7364.42400254.102300.520103.316701.83400K562FUS
GGCXENSG00000115486.7681.23690274.685401.3103019.2328017.03890K562GPKOW
GGCXENSG00000115486.7621.69600305.780001.0236012.3713011.18510K562HNRNPC
GGCXENSG00000115486.7633.56720426.391200.571205.073603.59410K562HNRNPL
GGCXENSG00000115486.7741.55130457.463100.696806.545905.33610K562HSPD1
GGCXENSG00000115486.7694.56110924.99360-0.413303.084102.20940K562KIF1C
GGCXENSG00000115486.7722.617101036.22350-0.520005.432804.07160K562MBNL1
GGCXENSG00000115486.7461.79860268.131000.784206.554905.18050K562METAP2
GGCXENSG00000115486.7890.85730684.610200.379802.434201.37750K562MSI2
GGCXENSG00000115486.7488.18890354.503300.461502.214301.48740K562MTPAP
GGCXENSG00000115486.7530.13330726.31570-0.454202.349701.55230K562NAA15
GGCXENSG00000115486.7670.73500446.668700.586404.088003.07540K562PCBP3
GGCXENSG00000115486.7543.75580342.617300.666306.126104.93960K562POLR2G
GGCXENSG00000115486.7636.46340842.20990-0.404103.623402.95780K562RBM15
GGCXENSG00000115486.7343.50710482.49790-0.490202.520001.57050K562RPS3
GGCXENSG00000115486.7600.75650388.675300.628106.849505.61410K562SF3A3
GGCXENSG00000115486.7561.65310404.901000.472002.882301.60230K562STAU1
GGCXENSG00000115486.7458.31430358.651300.353702.101801.40240K562U2AF2
GGCXENSG00000115486.7968.68430417.622301.2137030.8452028.74930K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for GGCX is not available on ENCORE database.





11 RBPs can affect the splicing of GGCX :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEGGCXENSG00000115486.7chr2-857812658578142985780354857806208578260685782713-0.128000.006360.09138excludedHepG2U2AF1
SEGGCXENSG00000115486.7chr2-857795388577969085778959857791048578006185780193-0.152000.000190.02169excludedHepG2QKI
SEGGCXENSG00000115486.7chr2-8578793785788108857858478578619885788508857886700.134000.000690.04429includedHepG2AKAP1
SEGGCXENSG00000115486.7chr2-857879378578810885785977857861988578850885788670-0.273000.000760.01366excludedK562PUS1
SEGGCXENSG00000115486.7chr2-8577953885779690857789598577910485780061857801930.147000.002170.07979includedHepG2SFPQ
SEGGCXENSG00000115486.7chr2-857795388577969085778959857791048578006185780193-0.326000.000000.00000excludedHepG2PTBP1
SEGGCXENSG00000115486.7chr2-857879378578810885786039857861988578850885788632-0.185000.000080.01450excludedHepG2PCBP2
SEGGCXENSG00000115486.7chr2-857879378578810885786039857861988578850885788632-0.194000.000070.03683excludedHepG2BCCIP
SEGGCXENSG00000115486.7chr2-857795388577969085778959857791048578006185780193-0.160000.000810.03965excludedHepG2SF3B4
SEGGCXENSG00000115486.7chr2-857879378578810885785847857861988578850885788632-0.364000.000000.00000excludedK562HNRNPU
SEGGCXENSG00000115486.7chr2-857879378578810885786068857861988578850885788596-0.256000.000000.00015excludedHepG2HNRNPU
SEGGCXENSG00000115486.7chr2-8578688885786938857857068578619885787937857881080.119000.001240.02311includedK562HNRNPC

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for GGCX is not avaliable on ENCORE database.