PHB

General Information

Gene Name       : PHB
Gene ID             : ENSG00000167085.11
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: PHB)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PHBENSG00000167085.11163.79238.27201.03ENCSR000AEF
HepG2PHBENSG00000167085.11920.76545.32733.04ENCSR985KAT
K562PHBENSG00000167085.11351.47383.29367.38ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PHB is not avaliable on ENCORE database.



Proteins bound to RNA
  • PHB RNA is bound by 14 proteins.  







eCLIP assay for PHB is not avaliable on ENCORE database.





14 proteins are bound to PHB RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr174748161947481678-3'-UTR,intron-Distal3.8295111.07283HepG2LIN28B
chr174748159547481619-3'-UTR,intron-Distal3.935146.31664HepG2LIN28B
chr174748183747481907-3'-UTR,intron-Distal,intron-Proximal4.802664.56348K562UPF1
chr174748158547481689-3'-UTR,intron-Distal5.200598.05720K562UPF1
chr174748230047482373-3'-UTR,CDS,intron-Distal,intron-Proximal3.6246110.06921HepG2RPS3
chr174748243047482567-3'-UTR,CDS,intron-Distal,intron-Proximal3.000516.93315HepG2G3BP1
chr174748159947481683-3'-UTR,intron-Distal4.9520011.02367HepG2UPF1
chr174748160047481691-3'-UTR,intron-Distal3.686954.53300K562LIN28B
chr174748664647486719-3'-UTR,CDS,intron-Distal,intron-Proximal3.701055.13777HepG2PRPF8
chr174748200647482132-3'-UTR,intron-Distal5.8889513.82898HepG2UPF1
chr174748183347481970-3'-UTR,intron-Distal,intron-Proximal5.0676522.37098HepG2UPF1
chr174748184047481975-3'-UTR,intron-Distal,intron-Proximal4.515857.46349HepG2AKAP1
chr174748240947482557-3'-UTR,CDS,intron-Distal,intron-Proximal3.156599.06344HepG2RPS3
chr174748159347481716-3'-UTR,intron-Distal4.163528.23922HepG2AKAP1
chr174748154047481593-3'-UTR,intron-Distal3.052323.27723HepG2AKAP1
chr174748199247482109-3'-UTR,intron-Distal,intron-Proximal3.847175.09002HepG2FAM120A
chr174749219647492234-5'-UTR,intron-Distal,intron-Proximal5.0712328.25493HepG2SUB1
chr174749219547492224-5'-UTR,intron-Distal,intron-Proximal3.376634.04629HepG2G3BP1
chr174749059347490654-5'-UTR,CDS,intron-Distal,intron-Proximal3.185135.88048HepG2G3BP1
chr174749060347490654-5'-UTR,CDS,intron-Distal,intron-Proximal4.332188.72791K562APOBEC3C
chr174749219447492236-5'-UTR,intron-Distal,intron-Proximal3.716295.58851K562NOLC1
chr174749219547492224-5'-UTR,intron-Distal,intron-Proximal5.072697.51217K562APOBEC3C
chr174749056347490654-5'-UTR,CDS,intron-Distal,intron-Proximal4.601229.45563HepG2LARP4
chr174749061647490653-5'-UTR,CDS,intron-Distal,intron-Proximal4.9297925.26873HepG2SUB1
chr174749061547490654-5'-UTR,CDS,intron-Distal,intron-Proximal3.476504.48863K562NOLC1
chr174749214647492208-5'-UTR,intron-Distal,intron-Proximal4.780035.93128HepG2PRPF8
chr174748404347484163-CDS,intron-Distal,intron-Proximal5.166326.01989HepG2PRPF8
chr174748240547482446-CDS,intron-Distal,intron-Proximal3.014126.35003K562YBX3
chr174749054647490593-CDS,intron-Distal4.406383.68241HepG2G3BP1
chr174748665247486697-CDS,intron-Distal,intron-Proximal4.527314.13847K562AQR
chr174748910547489124-CDS,intron-Distal3.6317310.74873K562YBX3
chr174749049647490554-CDS,intron-Distal,intron-Proximal4.301505.93840HepG2PRPF8
chr174748909947489105-CDS,intron-Distal3.707158.70833K562YBX3
chr174748910847489175-CDS,intron-Distal3.741555.15615HepG2RPS3
chr174749056547490613-CDS,intron-Distal4.427967.64619HepG2SUB1
chr174748907647489099-CDS,intron-Distal3.4110711.01249K562YBX3
chr174748904247489149-CDS,intron-Distal4.778055.44291K562LIN28B
chr174748904247489076-CDS,intron-Distal3.238858.95782K562YBX3
chr174748246047482504-CDS,intron-Distal,intron-Proximal3.576916.62719HepG2LARP4
chr174748419047484216-CDS,intron-Distal3.537903.77614HepG2G3BP1
chr174748665047486700-CDS,intron-Distal,intron-Proximal3.401034.20336HepG2AQR
chr174748903747489179-CDS,intron-Distal,intron-Proximal3.8955510.14700HepG2G3BP1
chr174748912447489160-CDS,intron-Distal4.1208812.72862K562YBX3
chr174748676447486829-CDS,intron-Distal,intron-Proximal3.0202414.64966K562YBX3
chr174748916047489182-CDS,intron-Distal3.8100613.93110K562YBX3
chr174748792847488048-intron-Distal4.817009.10156HepG2QKI
chr174748407647484092-intron-Distal,intron-Proximal4.942344.86944K562AQR
chr174748409247484121-intron-Distal,intron-Proximal4.278566.77156K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PHB is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PHB is not available on ENCORE database.

  • 117 RBPs can affect the levels of PHB.  








The Knockdown/knockout RNA-Seq assay for PHB is not available on ENCORE database.





117 RBPs can affect the gene expression of PHB :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PHBENSG00000167085.73619.946004509.49150-0.317004.793004.03380HepG2ACO1
PHBENSG00000167085.72630.118003472.87810-0.401003.815802.66610HepG2ADAR
PHBENSG00000167085.72969.046903836.13660-0.369703.157702.19560HepG2BCLAF1
PHBENSG00000167085.75134.296003811.106000.429905.186004.39860HepG2BOP1
PHBENSG00000167085.73391.659804089.55710-0.270002.775501.54020HepG2BUD13
PHBENSG00000167085.73831.570802810.920900.446802.433101.71900HepG2CNOT7
PHBENSG00000167085.72754.379603498.79570-0.345103.094302.37220HepG2CPSF6
PHBENSG00000167085.72363.573203938.42220-0.7366013.6753012.30560HepG2DDX21
PHBENSG00000167085.73188.698003854.32080-0.273502.793001.87450HepG2DDX24
PHBENSG00000167085.73067.512704314.19680-0.492005.423104.53260HepG2DKC1
PHBENSG00000167085.72366.834403626.93910-0.615805.666104.09000HepG2AGO1
PHBENSG00000167085.72677.363206411.00820-1.2597029.1254027.34160HepG2EIF2S1
PHBENSG00000167085.72442.534103719.38500-0.6067011.279509.40130HepG2EIF3G
PHBENSG00000167085.74630.049607084.39310-0.613606.755805.75380HepG2EIF4A3
PHBENSG00000167085.74671.336806221.25290-0.413406.743405.53800HepG2EIF4G1
PHBENSG00000167085.73630.519704728.64470-0.381304.296802.96400HepG2ESF1
PHBENSG00000167085.76513.389608579.12090-0.3974010.668109.61260HepG2ETF1
PHBENSG00000167085.75755.990904406.014000.385504.959203.84370HepG2EWSR1
PHBENSG00000167085.72029.088303613.26300-0.8325013.0540010.71230HepG2FKBP4
PHBENSG00000167085.73439.490405305.71410-0.6254011.372009.82570HepG2FUBP3
PHBENSG00000167085.75117.403306631.32180-0.373903.029402.33460HepG2G3BP1
PHBENSG00000167085.74925.498307041.08930-0.515506.127004.79050HepG2G3BP2
PHBENSG00000167085.73104.410303872.50740-0.318902.824401.79340HepG2GNB2L1
PHBENSG00000167085.72373.820703530.48830-0.572708.766407.71110HepG2HNRNPA1
PHBENSG00000167085.74668.851005795.08490-0.311803.759402.69650HepG2HNRNPA2B1
PHBENSG00000167085.71658.731802320.98090-0.484703.562601.97080HepG2HNRNPAB
PHBENSG00000167085.73268.354103927.04190-0.264902.270501.63660HepG2HNRNPC
PHBENSG00000167085.74670.534605309.30720-0.184902.425301.75100HepG2HNRNPF
PHBENSG00000167085.76347.870605743.227600.144301.993901.41010HepG2HNRNPL
PHBENSG00000167085.72454.237803784.96000-0.625008.315707.28790HepG2HNRNPLL
PHBENSG00000167085.73437.263003901.07670-0.182602.222601.67380HepG2HNRNPU
PHBENSG00000167085.74377.662005228.14190-0.256102.748802.02710HepG2IGF2BP1
PHBENSG00000167085.74868.809406740.29660-0.469204.871103.99770HepG2IGF2BP2
PHBENSG00000167085.72979.544506326.67390-1.086405.341203.99990HepG2IGF2BP3
PHBENSG00000167085.73130.690403984.81620-0.348008.970607.72530HepG2ILF2
PHBENSG00000167085.74953.325206780.14210-0.452903.371802.25030HepG2KHSRP
PHBENSG00000167085.72333.809303738.43420-0.679706.224904.34220HepG2KRR1
PHBENSG00000167085.74628.474307151.94620-0.627808.020206.91530HepG2MAGOH
PHBENSG00000167085.72516.742103860.21070-0.617104.504403.24740HepG2MTPAP
PHBENSG00000167085.75654.391807360.91190-0.380503.204002.52480HepG2NCBP2
PHBENSG00000167085.71810.127803987.48450-1.1394011.002308.76550HepG2NONO
PHBENSG00000167085.72495.786603356.10530-0.427304.555503.60200HepG2NSUN2
PHBENSG00000167085.73961.723606554.40770-0.7263010.282608.91180HepG2PABPC4
PHBENSG00000167085.74706.706707027.80180-0.5784019.8560018.46950HepG2PCBP1
PHBENSG00000167085.72424.573003659.63400-0.594004.181402.92040HepG2PCBP2
PHBENSG00000167085.73429.745603992.81050-0.219302.430601.70010HepG2PRPF4
PHBENSG00000167085.72775.633503347.90480-0.270402.157401.44060HepG2PRPF8
PHBENSG00000167085.74723.121307151.08340-0.5984020.5056019.28060HepG2PTBP1
PHBENSG00000167085.75079.721806331.39110-0.317803.900003.10630HepG2PUM2
PHBENSG00000167085.74274.970107744.73100-0.8573029.6685027.96320HepG2QKI
PHBENSG00000167085.72629.473703530.48150-0.425102.015001.40400HepG2RAVER1
PHBENSG00000167085.74305.382107028.86720-0.7072015.7049014.16640HepG2RBM25
PHBENSG00000167085.74418.621207958.44240-0.8489041.1760039.64260HepG2NELFE
PHBENSG00000167085.74601.214607412.25620-0.6879028.3202026.71760HepG2RECQL
PHBENSG00000167085.72275.564503470.10890-0.608804.116502.96930HepG2RPS10
PHBENSG00000167085.72419.033403311.66480-0.453104.275903.32130HepG2RRP9
PHBENSG00000167085.73867.071303474.065800.154501.986001.42520HepG2SAFB2
PHBENSG00000167085.74837.961807445.14290-0.6219023.3960021.96020HepG2SF3B4
PHBENSG00000167085.73132.752204168.47680-0.412102.327001.61320HepG2SNRNP70
PHBENSG00000167085.77036.474508098.74520-0.202803.846003.28460HepG2SRFBP1
PHBENSG00000167085.75770.605307771.14100-0.4294013.3752012.50260HepG2SRSF1
PHBENSG00000167085.74407.441005216.25350-0.243103.985003.17230HepG2SRSF7
PHBENSG00000167085.73353.409306322.25750-0.9148049.5549047.79050HepG2SRSF9
PHBENSG00000167085.73210.003807031.48370-1.1313074.6086072.87780HepG2SSB
PHBENSG00000167085.72446.865603299.63300-0.431402.473701.34030HepG2SUB1
PHBENSG00000167085.73024.806303721.53230-0.299103.132302.13750HepG2SUPT6H
PHBENSG00000167085.72957.929204321.41260-0.546906.333605.37160HepG2SUPV3L1
PHBENSG00000167085.74921.890306985.07010-0.5051011.8651010.82960HepG2TAF15
PHBENSG00000167085.73939.939106418.25820-0.7040016.3465014.37100HepG2TIA1
PHBENSG00000167085.73102.777803790.52600-0.288803.371302.82930HepG2TIAL1
PHBENSG00000167085.73790.535702552.577500.570306.143605.00150HepG2UCHL5
PHBENSG00000167085.76548.305404143.011300.6603027.7965026.19890HepG2UTP3
PHBENSG00000167085.73246.226203940.33010-0.279605.614604.70970HepG2ZC3H8
PHBENSG00000167085.74505.364206080.86340-0.432604.899303.25110K562ABCF1
PHBENSG00000167085.75125.679503447.489200.5721018.0531016.72700K562AGGF1
PHBENSG00000167085.75396.782603587.247700.589105.314104.39230K562AKAP8L
PHBENSG00000167085.78953.588907274.507600.299503.095601.78070K562APOBEC3C
PHBENSG00000167085.74593.259807138.68160-0.636105.635604.84910K562AQR
PHBENSG00000167085.73431.926204154.13630-0.275503.390902.32290K562BCLAF1
PHBENSG00000167085.71679.378402933.60440-0.8047012.9066010.97020K562BOP1
PHBENSG00000167085.73111.512504235.84510-0.445004.089602.29800K562BUD13
PHBENSG00000167085.72857.120903698.30540-0.372304.874002.84790K562CEBPZ
PHBENSG00000167085.73752.653805105.68480-0.444202.273301.32860K562CNOT7
PHBENSG00000167085.72002.992703119.24270-0.6390012.0440010.39880K562CPSF6
PHBENSG00000167085.77642.8061010136.77890-0.407407.062405.52550K562CELF1
PHBENSG00000167085.73606.972004250.62520-0.236903.072401.79330K562DDX21
PHBENSG00000167085.75257.646603860.267700.445606.763005.29790K562DKC1
PHBENSG00000167085.72114.016502861.60810-0.436804.636702.87830K562DNAJC21
PHBENSG00000167085.73949.643205986.21980-0.5999016.9226015.36460K562EIF2S2
PHBENSG00000167085.73104.771502280.827900.444807.424606.13030K562EIF3G
PHBENSG00000167085.76580.823908244.16780-0.325105.832004.49020K562EIF4G2
PHBENSG00000167085.73064.714104648.41190-0.601005.098902.81690K562ESF1
PHBENSG00000167085.72746.332402266.150500.277203.152101.75880K562EWSR1
PHBENSG00000167085.71777.430602440.09790-0.457105.945303.50330K562FASTKD2
PHBENSG00000167085.72374.065603140.52710-0.403603.481302.19690K562FKBP4
PHBENSG00000167085.71895.783503173.79510-0.7434012.0720010.20330K562FMR1
PHBENSG00000167085.71470.967902690.09490-0.8709013.2704011.14620K562FTO
PHBENSG00000167085.74936.782302699.899600.8706024.7308023.04240K562FXR1
PHBENSG00000167085.7834.502201874.80420-1.1678015.5497013.55120K562G3BP2
PHBENSG00000167085.73158.202004406.39390-0.480509.459907.46000K562GLRX3
PHBENSG00000167085.71836.502502978.09270-0.6974011.221909.59950K562GPKOW
PHBENSG00000167085.72906.899504777.53820-0.716805.769403.51400K562HNRNPAB
PHBENSG00000167085.72027.273203616.60790-0.8351018.9064017.42320K562HNRNPC
PHBENSG00000167085.72656.943303229.82190-0.281702.556301.46560K562HNRNPF
PHBENSG00000167085.75949.167503595.813500.726304.478603.27300K562HNRNPM
PHBENSG00000167085.74066.403805748.31540-0.499402.661001.78500K562HNRNPU
PHBENSG00000167085.73070.249604658.60800-0.601503.506401.87460K562ILF2
PHBENSG00000167085.72106.686402780.17210-0.400203.453701.78040K562ILF3
PHBENSG00000167085.71947.836302686.93340-0.464104.559602.65550K562KHDRBS1
PHBENSG00000167085.71499.327902542.96280-0.762207.792506.13480K562KRR1
PHBENSG00000167085.73887.990703085.521400.333402.420201.63120K562MAGOH
PHBENSG00000167085.75199.109204264.836500.285703.180502.19380K562MBNL1
PHBENSG00000167085.72135.340702906.95770-0.445005.430804.17710K562METAP2
PHBENSG00000167085.76944.905508787.46950-0.339503.366802.11920K562MSI2
PHBENSG00000167085.73466.924104632.77040-0.4182010.366908.90840K562MTPAP
PHBENSG00000167085.73498.007705147.30170-0.5573027.8419025.87480K562NSUN2
PHBENSG00000167085.73499.574804905.05560-0.487102.654201.44890K562PABPC1
PHBENSG00000167085.73718.015104644.57500-0.321002.397701.62490K562PCBP3
PHBENSG00000167085.77012.860108471.13290-0.272603.488401.88470K562PNPT1
PHBENSG00000167085.74675.373103455.145200.436204.734803.75650K562PRPF8
PHBENSG00000167085.74114.744602997.939800.456704.487703.66210K562PTBP1
PHBENSG00000167085.77966.395209567.57160-0.264203.073901.94870K562PUM1
PHBENSG00000167085.77140.993209374.36460-0.392608.161106.48460K562PUM2
PHBENSG00000167085.75388.801103557.716500.598908.286807.39560K562PUS1
PHBENSG00000167085.71249.259201788.83050-0.517902.757401.34610K562RAVER1
PHBENSG00000167085.74444.677203466.333600.358605.515604.70360K562RBM15
PHBENSG00000167085.74391.693703174.295100.468204.278102.92070K562SAFB
PHBENSG00000167085.73742.537605079.25490-0.440606.485705.28200K562SF3A3
PHBENSG00000167085.71774.844802832.33160-0.674307.749106.07440K562SF3B1
PHBENSG00000167085.72646.286401949.652500.440706.258604.93490K562SF3B4
PHBENSG00000167085.72116.458802931.05920-0.469805.139703.38010K562SLBP
PHBENSG00000167085.71676.325202094.38290-0.321202.941901.31060K562SND1
PHBENSG00000167085.74267.530205203.82270-0.286206.521905.15490K562SRPK2
PHBENSG00000167085.73820.640802939.224600.378302.192201.55450K562SRSF1
PHBENSG00000167085.73052.108203793.05360-0.313604.557303.03570K562SRSF7
PHBENSG00000167085.71840.478002352.70240-0.354202.721301.45780K562SSB
PHBENSG00000167085.74147.873605735.38710-0.467505.551103.57740K562SSRP1
PHBENSG00000167085.73332.908005245.56710-0.654308.603006.33740K562STAU1
PHBENSG00000167085.76561.568207848.24280-0.258303.194801.58820K562SUCLG1
PHBENSG00000167085.72862.979504730.58740-0.724502.814101.37450K562SUPT6H
PHBENSG00000167085.72326.543703344.82900-0.523705.270003.82720K562SUPV3L1
PHBENSG00000167085.75309.410903573.324400.5712011.445509.78510K562SYNCRIP
PHBENSG00000167085.72472.477403118.92370-0.335102.601801.69700K562TIAL1
PHBENSG00000167085.74132.767205112.67590-0.307002.651801.30980K562TRIP6
PHBENSG00000167085.71497.356901877.01720-0.326003.374502.49060K562U2AF2
PHBENSG00000167085.72456.479903540.33900-0.527306.231104.63470K562UCHL5
PHBENSG00000167085.73143.945005457.80280-0.7957035.8829033.63950K562UPF1
PHBENSG00000167085.73103.820204670.05370-0.5894010.470908.72340K562WDR3
PHBENSG00000167085.76692.271108456.26410-0.337503.220701.81770K562WRN
PHBENSG00000167085.72916.835903605.44810-0.305802.438201.32710K562XRN2
PHBENSG00000167085.74730.076908042.82700-0.765808.986707.30630K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PHB is not available on ENCORE database.





1 RBPs can affect the splicing of PHB :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPHBENSG00000167085.7chr17-4749160347491695474905384749065347492196474922460.068000.000000.00000includedHepG2HNRNPK
SEPHBENSG00000167085.7chr17-4749160347491695474905384749065347492196474922460.064000.000000.00037includedK562HNRNPK

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PHB is not avaliable on ENCORE database.