CUL4B

General Information

Gene Name       : CUL4B
Gene ID             : ENSG00000158290.16
Essential Gene : No

Functions

Localization

Domains (AlphaFold: CUL4B)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878CUL4BENSG00000158290.1624.2519.4421.84ENCSR000AEF
HepG2CUL4BENSG00000158290.169.2822.0815.68ENCSR985KAT
K562CUL4BENSG00000158290.1624.5226.2025.36ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for CUL4B is not avaliable on ENCORE database.



Proteins bound to RNA
  • CUL4B RNA is bound by 13 proteins.  







eCLIP assay for CUL4B is not avaliable on ENCORE database.





13 proteins are bound to CUL4B RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chrX119658800119658840-3'-UTR,intron-Distal3.033663.24816K562YBX3
chrX119660263119660377-3'-UTR,intron-Distal3.672953.91115K562LIN28B
chrX119660135119660236-3'-UTR,intron-Distal,intron-Proximal3.655355.96827K562PUM2
chrX119660481119660528-3'-UTR,intron-Distal,intron-Proximal4.461075.20626K562PUM2
chrX119660564119660627-3'-UTR,CDS,intron-Distal3.857396.81385HepG2BCLAF1
chrX119694553119694654-5'-UTR,intron-Distal,intron-Proximal4.7612013.25507HepG2PCBP2
chrX119694551119694617-5'-UTR,intron-Distal,intron-Proximal3.065044.26712HepG2PTBP1
chrX119694190119694306-CDS,intron-Distal4.419188.85903K562RBM15
chrX119666276119666332-CDS,intron-Distal,intron-Proximal3.512875.56491HepG2BCLAF1
chrX119677976119678013-CDS,intron-Distal3.520695.15500HepG2BCLAF1
chrX119691787119691798-CDS,intron-Distal4.665304.78529HepG2BCLAF1
chrX119670802119670889-CDS,intron-Distal5.2461510.11393K562LIN28B
chrX119674230119674390-CDS,intron-Distal5.0337820.89795HepG2BCLAF1
chrX119677607119677655-CDS,intron-Distal3.229625.79905HepG2BCLAF1
chrX119670788119670882-CDS,intron-Distal4.4287911.87770HepG2BCLAF1
chrX119671978119672047-CDS,intron-Distal,intron-Proximal3.678079.08790HepG2BCLAF1
chrX119668335119668368-CDS,intron-Distal,intron-Proximal3.819364.51739HepG2BCLAF1
chrX119677581119677606-CDS,intron-Distal,intron-Proximal3.913019.93259HepG2BCLAF1
chrX119677599119677651-CDS,intron-Distal,intron-Proximal3.136053.08145HepG2HLTF
chrX119673121119673152-CDS,intron-Distal,intron-Proximal5.422599.44272HepG2BCLAF1
chrX119660635119660656-CDS,intron-Distal5.483109.10017HepG2BCLAF1
chrX119672546119672626-CDS,intron-Distal,intron-Proximal3.6867112.82134HepG2BCLAF1
chrX119660656119660685-CDS,intron-Distal4.6702910.13662HepG2BCLAF1
chrX119694374119694425-CDS,intron-Distal4.328134.48692K562YBX3
chrX119664084119664108-CDS,intron-Distal4.190923.43980K562ZNF622
chrX119666399119666450-CDS,intron-Distal,intron-Proximal3.446865.23038K562ZNF622
chrX119676824119676888-CDS,intron-Distal4.0689812.82496HepG2BCLAF1
chrX119666275119666317-CDS,intron-Distal,intron-Proximal4.563894.10264K562ZNF622
chrX119691823119691887-CDS,intron-Distal3.787867.23562HepG2BCLAF1
chrX119694648119694700-intron-Distal,intron-Proximal5.250504.55547K562PCBP1
chrX119684283119684424-intron-Distal5.092617.43163HepG2QKI
chrX119686988119687048-intron-Distal3.101553.28806K562KHSRP
chrX119672369119672462-intron-Distal,intron-Proximal5.162068.49499K562KHSRP
chrX119691425119691489-intron-Distal3.252834.30679K562KHSRP
chrX119670896119671016-intron-Distal,intron-Proximal4.220304.31512K562KHSRP
chrX119689219119689278-intron-Distal4.077093.90026K562KHSRP
chrX119672394119672490-intron-Distal,intron-Proximal4.996915.70555K562PRPF8
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for CUL4B is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for CUL4B is not available on ENCORE database.

  • 107 RBPs can affect the levels of CUL4B.  








The Knockdown/knockout RNA-Seq assay for CUL4B is not available on ENCORE database.





107 RBPs can affect the gene expression of CUL4B :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
CUL4BENSG00000158290.121339.399401914.56620-0.515404.291403.13730HepG2ABCF1
CUL4BENSG00000158290.122470.472003362.90690-0.444903.486202.89760HepG2AKAP1
CUL4BENSG00000158290.121156.472301660.97690-0.522309.603308.27960HepG2AKAP8L
CUL4BENSG00000158290.122177.282202782.52700-0.353902.765701.98170HepG2ASCC1
CUL4BENSG00000158290.122949.892502314.720700.349706.029905.07900HepG2AUH
CUL4BENSG00000158290.121051.793501493.66970-0.506002.741301.80860HepG2BCCIP
CUL4BENSG00000158290.122173.243402643.59100-0.282601.991801.32870HepG2CIRBP
CUL4BENSG00000158290.121444.745601652.87400-0.194202.148201.55170HepG2CKAP4
CUL4BENSG00000158290.121243.942401526.32750-0.295103.109102.02870HepG2YBX3
CUL4BENSG00000158290.121206.219502082.05420-0.7875018.5848017.21950HepG2CELF1
CUL4BENSG00000158290.121200.053901528.94040-0.349405.182004.08770HepG2DDX19B
CUL4BENSG00000158290.12937.236301414.34540-0.593606.591905.59520HepG2DDX21
CUL4BENSG00000158290.122319.937903221.41880-0.473604.503103.71970HepG2DDX3X
CUL4BENSG00000158290.12861.876401468.50040-0.768805.547004.49730HepG2DDX55
CUL4BENSG00000158290.121131.159101852.74810-0.711904.427403.20130HepG2DDX59
CUL4BENSG00000158290.121329.208301691.97200-0.348102.748301.73890HepG2DDX5
CUL4BENSG00000158290.121943.507602767.24550-0.509804.410103.64410HepG2DDX6
CUL4BENSG00000158290.12670.729601498.81000-1.1600033.3507031.21830HepG2DNAJC21
CUL4BENSG00000158290.121043.175701485.47220-0.5099010.827409.63450HepG2DNAJC2
CUL4BENSG00000158290.121110.018701611.41140-0.537705.099103.88220HepG2EEF2
CUL4BENSG00000158290.12996.210801343.39530-0.431403.475502.22730HepG2EFTUD2
CUL4BENSG00000158290.121975.851402660.24000-0.429103.776203.09060HepG2EIF2S1
CUL4BENSG00000158290.121050.192001452.74970-0.468104.830403.30970HepG2EIF2S2
CUL4BENSG00000158290.121064.604202939.88740-1.4654029.2452027.19710HepG2EIF4A3
CUL4BENSG00000158290.121157.997302862.37480-1.3056018.8807017.19880HepG2EIF4B
CUL4BENSG00000158290.123056.090502208.667300.468409.595808.21820HepG2EIF4G1
CUL4BENSG00000158290.121037.604501883.53720-0.860204.211202.84680HepG2FUS
CUL4BENSG00000158290.121890.565102966.19440-0.649808.014006.88460HepG2FXR1
CUL4BENSG00000158290.121931.151402751.59540-0.510804.698503.84120HepG2G3BP1
CUL4BENSG00000158290.122204.858802921.15140-0.405903.609802.58560HepG2G3BP2
CUL4BENSG00000158290.12696.933001164.73110-0.740908.754307.20440HepG2GEMIN5
CUL4BENSG00000158290.12961.873101609.06920-0.742303.542202.38200HepG2GNB2L1
CUL4BENSG00000158290.121430.575801849.43410-0.370502.591701.96910HepG2GPKOW
CUL4BENSG00000158290.12966.113101484.94090-0.620104.563802.76750HepG2HNRNPA0
CUL4BENSG00000158290.12976.295801513.16780-0.632208.380107.34400HepG2HNRNPA1
CUL4BENSG00000158290.12820.700701683.08540-1.0362019.6265017.94080HepG2HNRNPC
CUL4BENSG00000158290.122106.876102786.20420-0.403203.922903.10460HepG2HNRNPK
CUL4BENSG00000158290.121703.485202039.62410-0.259804.314203.48570HepG2HNRNPL
CUL4BENSG00000158290.12987.020801671.96030-0.7604019.9978018.48140HepG2HNRNPU
CUL4BENSG00000158290.121544.069402796.94200-0.8571013.0453011.70270HepG2IGF2BP2
CUL4BENSG00000158290.122098.360802813.23560-0.423002.774801.77060HepG2KHSRP
CUL4BENSG00000158290.121451.674302967.22980-1.0314017.7978016.21020HepG2MAGOH
CUL4BENSG00000158290.121649.249002983.84170-0.8554011.3666010.15070HepG2MATR3
CUL4BENSG00000158290.121094.223201565.20420-0.516405.174204.09480HepG2MSI2
CUL4BENSG00000158290.121752.855403054.13170-0.8011010.810809.60030HepG2NCBP2
CUL4BENSG00000158290.121349.554902220.15840-0.7182015.7644014.02390HepG2NOL12
CUL4BENSG00000158290.121933.183401565.006700.304702.264901.58660HepG2NSUN2
CUL4BENSG00000158290.121924.948502719.92100-0.498704.726803.79460HepG2PABPC4
CUL4BENSG00000158290.121291.832202665.53610-1.0450042.4439040.58260HepG2PCBP1
CUL4BENSG00000158290.12857.034101081.78870-0.336002.886801.62950HepG2PKM
CUL4BENSG00000158290.121021.545501491.26100-0.545808.780207.51390HepG2PPIL4
CUL4BENSG00000158290.121612.499401287.614600.324504.100403.17810HepG2PRPF4
CUL4BENSG00000158290.121833.238102712.28170-0.5651013.3205012.29960HepG2PTBP1
CUL4BENSG00000158290.121517.444902119.26180-0.481906.091305.25200HepG2PUF60
CUL4BENSG00000158290.121573.626102248.01420-0.514608.246707.11490HepG2PUM2
CUL4BENSG00000158290.122978.722901721.231800.791205.119904.17560HepG2RAVER1
CUL4BENSG00000158290.123256.970902665.942200.288802.812002.13240HepG2RBM25
CUL4BENSG00000158290.121147.641901900.17180-0.727503.162302.09850HepG2RBM27
CUL4BENSG00000158290.121707.355203018.50990-0.8221027.6249026.28190HepG2NELFE
CUL4BENSG00000158290.121878.279202811.33030-0.5818014.9879013.73180HepG2RECQL
CUL4BENSG00000158290.121169.802901506.32920-0.364802.913102.21450HepG2RPLP0
CUL4BENSG00000158290.12602.086901272.85060-1.0800021.0089019.56170HepG2RPS19
CUL4BENSG00000158290.121362.597301763.58440-0.372202.069401.37720HepG2RPS3A
CUL4BENSG00000158290.121396.136701121.116900.316402.265301.54690HepG2RRP9
CUL4BENSG00000158290.121074.481101488.97470-0.470708.572007.53050HepG2SAFB2
CUL4BENSG00000158290.12846.364301277.53600-0.594005.819704.47030HepG2SERBP1
CUL4BENSG00000158290.121607.414302151.57870-0.420702.421101.79190HepG2SF3A3
CUL4BENSG00000158290.121264.884102823.83710-1.1587051.0163049.10670HepG2SF3B4
CUL4BENSG00000158290.121742.675602031.86460-0.221503.135202.39580HepG2SLBP
CUL4BENSG00000158290.121261.045301736.43000-0.461507.775106.78180HepG2SMN1
CUL4BENSG00000158290.123095.857302508.795100.303205.614204.97010HepG2SRFBP1
CUL4BENSG00000158290.121729.836502092.35900-0.274503.826003.11120HepG2SRSF5
CUL4BENSG00000158290.121890.326802397.92640-0.343206.056505.29640HepG2SRSF9
CUL4BENSG00000158290.121798.538802178.31720-0.276403.477802.91770HepG2SSB
CUL4BENSG00000158290.122275.994102649.30250-0.219102.314701.79380HepG2TAF15
CUL4BENSG00000158290.121543.436302434.35010-0.6574011.605409.92830HepG2TIA1
CUL4BENSG00000158290.12481.148701624.74980-1.7557061.4412059.66550HepG2TIAL1
CUL4BENSG00000158290.121334.861801639.13660-0.296203.836003.19460HepG2TRIM56
CUL4BENSG00000158290.121510.209902070.28820-0.455105.861404.52720HepG2TUFM
CUL4BENSG00000158290.122037.898101654.130600.300902.366401.78100HepG2U2AF1
CUL4BENSG00000158290.121621.013001908.12200-0.235302.873702.16360HepG2UPF1
CUL4BENSG00000158290.121010.234401842.21580-0.8668025.8505024.30160HepG2UTP3
CUL4BENSG00000158290.12843.979901439.18110-0.770005.529804.51640HepG2XRN2
CUL4BENSG00000158290.123742.073703159.598100.244003.648703.01330K562AGGF1
CUL4BENSG00000158290.122699.066703567.34110-0.402404.445803.73450K562AQR
CUL4BENSG00000158290.124194.413103449.583200.281903.713902.64220K562ATP5C1
CUL4BENSG00000158290.123226.894102129.099600.599807.686806.20560K562BOP1
CUL4BENSG00000158290.122766.795103499.33270-0.338905.328703.75530K562CPEB4
CUL4BENSG00000158290.122972.124903620.73790-0.284804.291203.50470K562DDX47
CUL4BENSG00000158290.124153.812103537.825000.231502.857501.96590K562DKC1
CUL4BENSG00000158290.122307.786902703.16660-0.228102.632001.45960K562EIF2S1
CUL4BENSG00000158290.121523.693502222.25780-0.544506.398605.20420K562EIF3G
CUL4BENSG00000158290.121745.073302571.02720-0.559107.430206.09050K562EIF4A3
CUL4BENSG00000158290.121751.403902315.40020-0.402704.993303.37260K562EIF4B
CUL4BENSG00000158290.122876.224602303.362600.320302.743801.89330K562FMR1
CUL4BENSG00000158290.121883.155002673.76920-0.505709.820908.76220K562FXR1
CUL4BENSG00000158290.124248.872202813.741400.594503.058302.30860K562G3BP2
CUL4BENSG00000158290.122151.315703179.39400-0.563508.391507.06260K562GRSF1
CUL4BENSG00000158290.121146.217801836.67840-0.680206.055905.20670K562HNRNPC
CUL4BENSG00000158290.122531.494503272.21990-0.370304.200602.87030K562HNRNPL
CUL4BENSG00000158290.122141.454102580.97180-0.269303.041702.10740K562HNRNPU
CUL4BENSG00000158290.124705.352303489.085600.431404.792803.65280K562KIF1C
CUL4BENSG00000158290.122263.886903369.40320-0.573707.928306.47690K562MAGOH
CUL4BENSG00000158290.122382.808903362.75700-0.497006.059904.62100K562MATR3
CUL4BENSG00000158290.122015.634502375.13660-0.236803.098902.24560K562MTPAP
CUL4BENSG00000158290.123927.237802739.683300.519402.620201.76540K562NAA15
CUL4BENSG00000158290.123564.995604718.69960-0.404504.723302.74430K562NOL12
CUL4BENSG00000158290.122247.006102789.57620-0.312002.551901.76940K562PPIG
CUL4BENSG00000158290.121957.706801568.412500.319802.482801.77170K562PRPF8
CUL4BENSG00000158290.122161.246003273.49320-0.599008.969707.81770K562PTBP1
CUL4BENSG00000158290.124188.768104905.17260-0.227802.895301.91430K562PUM2
CUL4BENSG00000158290.124619.503803260.524000.502506.296405.51620K562PUS1
CUL4BENSG00000158290.124213.318103176.867600.407306.936806.02580K562RBM15
CUL4BENSG00000158290.122164.474303139.56900-0.536505.884704.60070K562RBM22
CUL4BENSG00000158290.121760.619502454.64330-0.479403.600902.44230K562RPS3
CUL4BENSG00000158290.123014.783502604.066600.211202.450101.67980K562SF3A3
CUL4BENSG00000158290.122068.964102925.94940-0.500008.106906.59930K562SF3B4
CUL4BENSG00000158290.121660.753502667.93760-0.6839023.1853020.90430K562SRPK2
CUL4BENSG00000158290.121668.018502369.99240-0.506705.171003.65230K562SRSF4
CUL4BENSG00000158290.122088.288103247.99310-0.637207.949406.67240K562TARDBP
CUL4BENSG00000158290.122105.448203132.97700-0.573408.198806.67910K562TIA1
CUL4BENSG00000158290.12918.973901583.88810-0.785407.482605.88500K562TIAL1
CUL4BENSG00000158290.123203.516702697.029000.248203.321201.92140K562TROVE2
CUL4BENSG00000158290.122090.122601607.293100.378903.243802.13710K562UCHL5
CUL4BENSG00000158290.123244.403402798.065800.213402.949402.20740K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for CUL4B is not available on ENCORE database.





8 RBPs can affect the splicing of CUL4B :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SECUL4BENSG00000158290.12chrX-119673122119673227119672514119672625119674224119674417-0.230000.000000.00000excludedK562SF3B4
SECUL4BENSG00000158290.12chrX-119678335119678498119677968119678058119679298119679372-0.083000.002600.03120excludedHepG2U2AF2
SECUL4BENSG00000158290.12chrX-119673122119673227119672514119672625119674224119674417-0.117000.000000.00000excludedK562PUS1
SECUL4BENSG00000158290.12chrX-119673122119673227119672514119672625119674224119674417-0.231000.000000.00000excludedK562U2AF1
SECUL4BENSG00000158290.12chrX-119673122119673227119672514119672625119674224119674417-0.087000.000000.00001excludedK562UTP18
SECUL4BENSG00000158290.12chrX-119673122119673227119672514119672625119674224119674417-0.264000.000000.00000excludedK562U2AF2
SECUL4BENSG00000158290.12chrX-119673122119673227119672514119672625119674224119674417-0.088000.000000.00001excludedK562RBM15
SECUL4BENSG00000158290.12chrX-119673122119673227119672514119672625119674224119674417-0.056000.000070.00337excludedK562AGGF1
A3SSCUL4BENSG00000158290.12chrX-1196809901196812131196809901196810941196917781196918940.105000.000000.00001longerK562AQR
A3SSCUL4BENSG00000158290.12chrX-1196639561196642031196639561196641091196662761196664490.076000.000000.00000longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for CUL4B is not avaliable on ENCORE database.