NPC1L1

General Information

Gene Name       : NPC1L1
Gene ID             : ENSG00000015520.14
Essential Gene : No

Functions

Localization

Domains (AlphaFold: NPC1L1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878NPC1L1ENSG00000015520.140.000.010.01ENCSR000AEF
HepG2NPC1L1ENSG00000015520.1411.927.059.48ENCSR985KAT
K562NPC1L1ENSG00000015520.140.040.010.03ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for NPC1L1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • NPC1L1 RNA is bound by 19 proteins.  







eCLIP assay for NPC1L1 is not avaliable on ENCORE database.





19 proteins are bound to NPC1L1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr74455250944552614-3'-UTR,intron-Distal4.679746.52213HepG2UPF1
chr74455256544552633-3'-UTR,intron-Distal4.073113.72506HepG2PABPN1
chr74455276644552875-3'-UTR,intron-Distal,intron-Proximal4.858486.71037HepG2UPF1
chr74455230944552377-3'-UTR,intron-Distal4.047223.45275HepG2LARP4
chr74455228244552351-3'-UTR,intron-Distal4.230534.68979HepG2UPF1
chr74458086844580902-5'-UTR,intron-Distal4.946188.88833HepG2DDX3X
chr74458080444580868-5'-UTR,CDS,intron-Distal3.5733115.07493HepG2DDX3X
chr74455536044555408-CDS,intron-Distal,intron-Proximal3.082065.63451HepG2PRPF8
chr74456059144560631-CDS,intron-Distal3.372794.27261HepG2GRWD1
chr74457174944571799-CDS,intron-Distal3.750977.83545HepG2PPIG
chr74457594844576094-CDS,intron-Distal,intron-Proximal4.903436.71013HepG2GTF2F1
chr74457834144578429-CDS,intron-Distal,intron-Proximal3.604433.39008HepG2AQR
chr74455675244556816-CDS,intron-Distal,intron-Proximal4.287885.29549HepG2EFTUD2
chr74455569744555735-CDS,intron-Distal3.517934.13746HepG2PPIG
chr74457418944574227-CDS,intron-Distal4.008886.39364HepG2PPIG
chr74457928644579332-CDS,intron-Distal4.359693.86169HepG2RBM15
chr74456031444560367-CDS,intron-Distal,intron-Proximal5.220538.04585HepG2PRPF8
chr74457830944578418-CDS,intron-Distal,intron-Proximal3.456859.31341HepG2PRPF8
chr74457162744571689-CDS,intron-Distal,intron-Proximal3.7353910.32093HepG2PRPF8
chr74457543744575481-CDS,intron-Distal,intron-Proximal3.615586.98305HepG2PPIG
chr74455321044553296-CDS,intron-Distal3.589684.52919HepG2SF3B4
chr74457599344576093-CDS,intron-Distal,intron-Proximal4.4058511.61767HepG2PRPF4
chr74455571444555788-CDS,intron-Distal3.291163.28107HepG2PABPN1
chr74457800744578101-intron-Distal3.911973.20552HepG2KHSRP
chr74457832644578398-intron-Distal,intron-Proximal3.442977.78532HepG2RBM22
chr74457122944571300-intron-Distal,intron-Proximal4.2508810.90788HepG2EFTUD2
chr74457603744576113-intron-Distal,intron-Proximal4.536767.98928HepG2FAM120A
chr74455669644556803-intron-Distal,intron-Proximal3.987558.08346HepG2PRPF8
chr74457156044571627-intron-Distal,intron-Proximal4.400197.08947HepG2PRPF8
chr74457631544576358-intron-Distal,intron-Proximal4.170203.63122HepG2PRPF4
chr74456765844567724-intron-Distal3.951863.82697HepG2HNRNPC
chr74457512444575211-intron-Distal6.0248016.83057HepG2PTBP1
chr74457832544578378-intron-Distal,intron-Proximal5.588338.08771HepG2EFTUD2
chr74455669644556793-intron-Distal,intron-Proximal3.104224.63569HepG2RBFOX2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for NPC1L1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for NPC1L1 is not available on ENCORE database.

  • 108 RBPs can affect the levels of NPC1L1.  








The Knockdown/knockout RNA-Seq assay for NPC1L1 is not available on ENCORE database.





108 RBPs can affect the gene expression of NPC1L1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
NPC1L1ENSG00000015520.10431.23420676.85840-0.650403.848202.59750HepG2AATF
NPC1L1ENSG00000015520.101054.839401406.04840-0.414602.245401.39270HepG2ABCF1
NPC1L1ENSG00000015520.10947.791601130.80110-0.254702.150001.59930HepG2ACO1
NPC1L1ENSG00000015520.101012.86300597.262900.761905.308903.99190HepG2ADAR
NPC1L1ENSG00000015520.10719.212001857.54310-1.3689013.5188012.43470HepG2AKAP1
NPC1L1ENSG00000015520.102040.641801135.957300.8450024.9147022.96470HepG2AKAP8L
NPC1L1ENSG00000015520.101917.036501498.084100.355705.268404.37090HepG2AUH
NPC1L1ENSG00000015520.101175.81580741.130800.665802.972602.03940HepG2BCLAF1
NPC1L1ENSG00000015520.102844.750301051.335001.4360040.9907039.19130HepG2BOP1
NPC1L1ENSG00000015520.101040.15760786.311400.403503.921803.02680HepG2CALR
NPC1L1ENSG00000015520.101577.609801138.483300.470503.079002.04770HepG2CCAR1
NPC1L1ENSG00000015520.101581.447201130.367000.484409.813308.71530HepG2CKAP4
NPC1L1ENSG00000015520.10683.55190458.572300.575801.990101.34560HepG2CNOT7
NPC1L1ENSG00000015520.101598.12680965.171500.727409.381508.18820HepG2CPSF6
NPC1L1ENSG00000015520.10354.13720693.39950-0.969403.311501.77890HepG2CSTF2T
NPC1L1ENSG00000015520.101228.819801021.887000.265902.318501.72110HepG2CELF1
NPC1L1ENSG00000015520.101741.213501098.863600.6640010.000208.72970HepG2DAZAP1
NPC1L1ENSG00000015520.10821.732001045.74250-0.347804.283803.27350HepG2DDX19B
NPC1L1ENSG00000015520.101569.89410745.898901.0735021.0016019.35870HepG2DDX21
NPC1L1ENSG00000015520.101024.87570730.650000.488105.039103.79810HepG2DDX24
NPC1L1ENSG00000015520.101025.712701779.14480-0.794606.592905.66930HepG2DDX3X
NPC1L1ENSG00000015520.101438.93280755.533900.9293015.0404012.44570HepG2DDX47
NPC1L1ENSG00000015520.101646.418201150.889500.516505.345903.98540HepG2DDX5
NPC1L1ENSG00000015520.101026.52570580.057900.8234011.327309.52330HepG2DHX30
NPC1L1ENSG00000015520.101603.965001081.821600.568106.363005.41570HepG2DKC1
NPC1L1ENSG00000015520.10973.32200601.400200.6945010.854209.53710HepG2DNAJC21
NPC1L1ENSG00000015520.10905.33680596.123200.6027010.420809.25300HepG2DNAJC2
NPC1L1ENSG00000015520.102539.706501623.361200.645606.444005.46800HepG2EIF4A3
NPC1L1ENSG00000015520.101513.792001084.023900.481707.670806.40590HepG2EIF4G1
NPC1L1ENSG00000015520.101464.795601719.91330-0.231602.316901.75820HepG2ETF1
NPC1L1ENSG00000015520.10698.279401104.82760-0.661908.510907.06140HepG2EWSR1
NPC1L1ENSG00000015520.10689.39450400.527600.783303.767701.37330HepG2FASTKD1
NPC1L1ENSG00000015520.101252.343101638.72800-0.387902.319201.68340HepG2FXR1
NPC1L1ENSG00000015520.102116.236401519.726700.477603.925103.13920HepG2G3BP1
NPC1L1ENSG00000015520.102015.415501613.951500.320402.231701.43670HepG2G3BP2
NPC1L1ENSG00000015520.10767.31940588.619300.382402.482801.63950HepG2GEMIN5
NPC1L1ENSG00000015520.101126.91590714.782300.656705.451104.01430HepG2GNB2L1
NPC1L1ENSG00000015520.102236.432901094.066001.0314015.8688014.45610HepG2GPKOW
NPC1L1ENSG00000015520.10801.29680424.613500.916105.675804.07060HepG2GRSF1
NPC1L1ENSG00000015520.101195.05280607.162100.9768015.9373014.59390HepG2HNRNPA1
NPC1L1ENSG00000015520.10823.03590397.253901.050806.288004.02420HepG2HNRNPD
NPC1L1ENSG00000015520.101116.65280813.911200.456105.655504.67480HepG2HNRNPF
NPC1L1ENSG00000015520.101187.500601539.87370-0.374902.075801.46510HepG2HNRNPK
NPC1L1ENSG00000015520.102125.950601044.090201.0258017.8829016.48590HepG2HNRNPLL
NPC1L1ENSG00000015520.101150.42520670.900800.7779016.4231015.04290HepG2HNRNPU
NPC1L1ENSG00000015520.101482.82200801.462700.8875012.5606011.13460HepG2IGF2BP1
NPC1L1ENSG00000015520.102531.863101544.614700.712909.157508.00820HepG2IGF2BP2
NPC1L1ENSG00000015520.10528.20050685.30100-0.375703.785902.94110HepG2ILF2
NPC1L1ENSG00000015520.10931.03040447.160201.057909.559107.05490HepG2ILF3
NPC1L1ENSG00000015520.10824.82900437.538800.914606.810204.84160HepG2KHDRBS1
NPC1L1ENSG00000015520.101628.257601033.576900.6556017.5257015.24940HepG2KIF1C
NPC1L1ENSG00000015520.102244.831101202.834800.9001010.362908.76000HepG2LARP4
NPC1L1ENSG00000015520.102043.887701639.303800.318102.090401.51720HepG2MAGOH
NPC1L1ENSG00000015520.101768.944501064.904200.732102.900101.90550HepG2MTPAP
NPC1L1ENSG00000015520.10884.05960419.318001.076008.146506.57510HepG2PABPC1
NPC1L1ENSG00000015520.101905.007701501.939000.342902.320901.65500HepG2PABPC4
NPC1L1ENSG00000015520.102117.742601579.844500.422603.032402.40140HepG2PCBP1
NPC1L1ENSG00000015520.10965.62220598.388000.690303.653402.81840HepG2PPIL4
NPC1L1ENSG00000015520.101445.228801110.658000.379805.106504.09000HepG2PRPF4
NPC1L1ENSG00000015520.101262.149001040.120400.279001.915201.40610HepG2PUF60
NPC1L1ENSG00000015520.10901.992701104.10630-0.291703.585002.92790HepG2PUM1
NPC1L1ENSG00000015520.101846.619201103.316800.7429013.8191012.38960HepG2PUM2
NPC1L1ENSG00000015520.102446.664901151.766701.0869026.0824024.54910HepG2PUS1
NPC1L1ENSG00000015520.102384.702501740.949600.453807.008006.07920HepG2QKI
NPC1L1ENSG00000015520.10286.68720747.76770-1.383106.984405.89090HepG2RAVER1
NPC1L1ENSG00000015520.101312.96920940.243400.481603.690801.66300HepG2RBM14
NPC1L1ENSG00000015520.10992.347301437.54760-0.534706.127405.43000HepG2RBM22
NPC1L1ENSG00000015520.10976.70550685.980300.509703.075201.95690HepG2RCC2
NPC1L1ENSG00000015520.10934.579501789.06790-0.9368026.3593025.03680HepG2NELFE
NPC1L1ENSG00000015520.101084.003801666.37090-0.6203012.6020011.43220HepG2RECQL
NPC1L1ENSG00000015520.101462.19400876.893600.737607.296806.26640HepG2RPLP0
NPC1L1ENSG00000015520.101323.40670735.117000.848106.008704.64720HepG2RPS10
NPC1L1ENSG00000015520.101104.48170643.385700.7795010.764909.64930HepG2RPS19
NPC1L1ENSG00000015520.101220.21350461.036801.4041018.7207016.73940HepG2RPS3A
NPC1L1ENSG00000015520.10889.92300434.130901.035507.114005.06280HepG2SART3
NPC1L1ENSG00000015520.10821.36820437.646200.908204.976902.95660HepG2SBDS
NPC1L1ENSG00000015520.101017.19830645.604200.655806.234204.83660HepG2SERBP1
NPC1L1ENSG00000015520.10667.241001033.42510-0.631205.807004.81710HepG2SF3B1
NPC1L1ENSG00000015520.10917.271901673.61940-0.8676022.5588021.14250HepG2SF3B4
NPC1L1ENSG00000015520.101381.19990997.257000.469808.212207.10090HepG2SLBP
NPC1L1ENSG00000015520.101028.18780420.679601.289205.053103.14450HepG2SNRNP200
NPC1L1ENSG00000015520.10623.414501149.87300-0.883206.831205.59740HepG2SNRNP70
NPC1L1ENSG00000015520.10535.616501623.68940-1.6000047.2101045.80490HepG2SRFBP1
NPC1L1ENSG00000015520.10735.471501746.94350-1.2481045.4905044.08120HepG2SRSF1
NPC1L1ENSG00000015520.10605.576701112.02000-0.876808.207906.40790HepG2SRSF3
NPC1L1ENSG00000015520.101275.516901026.934500.312603.400102.71850HepG2SRSF5
NPC1L1ENSG00000015520.101251.99050799.666700.646709.080807.94710HepG2SRSF7
NPC1L1ENSG00000015520.10974.811401421.27230-0.5440010.004009.06790HepG2SRSF9
NPC1L1ENSG00000015520.103380.542301409.803301.2617070.8605069.15610HepG2SSB
NPC1L1ENSG00000015520.101433.50870947.740400.596904.476502.93640HepG2STAU1
NPC1L1ENSG00000015520.10843.63710401.243401.0720010.235407.98160HepG2STIP1
NPC1L1ENSG00000015520.101385.65670834.984500.730603.040502.33560HepG2SUPV3L1
NPC1L1ENSG00000015520.101033.145401570.35200-0.6040010.112309.14820HepG2TAF15
NPC1L1ENSG00000015520.101297.572701017.747100.350302.606901.90000HepG2TARDBP
NPC1L1ENSG00000015520.103016.789001338.513201.172303.639602.42200HepG2TBRG4
NPC1L1ENSG00000015520.101392.47710651.863601.0949025.5250024.29360HepG2TIAL1
NPC1L1ENSG00000015520.101013.55830657.735800.6237010.672309.67270HepG2TRIM56
NPC1L1ENSG00000015520.101657.375501016.108800.705706.960005.47250HepG2TUFM
NPC1L1ENSG00000015520.102106.759301658.278300.345205.674904.73130HepG2UPF1
NPC1L1ENSG00000015520.10879.11980412.983001.089908.392806.48850HepG2XPO5
NPC1L1ENSG00000015520.101424.229601096.062900.377805.875304.95290HepG2ZC3H8
NPC1L1ENSG00000015520.102669.887001823.787300.5497017.5125016.43130HepG2ZNF622
NPC1L1ENSG00000015520.10142.475005.407204.7196027.8625026.20440K562AQR
NPC1L1ENSG00000015520.1028.717405.631302.350302.760101.88830K562BOP1
NPC1L1ENSG00000015520.1023.979405.985502.002202.306701.58410K562CPSF6
NPC1L1ENSG00000015520.1028.002206.094402.199902.961802.07570K562FMR1
NPC1L1ENSG00000015520.1026.788605.167402.374003.210802.21920K562FTO
NPC1L1ENSG00000015520.1022.090005.712901.951002.092301.39770K562GPKOW
NPC1L1ENSG00000015520.1040.680705.013903.020205.809204.97490K562HNRNPC
NPC1L1ENSG00000015520.1023.649004.882702.275902.473701.59480K562KRR1
NPC1L1ENSG00000015520.1022.758205.577102.028702.250401.46220K562METAP2
NPC1L1ENSG00000015520.1026.433204.907802.429103.303601.90770K562STAU1
NPC1L1ENSG00000015520.1022.735506.095101.899102.356101.56930K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for NPC1L1 is not available on ENCORE database.





3 RBPs can affect the splicing of NPC1L1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SENPC1L1ENSG00000015520.10chr7-445563014455653344555682445557964455680544556956-0.173000.000000.00006excludedHepG2U2AF1
SENPC1L1ENSG00000015520.10chr7-445758544457602744575438445755674457644044576541-0.247000.001250.02485excludedHepG2U2AF1
SENPC1L1ENSG00000015520.10chr7-445733374457345244573029445731574457404544574228-0.567000.000000.00003excludedHepG2U2AF1
SENPC1L1ENSG00000015520.10chr7-445563014455653344555682445557964455680544556956-0.189000.001050.01471excludedHepG2U2AF2
SENPC1L1ENSG00000015520.10chr7-445733374457345244573029445731574457404544574228-0.602000.006710.06696excludedHepG2U2AF2
SENPC1L1ENSG00000015520.10chr7-4457333744573452445730294457315744574045445742280.317000.001210.04978includedHepG2HNRNPU
A3SSNPC1L1ENSG00000015520.10chr7-4456059044560736445605904456071744561310445614710.198000.000340.01089longerHepG2U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for NPC1L1 is not avaliable on ENCORE database.