FH

General Information

Gene Name       : FH
Gene ID             : ENSG00000091483.6
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: FH)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878FHENSG00000091483.652.6351.2251.92ENCSR000AEF
HepG2FHENSG00000091483.665.8278.3172.06ENCSR985KAT
K562FHENSG00000091483.6134.91131.77133.34ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for FH is not avaliable on ENCORE database.



Proteins bound to RNA
  • FH RNA is bound by 14 proteins.  







eCLIP assay for FH is not avaliable on ENCORE database.





14 proteins are bound to FH RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr1241661055241661093-3'-UTR,intron-Distal5.448349.39648K562PABPC4
chr1241661176241661219-CDS,intron-Distal3.123266.78138K562YBX3
chr1241675369241675434-CDS,intron-Distal4.658404.54659HepG2G3BP1
chr1241682874241682892-CDS,intron-Distal4.374887.50107K562AQR
chr1241680515241680585-CDS,intron-Distal3.355473.71253K562LIN28B
chr1241665853241665871-CDS,intron-Distal,intron-Proximal5.913187.43897K562RPS3
chr1241661226241661276-CDS,intron-Distal3.823275.04653K562SF3B4
chr1241667365241667422-CDS,intron-Distal3.016633.05729K562SND1
chr1241665845241665899-CDS,intron-Distal,intron-Proximal4.811915.40008K562SF3B4
chr1241682915241682963-CDS,intron-Distal3.4331812.71908K562DDX3X
chr1241682905241682972-CDS,intron-Distal4.1388617.74408K562RPS3
chr1241667341241667350-CDS,intron-Distal,intron-Proximal5.790986.70843K562RPS3
chr1241680554241680580-CDS,intron-Distal3.617075.15749K562YBX3
chr1241675275241675348-CDS,intron-Distal5.280968.66806HepG2G3BP1
chr1241673026241673103-intron-Distal4.957197.88729K562TARDBP
chr1241682846241682858-intron-Distal5.234826.75320K562AQR
chr1241667296241667340-intron-Distal,intron-Proximal4.819794.13847K562AQR
chr1241673252241673368-intron-Distal3.579719.27366K562KHSRP
chr1241682858241682874-intron-Distal5.234826.75320K562AQR
chr1241677056241677223-intron-Distal,intron-Proximal3.530289.68785K562KHSRP
chr1241675153241675262-intron-Distal,intron-Proximal4.5320510.02061K562PRPF8
chr1241672992241673098-intron-Distal3.759444.74394K562EIF4G2
chr1241663987241664101-intron-Distal,intron-Proximal3.752838.86655K562KHSRP
chr1241677810241677885-intron-Distal4.232124.69074K562PTBP1
chr1241673373241673460-intron-Distal3.666845.95946K562KHSRP
chr1241669204241669265-intron-Distal,intron-Proximal4.418094.76003K562KHSRP
chr1241661276241661334-intron-Distal6.4152416.14972K562SF3B4
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for FH is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for FH is not available on ENCORE database.

  • 126 RBPs can affect the levels of FH.  








The Knockdown/knockout RNA-Seq assay for FH is not available on ENCORE database.





126 RBPs can affect the gene expression of FH :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
FHENSG00000091483.6979.360901174.31060-0.261902.730302.12620HepG2ACO1
FHENSG00000091483.6515.33880680.03730-0.400102.292801.33960HepG2AKAP8
FHENSG00000091483.6932.773401179.70790-0.338803.870302.97580HepG2AKAP8L
FHENSG00000091483.6924.531601566.33050-0.760609.117507.74670HepG2ASCC1
FHENSG00000091483.61562.482401814.23730-0.215502.127601.51180HepG2AUH
FHENSG00000091483.6904.198601205.92900-0.415402.674201.75490HepG2BCCIP
FHENSG00000091483.6462.23720757.49520-0.712607.174606.26400HepG2BOP1
FHENSG00000091483.61007.317701173.91120-0.220802.190601.58790HepG2CKAP4
FHENSG00000091483.6512.63930695.41360-0.439902.947302.24120HepG2CPSF6
FHENSG00000091483.61289.212701726.63540-0.421505.933805.05980HepG2CELF1
FHENSG00000091483.6782.701901016.59480-0.377202.992602.29020HepG2DDX21
FHENSG00000091483.62320.742401813.393100.355802.617902.00800HepG2DDX3X
FHENSG00000091483.6722.46520551.520700.389402.634901.36680HepG2DDX47
FHENSG00000091483.6701.531301185.69570-0.757207.359506.16800HepG2DDX55
FHENSG00000091483.6983.139801557.71520-0.664006.155605.26290HepG2DDX6
FHENSG00000091483.6574.01190808.32310-0.493903.005202.33020HepG2DNAJC2
FHENSG00000091483.6831.582801497.49620-0.8486010.749609.62900HepG2EIF2S1
FHENSG00000091483.6946.657001654.92230-0.805809.008307.86030HepG2EIF4A3
FHENSG00000091483.61012.451901611.27430-0.670305.165304.24490HepG2EIF4B
FHENSG00000091483.62359.057701831.591500.365006.041804.89110HepG2EIF4G1
FHENSG00000091483.61323.388102082.96280-0.6544015.5206014.28790HepG2ETF1
FHENSG00000091483.6455.59730585.25450-0.361302.494101.38770HepG2FAM120A
FHENSG00000091483.6843.944901087.85380-0.366301.996901.33690HepG2FIP1L1
FHENSG00000091483.6369.23740696.62280-0.915803.876102.67330HepG2FTO
FHENSG00000091483.6678.889901147.84800-0.757705.991904.39750HepG2FUS
FHENSG00000091483.61064.809901669.70800-0.649007.021205.95330HepG2FXR1
FHENSG00000091483.6843.698001548.91960-0.8765010.842709.56960HepG2G3BP1
FHENSG00000091483.6780.398301026.49390-0.395402.608001.62180HepG2GNB2L1
FHENSG00000091483.6452.65270823.50810-0.863406.376405.45450HepG2HNRNPA1
FHENSG00000091483.61423.503401706.17330-0.261302.651101.73490HepG2HNRNPA2B1
FHENSG00000091483.6870.159701090.37040-0.325503.518502.71810HepG2HNRNPF
FHENSG00000091483.61182.723801568.37330-0.407203.451802.67520HepG2HNRNPK
FHENSG00000091483.61238.611901691.02630-0.449208.644307.51740HepG2HNRNPL
FHENSG00000091483.61059.773101574.45030-0.571105.541104.61620HepG2IGF2BP2
FHENSG00000091483.61097.878401583.61420-0.528503.729202.54660HepG2KHSRP
FHENSG00000091483.6881.437101073.37740-0.284203.189502.09690HepG2KIF1C
FHENSG00000091483.6929.720701225.94670-0.399002.295301.54490HepG2LARP4
FHENSG00000091483.61111.337801670.29070-0.587805.692704.76400HepG2MAGOH
FHENSG00000091483.6547.91920739.29100-0.432203.265001.94200HepG2NAA15
FHENSG00000091483.61252.889101840.83830-0.555108.769507.43790HepG2NOL12
FHENSG00000091483.61045.125401531.09760-0.550905.022604.06150HepG2PABPC4
FHENSG00000091483.61172.206901551.22930-0.404206.191205.33880HepG2PCBP1
FHENSG00000091483.6715.229101086.61390-0.603403.834302.61760HepG2PCBP2
FHENSG00000091483.6392.91220541.52020-0.462803.476002.09680HepG2PKM
FHENSG00000091483.6615.65820914.57880-0.571004.659103.64150HepG2PRPF8
FHENSG00000091483.61128.341601578.37730-0.484208.279107.43800HepG2PTBP1
FHENSG00000091483.61260.716801865.46810-0.5653014.4495013.31610HepG2PUM1
FHENSG00000091483.61222.786601864.07980-0.608309.719208.50130HepG2PUM2
FHENSG00000091483.6932.102201196.09040-0.359804.681503.92090HepG2PUS1
FHENSG00000091483.61335.042001709.54210-0.356704.163503.41890HepG2QKI
FHENSG00000091483.6896.856401206.16940-0.427504.694603.61400HepG2RBM15
FHENSG00000091483.6947.187701740.97650-0.8782020.7244019.57520HepG2RBM22
FHENSG00000091483.61372.746801756.62940-0.355705.051604.35670HepG2NELFE
FHENSG00000091483.61142.366601635.97630-0.518109.503808.46340HepG2RECQL
FHENSG00000091483.6890.886801174.65890-0.398903.423102.67580HepG2RPLP0
FHENSG00000091483.6361.41100637.17490-0.818009.055208.01830HepG2RPS19
FHENSG00000091483.6823.986401118.39080-0.440703.464602.56910HepG2RPS2
FHENSG00000091483.6492.20550904.69890-0.878208.862807.56210HepG2RRP9
FHENSG00000091483.61430.660101685.03930-0.236102.755202.05510HepG2SLBP
FHENSG00000091483.6729.55170945.04100-0.373401.862601.31730HepG2SMN1
FHENSG00000091483.6761.327801069.08320-0.489802.970301.97470HepG2SMNDC1
FHENSG00000091483.6603.85670828.49200-0.456302.130401.44710HepG2SNRNP70
FHENSG00000091483.61228.064001966.37790-0.6792017.7593016.78100HepG2SRFBP1
FHENSG00000091483.62027.669301715.308100.241302.718202.24840HepG2SRSF1
FHENSG00000091483.61057.458401735.10430-0.7144016.6461015.29380HepG2SRSF5
FHENSG00000091483.6917.312901071.26740-0.223802.033801.42670HepG2SRSF7
FHENSG00000091483.6662.507401395.45890-1.0747033.5749032.06320HepG2SRSF9
FHENSG00000091483.6477.38940726.59000-0.606003.757602.33330HepG2STAU1
FHENSG00000091483.61493.500901973.24910-0.401907.385706.44990HepG2SUCLG1
FHENSG00000091483.6492.373101180.31580-1.2613018.0228016.55620HepG2SUPV3L1
FHENSG00000091483.6581.31150733.29530-0.335101.975701.35050HepG2TARDBP
FHENSG00000091483.61164.183301416.70750-0.283202.381601.60400HepG2TIA1
FHENSG00000091483.6570.00010884.34190-0.633603.572803.02000HepG2TIAL1
FHENSG00000091483.6698.374901052.89600-0.592303.733102.03560HepG2TRA2A
FHENSG00000091483.6631.14470892.02070-0.499102.962302.38330HepG2TRIM56
FHENSG00000091483.61418.829401716.85240-0.275102.147201.38450HepG2TUFM
FHENSG00000091483.6715.98460930.57320-0.378202.678202.05900HepG2U2AF1
FHENSG00000091483.6523.606101006.94250-0.943402.744401.75860HepG2U2AF2
FHENSG00000091483.61379.008801817.30560-0.398202.698201.87200HepG2UBE2L3
FHENSG00000091483.6847.908001099.04330-0.374304.341303.61810HepG2UTP3
FHENSG00000091483.6610.48040767.46840-0.330203.072802.37300HepG2ZC3H8
FHENSG00000091483.61029.148101251.98080-0.282803.518602.92230HepG2ZNF622
FHENSG00000091483.6701.391201047.63050-0.578803.950602.37330HepG2ZRANB2
FHENSG00000091483.63610.489102867.963000.332102.803501.61380K562AARS
FHENSG00000091483.63743.332405151.69600-0.460705.446303.72440K562ABCF1
FHENSG00000091483.65842.228504898.269000.254104.377803.69300K562AGGF1
FHENSG00000091483.66571.129405096.851600.366404.137103.33540K562AKAP8L
FHENSG00000091483.62545.303707543.80950-1.5675055.5909053.29210K562AQR
FHENSG00000091483.63651.676704243.59930-0.216702.669401.38710K562BCCIP
FHENSG00000091483.63254.156004100.91770-0.333706.729305.20190K562BCLAF1
FHENSG00000091483.61286.098502543.67340-0.9839017.1093014.92150K562BOP1
FHENSG00000091483.62741.274603588.50980-0.388503.215201.65990K562BUD13
FHENSG00000091483.61092.539801641.36590-0.587206.349504.58220K562CCAR1
FHENSG00000091483.62579.655304431.84620-0.780705.689204.11020K562CNOT7
FHENSG00000091483.61726.758602704.72180-0.6474011.309509.70690K562CPSF6
FHENSG00000091483.62395.667503111.15740-0.377005.713204.11780K562CSTF2
FHENSG00000091483.61244.246901837.37800-0.562406.072903.98570K562DHX30
FHENSG00000091483.66639.116005484.698500.275504.146103.04380K562DKC1
FHENSG00000091483.61378.093701765.07600-0.357102.973501.57760K562DNAJC21
FHENSG00000091483.62108.420403504.63750-0.7331010.249508.38040K562EFTUD2
FHENSG00000091483.63679.434104913.22260-0.417208.301507.15570K562EIF2S2
FHENSG00000091483.61147.460301669.60510-0.541103.199002.11040K562EIF3A
FHENSG00000091483.62072.761103547.12610-0.7751014.4014012.45730K562EIF4A3
FHENSG00000091483.66677.279308366.71010-0.325405.845504.50230K562EIF4G2
FHENSG00000091483.61913.687102598.66070-0.441403.519702.06890K562EXOSC5
FHENSG00000091483.61904.744902751.86020-0.530806.262304.95900K562FMR1
FHENSG00000091483.61274.660302332.39320-0.8717013.0222010.92130K562FTO
FHENSG00000091483.62731.135803513.58200-0.363402.810101.37670K562GEMIN5
FHENSG00000091483.63095.853303684.03960-0.251002.940901.76540K562GLRX3
FHENSG00000091483.61589.856602582.39750-0.6998011.554209.90360K562GPKOW
FHENSG00000091483.65177.396406547.44440-0.338704.054603.14220K562GRSF1
FHENSG00000091483.63635.632904941.09920-0.442606.487704.88730K562HNRNPA1
FHENSG00000091483.62886.802904146.93710-0.522603.053801.39880K562HNRNPAB
FHENSG00000091483.61618.557603137.28480-0.9548023.3684021.71470K562HNRNPC
FHENSG00000091483.61910.242502801.97060-0.552707.955405.93840K562HNRNPF
FHENSG00000091483.64174.853505471.96760-0.390306.698005.30240K562HNRNPU
FHENSG00000091483.61255.880401657.45050-0.400303.286601.66100K562KHDRBS1
FHENSG00000091483.66474.205405409.101100.259202.256701.52160K562KIF1C
FHENSG00000091483.61275.517902204.90450-0.789608.003506.32320K562KRR1
FHENSG00000091483.62464.344103182.71020-0.369103.256901.64030K562LIN28B
FHENSG00000091483.63298.096104895.30940-0.569809.282707.68200K562MAGOH
FHENSG00000091483.61673.448902520.68540-0.591008.846807.21270K562METAP2
FHENSG00000091483.63214.284303873.28850-0.269104.605203.58340K562MTPAP
FHENSG00000091483.65665.297804247.299800.415502.356101.55740K562NAA15
FHENSG00000091483.63031.136004303.56400-0.5057021.4504019.65940K562NSUN2
FHENSG00000091483.63619.342804355.59380-0.267102.478701.55580K562PCBP2
FHENSG00000091483.61945.471402813.00780-0.532006.846305.31110K562PSIP1
FHENSG00000091483.67180.866509513.66210-0.405808.860707.11590K562PUM2
FHENSG00000091483.67528.529005054.816800.574608.324507.43100K562PUS1
FHENSG00000091483.65998.844804925.042600.284403.932803.24280K562RBM15
FHENSG00000091483.63401.274604560.48140-0.423104.831203.68260K562RBM22
FHENSG00000091483.62786.858404036.61470-0.534503.199601.54510K562SBDS
FHENSG00000091483.62897.166204246.53030-0.5516013.6292011.93060K562SF3A3
FHENSG00000091483.61581.144502455.75580-0.635206.818905.25040K562SF3B1
FHENSG00000091483.61325.759201808.03430-0.447604.422002.78490K562SLBP
FHENSG00000091483.61728.023802433.39840-0.493805.877304.22330K562SRFBP1
FHENSG00000091483.62627.656603405.04160-0.373903.188501.41580K562SRP68
FHENSG00000091483.63871.341904350.66300-0.168402.460501.57160K562SRPK2
FHENSG00000091483.61627.542602069.25560-0.346403.420302.23400K562SRSF4
FHENSG00000091483.62492.848703144.42060-0.335004.836603.27250K562SRSF7
FHENSG00000091483.61829.187603302.65730-0.852409.200407.28450K562SUPV3L1
FHENSG00000091483.63244.221104718.81260-0.540606.774505.62550K562TARDBP
FHENSG00000091483.61657.765802705.58260-0.706709.240807.45560K562TIAL1
FHENSG00000091483.61724.179802874.88690-0.7376012.7982010.44320K562TRIM56
FHENSG00000091483.62470.961503495.13080-0.500304.186302.90790K562UCHL5
FHENSG00000091483.62419.666004563.16080-0.9152044.4664042.03180K562UPF1
FHENSG00000091483.62893.570003904.55160-0.432305.912704.60890K562WDR3
FHENSG00000091483.63319.923004060.28710-0.290405.677704.50960K562WDR43
FHENSG00000091483.62495.962403558.50710-0.511705.455803.54610K562XRN2
FHENSG00000091483.66414.518408497.89650-0.405804.977003.76460K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for FH is not available on ENCORE database.





1 RBPs can affect the splicing of FH :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEFHENSG00000091483.6chr1-241665742241665902241663736241663890241667341241667587-0.091000.000000.00000excludedK562AQR
A3SSFHENSG00000091483.6chr1-2416804812416806362416804812416806162416828902416830610.065000.000000.00000longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for FH is not avaliable on ENCORE database.