RUVBL2

General Information

Gene Name : RUVBL2
Gene ID : ENSG00000183207.13
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: RUVBL2)

Not Available

Antibody Validation

Bethyl Labs: A302-536A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	RUVBL2	ENSG00000183207.13	7.43	36.61	22.02	ENCSR000AEF
HepG2	RUVBL2	ENSG00000183207.13	192.96	33.82	113.39	ENCSR985KAT
K562	RUVBL2	ENSG00000183207.13	245.26	111.09	178.18	ENCSR000AEO

Assays

1 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	RUVBL2-BGHcLV31-HepG2	ENCSR153WFE	RUVBL2	HepG2	Released		ENCSR452TFV	CRISPR	KD% = 68.5,61.9

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
RUVBL2	ENCAB112NIX	A302-536A	1				BGHcLV31-21, Released, ENCODE4

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
RUVBL2	K562	CRISPR			BGKcLV33-19,BGKcLV33-20	BGKcLV33-1,BGKcLV33-2	0.0,0.0	NotSatisfied	ENCODE4
RUVBL2	K562	CRISPR			BGKcLV33-25,BGKcLV33-26	BGKcLV33-1,BGKcLV33-2	0.0,0.0	NotSatisfied	ENCODE4
RUVBL2	K562	CRISPR			BGKcLV46-85,BGKcLV46-86	BGKcLV46-1,BGKcLV46-2	61.4,63.0	NotSatisfied	ENCORE2
RUVBL2	K562	CRISPR			RUVBL2-BGKcLV46-87,RUVBL2-BGKcLV46-88	NT-BGKcLV46-1,NT-BGKcLV46-2	83.3,86.7	Submitting	ENCORE2
RUVBL2	HepG2	CRISPR	ENCSR153WFE	ENCSR452TFV	RUVBL2-BGHcLV31-21,RUVBL2-BGHcLV31-22	NT-BGHcLV31-1,NT-BGHcLV31-2	68.5,61.9	Released	ENCODE4

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
RUVBL2	Product_ID: A302-536A Lot_ID: 1 Source: Bethyl Labs Target Name: RUVBL2-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for RUVBL2 is not avaliable on ENCORE database.

Proteins bound to RNA

RUVBL2 RNA is bound by 19 proteins.

CanvasJS.com

eCLIP assay for RUVBL2 is not avaliable on ENCORE database.

19 proteins are bound to RUVBL2 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr19	49518277	49518408	+	3'-UTR,CDS,intron-Distal,intron-Proximal	4.21836	17.44235	K562	RPS3
chr19	49507534	49507619	+	3'-UTR,5'-UTR,CDS	5.15724	16.53878	K562	RPS3
chr19	49519073	49519076	+	3'-UTR,CDS,intron-Proximal	3.92145	15.41209	K562	YBX3
chr19	49513282	49513323	+	3'-UTR,CDS	4.24306	14.92488	K562	YBX3
chr19	49518930	49518938	+	3'-UTR,CDS	3.85546	14.45532	K562	YBX3
chr19	49514385	49514469	+	3'-UTR,CDS,intron-Proximal	4.45860	13.70545	K562	EFTUD2
chr19	49513322	49513366	+	3'-UTR,CDS,intron-Proximal	6.01285	13.18785	K562	AQR
chr19	49519076	49519087	+	3'-UTR,CDS	3.36362	12.53474	K562	YBX3
chr19	49497219	49497388	+	5'-UTR,intron-Distal,intron-Proximal	4.67417	11.56048	K562	EFTUD2
chr19	49507533	49507620	+	3'-UTR,5'-UTR,CDS,intron-Proximal	3.85764	10.88170	HepG2	RPS3
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 57 entries

eCLIP assay for RUVBL2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for RUVBL2 is not available on ENCORE database.
101 RBPs can affect the levels of RUVBL2.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for RUVBL2 is not available on ENCORE database.

101 RBPs can affect the gene expression of RUVBL2 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
RUVBL2	ENSG00000183207.8	2137.90090	5574.89450	-1.38270	39.76170	37.74940	K562	AQR
RUVBL2	ENSG00000183207.8	1371.69850	622.95880	1.13870	38.19520	36.22630	HepG2	SAFB2
RUVBL2	ENSG00000183207.8	240.10280	709.92310	-1.56400	31.56890	28.94860	K562	U2AF2
RUVBL2	ENSG00000183207.8	1365.97570	685.82120	0.99390	28.27830	26.71470	HepG2	TRIM56
RUVBL2	ENSG00000183207.8	1305.23270	2782.77960	-1.09220	27.10970	25.32590	K562	HNRNPC
RUVBL2	ENSG00000183207.8	1979.04830	1266.47930	0.64390	19.56450	18.27720	HepG2	PUM1
RUVBL2	ENSG00000183207.8	169.20170	709.43450	-2.06790	19.62670	17.28220	K562	G3BP2
RUVBL2	ENSG00000183207.8	1037.81410	621.60930	0.73940	16.40410	14.94480	HepG2	DNAJC2
RUVBL2	ENSG00000183207.8	742.93780	1449.61710	-0.96440	15.51650	13.41150	K562	FMR1
RUVBL2	ENSG00000183207.8	1152.03280	699.54440	0.71960	14.65880	13.35670	HepG2	HNRNPU
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 117 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for RUVBL2 is not available on ENCORE database.

10 RBPs can affect the splicing of RUVBL2 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
RI	RUVBL2	ENSG00000183207.8	chr19	+	49513229	49513868			49513229	49513323	49513744	49513868	0.12000	0.00000	0.00000	included	HepG2	PCBP2
RI	RUVBL2	ENSG00000183207.8	chr19	+	49513229	49513868			49513229	49513323	49513744	49513868	0.07400	0.00000	0.00001	included	HepG2	SF3A3
RI	RUVBL2	ENSG00000183207.8	chr19	+	49513229	49513868			49513229	49513323	49513744	49513868	0.05400	0.00000	0.00003	included	HepG2	SF3B4
MXE	RUVBL2	ENSG00000183207.8	chr19	+	49502575	49502630	49506535	49506591	49497154	49497180	49507463	49507675	-0.06000	0.00000	0.00001	2included	K562	AQR
RI	RUVBL2	ENSG00000183207.8	chr19	+	49513229	49513868			49513229	49513323	49513744	49513868	0.05300	0.00001	0.00036	included	HepG2	NCBP2
A3SS	RUVBL2	ENSG00000183207.8	chr19	+	49507463	49507675			49507533	49507675	49506535	49506591	0.19500	0.00006	0.01070	longer	K562	HNRNPC
MXE	RUVBL2	ENSG00000183207.8	chr19	+	49506535	49506591	49507463	49507675	49502575	49502630	49510274	49510404	-0.15400	0.00010	0.01828	2included	K562	AARS
SE	RUVBL2	ENSG00000183207.8	chr19	+	49510514	49510625			49510274	49510404	49513032	49513128	-0.05400	0.00021	0.01179	excluded	K562	SF3B1
MXE	RUVBL2	ENSG00000183207.8	chr19	+	49502575	49502630	49506535	49506591	49497154	49497180	49507463	49507675	-0.09600	0.00134	0.04375	2included	K562	DDX55
RI	RUVBL2	ENSG00000183207.8	chr19	+	49513229	49513868			49513229	49513323	49513744	49513868	0.07700	0.00566	0.07857	included	K562	U2AF1

Showing 1 to 10 of 11 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

RUVBL2

General Information

Functions

Localization

Domains (AlphaFold: RUVBL2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for RUVBL2 is not avaliable on ENCORE database.

19 proteins are bound to RUVBL2 RNA:

eCLIP assay for RUVBL2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for RUVBL2 is not available on ENCORE database.

101 RBPs can affect the gene expression of RUVBL2 :

The Knockdown/knockout RNA-Seq assay for RUVBL2 is not available on ENCORE database.

10 RBPs can affect the splicing of RUVBL2 :

The Knockdown/knockout RNA-Seq assay for RUVBL2 is not avaliable on ENCORE database.