RUVBL2

General Information

Gene Name       : RUVBL2
Gene ID             : ENSG00000183207.13
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: RUVBL2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878RUVBL2ENSG00000183207.137.4336.6122.02ENCSR000AEF
HepG2RUVBL2ENSG00000183207.13192.9633.82113.39ENCSR985KAT
K562RUVBL2ENSG00000183207.13245.26111.09178.18ENCSR000AEO

Assays

1 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
knockdown followed by RNA-seq RUVBL2-BGHcLV31-HepG2ENCSR153WFERUVBL2HepG2ReleasedENCSR452TFV   CRISPRKD% = 68.5,61.9






  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
RUVBL2ENCAB112NIXA302-536A1BGHcLV31-21, Released, ENCODE4


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
RUVBL2K562CRISPRBGKcLV33-19,BGKcLV33-20BGKcLV33-1,BGKcLV33-20.0,0.0NotSatisfiedENCODE4
RUVBL2K562CRISPRBGKcLV33-25,BGKcLV33-26BGKcLV33-1,BGKcLV33-20.0,0.0NotSatisfiedENCODE4
RUVBL2K562CRISPRBGKcLV46-85,BGKcLV46-86BGKcLV46-1,BGKcLV46-261.4,63.0ExperimentedENCORE2
RUVBL2K562CRISPRBGKcLV46-87,BGKcLV46-88BGKcLV46-1,BGKcLV46-283.3,86.7ExperimentedENCORE2
RUVBL2HepG2CRISPRENCSR153WFEENCSR452TFVRUVBL2-BGHcLV31-21,RUVBL2-BGHcLV31-22NT-BGHcLV31-1,NT-BGHcLV31-268.5,61.9ReleasedENCODE4


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
RUVBL2Product_ID: A302-536A
Lot_ID: 1
Source: Bethyl Labs
Target Name: RUVBL2-human		 RUVBL2-HEPG2-CRISPR-A302-536A.png<br>Caption: Western blot following CRISPR against RUVBL2 in HepG2 whole cell lysate using RUVBL2 specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against RUVBL2. RUVBL2 protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for RUVBL2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • RUVBL2 RNA is bound by 19 proteins.  







eCLIP assay for RUVBL2 is not avaliable on ENCORE database.





19 proteins are bound to RUVBL2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr194950760349507673+3'-UTR,5'-UTR,CDS4.274444.12139K562DDX24
chr194951907649519087+3'-UTR,CDS3.3636212.53474K562YBX3
chr194951383649513858+3'-UTR,CDS3.440848.26386K562YBX3
chr194951331349513366+3'-UTR,CDS,intron-Proximal4.463098.17589HepG2PRPF8
chr194950653249506592+3'-UTR,5'-UTR,CDS,intron-Proximal3.313786.49064K562DDX3X
chr194951300049513049+3'-UTR,CDS,intron-Proximal3.649866.06472K562AQR
chr194951907349519116+3'-UTR,CDS,intron-Proximal3.848783.79347HepG2GRWD1
chr194951438349514450+3'-UTR,CDS,intron-Proximal6.093609.77790HepG2EFTUD2
chr194951893849518943+3'-UTR,CDS3.514129.86022K562YBX3
chr194951445349514481+3'-UTR,CDS3.494129.61197K562YBX3
chr194951446149514516+3'-UTR,CDS3.625594.51003HepG2PPIG
chr194951425549514280+3'-UTR,CDS,intron-Proximal3.227086.56666K562YBX3
chr194951027449510309+3'-UTR,CDS,intron-Proximal5.859737.43791K562RPS3
chr194951827749518408+3'-UTR,CDS,intron-Distal,intron-Proximal4.2183617.44235K562RPS3
chr194950753449507619+3'-UTR,5'-UTR,CDS5.1572416.53878K562RPS3
chr194950756049507667+3'-UTR,5'-UTR,CDS4.458704.13050K562LIN28B
chr194951055649510624+3'-UTR,CDS,intron-Proximal3.144804.96885HepG2G3BP1
chr194950653449506588+3'-UTR,5'-UTR,CDS,intron-Proximal3.753988.85114K562RPS3
chr194951893049518938+3'-UTR,CDS3.8554614.45532K562YBX3
chr194951424449514295+3'-UTR,CDS,intron-Proximal4.460035.63984HepG2SRSF9
chr194950760749507673+3'-UTR,5'-UTR,CDS4.524397.79455HepG2PPIG
chr194950753349507620+3'-UTR,5'-UTR,CDS,intron-Proximal3.8576410.88170HepG2RPS3
chr194951306549513101+3'-UTR,CDS3.113883.89560K562UCHL5
chr194950761949507673+3'-UTR,5'-UTR,CDS4.4497210.25818K562RPS3
chr194951385849513868+3'-UTR,CDS3.122036.13273K562YBX3
chr194951438549514469+3'-UTR,CDS,intron-Proximal4.4586013.70545K562EFTUD2
chr194951374749513824+3'-UTR,CDS4.203797.70120K562RPS3
chr194950658749506638+3'-UTR,5'-UTR,CDS,intron-Proximal4.300454.89208K562AQR
chr194951439949514453+3'-UTR,CDS,intron-Proximal3.739726.26407K562SF3B4
chr194951056049510617+3'-UTR,CDS3.489278.52682HepG2PPIG
chr194951916549519206+3'-UTR,polyA_site5.735695.71015K562PABPC4
chr194951312549513139+3'-UTR,CDS,intron-Proximal3.411924.74241K562YBX3
chr194950654449506593+3'-UTR,5'-UTR,CDS,intron-Proximal3.934615.18795HepG2RPS3
chr194951332249513366+3'-UTR,CDS,intron-Proximal6.0128513.18785K562AQR
chr194951456549514617+3'-UTR,CDS,intron-Proximal3.649866.06472K562AQR
chr194950753349507673+3'-UTR,5'-UTR,CDS,intron-Proximal3.058254.60423HepG2G3BP1
chr194951303149513123+3'-UTR,CDS,intron-Proximal3.453935.73981HepG2GRWD1
chr194951785349517908+3'-UTR,CDS,intron-Proximal4.837775.93128HepG2PRPF8
chr194950754849507607+3'-UTR,5'-UTR,CDS3.999728.40792HepG2PPIG
chr194951907349519076+3'-UTR,CDS,intron-Proximal3.9214515.41209K562YBX3
chr194951328249513323+3'-UTR,CDS4.2430614.92488K562YBX3
chr194951056949510626+3'-UTR,CDS,intron-Proximal4.203799.67356K562RPS3
chr194951309949513125+3'-UTR,CDS3.175084.74027K562YBX3
chr194951448149514513+3'-UTR,CDS3.411929.01971K562YBX3
chr194951303249513062+3'-UTR,CDS,intron-Proximal3.062484.88012HepG2PPIG
chr194951445149514553+3'-UTR,CDS3.418715.00580K562METAP2
chr194950257449502631+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.6514810.35368K562DDX3X
chr194949723649497306+5'-UTR,intron-Distal,intron-Proximal5.823078.08771HepG2EFTUD2
chr194949713549497180+5'-UTR,CDS,intron-Proximal3.032704.97367K562DDX3X
chr194949725449497434+5'-UTR,CDS,intron-Distal,intron-Proximal3.799664.76009HepG2PRPF4
chr194949721949497388+5'-UTR,intron-Distal,intron-Proximal4.6741711.56048K562EFTUD2
chr194951463249514679+intron-Distal,intron-Proximal4.784595.26064K562AQR
chr194951337649513509+intron-Distal,intron-Proximal4.310894.76505K562HNRNPK
chr194951339649513523+intron-Distal,intron-Proximal3.995628.10864K562PRPF8
chr194951820149518270+intron-Distal,intron-Proximal5.104395.58150K562SF3B4
chr194950958349509632+intron-Distal4.460263.18269HepG2XPO5
chr194951386849513913+intron-Proximal4.823594.65563K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for RUVBL2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for RUVBL2 is not available on ENCORE database.

  • 101 RBPs can affect the levels of RUVBL2.  








The Knockdown/knockout RNA-Seq assay for RUVBL2 is not available on ENCORE database.





101 RBPs can affect the gene expression of RUVBL2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
RUVBL2ENSG00000183207.8510.85560797.65590-0.642902.363601.36920HepG2AATF
RUVBL2ENSG00000183207.82489.795601644.195700.598503.706903.10330HepG2AKAP1
RUVBL2ENSG00000183207.81015.138401470.11580-0.534309.475708.16080HepG2AKAP8L
RUVBL2ENSG00000183207.81411.35940890.734900.663903.934602.81590HepG2BCCIP
RUVBL2ENSG00000183207.81157.05760834.778100.470902.862502.25390HepG2BOP1
RUVBL2ENSG00000183207.8541.67380927.82070-0.776407.034805.87760HepG2CALR
RUVBL2ENSG00000183207.8868.333601292.42750-0.573802.268001.56320HepG2CIRBP
RUVBL2ENSG00000183207.8907.30660638.664100.506405.519204.08250HepG2YBX3
RUVBL2ENSG00000183207.8431.12560817.30150-0.922802.781401.42350HepG2CSTF2T
RUVBL2ENSG00000183207.8451.15260860.99390-0.932404.143403.01480HepG2DDX24
RUVBL2ENSG00000183207.81114.759101399.96090-0.328703.915103.13670HepG2DKC1
RUVBL2ENSG00000183207.81037.81410621.609300.7394016.4041014.94480HepG2DNAJC2
RUVBL2ENSG00000183207.8408.97640810.09380-0.986103.231702.02580HepG2AGO1
RUVBL2ENSG00000183207.8534.40170878.73430-0.717502.245601.42310HepG2EIF3D
RUVBL2ENSG00000183207.8559.881701436.79410-1.359707.629506.57020HepG2EIF4A3
RUVBL2ENSG00000183207.81089.874101335.86360-0.293602.326101.60150HepG2FUBP3
RUVBL2ENSG00000183207.82006.292701450.582500.467802.904202.19420HepG2FXR1
RUVBL2ENSG00000183207.8556.10100868.57070-0.643302.721402.08520HepG2GPKOW
RUVBL2ENSG00000183207.8461.15930633.07100-0.457101.899401.35290HepG2HNRNPA1
RUVBL2ENSG00000183207.81682.456501148.140600.5512013.1034011.73840HepG2HNRNPL
RUVBL2ENSG00000183207.81152.03280699.544400.7196014.6588013.35670HepG2HNRNPU
RUVBL2ENSG00000183207.8982.36290714.556700.459106.908605.80370HepG2ILF2
RUVBL2ENSG00000183207.8973.089401245.59290-0.356202.921002.09080HepG2MSI2
RUVBL2ENSG00000183207.81712.970301249.818900.454705.349904.29670HepG2NOL12
RUVBL2ENSG00000183207.8762.013001329.33540-0.802803.950903.09860HepG2PABPC4
RUVBL2ENSG00000183207.8992.26670623.932900.669204.785103.84250HepG2PPIL4
RUVBL2ENSG00000183207.81088.176701444.64710-0.408806.015805.27200HepG2PTBP1
RUVBL2ENSG00000183207.81979.048301266.479300.6439019.5645018.27720HepG2PUM1
RUVBL2ENSG00000183207.81024.656901490.45260-0.5406010.769309.69000HepG2PUS1
RUVBL2ENSG00000183207.81082.028301564.50970-0.532007.574906.61880HepG2QKI
RUVBL2ENSG00000183207.81302.471001935.29530-0.571306.534105.81920HepG2RBM22
RUVBL2ENSG00000183207.8783.445101419.92290-0.8579014.6745013.18770HepG2RBM25
RUVBL2ENSG00000183207.81371.69850622.958801.1387038.1952036.22630HepG2SAFB2
RUVBL2ENSG00000183207.81197.810601503.99780-0.328403.936903.25220HepG2SF3B4
RUVBL2ENSG00000183207.81594.018701143.947700.478509.509408.33310HepG2SLBP
RUVBL2ENSG00000183207.8975.55920726.447600.425305.879004.99590HepG2SMN1
RUVBL2ENSG00000183207.81160.05190757.307900.615102.266901.40900HepG2SMNDC1
RUVBL2ENSG00000183207.8353.18780912.84310-1.369906.642905.42270HepG2SNRNP70
RUVBL2ENSG00000183207.81535.975202185.77380-0.509006.650105.96630HepG2SRFBP1
RUVBL2ENSG00000183207.81125.356501569.87520-0.480307.948307.24340HepG2SRSF1
RUVBL2ENSG00000183207.81676.785601177.965700.509303.410902.72810HepG2SRSF5
RUVBL2ENSG00000183207.81029.367701277.20040-0.311203.601302.99010HepG2SRSF9
RUVBL2ENSG00000183207.81279.115001897.64510-0.569107.998907.21410HepG2SSB
RUVBL2ENSG00000183207.81945.667301339.675900.5383012.4626011.30500HepG2SUCLG1
RUVBL2ENSG00000183207.8747.066801411.14010-0.9176011.9012010.86410HepG2TAF15
RUVBL2ENSG00000183207.81053.571701296.56590-0.299402.076001.34920HepG2TIA1
RUVBL2ENSG00000183207.8925.65110679.633700.445604.219803.63090HepG2TIAL1
RUVBL2ENSG00000183207.81365.97570685.821200.9939028.2783026.71470HepG2TRIM56
RUVBL2ENSG00000183207.81654.508901165.560000.505306.210604.82450HepG2TUFM
RUVBL2ENSG00000183207.8688.379201316.54240-0.9355012.5079011.14010HepG2U2AF1
RUVBL2ENSG00000183207.8728.17240514.903100.499902.168001.49560HepG2UCHL5
RUVBL2ENSG00000183207.8794.13600942.72960-0.247502.259601.64450HepG2ZC3H8
RUVBL2ENSG00000183207.85775.140304249.427500.442507.673706.79530K562AGGF1
RUVBL2ENSG00000183207.83428.696402888.236300.247402.931601.37870K562AKAP1
RUVBL2ENSG00000183207.82137.900905574.89450-1.3827039.7617037.74940K562AQR
RUVBL2ENSG00000183207.85573.920204639.649400.264603.712902.64160K562ATP5C1
RUVBL2ENSG00000183207.83334.241502620.437900.347502.973301.60360K562BCCIP
RUVBL2ENSG00000183207.8866.615301339.90950-0.628706.653505.28260K562BOP1
RUVBL2ENSG00000183207.82626.038603580.25540-0.447202.377501.40630K562CNOT7
RUVBL2ENSG00000183207.81118.968301424.69710-0.348503.167902.32750K562CPSF6
RUVBL2ENSG00000183207.82865.930901921.273500.5768011.684609.32590K562CSTF2
RUVBL2ENSG00000183207.86138.099808382.17410-0.449503.830102.67270K562CELF1
RUVBL2ENSG00000183207.82804.333902220.205900.336903.650102.10730K562DDX27
RUVBL2ENSG00000183207.85619.054904757.738300.240003.456802.46260K562DKC1
RUVBL2ENSG00000183207.81558.457901076.519000.533607.541006.23500K562EIF3G
RUVBL2ENSG00000183207.82497.421903057.13510-0.291702.568701.77830K562EIF4A3
RUVBL2ENSG00000183207.81781.033302455.68600-0.463403.071601.35290K562ESF1
RUVBL2ENSG00000183207.82846.592102309.243800.301702.290501.51840K562FIP1L1
RUVBL2ENSG00000183207.81422.177202417.91570-0.765707.490805.48810K562FKBP4
RUVBL2ENSG00000183207.8742.937801449.61710-0.9644015.5165013.41150K562FMR1
RUVBL2ENSG00000183207.8824.676401228.69060-0.575205.109403.82380K562FTO
RUVBL2ENSG00000183207.8169.20170709.43450-2.0679019.6267017.28220K562G3BP2
RUVBL2ENSG00000183207.83144.509304368.25520-0.474204.149702.76360K562GLRX3
RUVBL2ENSG00000183207.81018.291201360.22620-0.417703.756602.83730K562GPKOW
RUVBL2ENSG00000183207.81305.232702782.77960-1.0922027.1097025.32590K562HNRNPC
RUVBL2ENSG00000183207.82687.066801899.588400.500204.722503.47510K562HNRNPM
RUVBL2ENSG00000183207.82650.294301714.201000.628503.356502.00940K562IGF2BP3
RUVBL2ENSG00000183207.82055.602103268.87240-0.669204.164902.40570K562ILF2
RUVBL2ENSG00000183207.8668.889601161.48690-0.796106.222604.76220K562KRR1
RUVBL2ENSG00000183207.82133.921602696.42470-0.337502.944201.50550K562LARP7
RUVBL2ENSG00000183207.82922.457001770.288800.723106.365805.06760K562MAGOH
RUVBL2ENSG00000183207.82388.736901766.457500.435302.107301.31180K562MATR3
RUVBL2ENSG00000183207.86208.647405256.691600.240002.139601.35610K562MBNL1
RUVBL2ENSG00000183207.84957.697407263.88610-0.551106.431704.72150K562MSI2
RUVBL2ENSG00000183207.83311.705804592.69870-0.4718012.8537011.26610K562MTPAP
RUVBL2ENSG00000183207.83418.019502083.001500.714402.792401.49370K562NONO
RUVBL2ENSG00000183207.83967.422105102.63110-0.363007.314406.18220K562NSUN2
RUVBL2ENSG00000183207.82480.407003439.58440-0.471702.585901.40430K562PABPC1
RUVBL2ENSG00000183207.82595.595601731.196600.584203.504201.97660K562PCBP1
RUVBL2ENSG00000183207.82353.056803544.25850-0.590906.540105.25730K562PCBP3
RUVBL2ENSG00000183207.82141.283302718.55740-0.344404.060903.08680K562POLR2G
RUVBL2ENSG00000183207.84107.409902621.740400.647605.742704.48730K562PPIG
RUVBL2ENSG00000183207.83043.611801720.064300.823209.570708.39020K562PTBP1
RUVBL2ENSG00000183207.84643.921307435.53360-0.679108.296606.88080K562PUF60
RUVBL2ENSG00000183207.86067.025007911.11480-0.382903.373102.18990K562PUM1
RUVBL2ENSG00000183207.82234.276003193.92580-0.515503.149201.45470K562RPS3A
RUVBL2ENSG00000183207.81568.280201168.655800.424202.879001.85540K562RPS3
RUVBL2ENSG00000183207.81890.321802504.39550-0.405803.873102.14500K562SDAD1
RUVBL2ENSG00000183207.83442.893305035.39580-0.548509.357607.92280K562SF3A3
RUVBL2ENSG00000183207.8695.274801293.65590-0.8958010.533808.55470K562SF3B1
RUVBL2ENSG00000183207.84197.913505158.90790-0.297403.767102.69350K562SRPK2
RUVBL2ENSG00000183207.83175.489401686.413600.912905.936904.90990K562SRSF1
RUVBL2ENSG00000183207.81624.177101128.027300.525806.286904.58730K562SRSF4
RUVBL2ENSG00000183207.82623.881501593.129000.719703.580902.35720K562SRSF5
RUVBL2ENSG00000183207.82634.833604228.68290-0.682502.837901.38710K562SUPT6H
RUVBL2ENSG00000183207.8294.33140696.36280-1.242403.220801.60100K562TAF15
RUVBL2ENSG00000183207.82800.939401706.379000.714902.907402.18220K562TARDBP
RUVBL2ENSG00000183207.83188.061901646.095500.953505.160403.99090K562TIA1
RUVBL2ENSG00000183207.83144.818301616.212700.960304.982003.43790K562TRA2A
RUVBL2ENSG00000183207.8352.40450687.25740-0.963603.599902.31590K562U2AF1
RUVBL2ENSG00000183207.8240.10280709.92310-1.5640031.5689028.94860K562U2AF2
RUVBL2ENSG00000183207.84284.805005410.44930-0.336507.041005.95360K562UPF1
RUVBL2ENSG00000183207.83129.656304629.51580-0.564906.032804.71250K562WDR3
RUVBL2ENSG00000183207.83888.335204814.39860-0.308206.527505.27870K562WDR43
RUVBL2ENSG00000183207.84764.858306605.03920-0.471107.032704.98060K562WRN
RUVBL2ENSG00000183207.82542.900404160.48920-0.710303.289901.51270K562YTHDC2
RUVBL2ENSG00000183207.84324.952106280.39410-0.538208.153506.54810K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for RUVBL2 is not available on ENCORE database.





10 RBPs can affect the splicing of RUVBL2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SERUVBL2ENSG00000183207.8chr19+495105144951062549510274495104044951303249513128-0.054000.000210.01179excludedK562SF3B1
A3SSRUVBL2ENSG00000183207.8chr19+4950746349507675495075334950767549506535495065910.195000.000060.01070longerK562HNRNPC
RIRUVBL2ENSG00000183207.8chr19+4951322949513868495132294951332349513744495138680.063000.007300.08529includedK562SF3B4
RIRUVBL2ENSG00000183207.8chr19+4951322949513868495132294951332349513744495138680.120000.000000.00000includedHepG2PCBP2
RIRUVBL2ENSG00000183207.8chr19+4951322949513868495132294951332349513744495138680.074000.000000.00001includedHepG2SF3A3
RIRUVBL2ENSG00000183207.8chr19+4951322949513868495132294951332349513744495138680.077000.005660.07857includedK562U2AF1
RIRUVBL2ENSG00000183207.8chr19+4951322949513868495132294951332349513744495138680.053000.000010.00036includedHepG2NCBP2
RIRUVBL2ENSG00000183207.8chr19+4951322949513868495132294951332349513744495138680.054000.000000.00003includedHepG2SF3B4
MXERUVBL2ENSG00000183207.8chr19+4950257549502630495065354950659149497154494971804950746349507675-0.060000.000000.000012includedK562AQR
MXERUVBL2ENSG00000183207.8chr19+4950653549506591495074634950767549502575495026304951027449510404-0.154000.000100.018282includedK562AARS
MXERUVBL2ENSG00000183207.8chr19+4950257549502630495065354950659149497154494971804950746349507675-0.096000.001340.043752includedK562DDX55

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for RUVBL2 is not avaliable on ENCORE database.