RFC4

General Information

Gene Name       : RFC4
Gene ID             : ENSG00000163918.10
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: RFC4)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878RFC4ENSG00000163918.1088.7270.5579.63ENCSR000AEF
HepG2RFC4ENSG00000163918.1050.1880.7165.44ENCSR985KAT
K562RFC4ENSG00000163918.10116.03121.67118.85ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for RFC4 is not avaliable on ENCORE database.



Proteins bound to RNA
  • RFC4 RNA is bound by 20 proteins.  







eCLIP assay for RFC4 is not avaliable on ENCORE database.





20 proteins are bound to RFC4 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr3186507701186507797-3'-UTR,CDS,intron-Distal6.37060400.00000K562PUM2
chr3186510582186510703-3'-UTR,CDS,intron-Distal,intron-Proximal3.076204.22851HepG2BCLAF1
chr3186507698186507756-3'-UTR,intron-Distal4.490538.47309K562APOBEC3C
chr3186512416186512467-3'-UTR,CDS,intron-Distal,intron-Proximal5.522744.02817HepG2PRPF8
chr3186510373186510399-3'-UTR,CDS,intron-Distal3.729799.13328K562YBX3
chr3186510610186510716-3'-UTR,CDS,intron-Distal,intron-Proximal3.189488.13987K562DDX24
chr3186510344186510373-3'-UTR,CDS,intron-Distal3.292818.67981K562YBX3
chr3186522481186522528-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.608296.12211K562U2AF2
chr3186507703186507837-3'-UTR,CDS,intron-Distal,intron-Proximal3.8578212.88857K562CPSF6
chr3186522480186522531-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.351415.25527HepG2U2AF2
chr3186512560186512626-3'-UTR,CDS,intron-Distal,intron-Proximal4.539136.13339K562KHSRP
chr3186510592186510661-3'-UTR,CDS,intron-Distal,intron-Proximal3.950369.54307K562YBX3
chr3186507720186507803-3'-UTR,CDS,intron-Distal3.620245.52205K562DDX55
chr3186524181186524252-5'-UTR,intron-Distal,intron-Proximal6.0947110.43516HepG2PRPF8
chr3186524146186524184-5'-UTR,intron-Distal,intron-Proximal4.020619.45490K562DDX3X
chr3186524184186524271-5'-UTR,intron-Distal,intron-Proximal4.4807218.89904K562DDX3X
chr3186515341186515396-CDS,intron-Distal3.5151411.18253K562YBX3
chr3186518887186519031-CDS,intron-Distal,intron-Proximal4.170019.23765K562SF3B4
chr3186522373186522468-CDS,intron-Distal3.438508.81096HepG2PPIG
chr3186508081186508164-CDS,intron-Distal,intron-Proximal4.855435.13777HepG2PRPF8
chr3186507969186508053-CDS,intron-Distal,intron-Proximal3.7118925.54121K562EFTUD2
chr3186507847186507944-CDS,intron-Distal,intron-Proximal3.715888.83324K562EFTUD2
chr3186507874186507945-CDS,intron-Distal,intron-Proximal3.884437.75444K562PRPF8
chr3186522379186522441-CDS,intron-Distal3.272059.54151K562ZNF622
chr3186507986186508042-CDS,intron-Distal,intron-Proximal3.071637.54133K562PRPF8
chr3186522423186522497-CDS,intron-Distal3.452108.60308K562YBX3
chr3186518902186518972-CDS,intron-Distal,intron-Proximal3.606213.59112HepG2PPIG
chr3186522372186522487-CDS,intron-Distal3.448804.71502HepG2GRWD1
chr3186509553186509642-CDS,intron-Distal,intron-Proximal3.428349.71113K562LIN28B
chr3186508097186508165-CDS,intron-Distal,intron-Proximal4.611845.23259HepG2BCLAF1
chr3186522375186522476-CDS,intron-Distal3.365139.89473K562UCHL5
chr3186515350186515397-CDS,intron-Distal3.372823.28366HepG2BCLAF1
chr3186523863186523969-intron-Distal5.1499534.52040HepG2DKC1
chr3186512701186512780-intron-Distal,intron-Proximal3.531855.56048K562KHSRP
chr3186513781186513840-intron-Distal4.439385.44904K562TARDBP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for RFC4 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for RFC4 is not available on ENCORE database.

  • 114 RBPs can affect the levels of RFC4.  








The Knockdown/knockout RNA-Seq assay for RFC4 is not available on ENCORE database.





114 RBPs can affect the gene expression of RFC4 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
RFC4ENSG00000163918.6456.86020623.87800-0.449504.497203.75820HepG2ACO1
RFC4ENSG00000163918.6456.99590626.76930-0.455804.320803.37750HepG2AKAP8L
RFC4ENSG00000163918.6216.92700508.68340-1.2296012.8307011.24340HepG2ASCC1
RFC4ENSG00000163918.6569.841601094.88670-0.9421020.7098019.14570HepG2AUH
RFC4ENSG00000163918.6331.84670675.16570-1.024707.376305.98990HepG2BCLAF1
RFC4ENSG00000163918.6342.85910918.03370-1.4209025.5277024.01210HepG2BOP1
RFC4ENSG00000163918.6362.60060836.28280-1.2056012.1288010.70340HepG2CALR
RFC4ENSG00000163918.6268.81580483.28120-0.846206.713505.54200HepG2CIRBP
RFC4ENSG00000163918.6266.15750623.69450-1.2286024.9259023.38240HepG2CKAP4
RFC4ENSG00000163918.6320.92750842.79390-1.3929021.8857020.18700HepG2CPSF6
RFC4ENSG00000163918.6853.206201171.51250-0.457406.002805.12510HepG2CELF1
RFC4ENSG00000163918.6920.607001259.74370-0.452507.610106.47060HepG2DAZAP1
RFC4ENSG00000163918.6440.23550576.97570-0.390203.644502.70540HepG2DDX19B
RFC4ENSG00000163918.6310.15390651.02590-1.0697013.8806012.50210HepG2DDX21
RFC4ENSG00000163918.6400.70430636.94780-0.668606.623305.21580HepG2DDX24
RFC4ENSG00000163918.6233.37230588.92750-1.3355015.5436014.18190HepG2DDX3X
RFC4ENSG00000163918.6409.63800763.81020-0.898906.169205.06930HepG2DDX55
RFC4ENSG00000163918.6513.28350957.05800-0.898903.838402.69520HepG2DDX59
RFC4ENSG00000163918.6419.03930663.38540-0.662803.631002.47870HepG2DDX5
RFC4ENSG00000163918.6280.27830505.85240-0.851906.262005.36190HepG2DDX6
RFC4ENSG00000163918.6306.66910593.18130-0.9518010.889609.10450HepG2DHX30
RFC4ENSG00000163918.6484.43130596.86980-0.301102.030201.43600HepG2DKC1
RFC4ENSG00000163918.6348.55170615.00570-0.8192010.612809.30960HepG2DNAJC21
RFC4ENSG00000163918.6364.66000609.61230-0.7413010.859809.66460HepG2DNAJC2
RFC4ENSG00000163918.6395.51550603.79200-0.610304.272103.14940HepG2EEF2
RFC4ENSG00000163918.6354.33670599.38880-0.758405.485503.93280HepG2AGO1
RFC4ENSG00000163918.6164.00670486.33630-1.5682017.9031016.48440HepG2EIF2S1
RFC4ENSG00000163918.6278.21790490.14420-0.817006.020404.72280HepG2EIF3D
RFC4ENSG00000163918.6377.40640537.48210-0.510102.788902.14730HepG2EIF4A3
RFC4ENSG00000163918.6933.100201242.74550-0.413405.684904.55880HepG2EIF4G1
RFC4ENSG00000163918.6726.370101190.48300-0.712808.627907.22030HepG2EIF4G2
RFC4ENSG00000163918.6596.327501257.08070-1.0759027.9520026.37510HepG2ETF1
RFC4ENSG00000163918.6478.65330620.33570-0.374102.438001.36200HepG2FASTKD2
RFC4ENSG00000163918.6399.79160844.26150-1.078405.364303.95720HepG2FTO
RFC4ENSG00000163918.6782.27330542.226500.528703.845303.03980HepG2FXR1
RFC4ENSG00000163918.6382.04870503.03160-0.396901.941201.37960HepG2G3BP1
RFC4ENSG00000163918.6260.86700436.40990-0.742405.384604.13060HepG2GEMIN5
RFC4ENSG00000163918.6490.48100736.91420-0.587304.214902.95790HepG2GNB2L1
RFC4ENSG00000163918.6307.79790955.34220-1.6340026.5145024.76940HepG2GPKOW
RFC4ENSG00000163918.6295.28380620.89800-1.0723012.4563011.24540HepG2HNRNPA1
RFC4ENSG00000163918.6732.458401157.70190-0.6604011.519609.85150HepG2HNRNPA2B1
RFC4ENSG00000163918.6402.01530690.64670-0.780707.785906.67010HepG2HNRNPC
RFC4ENSG00000163918.6451.64570708.09760-0.648808.680107.49950HepG2HNRNPF
RFC4ENSG00000163918.6817.293601147.55440-0.489608.377007.26160HepG2HNRNPL
RFC4ENSG00000163918.6223.19440911.70340-2.0303040.3825038.41730HepG2HNRNPLL
RFC4ENSG00000163918.6572.16350686.07960-0.261902.011801.48490HepG2HNRNPU
RFC4ENSG00000163918.6385.92160697.26930-0.8534011.4123010.03980HepG2IGF2BP1
RFC4ENSG00000163918.6177.27480511.33380-1.5283018.3091016.75290HepG2IGF2BP2
RFC4ENSG00000163918.6532.033301072.79500-1.011807.693006.29550HepG2LARP4
RFC4ENSG00000163918.6578.62770758.04890-0.389702.582101.41370HepG2LIN28B
RFC4ENSG00000163918.6579.38770929.88530-0.682504.546903.28220HepG2MTPAP
RFC4ENSG00000163918.6379.28570558.32080-0.557803.425802.72460HepG2NCBP2
RFC4ENSG00000163918.6354.34990701.12650-0.984505.538803.96430HepG2NONO
RFC4ENSG00000163918.6624.55770808.42140-0.372302.412501.71190HepG2NSUN2
RFC4ENSG00000163918.6162.96400497.26390-1.6095019.8466017.95890HepG2PABPC4
RFC4ENSG00000163918.6542.28730679.08580-0.324502.559601.74210HepG2PARN
RFC4ENSG00000163918.6337.31850718.99180-1.091909.600507.80920HepG2PCBP2
RFC4ENSG00000163918.6409.61910578.67800-0.498504.777203.79210HepG2PRPF4
RFC4ENSG00000163918.6206.09180589.48680-1.5162012.7307011.17520HepG2PRPF8
RFC4ENSG00000163918.6500.780701192.40550-1.2516019.7376018.34050HepG2PUF60
RFC4ENSG00000163918.6907.285201265.76500-0.480408.869707.93580HepG2PUM1
RFC4ENSG00000163918.6645.857301264.85660-0.9697019.2961017.62220HepG2PUM2
RFC4ENSG00000163918.6374.48610583.47460-0.639805.914505.04950HepG2QKI
RFC4ENSG00000163918.6439.065501050.68600-1.2588029.5510028.21720HepG2RBM22
RFC4ENSG00000163918.6333.51190529.56560-0.667105.622904.69380HepG2RBM25
RFC4ENSG00000163918.6673.97490870.56760-0.369302.339001.43570HepG2RBM27
RFC4ENSG00000163918.6245.67610762.86430-1.6347029.9062028.18580HepG2RPLP0
RFC4ENSG00000163918.6264.99590681.54760-1.3628013.2487011.35600HepG2RPS10
RFC4ENSG00000163918.6209.60460476.93410-1.1861014.0173012.77290HepG2RPS19
RFC4ENSG00000163918.6384.94680802.89350-1.0605013.6602011.98080HepG2RPS2
RFC4ENSG00000163918.6241.52850402.89260-0.738204.247603.25570HepG2RPS3A
RFC4ENSG00000163918.6212.84610583.15080-1.4541011.6634010.22800HepG2RRP9
RFC4ENSG00000163918.6487.19830610.97690-0.326602.592101.96500HepG2SAFB2
RFC4ENSG00000163918.6310.35700478.67410-0.625104.217203.06280HepG2SERBP1
RFC4ENSG00000163918.6490.07370739.87950-0.594303.528702.76370HepG2SF3A3
RFC4ENSG00000163918.6537.20530902.38870-0.748308.455707.28590HepG2SF3B1
RFC4ENSG00000163918.6688.060401143.27740-0.732609.118407.96120HepG2SLBP
RFC4ENSG00000163918.6545.47780712.49000-0.385303.973303.22510HepG2SMN1
RFC4ENSG00000163918.6416.30160707.36260-0.764805.682804.27520HepG2SMNDC1
RFC4ENSG00000163918.6417.641301004.07200-1.2655012.5052010.86060HepG2SNRNP70
RFC4ENSG00000163918.6392.756601186.70950-1.5953055.5206054.01920HepG2SRFBP1
RFC4ENSG00000163918.6903.22820585.492800.625308.919308.17850HepG2SRSF1
RFC4ENSG00000163918.6563.068301177.29550-1.0641027.4171025.73200HepG2SRSF5
RFC4ENSG00000163918.6342.16700695.69860-1.0238018.1489016.64740HepG2SRSF7
RFC4ENSG00000163918.6289.39030476.34900-0.719007.735406.89780HepG2SRSF9
RFC4ENSG00000163918.6655.233501030.34200-0.6530011.3717010.46900HepG2SSB
RFC4ENSG00000163918.6432.68810648.42810-0.583602.825101.60980HepG2SUB1
RFC4ENSG00000163918.6905.436401338.93610-0.5644011.043709.94110HepG2SUCLG1
RFC4ENSG00000163918.6213.89300326.72880-0.611202.729101.41410HepG2SUGP2
RFC4ENSG00000163918.6185.19620760.43920-2.0378018.5793017.09400HepG2SUPV3L1
RFC4ENSG00000163918.6713.01200526.326500.437904.012403.35660HepG2TAF15
RFC4ENSG00000163918.6241.49020888.70900-1.8797038.0133035.90910HepG2TARDBP
RFC4ENSG00000163918.6192.53170509.74330-1.4047011.710609.94590HepG2TFIP11
RFC4ENSG00000163918.6201.61620666.60800-1.7252035.1574033.74050HepG2TIAL1
RFC4ENSG00000163918.6395.35390672.61690-0.7666011.5543010.51860HepG2TRIM56
RFC4ENSG00000163918.6702.624101164.88700-0.7294010.308508.42280HepG2TUFM
RFC4ENSG00000163918.6436.843001599.74830-1.872703.459502.35200HepG2U2AF2
RFC4ENSG00000163918.6834.045401232.98660-0.564004.773503.65730HepG2UBE2L3
RFC4ENSG00000163918.6286.64650656.15990-1.1948022.8915021.26650HepG2UPF1
RFC4ENSG00000163918.6501.84090674.44110-0.426503.824102.61110HepG2UTP18
RFC4ENSG00000163918.6485.35840633.49670-0.384303.387002.73600HepG2UTP3
RFC4ENSG00000163918.6209.96050360.86840-0.781404.565103.14290HepG2XPO5
RFC4ENSG00000163918.6215.24950721.65040-1.7453049.7945048.22040HepG2ZNF622
RFC4ENSG00000163918.62717.857103981.08100-0.550707.360806.47820K562AQR
RFC4ENSG00000163918.64105.409305565.64730-0.439002.252801.31350K562CNOT7
RFC4ENSG00000163918.61411.375301854.33640-0.393804.179602.85990K562DDX3X
RFC4ENSG00000163918.63040.876503592.55830-0.240503.278702.57910K562DDX47
RFC4ENSG00000163918.63893.700903409.275700.191602.108801.35590K562DKC1
RFC4ENSG00000163918.61304.547001940.33800-0.572804.927503.50010K562EIF3D
RFC4ENSG00000163918.63047.334503589.56380-0.236302.052301.39510K562GRSF1
RFC4ENSG00000163918.63168.467702511.744100.335002.644001.44140K562HNRNPK
RFC4ENSG00000163918.64738.311503766.669300.331003.701802.62490K562MBNL1
RFC4ENSG00000163918.62580.711502911.16260-0.173802.617201.88870K562NSUN2
RFC4ENSG00000163918.66615.221105332.534700.310903.957802.66050K562PUM1
RFC4ENSG00000163918.61980.329402462.34770-0.314302.664901.84120K562RBM22
RFC4ENSG00000163918.61296.095801747.72750-0.431303.724902.57460K562RCC2
RFC4ENSG00000163918.61469.262302036.43720-0.471004.307903.02480K562RPS3
RFC4ENSG00000163918.61207.211101622.32660-0.426402.293201.31350K562SAFB
RFC4ENSG00000163918.63233.205902517.205400.361004.232303.36580K562SRSF1
RFC4ENSG00000163918.62755.356002127.270500.373102.773401.67980K562U2AF1
RFC4ENSG00000163918.63696.549304484.63310-0.278802.486501.67610K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for RFC4 is not available on ENCORE database.





10 RBPs can affect the splicing of RFC4 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SERFC4ENSG00000163918.6chr3-186510278186510375186509478186509639186510592186510736-0.063000.000010.00058excludedK562SF3B4
SERFC4ENSG00000163918.6chr3-186507930186508044186507688186507853186509513186509639-0.180000.000000.00000excludedK562AQR
SERFC4ENSG00000163918.6chr3-186512446186512570186510592186510736186515323186515403-0.063000.000000.00000excludedK562PUS1
SERFC4ENSG00000163918.6chr3-186512446186512570186510592186510736186515323186515403-0.078000.000000.00003excludedK562UTP18
SERFC4ENSG00000163918.6chr3-186512446186512570186510592186510736186515323186515403-0.052000.000010.00056excludedK562RBM15
SERFC4ENSG00000163918.6chr3-186512446186512570186510592186510736186515323186515403-0.075000.000000.00000excludedK562AGGF1
A3SSRFC4ENSG00000163918.6chr3-1865223711865225541865223711865225131865240781865242470.088000.000000.00000longerK562AQR
A3SSRFC4ENSG00000163918.6chr3-1865094781865096921865094781865096391865102781865104560.092000.000000.00000longerK562AQR
MXERFC4ENSG00000163918.6chr3-1865079301865080441865081141865081951865076831865078531865095131865096390.221000.009100.082291includedK562DROSHA
MXERFC4ENSG00000163918.6chr3-1865079301865080441865095131865096391865076881865078531865102781865103990.068000.006510.044751includedK562AQR
MXERFC4ENSG00000163918.6chr3-1865079301865080441865095131865096921865076881865078531865102781865103990.138000.000000.000001includedK562AQR
MXERFC4ENSG00000163918.6chr3-1865079301865080441865095131865096651865076881865078531865102781865103990.223000.000000.000001includedK562AQR
MXERFC4ENSG00000163918.6chr3-1865081141865081951865095131865096651865079301865080441865102781865103990.083000.000000.000001includedK562AQR
MXERFC4ENSG00000163918.6chr3-1865079301865080441865081141865081951865076831865078531865095131865096390.113000.000040.003761includedK562SBDS
MXERFC4ENSG00000163918.6chr3-1865079301865080441865081141865081951865076831865078531865095131865096390.101000.000640.051591includedK562CPSF6
MXERFC4ENSG00000163918.6chr3-186510592186510736186512446186512566186510310186510399186515323186515403-0.123000.000040.003412includedK562DDX55
MXERFC4ENSG00000163918.6chr3-186510278186510399186510592186510736186509478186509639186512446186512648-0.082000.002790.072852includedK562DDX55
MXERFC4ENSG00000163918.6chr3-1865081141865081951865095131865096321865079301865080441865102781865103990.059000.000000.000181includedK562SF3B4
MXERFC4ENSG00000163918.6chr3-186509513186509639186510278186510399186507930186508044186510592186510736-0.063000.000000.000002includedK562SF3B4

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for RFC4 is not avaliable on ENCORE database.