IRS1

General Information

Gene Name       : IRS1
Gene ID             : ENSG00000169047.5
Essential Gene : No

Functions

Localization

Domains (AlphaFold: IRS1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878IRS1ENSG00000169047.50.070.190.13ENCSR000AEF
HepG2IRS1ENSG00000169047.55.883.664.77ENCSR985KAT
K562IRS1ENSG00000169047.50.040.040.04ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for IRS1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • IRS1 RNA is bound by 13 proteins.  







eCLIP assay for IRS1 is not avaliable on ENCORE database.





13 proteins are bound to IRS1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr2227600655227600704-3'-UTR,intron-Distal4.002543.29371HepG2IGF2BP1
chr2227600414227600505-3'-UTR,intron-Distal3.499875.45107HepG2FUBP3
chr2227663940227664032-5'-UTR,intron-Distal4.2938016.85393HepG2SLTM
chr2227664185227664237-5'-UTR,intron-Distal3.9839221.91339HepG2DDX3X
chr2227663683227663742-5'-UTR,intron-Distal3.877439.23400HepG2DDX3X
chr2227664098227664165-5'-UTR,intron-Distal3.907947.64593HepG2EIF3H
chr2227663419227663484-5'-UTR,CDS,intron-Distal4.676978.98329HepG2EIF3H
chr2227664232227664289-5'-UTR,intron-Distal4.010275.59033HepG2FTO
chr2227663789227663892-5'-UTR,intron-Distal4.132078.11960HepG2EIF3H
chr2227663509227663562-5'-UTR,intron-Distal4.4623910.34792HepG2DDX3X
chr2227664210227664304-5'-UTR,intron-Distal3.6812410.18636HepG2SLTM
chr2227663783227663838-5'-UTR,intron-Distal3.734129.39478HepG2DDX3X
chr2227664111227664168-5'-UTR,intron-Distal4.745918.90399HepG2DDX3X
chr2227664382227664411-5'-UTR,intron-Distal3.821757.77439HepG2DDX3X
chr2227663838227663912-5'-UTR,intron-Distal3.5350915.85902HepG2DDX3X
chr2227660204227660271-CDS,intron-Distal3.015703.84967HepG2G3BP1
chr2227662158227662163-CDS,intron-Distal4.673244.29511HepG2EIF3H
chr2227662700227662763-CDS,intron-Distal3.481577.55550HepG2EIF3H
chr2227660531227660580-CDS,intron-Distal4.597244.56106HepG2EIF3H
chr2227659966227660015-CDS,intron-Distal,intron-Proximal3.698058.30210HepG2EIF3H
chr2227660561227660613-CDS,intron-Distal5.553959.34462HepG2SLTM
chr2227661265227661335-CDS,intron-Distal4.515703.36483HepG2G3BP1
chr2227660682227660738-CDS,intron-Distal3.910276.52185HepG2HLTF
chr2227661945227661999-CDS,intron-Distal3.130015.55322HepG2HLTF
chr2227660480227660534-CDS,intron-Distal3.469154.31813HepG2G3BP1
chr2227661400227661428-CDS,intron-Distal4.984704.77840HepG2EIF3H
chr2227662970227663059-CDS,intron-Distal4.573099.92415HepG2EIF3H
chr2227662980227663054-CDS,intron-Distal3.311564.88774HepG2RBM15
chr2227660580227660629-CDS,intron-Distal3.985054.43601HepG2EIF3H
chr2227660479227660538-CDS,intron-Distal4.561268.46394HepG2SLTM
chr2227661958227662003-CDS,intron-Distal3.790675.01882HepG2SLTM
chr2227660053227660088-CDS,intron-Distal,intron-Proximal4.149056.10603HepG2SLTM
chr2227662966227663082-CDS,intron-Distal4.7369713.94131HepG2SLTM
chr2227660222227660269-CDS,intron-Distal5.067306.38758HepG2SLTM
chr2227662078227662119-CDS,intron-Distal3.338043.94960HepG2EIF3H
chr2227636123227636246-intron-Distal4.663296.23638HepG2QKI
chr2227656536227656634-intron-Distal3.077003.64049HepG2XRN2
chr2227656600227656696-intron-Distal3.882385.91072HepG2PCBP2
chr2227657124227657200-intron-Distal3.854874.19039HepG2PTBP1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for IRS1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for IRS1 is not available on ENCORE database.

  • 112 RBPs can affect the levels of IRS1.  








The Knockdown/knockout RNA-Seq assay for IRS1 is not available on ENCORE database.





112 RBPs can affect the gene expression of IRS1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
IRS1ENSG00000169047.52704.195601443.162100.9059013.7776011.94510HepG2ABCF1
IRS1ENSG00000169047.51208.245101047.946400.205201.874501.35620HepG2ACO1
IRS1ENSG00000169047.5993.84660540.419400.8788011.148509.32590HepG2ADAR
IRS1ENSG00000169047.5982.461802154.13120-1.1326010.321709.35980HepG2AKAP1
IRS1ENSG00000169047.51518.589901052.818200.528409.347208.03870HepG2AKAP8L
IRS1ENSG00000169047.51949.061901483.486200.393706.162105.20120HepG2AUH
IRS1ENSG00000169047.52075.166301693.284900.293301.959201.30330HepG2CIRBP
IRS1ENSG00000169047.51895.311801047.656400.8552029.8845028.22730HepG2CKAP4
IRS1ENSG00000169047.51051.114101506.47940-0.519302.871002.09140HepG2CNOT7
IRS1ENSG00000169047.51964.22260865.910001.1816024.4102022.62170HepG2CPSF6
IRS1ENSG00000169047.5612.26610355.083100.785907.079805.47620HepG2CSTF2
IRS1ENSG00000169047.51277.37940775.199300.7204016.2637014.72520HepG2DAZAP1
IRS1ENSG00000169047.51591.65900969.171700.7156019.6759017.93060HepG2DDX19B
IRS1ENSG00000169047.51428.32730708.336201.0117018.0945016.55300HepG2DDX21
IRS1ENSG00000169047.5939.91090693.553700.438404.002602.89140HepG2DDX24
IRS1ENSG00000169047.5924.38320528.909600.805406.132004.29870HepG2DDX27
IRS1ENSG00000169047.52581.970402063.212900.323502.231701.66430HepG2DDX3X
IRS1ENSG00000169047.52133.910802650.59600-0.312802.674001.39660HepG2DDX47
IRS1ENSG00000169047.5986.51290565.352500.803106.672605.53230HepG2DDX55
IRS1ENSG00000169047.52442.46290983.302901.3125013.1721011.14510HepG2DDX59
IRS1ENSG00000169047.51768.126001104.524100.678708.702907.02780HepG2DDX5
IRS1ENSG00000169047.51984.522201002.584700.9850031.7226030.07500HepG2DKC1
IRS1ENSG00000169047.5751.77140544.168100.466104.735203.83640HepG2DNAJC21
IRS1ENSG00000169047.5790.90350539.381500.552108.113807.06980HepG2DNAJC2
IRS1ENSG00000169047.51555.75000907.263600.777905.324704.08200HepG2EEF2
IRS1ENSG00000169047.51140.97520736.401100.631603.196102.23050HepG2EIF3D
IRS1ENSG00000169047.51126.10310669.170800.7508011.091909.22770HepG2EIF3G
IRS1ENSG00000169047.53706.553201882.553200.9773014.3607012.92840HepG2EIF4A3
IRS1ENSG00000169047.52459.237501833.538000.423502.535701.87580HepG2EIF4B
IRS1ENSG00000169047.51100.72090764.664300.525507.233005.99400HepG2EIF4G1
IRS1ENSG00000169047.52429.03710732.520501.7293049.8789047.02830HepG2EIF4G2
IRS1ENSG00000169047.51891.401901249.981200.597406.863905.23980HepG2ESF1
IRS1ENSG00000169047.52303.332601703.312900.435307.503506.59460HepG2ETF1
IRS1ENSG00000169047.51443.935701023.975600.495705.655704.45910HepG2EWSR1
IRS1ENSG00000169047.5861.71150675.225200.351702.553601.45010HepG2FASTKD2
IRS1ENSG00000169047.52091.50410867.384901.269708.209906.47420HepG2FTO
IRS1ENSG00000169047.51228.292801900.38150-0.629604.386503.52940HepG2FXR1
IRS1ENSG00000169047.51140.612301762.37530-0.627704.206903.39510HepG2G3BP1
IRS1ENSG00000169047.53142.844601871.650000.7477010.645708.89820HepG2G3BP2
IRS1ENSG00000169047.5958.33860655.642000.547502.727301.83590HepG2GEMIN5
IRS1ENSG00000169047.51394.86210981.588700.506804.061203.29790HepG2GPKOW
IRS1ENSG00000169047.51301.25120549.381601.2439024.9193023.32630HepG2HNRNPA1
IRS1ENSG00000169047.51501.24900611.091601.2966024.6951022.86720HepG2HNRNPC
IRS1ENSG00000169047.52100.722901075.611400.9656033.6956031.66420HepG2HNRNPF
IRS1ENSG00000169047.5923.43690706.188600.386904.245903.42460HepG2HNRNPL
IRS1ENSG00000169047.51448.50380936.747100.628706.717205.78430HepG2HNRNPLL
IRS1ENSG00000169047.5664.802901005.25470-0.596607.047005.63220HepG2HNRNPM
IRS1ENSG00000169047.51101.99460607.051000.8601019.2807017.79190HepG2HNRNPU
IRS1ENSG00000169047.52225.980601059.183701.0714027.2640025.28830HepG2IGF2BP1
IRS1ENSG00000169047.52423.485301791.235500.436003.556902.80100HepG2IGF2BP2
IRS1ENSG00000169047.5739.36500620.081400.253702.256701.58600HepG2ILF2
IRS1ENSG00000169047.51821.587401358.641300.422902.673401.85720HepG2LARP4
IRS1ENSG00000169047.5869.31630624.593200.476903.372202.02950HepG2LIN28B
IRS1ENSG00000169047.51452.016701911.53240-0.396702.351701.76740HepG2MATR3
IRS1ENSG00000169047.5780.85910538.020700.537304.126902.38480HepG2NIP7
IRS1ENSG00000169047.51133.06530768.678700.559706.948605.74690HepG2NOL12
IRS1ENSG00000169047.51677.954401134.455700.564603.643301.99470HepG2NOLC1
IRS1ENSG00000169047.5887.09900519.283100.772503.736502.45110HepG2NONO
IRS1ENSG00000169047.51170.60390830.596500.494904.474503.52840HepG2NSUN2
IRS1ENSG00000169047.5804.90350600.868800.421704.402403.36430HepG2PARN
IRS1ENSG00000169047.51358.052501845.50260-0.442507.504106.58320HepG2PCBP1
IRS1ENSG00000169047.51074.85100786.813600.449902.365701.40230HepG2PCBP2
IRS1ENSG00000169047.51685.03800987.367300.7710014.6209013.06380HepG2PRPF4
IRS1ENSG00000169047.51184.49370827.071700.518102.927501.67670HepG2PRPF6
IRS1ENSG00000169047.5763.08180435.972300.807507.016405.79820HepG2PRPF8
IRS1ENSG00000169047.51281.613601877.94940-0.551209.313808.42740HepG2PTBP1
IRS1ENSG00000169047.51611.38220733.733301.134907.058406.16310HepG2PUF60
IRS1ENSG00000169047.51233.35480778.846000.6631014.1774013.05280HepG2PUM1
IRS1ENSG00000169047.51024.56170778.304600.396503.368702.63030HepG2PUM2
IRS1ENSG00000169047.52464.909901512.697400.7043014.3232012.61230HepG2RBM15
IRS1ENSG00000169047.52612.409901423.639300.8757024.7418023.50160HepG2RBM22
IRS1ENSG00000169047.51163.65950717.574800.697406.879305.31000HepG2RBM27
IRS1ENSG00000169047.5930.43820582.705000.675005.492303.98870HepG2RCC2
IRS1ENSG00000169047.52403.592902089.909600.201702.235601.73890HepG2NELFE
IRS1ENSG00000169047.52324.907401946.589800.256103.411502.73590HepG2RECQL
IRS1ENSG00000169047.53187.104501158.495301.4599044.7908042.84100HepG2RPLP0
IRS1ENSG00000169047.51394.97370746.030200.902807.797306.28080HepG2RPS10
IRS1ENSG00000169047.51161.44710716.646000.696508.151907.16260HepG2RPS19
IRS1ENSG00000169047.51325.98150661.747201.0026014.1927012.48550HepG2RPS2
IRS1ENSG00000169047.52121.906101512.908300.487903.291702.41950HepG2RPS3A
IRS1ENSG00000169047.5901.51320675.550800.416202.521301.49710HepG2RPS5
IRS1ENSG00000169047.5816.36320431.251900.920608.390007.11790HepG2RRP9
IRS1ENSG00000169047.51096.44050540.602101.0201027.0706025.34890HepG2SAFB2
IRS1ENSG00000169047.51537.48500927.201700.729509.851708.59400HepG2SF3B1
IRS1ENSG00000169047.51535.405101955.04150-0.348604.928804.17540HepG2SF3B4
IRS1ENSG00000169047.51332.18500703.444900.9212025.7834024.05940HepG2SLBP
IRS1ENSG00000169047.53071.001201607.921600.9334040.3533039.02330HepG2SRFBP1
IRS1ENSG00000169047.51482.217102040.69970-0.461308.475407.75050HepG2SRSF1
IRS1ENSG00000169047.5988.93010724.401600.449005.122404.31180HepG2SRSF5
IRS1ENSG00000169047.51918.298601056.706100.8602026.8424025.11340HepG2SRSF7
IRS1ENSG00000169047.51415.213501660.26940-0.230402.466901.93890HepG2SRSF9
IRS1ENSG00000169047.53040.942201396.010101.1231053.7873052.23100HepG2SSB
IRS1ENSG00000169047.51298.01270823.889700.655709.766708.71810HepG2SUCLG1
IRS1ENSG00000169047.51093.68300562.755700.958509.714208.57460HepG2SUPV3L1
IRS1ENSG00000169047.51573.927901834.42620-0.221001.876401.39800HepG2TAF15
IRS1ENSG00000169047.51388.86430913.005800.605106.813405.74330HepG2TARDBP
IRS1ENSG00000169047.51297.552701685.41200-0.377303.918702.93230HepG2TIA1
IRS1ENSG00000169047.51363.62420589.840301.2089029.9180028.59670HepG2TIAL1
IRS1ENSG00000169047.5794.41310595.137900.416604.626803.93490HepG2TRIM56
IRS1ENSG00000169047.5916.56980716.754000.354702.470901.64750HepG2TUFM
IRS1ENSG00000169047.52186.392101246.402200.8107011.9695010.63420HepG2U2AF1
IRS1ENSG00000169047.51238.53490642.308800.947202.882801.87350HepG2U2AF2
IRS1ENSG00000169047.51971.03250758.625201.3774012.0759010.28180HepG2UBE2L3
IRS1ENSG00000169047.51962.469601645.720200.253902.834601.77560HepG2UTP18
IRS1ENSG00000169047.51881.997901545.820100.283803.912203.21860HepG2UTP3
IRS1ENSG00000169047.5962.81540553.972600.797307.368906.19960HepG2XRN2
IRS1ENSG00000169047.51634.07260974.382600.7458020.9786019.44720HepG2ZC3H8
IRS1ENSG00000169047.52163.609701760.927900.297005.263004.57010HepG2ZNF622
IRS1ENSG00000169047.51426.33010758.759000.910509.283206.80560HepG2ZRANB2
IRS1ENSG00000169047.532.8115012.339701.410802.030401.51200K562AQR
IRS1ENSG00000169047.522.209605.843801.926102.630401.34430K562DDX27
IRS1ENSG00000169047.555.7541014.638701.929205.468504.59780K562DDX47
IRS1ENSG00000169047.552.173405.719703.189206.821905.19040K562EIF3A
IRS1ENSG00000169047.527.520104.472202.621303.266902.13580K562EIF3D
IRS1ENSG00000169047.515.489503.157802.294202.163401.43380K562EIF4A3
IRS1ENSG00000169047.532.011507.802602.036503.527602.51790K562HNRNPU
IRS1ENSG00000169047.527.299705.182602.397003.785502.79340K562MAGOH
IRS1ENSG00000169047.517.688105.035201.812601.912601.34220K562PTBP1
IRS1ENSG00000169047.546.124704.142503.476906.991705.67940K562RPS19
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for IRS1 is not available on ENCORE database.






No RBPs affect the alternative splcing events of IRS1 on ENCORE database.





The Knockdown/knockout RNA-Seq assay for IRS1 is not avaliable on ENCORE database.