LIMK2

General Information

Gene Name       : LIMK2
Gene ID             : ENSG00000182541.17
Essential Gene : No

Functions

Localization

Domains (AlphaFold: LIMK2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878LIMK2ENSG00000182541.1713.0320.2816.66ENCSR000AEF
HepG2LIMK2ENSG00000182541.1730.3422.4026.37ENCSR985KAT
K562LIMK2ENSG00000182541.178.708.298.49ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for LIMK2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • LIMK2 RNA is bound by 25 proteins.  







eCLIP assay for LIMK2 is not avaliable on ENCORE database.





25 proteins are bound to LIMK2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr223167570431675834+3'-UTR4.053915.24353K562UPF1
chr223167334331673375+3'-UTR,intron-Distal3.612874.98353HepG2CSTF2T
chr223167337531673389+3'-UTR,intron-Distal3.942355.62912HepG2CSTF2T
chr223165435131654445+3'-UTR,CDS,intron-Distal,intron-Proximal3.097295.39266HepG2GRWD1
chr223167333731673370+3'-UTR,intron-Distal3.885935.73360HepG2CSTF2
chr223165429731654397+3'-UTR,CDS,intron-Distal3.112259.21044HepG2PPIG
chr223165437731654404+3'-UTR,CDS,intron-Distal4.4683639.62399HepG2PRPF8
chr223167337031673421+3'-UTR,intron-Distal4.710725.65087HepG2CSTF2
chr223160833631608411+5'-UTR,CDS,intron-Proximal4.278908.22731HepG2NCBP2
chr223160839831608450+5'-UTR,CDS,intron-Proximal3.195825.56806HepG2PRPF8
chr223160823631608277+5'-UTR3.809064.77154HepG2NCBP2
chr223160837931608430+5'-UTR,CDS,intron-Proximal3.960643.80990HepG2SRSF1
chr223162170431621755+CDS,intron-Distal,intron-Proximal4.026604.54756HepG2SRSF1
chr223167116531671203+CDS3.623684.13746HepG2PPIG
chr223166375231663817+CDS,intron-Proximal3.7615010.42618HepG2PPIG
chr223165440031654478+CDS,intron-Distal,intron-Proximal4.369245.99968K562PRPF8
chr223165501531655125+CDS,intron-Distal,intron-Proximal3.0565119.25908HepG2BUD13
chr223165505931655136+CDS,intron-Distal,intron-Proximal5.9051711.56697K562AQR
chr223165806531658144+CDS,intron-Distal,intron-Proximal5.253766.74224HepG2AQR
chr223165507831655134+CDS,intron-Distal,intron-Proximal4.077798.67297HepG2U2AF2
chr223166302331663057+CDS,intron-Proximal3.015935.14343HepG2PPIG
chr223166717931667230+CDS,intron-Proximal3.496515.90285HepG2PRPF8
chr223165807231658140+CDS,intron-Distal,intron-Proximal3.581398.35379HepG2SF3A3
chr223165440931654482+CDS,intron-Distal,intron-Proximal5.711927.63570K562AQR
chr223165442131654474+CDS,intron-Distal,intron-Proximal4.062337.73763HepG2BUD13
chr223167426931674325+CDS,intron-Proximal3.552227.15565HepG2BUD13
chr223162178531621835+CDS,intron-Distal,intron-Proximal5.8232316.49005HepG2PRPF8
chr223165441931654486+CDS,intron-Distal,intron-Proximal3.834436.99774HepG2EFTUD2
chr223165858231658700+CDS,intron-Distal3.5903110.76242HepG2GRWD1
chr223166305331663096+CDS,intron-Proximal4.900196.26248HepG2PRPF8
chr223165516131655216+CDS,intron-Distal3.490554.51003HepG2PPIG
chr223165859031658687+CDS,intron-Distal3.379887.15397HepG2PPIG
chr223165502131655118+CDS,intron-Distal,intron-Proximal3.585699.11312HepG2EFTUD2
chr223166856331668603+CDS4.346593.45943HepG2BCLAF1
chr223166381731663881+CDS3.999728.40792HepG2PPIG
chr223166201031662082+CDS3.308863.85127HepG2GRWD1
chr223166866131668746+CDS,intron-Proximal4.7665515.12562HepG2PRPF8
chr223165505331655127+CDS,intron-Distal,intron-Proximal4.815965.55733K562BUD13
chr223166207831662172+CDS,intron-Proximal4.9030418.47587HepG2PRPF8
chr223165442531654504+CDS,intron-Distal,intron-Proximal4.804227.82992HepG2RBM22
chr223166852931668597+CDS3.653366.13978HepG2PPIG
chr223165440431654457+CDS,intron-Distal,intron-Proximal4.8470540.70912HepG2PRPF8
chr223167276231672833+CDS,intron-Distal,intron-Proximal3.323836.59225HepG2CSTF2T
chr223166534831665411+intron-Distal4.139414.18168HepG2ILF3
chr223167246031672531+intron-Distal3.095744.64240HepG2XRN2
chr223163123031631298+intron-Distal3.684515.33975HepG2HNRNPK
chr223160855531608687+intron-Distal3.135495.59141HepG2PRPF4
chr223165506931655107+intron-Distal,intron-Proximal3.525605.43815HepG2PRPF8
chr223166275131662815+intron-Distal4.002333.65854HepG2RBFOX2
chr223165450231654576+intron-Distal,intron-Proximal3.071605.24728HepG2U2AF2
chr223165790331657956+intron-Distal3.961433.43967HepG2TAF15
chr223165496831655089+intron-Distal,intron-Proximal3.980333.31322HepG2SF3B4
chr223166212031662230+intron-Distal,intron-Proximal4.296848.13631HepG2EFTUD2
chr223165786131657988+intron-Distal3.067003.63033HepG2HNRNPU
chr223167249731672553+intron-Distal3.356566.38521HepG2SLTM
chr223166231431662416+intron-Distal5.1060712.42422HepG2XPO5
chr223167248531672563+intron-Distal4.297608.28918HepG2CSTF2T
chr223165850231658563+intron-Distal,intron-Proximal4.227773.74254HepG2SF3B4
chr223166423631664297+intron-Distal,intron-Proximal5.269629.24251HepG2EFTUD2
chr223166186931661922+intron-Proximal4.400425.32775HepG2SF3B4
chr223166186731661909+intron-Proximal3.346093.55754HepG2U2AF2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for LIMK2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for LIMK2 is not available on ENCORE database.

  • 99 RBPs can affect the levels of LIMK2.  








The Knockdown/knockout RNA-Seq assay for LIMK2 is not available on ENCORE database.





99 RBPs can affect the gene expression of LIMK2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
LIMK2ENSG00000182541.131094.61650799.926300.452404.040502.76950HepG2AATF
LIMK2ENSG00000182541.13690.874401194.46710-0.789907.954706.47290HepG2ABCF1
LIMK2ENSG00000182541.131321.496701004.826200.395105.815904.99780HepG2ACO1
LIMK2ENSG00000182541.131506.358401009.603700.5772010.901409.50660HepG2AKAP8L
LIMK2ENSG00000182541.131245.56930712.530900.805709.382107.99530HepG2ASCC1
LIMK2ENSG00000182541.131811.931401540.951800.233602.514601.85500HepG2AUH
LIMK2ENSG00000182541.13695.87060866.88300-0.317002.228901.53250HepG2CALR
LIMK2ENSG00000182541.131018.701701565.65120-0.620004.907303.59500HepG2CCAR1
LIMK2ENSG00000182541.13983.987801348.96220-0.455102.252101.56700HepG2CNOT7
LIMK2ENSG00000182541.131679.28220983.769500.7714012.7733010.60950HepG2CPSF7
LIMK2ENSG00000182541.13725.34190977.38790-0.430304.519403.21840HepG2YBX3
LIMK2ENSG00000182541.13749.29630929.35150-0.310703.416802.50170HepG2DDX19B
LIMK2ENSG00000182541.13518.74370882.16610-0.766009.033207.88130HepG2DDX21
LIMK2ENSG00000182541.13526.45230863.59500-0.714108.710207.11300HepG2DDX24
LIMK2ENSG00000182541.13508.43160946.46750-0.8965011.376509.49360HepG2DDX5
LIMK2ENSG00000182541.132318.56150708.749001.7098036.3731034.51890HepG2DDX6
LIMK2ENSG00000182541.13618.75760925.62920-0.581105.861604.47120HepG2DHX30
LIMK2ENSG00000182541.13458.22760961.36400-1.0690023.5734022.07220HepG2DKC1
LIMK2ENSG00000182541.13728.66450959.68700-0.397304.092803.25120HepG2DNAJC21
LIMK2ENSG00000182541.131202.03290906.179100.407503.111401.86770HepG2EIF2S2
LIMK2ENSG00000182541.13656.63480833.28190-0.343702.499401.47160HepG2EIF3G
LIMK2ENSG00000182541.131288.13310733.015900.813306.855705.80320HepG2EIF4B
LIMK2ENSG00000182541.131287.388501550.33540-0.268102.727201.89490HepG2EIF4G1
LIMK2ENSG00000182541.13954.099301485.09730-0.638307.308206.01400HepG2EIF4G2
LIMK2ENSG00000182541.13541.255001034.77410-0.9349012.7625010.71840HepG2ESF1
LIMK2ENSG00000182541.132031.737901769.232800.199501.874601.35920HepG2ETF1
LIMK2ENSG00000182541.13372.38170668.20790-0.843503.380302.25250HepG2FTO
LIMK2ENSG00000182541.13688.28930477.635400.527004.267703.30310HepG2FUBP3
LIMK2ENSG00000182541.131418.54850759.682100.9008011.8893010.55740HepG2FXR1
LIMK2ENSG00000182541.13931.28470704.599900.402302.491101.85790HepG2G3BP1
LIMK2ENSG00000182541.13574.26690748.17560-0.381702.292101.48450HepG2G3BP2
LIMK2ENSG00000182541.13521.20050697.75680-0.420902.940602.01480HepG2GEMIN5
LIMK2ENSG00000182541.13432.72840756.05630-0.805005.551204.66610HepG2GPKOW
LIMK2ENSG00000182541.131409.44970959.362600.5549010.184208.46780HepG2HDGF
LIMK2ENSG00000182541.13395.83120968.88160-1.2914022.6774021.13920HepG2HNRNPA1
LIMK2ENSG00000182541.131792.507901444.159500.311604.088002.98660HepG2HNRNPA2B1
LIMK2ENSG00000182541.131637.608901114.255500.555404.250902.50700HepG2HNRNPAB
LIMK2ENSG00000182541.13809.869501077.71840-0.412203.298302.54660HepG2HNRNPC
LIMK2ENSG00000182541.13953.49720713.743600.417703.006602.27960HepG2HNRNPK
LIMK2ENSG00000182541.13376.69360721.52400-0.9377010.054008.93960HepG2HNRNPLL
LIMK2ENSG00000182541.13740.775001070.59190-0.531307.991707.00170HepG2HNRNPU
LIMK2ENSG00000182541.13994.763301205.36260-0.277002.219301.56600HepG2IGF2BP1
LIMK2ENSG00000182541.131271.06220672.260700.918804.285203.06330HepG2IGF2BP3
LIMK2ENSG00000182541.13712.957001260.24090-0.821807.335405.33510HepG2KRR1
LIMK2ENSG00000182541.13754.02870975.32050-0.371302.719601.51890HepG2LIN28B
LIMK2ENSG00000182541.131049.34430764.165600.457402.977902.32640HepG2MATR3
LIMK2ENSG00000182541.13648.06420976.26360-0.591106.197505.03240HepG2MSI2
LIMK2ENSG00000182541.131240.87560782.136600.665806.274305.33610HepG2NCBP2
LIMK2ENSG00000182541.13597.74920839.94440-0.490804.126702.38480HepG2NIP7
LIMK2ENSG00000182541.13305.24880639.81320-1.0677011.8998010.45170HepG2NSUN2
LIMK2ENSG00000182541.13999.87960696.408900.521704.020903.16090HepG2PABPC4
LIMK2ENSG00000182541.13876.312001059.68180-0.274102.517001.70480HepG2PARN
LIMK2ENSG00000182541.131344.28840778.465400.7880017.9151016.58660HepG2PCBP1
LIMK2ENSG00000182541.13725.185401224.95860-0.756307.272404.23710HepG2PPIG
LIMK2ENSG00000182541.13440.90900874.51970-0.9880019.8407018.09960HepG2PRPF4
LIMK2ENSG00000182541.13614.64660893.42760-0.539602.907401.66050HepG2PRPF6
LIMK2ENSG00000182541.131937.72430792.130901.2905050.3990048.69690HepG2PTBP1
LIMK2ENSG00000182541.13555.539301487.40610-1.4208034.5080032.69590HepG2PUF60
LIMK2ENSG00000182541.131056.812201577.81360-0.578208.206207.07720HepG2PUM2
LIMK2ENSG00000182541.131497.161401023.490600.5486011.006209.91620HepG2PUS1
LIMK2ENSG00000182541.131447.42480820.055200.819605.404804.43840HepG2RAVER1
LIMK2ENSG00000182541.131428.161101178.912900.276602.293301.50450HepG2RBM15
LIMK2ENSG00000182541.13919.162001478.74830-0.6860012.5360011.59480HepG2RBM22
LIMK2ENSG00000182541.13971.16730778.582000.318802.344301.71790HepG2RBM25
LIMK2ENSG00000182541.131076.98440881.554600.288802.456801.94180HepG2NELFE
LIMK2ENSG00000182541.131246.96390821.068300.6027010.319409.24480HepG2RECQL
LIMK2ENSG00000182541.13932.878401318.65870-0.499305.042004.15690HepG2RPLP0
LIMK2ENSG00000182541.13540.40290805.78120-0.576403.210102.19400HepG2RPS10
LIMK2ENSG00000182541.13572.17080762.55410-0.414403.231502.57390HepG2RPS19
LIMK2ENSG00000182541.13691.012301354.96270-0.9715010.098108.61040HepG2RPS3A
LIMK2ENSG00000182541.13585.117201275.92230-1.1247014.2048011.49290HepG2SART3
LIMK2ENSG00000182541.13741.973901286.93290-0.794505.740803.57910HepG2SBDS
LIMK2ENSG00000182541.131108.62780847.142400.388002.159701.56290HepG2SF3A3
LIMK2ENSG00000182541.13464.58240714.13100-0.620305.337304.38030HepG2SF3B1
LIMK2ENSG00000182541.131696.65410824.686701.0407031.5860029.97890HepG2SF3B4
LIMK2ENSG00000182541.13961.920901426.29740-0.5683011.4166010.15240HepG2SLBP
LIMK2ENSG00000182541.131120.95190836.842500.421602.353501.47780HepG2SMNDC1
LIMK2ENSG00000182541.132056.499801670.186700.300103.025702.50910HepG2SRFBP1
LIMK2ENSG00000182541.131141.23880860.804100.406705.047504.45860HepG2SRSF1
LIMK2ENSG00000182541.131565.93850700.318401.1608041.7364040.09420HepG2SRSF9
LIMK2ENSG00000182541.13498.060301450.10850-1.5418060.8855059.26430HepG2SSB
LIMK2ENSG00000182541.13423.10900805.70600-0.929207.868105.92810HepG2STAU1
LIMK2ENSG00000182541.131272.07050766.396600.730905.251603.59610HepG2SUB1
LIMK2ENSG00000182541.131404.180601670.21680-0.250302.892402.25960HepG2SUCLG1
LIMK2ENSG00000182541.131205.27130773.751300.6393010.241309.27060HepG2TAF15
LIMK2ENSG00000182541.13765.810901234.32920-0.688703.099301.97290HepG2TBRG4
LIMK2ENSG00000182541.13867.33490616.019800.493502.761101.76590HepG2TFIP11
LIMK2ENSG00000182541.131092.55220710.943400.619808.014406.60690HepG2TIA1
LIMK2ENSG00000182541.13516.021001040.21730-1.0114019.1658018.06760HepG2TIAL1
LIMK2ENSG00000182541.13763.346301049.58350-0.459406.270905.48340HepG2TRIM56
LIMK2ENSG00000182541.13533.60490751.28410-0.493605.331204.41280HepG2UPF1
LIMK2ENSG00000182541.13558.46430841.52600-0.591503.654602.48760HepG2UPF2
LIMK2ENSG00000182541.13729.910001213.66570-0.733605.899504.30060HepG2XPO5
LIMK2ENSG00000182541.131196.04460806.628000.568203.542702.09280HepG2XRCC5
LIMK2ENSG00000182541.13611.03480904.75350-0.566304.711703.77400HepG2XRN2
LIMK2ENSG00000182541.13695.06570863.04970-0.312303.116002.41060HepG2ZC3H8
LIMK2ENSG00000182541.13973.48020826.271100.236402.253501.74500HepG2ZNF622
LIMK2ENSG00000182541.13301.32060195.232800.626003.272002.40880K562EIF3G
LIMK2ENSG00000182541.13134.75000225.27380-0.741403.269602.48930K562G3BP2
LIMK2ENSG00000182541.13499.00790298.744200.740106.209905.35140K562HNRNPC
LIMK2ENSG00000182541.13550.05650424.662300.373202.188701.51790K562NSUN2
LIMK2ENSG00000182541.13538.31630418.974900.361502.334501.58010K562SF3A3
LIMK2ENSG00000182541.13425.48910291.591200.545103.611902.81210K562SRSF1
LIMK2ENSG00000182541.13426.10220295.068300.530103.257502.48940K562TARDBP
LIMK2ENSG00000182541.13537.58860385.291500.480503.454302.47900K562WDR3
LIMK2ENSG00000182541.13703.92790553.382900.347002.239501.47460K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for LIMK2 is not available on ENCORE database.





1 RBPs can affect the splicing of LIMK2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SELIMK2ENSG00000182541.13chr22+316217053162180531608280316084103165427631655032-0.196000.001710.03207excludedHepG2U2AF1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for LIMK2 is not avaliable on ENCORE database.