JAK1

General Information

Gene Name       : JAK1
Gene ID             : ENSG00000162434.11
Essential Gene : No

Functions

Localization

Domains (AlphaFold: JAK1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878JAK1ENSG00000162434.1135.9129.7632.84ENCSR000AEF
HepG2JAK1ENSG00000162434.1125.5932.6029.09ENCSR985KAT
K562JAK1ENSG00000162434.1126.9829.6328.30ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for JAK1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • JAK1 RNA is bound by 21 proteins.  







eCLIP assay for JAK1 is not avaliable on ENCORE database.





21 proteins are bound to JAK1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr16535194565351979-3'-UTR,CDS,intron-Distal3.720394.17155HepG2BCLAF1
chr16529938565299444-3'-UTR,intron-Distal3.768076.56922K562IGF2BP1
chr16529903465299101-3'-UTR,intron-Distal4.994713.81167HepG2SUB1
chr16535196765352006-3'-UTR,intron-Distal4.021033.32022K562UCHL5
chr16535196065352006-3'-UTR,intron-Distal3.305334.45064HepG2GRWD1
chr16529960865299733-3'-UTR,intron-Distal3.689715.27876K562IGF2BP1
chr16543205165432120-5'-UTR,intron-Distal4.352795.37099K562FXR2
chr16543209565432148-5'-UTR,intron-Distal3.204283.40321HepG2GRWD1
chr16543207965432152-5'-UTR,intron-Distal4.113579.88902HepG2DDX3X
chr16543213365432176-5'-UTR,intron-Distal3.497674.30911K562FXR2
chr16543202465432079-5'-UTR,intron-Distal4.725008.90399HepG2DDX3X
chr16534895965349044-CDS,intron-Distal,intron-Proximal5.501289.52979K562FXR2
chr16532122065321272-CDS,intron-Distal3.313523.12941K562UCHL5
chr16534470765344755-CDS,intron-Distal,intron-Proximal3.559403.90826K562ZNF622
chr16533503565335084-CDS,intron-Distal3.881085.37099K562FXR2
chr16530358965303654-CDS,intron-Distal,intron-Proximal4.318085.64484HepG2PRPF8
chr16530421765304263-CDS,intron-Distal3.161093.12941K562UCHL5
chr16533500865335084-CDS,intron-Distal3.691625.80880HepG2GRWD1
chr16533049565330540-CDS,intron-Distal,intron-Proximal3.842124.93978HepG2BCLAF1
chr16531648665316579-CDS,intron-Distal,intron-Proximal4.316483.88780HepG2G3BP1
chr16533508665335197-CDS,intron-Distal,intron-Proximal3.775879.05957K562BUD13
chr16531119565311287-CDS,intron-Distal,intron-Proximal4.681665.50717HepG2G3BP1
chr16532338665323429-CDS,intron-Distal3.881553.01428K562UCHL5
chr16531643265316544-CDS,intron-Distal,intron-Proximal4.2772111.57027HepG2PRPF8
chr16533270665332797-CDS,intron-Distal4.957669.07433K562YBX3
chr16531652765316583-CDS,intron-Distal3.970993.14999HepG2GRWD1
chr16533511965335182-CDS,intron-Distal,intron-Proximal4.560864.09264K562AQR
chr16533508465335124-CDS,intron-Distal4.228653.75233K562FXR2
chr16534906165349111-CDS,intron-Distal3.076283.41665HepG2GRWD1
chr16530421265304257-CDS,intron-Distal4.805355.37137HepG2BCLAF1
chr16533269165332780-CDS,intron-Distal3.098875.66840K562ZNF622
chr16532333865323394-CDS,intron-Distal,intron-Proximal3.234813.85127HepG2GRWD1
chr16533896565339020-intron-Distal,intron-Proximal3.297173.82121HepG2RBM22
chr16542262065422711-intron-Distal4.428283.91475K562PTBP1
chr16540491965405012-intron-Distal4.139654.38266K562TARDBP
chr16542100665421089-intron-Distal3.743833.06084HepG2HNRNPK
chr16531219865312293-intron-Distal,intron-Proximal3.442173.54718K562PRPF8
chr16532660065326706-intron-Distal3.712264.77135HepG2HNRNPL
chr16541105565411225-intron-Distal4.431035.91698K562KHSRP
chr16533896165339053-intron-Distal,intron-Proximal3.986074.15711K562AQR
chr16541623265416288-intron-Distal4.030843.27946HepG2HNRNPM
chr16538288565382967-intron-Distal4.102143.34098HepG2HNRNPM
chr16539889465398966-intron-Distal3.116153.11000HepG2HNRNPM
chr16542150065421573-intron-Distal3.941715.00478HepG2PCBP2
chr16537504565375123-intron-Distal4.428283.91475K562PTBP1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for JAK1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for JAK1 is not available on ENCORE database.

  • 108 RBPs can affect the levels of JAK1.  








The Knockdown/knockout RNA-Seq assay for JAK1 is not available on ENCORE database.





108 RBPs can affect the gene expression of JAK1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
JAK1ENSG00000162434.72012.218301534.199600.391203.734202.49900HepG2AATF
JAK1ENSG00000162434.71397.522301946.00570-0.4776010.063309.05280HepG2ACO1
JAK1ENSG00000162434.73933.938202706.376000.539504.972404.28570HepG2AKAP1
JAK1ENSG00000162434.72374.650901955.221100.280303.800602.91470HepG2AKAP8L
JAK1ENSG00000162434.72898.125702239.271800.372003.021802.20140HepG2ASCC1
JAK1ENSG00000162434.73628.092202712.596600.419408.802607.69170HepG2AUH
JAK1ENSG00000162434.71344.734201756.45570-0.385302.173601.34620HepG2BCCIP
JAK1ENSG00000162434.72486.096102067.169900.266102.066401.54350HepG2BOP1
JAK1ENSG00000162434.72150.384801620.403200.408104.439502.89920HepG2BUD13
JAK1ENSG00000162434.72375.638001974.519400.266702.516201.77830HepG2CALR
JAK1ENSG00000162434.7863.188502564.47320-1.5709021.5144019.42490HepG2CNOT7
JAK1ENSG00000162434.72313.902201781.077500.377503.874202.57030HepG2CPSF7
JAK1ENSG00000162434.73225.929302270.362800.5067011.4731010.33960HepG2CELF1
JAK1ENSG00000162434.73066.380401693.022700.8568016.8953015.39330HepG2DDX21
JAK1ENSG00000162434.72713.154001726.906500.651707.214006.03420HepG2DDX55
JAK1ENSG00000162434.71532.992101990.34720-0.376703.197002.11750HepG2DDX5
JAK1ENSG00000162434.74085.596102227.101100.8753011.9319010.75650HepG2DDX6
JAK1ENSG00000162434.71557.450501861.82270-0.257502.941802.24490HepG2DKC1
JAK1ENSG00000162434.71302.722301793.92100-0.461609.987208.84030HepG2DNAJC2
JAK1ENSG00000162434.72147.912401558.791300.462403.213502.01160HepG2AGO1
JAK1ENSG00000162434.72018.113501405.804800.521505.133103.92920HepG2EIF3D
JAK1ENSG00000162434.73144.667002303.567200.448902.896302.19300HepG2EIF4B
JAK1ENSG00000162434.73260.844502408.352800.437109.715708.33000HepG2EIF4G1
JAK1ENSG00000162434.74079.926003114.414500.389507.950407.02160HepG2ETF1
JAK1ENSG00000162434.72315.066201613.244500.521006.839905.18490HepG2FASTKD2
JAK1ENSG00000162434.73064.664002184.018100.488604.144403.21790HepG2FIP1L1
JAK1ENSG00000162434.72233.244901581.851000.497406.257405.10230HepG2FUBP3
JAK1ENSG00000162434.72759.174002214.369300.317202.131801.54490HepG2G3BP1
JAK1ENSG00000162434.71766.903602374.00010-0.426102.430001.38560HepG2GRSF1
JAK1ENSG00000162434.72364.885701857.931300.348005.734704.38510HepG2HDGF
JAK1ENSG00000162434.72697.028802243.396500.265603.903802.82360HepG2HNRNPA2B1
JAK1ENSG00000162434.71867.756802181.49630-0.224002.670101.96440HepG2HNRNPF
JAK1ENSG00000162434.71803.418002223.37190-0.302004.877604.00110HepG2HNRNPL
JAK1ENSG00000162434.71770.989702018.99620-0.189101.983401.46070HepG2HNRNPU
JAK1ENSG00000162434.71818.333202148.14340-0.240502.211701.55980HepG2IGF2BP1
JAK1ENSG00000162434.72740.435302250.820700.283901.939601.36510HepG2IGF2BP2
JAK1ENSG00000162434.71608.957702500.11850-0.635904.808003.04740HepG2ILF3
JAK1ENSG00000162434.71818.929602443.81810-0.426002.918901.69050HepG2KHDRBS1
JAK1ENSG00000162434.71516.884102388.02980-0.654707.565506.49550HepG2MAGOH
JAK1ENSG00000162434.72621.572501767.460400.568708.297606.96390HepG2MSI2
JAK1ENSG00000162434.71931.990901484.176800.380303.667202.27190HepG2NAA15
JAK1ENSG00000162434.72787.314202188.801400.348602.593601.89260HepG2PABPC4
JAK1ENSG00000162434.72410.088401998.442200.270103.581202.62950HepG2PARN
JAK1ENSG00000162434.71429.942701800.78070-0.332703.998103.12820HepG2PPIL4
JAK1ENSG00000162434.72436.311001887.488300.368106.105005.00570HepG2PRPF4
JAK1ENSG00000162434.71912.569001332.464700.521305.336604.25050HepG2PRPF8
JAK1ENSG00000162434.71945.838202310.56740-0.247901.795801.30170HepG2PUF60
JAK1ENSG00000162434.72783.045702452.868700.182102.963002.35410HepG2PUM1
JAK1ENSG00000162434.73478.257502451.015300.504909.090807.90870HepG2PUM2
JAK1ENSG00000162434.72887.404902467.420200.226702.288201.71010HepG2QKI
JAK1ENSG00000162434.75277.899101892.475901.4796017.9714016.32910HepG2RAVER1
JAK1ENSG00000162434.73938.484502567.152900.6174012.6057010.98480HepG2RBM15
JAK1ENSG00000162434.74100.537102603.076200.6555017.8844016.80000HepG2RBM22
JAK1ENSG00000162434.73368.852602239.389200.589109.980808.75790HepG2RBM25
JAK1ENSG00000162434.72906.659102535.572200.197002.247701.75000HepG2NELFE
JAK1ENSG00000162434.71891.160402361.62850-0.320504.712403.93740HepG2RECQL
JAK1ENSG00000162434.71990.059002350.12140-0.239901.898301.32060HepG2RPLP0
JAK1ENSG00000162434.71842.664202575.34710-0.483003.310202.43540HepG2RPS3A
JAK1ENSG00000162434.71678.804701318.112500.348902.465901.71990HepG2RRP9
JAK1ENSG00000162434.71784.186401372.919500.377903.211002.19450HepG2SERBP1
JAK1ENSG00000162434.72662.644002032.080900.389803.882303.05830HepG2SF3B1
JAK1ENSG00000162434.74296.453002261.044600.926109.269707.84530HepG2SNRNP70
JAK1ENSG00000162434.73796.952202475.882000.6168020.2070019.17650HepG2SRSF1
JAK1ENSG00000162434.72844.563102281.467900.318105.477904.64060HepG2SRSF5
JAK1ENSG00000162434.73005.630302014.298500.5773016.7036015.55250HepG2SRSF9
JAK1ENSG00000162434.72612.361301768.473500.562703.847302.41920HepG2SUB1
JAK1ENSG00000162434.73056.008402594.555600.236103.468202.78710HepG2SUCLG1
JAK1ENSG00000162434.73210.573301719.194600.9010013.5056012.19680HepG2SUPV3L1
JAK1ENSG00000162434.71381.255402719.62830-0.977405.903104.40270HepG2TBRG4
JAK1ENSG00000162434.72595.313802044.840300.343803.306302.39700HepG2TIA1
JAK1ENSG00000162434.72541.405101961.777000.373404.769304.14940HepG2TIAL1
JAK1ENSG00000162434.72307.913301979.372900.221402.726402.16490HepG2TRIM56
JAK1ENSG00000162434.73247.963801868.205200.7978012.9256011.53390HepG2U2AF1
JAK1ENSG00000162434.71392.822501974.58270-0.503505.290604.37430HepG2UPF1
JAK1ENSG00000162434.71016.943701574.48200-0.630604.090402.86050HepG2UPF2
JAK1ENSG00000162434.72510.371901906.368900.397005.731904.92100HepG2UTP3
JAK1ENSG00000162434.71174.967801692.35590-0.526404.409003.50030HepG2XRN2
JAK1ENSG00000162434.72122.864701862.697600.188502.278501.66160HepG2ZC3H8
JAK1ENSG00000162434.73752.200402961.732900.341203.122601.81260K562ABCF1
JAK1ENSG00000162434.72565.433403291.43860-0.359506.573605.75320K562AGGF1
JAK1ENSG00000162434.72792.302303424.88620-0.294602.567601.93740K562AKAP8L
JAK1ENSG00000162434.71977.430002921.02680-0.562807.407806.52280K562AQR
JAK1ENSG00000162434.72972.231803593.52090-0.273903.332002.32220K562ATP5C1
JAK1ENSG00000162434.71893.150001600.898900.241802.732101.77720K562BCLAF1
JAK1ENSG00000162434.72243.444601656.146200.437804.122103.05380K562BOP1
JAK1ENSG00000162434.74672.634003933.465300.248302.586201.45840K562CCDC124
JAK1ENSG00000162434.73193.133302341.194600.447605.057003.33470K562CIRBP
JAK1ENSG00000162434.71949.275202844.02180-0.545003.052901.92900K562CNOT7
JAK1ENSG00000162434.72223.679601760.909400.336503.474702.59360K562CPSF6
JAK1ENSG00000162434.71158.439001403.64700-0.277003.010801.62540K562DDX27
JAK1ENSG00000162434.73198.156403685.45310-0.204602.227301.45280K562DKC1
JAK1ENSG00000162434.72801.101802316.984700.273603.457402.66730K562EIF2S2
JAK1ENSG00000162434.71326.220501580.93480-0.253502.493101.73710K562EIF3G
JAK1ENSG00000162434.71317.502501740.90360-0.402003.883702.91620K562EIF4A3
JAK1ENSG00000162434.72145.146001691.334700.342803.213301.48510K562FASTKD2
JAK1ENSG00000162434.71963.968801489.657100.398703.164001.94140K562FKBP4
JAK1ENSG00000162434.72732.269401791.778800.608608.102306.59140K562FMR1
JAK1ENSG00000162434.72037.851801518.735600.424103.587402.53480K562FTO
JAK1ENSG00000162434.71866.722701397.626200.417405.033303.16070K562FUS
JAK1ENSG00000162434.71609.594503087.61360-0.9398022.0342019.78900K562GRSF1
JAK1ENSG00000162434.72068.308202782.85750-0.428105.237703.73170K562HNRNPL
JAK1ENSG00000162434.71288.488201751.26200-0.442703.439002.39240K562HNRNPM
JAK1ENSG00000162434.7672.311101082.78540-0.687507.153604.78310K562ILF3
JAK1ENSG00000162434.73083.062203634.67720-0.237502.030001.33240K562KIF1C
JAK1ENSG00000162434.71658.379502295.74130-0.469205.738904.51450K562MAGOH
JAK1ENSG00000162434.72194.549601641.051300.419204.510003.37460K562METAP2
JAK1ENSG00000162434.75002.816304119.008000.280302.726401.60590K562MSI2
JAK1ENSG00000162434.71724.584502327.71210-0.432708.674707.31840K562MTPAP
JAK1ENSG00000162434.72475.318402042.712200.277002.261301.38140K562PCBP2
JAK1ENSG00000162434.72180.816701816.436400.263702.470701.71610K562POLR2G
JAK1ENSG00000162434.71843.290302417.01760-0.390903.574202.62240K562PPIG
JAK1ENSG00000162434.71086.740001538.57410-0.501605.071703.79790K562PSIP1
JAK1ENSG00000162434.72568.217003396.58220-0.403303.870703.24340K562PUS1
JAK1ENSG00000162434.72513.613001695.033300.568303.493401.86330K562RAVER1
JAK1ENSG00000162434.72598.621803309.42880-0.348804.841404.07730K562RBM15
JAK1ENSG00000162434.71302.574901618.39030-0.313202.632801.57950K562SAFB
JAK1ENSG00000162434.73211.030102552.012500.331303.870602.91480K562SF3A3
JAK1ENSG00000162434.72098.997701599.020300.392402.851601.86250K562SF3B1
JAK1ENSG00000162434.71501.157401821.88970-0.279402.551901.76560K562SYNCRIP
JAK1ENSG00000162434.71353.346402212.99370-0.709509.846608.38260K562TARDBP
JAK1ENSG00000162434.72628.716501721.876800.610306.301204.51010K562U2AF1
JAK1ENSG00000162434.72849.982401778.392300.6803013.8358012.02310K562U2AF2
JAK1ENSG00000162434.72052.200802742.31120-0.418208.623307.44150K562UPF1
JAK1ENSG00000162434.73357.873102541.749000.401603.258601.94770K562UTP3
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for JAK1 is not available on ENCORE database.





1 RBPs can affect the splicing of JAK1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSJAK1ENSG00000162434.7chr1-6530713365307333653071336530728465309746653099170.098000.000000.00000longerK562AQR
A3SSJAK1ENSG00000162434.7chr1-6530528565305499653052856530547865306927653070220.144000.000000.00000longerK562AQR
A3SSJAK1ENSG00000162434.7chr1-6530178065301931653017806530189865303614653037870.092000.002080.01334longerK562AQR
A3SSJAK1ENSG00000162434.7chr1-6530107865301320653010786530118965301780653019310.052000.000690.00501longerK562AQR
A3SSJAK1ENSG00000162434.7chr1-6530977865309963653097786530989865310436653105720.091000.000000.00000longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for JAK1 is not avaliable on ENCORE database.