PSMB4

General Information

Gene Name       : PSMB4
Gene ID             : ENSG00000159377.10
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: PSMB4)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PSMB4ENSG00000159377.10179.64292.12235.88ENCSR000AEF
HepG2PSMB4ENSG00000159377.10281.10261.21271.15ENCSR985KAT
K562PSMB4ENSG00000159377.10403.85382.34393.10ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PSMB4 is not avaliable on ENCORE database.



Proteins bound to RNA
  • PSMB4 RNA is bound by 18 proteins.  







eCLIP assay for PSMB4 is not avaliable on ENCORE database.





18 proteins are bound to PSMB4 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr1151374339151374398+3'-UTR3.184566.21391K562PUM2
chr1151374307151374340+3'-UTR5.980238.90713K562RPS3
chr1151374303151374335+3'-UTR3.309433.75245K562BUD13
chr1151374312151374346+3'-UTR4.4517414.79781K562PABPC4
chr1151374346151374386+3'-UTR3.9655112.14680K562PABPC4
chr1151374299151374312+3'-UTR,CDS4.465408.77854K562PABPC4
chr1151374292151374387+3'-UTR,CDS,intron-Proximal4.253407.96199K562APOBEC3C
chr1151374297151374380+3'-UTR,CDS6.0019611.71673HepG2SUB1
chr1151374016151374041+CDS,intron-Proximal4.380475.01572HepG2SUB1
chr1151373713151373743+CDS,intron-Proximal3.714978.23581K562RPS3
chr1151372661151372784+CDS,intron-Distal,intron-Proximal7.6869846.10951K562AQR
chr1151372504151372595+CDS3.776326.30471HepG2G3BP1
chr1151372466151372486+CDS4.669017.45481K562RPS3
chr1151373251151373322+CDS,intron-Proximal4.5871313.85045HepG2RPS3
chr1151372464151372554+CDS3.515033.84718K562METAP2
chr1151372917151372977+CDS,intron-Proximal3.891555.16259K562LIN28B
chr1151373673151373731+CDS,intron-Proximal5.4089813.75908K562AQR
chr1151373260151373300+CDS4.039193.04123K562LIN28B
chr1151373713151373807+CDS,intron-Proximal3.930399.87480HepG2G3BP1
chr1151372139151372180+CDS3.747939.04477K562RPS3
chr1151372864151372953+CDS,intron-Proximal5.7830329.77777K562AQR
chr1151374017151374038+CDS,intron-Proximal4.228514.30926HepG2LARP4
chr1151372854151372953+CDS,intron-Proximal3.322079.93659K562BUD13
chr1151372500151372578+CDS4.178789.14318HepG2RPS3
chr1151372566151372613+CDS4.8625210.22224K562RPS3
chr1151372180151372204+CDS,intron-Proximal6.268439.64515K562RPS3
chr1151372147151372205+CDS,intron-Proximal3.937718.63182HepG2RPS3
chr1151374028151374091+CDS3.827955.41973HepG2G3BP1
chr1151372917151372992+CDS,intron-Proximal4.102895.69815HepG2G3BP1
chr1151372070151372147+CDS3.3887015.00096HepG2RPS3
chr1151373686151373722+CDS,intron-Proximal3.422563.81059HepG2AQR
chr1151373714151373724+CDS,intron-Proximal5.125335.44904HepG2RPS3
chr1151374017151374046+CDS,intron-Proximal3.366869.83933K562YBX3
chr1151373742151373776+CDS4.318844.75480HepG2RPS3
chr1151373730151373783+CDS4.9048016.02911K562LIN28B
chr1151373249151373322+CDS,intron-Proximal3.743367.98704HepG2G3BP1
chr1151373269151373322+CDS,intron-Proximal4.5370825.39190K562RPS3
chr1151373714151373780+CDS,intron-Proximal5.600419.06173HepG2LIN28B
chr1151373818151373832+CDS,intron-Proximal4.139464.10177HepG2SUB1
chr1151373406151373498+intron-Distal,intron-Proximal4.226855.12007K562DDX42
chr1151373450151373496+intron-Distal4.609224.84906K562U2AF1
chr1151372756151372792+intron-Distal,intron-Proximal3.777735.28701K562PRPF8
chr1151373393151373494+intron-Distal,intron-Proximal3.299394.86939K562EFTUD2
chr1151373455151373503+intron-Distal3.720045.37381K562TIA1
chr1151373448151373499+intron-Distal3.114145.25094K562PRPF8
chr1151373463151373487+intron-Distal5.342336.22530K562AQR
chr1151373116151373160+intron-Proximal4.074763.19904K562TIA1
chr1151372854151372917+intron-Proximal3.541974.57435K562SF3B4
chr1151373674151373686+intron-Proximal3.958763.25089HepG2AQR
chr1151372663151372720+intron-Proximal5.074997.23427HepG2AQR
chr1151373831151373846+intron-Proximal4.091778.29266K562AQR
chr1151373851151373878+intron-Proximal4.9244110.60410K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PSMB4 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PSMB4 is not available on ENCORE database.

  • 96 RBPs can affect the levels of PSMB4.  








The Knockdown/knockout RNA-Seq assay for PSMB4 is not available on ENCORE database.





96 RBPs can affect the gene expression of PSMB4 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PSMB4ENSG00000159377.62310.656102021.356000.192902.291401.72840HepG2ACO1
PSMB4ENSG00000159377.61586.075601991.95440-0.328702.325901.50410HepG2BCLAF1
PSMB4ENSG00000159377.61542.218801211.061500.348602.815502.21200HepG2BOP1
PSMB4ENSG00000159377.64045.236203098.623700.384503.515202.65020HepG2CIRBP
PSMB4ENSG00000159377.61982.492103123.67170-0.6559017.2098015.87980HepG2CELF1
PSMB4ENSG00000159377.61364.391801558.79680-0.192201.898401.33970HepG2DNAJC2
PSMB4ENSG00000159377.62222.140203118.10520-0.488704.799104.03010HepG2EIF2S1
PSMB4ENSG00000159377.62788.467503313.57740-0.248903.400302.48720HepG2EIF4G1
PSMB4ENSG00000159377.61489.992201884.09370-0.338603.030202.21070HepG2FUBP3
PSMB4ENSG00000159377.62431.789603225.20150-0.407403.267602.54820HepG2G3BP1
PSMB4ENSG00000159377.62665.034303424.07100-0.361603.050802.11650HepG2G3BP2
PSMB4ENSG00000159377.61010.978301260.27070-0.318001.868501.33520HepG2GPKOW
PSMB4ENSG00000159377.61250.062501587.90870-0.345102.888002.22830HepG2HNRNPA1
PSMB4ENSG00000159377.62520.088903265.99840-0.374003.564402.77730HepG2HNRNPK
PSMB4ENSG00000159377.63576.382703059.530900.225103.938703.14550HepG2HNRNPL
PSMB4ENSG00000159377.62396.687803278.31790-0.451904.171503.35750HepG2IGF2BP2
PSMB4ENSG00000159377.62551.103103297.48170-0.370202.254901.36210HepG2KHSRP
PSMB4ENSG00000159377.61620.010901847.66720-0.189702.220001.30450HepG2KIF1C
PSMB4ENSG00000159377.62759.938003478.05870-0.333602.499401.87510HepG2MAGOH
PSMB4ENSG00000159377.62661.367903579.86510-0.427703.668202.94300HepG2NCBP2
PSMB4ENSG00000159377.6854.344301066.45990-0.319901.991901.35210HepG2NSUN2
PSMB4ENSG00000159377.62419.636203188.00950-0.397903.294502.51020HepG2PABPC4
PSMB4ENSG00000159377.62547.490003236.10920-0.345206.415605.55090HepG2PCBP1
PSMB4ENSG00000159377.61251.621301738.56950-0.474104.326403.34130HepG2PRPF8
PSMB4ENSG00000159377.61969.107203292.78360-0.7418024.2831022.96860HepG2PTBP1
PSMB4ENSG00000159377.62260.182003179.24750-0.492206.732105.85630HepG2PUF60
PSMB4ENSG00000159377.62115.791903566.33320-0.7532019.7969018.33890HepG2QKI
PSMB4ENSG00000159377.63762.331403256.250100.208302.434601.94000HepG2RBM22
PSMB4ENSG00000159377.62048.735503236.61340-0.6598012.2165010.86120HepG2RBM25
PSMB4ENSG00000159377.62412.573103664.61730-0.6031017.4711016.33580HepG2NELFE
PSMB4ENSG00000159377.62203.817003412.97470-0.6310019.0729017.69780HepG2RECQL
PSMB4ENSG00000159377.61818.463202285.78210-0.330002.497801.73510HepG2RPS2
PSMB4ENSG00000159377.61410.466401833.13380-0.378102.118601.41810HepG2RPS3A
PSMB4ENSG00000159377.61299.920701719.77430-0.403802.986702.17350HepG2RRP9
PSMB4ENSG00000159377.62464.122801813.278700.442402.583201.93110HepG2SF3A3
PSMB4ENSG00000159377.62293.363703428.35350-0.5801016.2665015.01310HepG2SF3B4
PSMB4ENSG00000159377.62558.000003048.40260-0.253004.353403.50220HepG2SLBP
PSMB4ENSG00000159377.62816.941303578.40140-0.345207.086806.41290HepG2SRSF1
PSMB4ENSG00000159377.62687.360203139.04370-0.224102.937702.29320HepG2SRSF5
PSMB4ENSG00000159377.61742.683901973.48040-0.179402.049001.44000HepG2SRSF7
PSMB4ENSG00000159377.61913.491302911.17070-0.6054018.1109016.92470HepG2SRSF9
PSMB4ENSG00000159377.62292.409203216.24730-0.488509.314808.38240HepG2TAF15
PSMB4ENSG00000159377.6874.212101172.38460-0.423403.487302.68420HepG2TARDBP
PSMB4ENSG00000159377.62092.409502955.46220-0.498207.742306.36090HepG2TIA1
PSMB4ENSG00000159377.61487.788401720.08090-0.209302.170101.65850HepG2TRIM56
PSMB4ENSG00000159377.62530.412503105.99000-0.295702.983402.07130HepG2TUFM
PSMB4ENSG00000159377.62273.048703287.64150-0.532404.968403.82420HepG2UBE2L3
PSMB4ENSG00000159377.61212.686101608.09970-0.407206.772305.75870HepG2UPF1
PSMB4ENSG00000159377.61967.954901552.559100.341905.331704.54530HepG2UTP3
PSMB4ENSG00000159377.61152.273301742.10610-0.596304.047802.51490HepG2XRCC5
PSMB4ENSG00000159377.63052.467501768.603700.7873035.8913034.49990HepG2ZNF622
PSMB4ENSG00000159377.64279.688002561.946200.7402027.7199026.02600K562AGGF1
PSMB4ENSG00000159377.63584.267702815.203700.348303.585102.43060K562AKAP8
PSMB4ENSG00000159377.64002.117502665.824200.586109.003807.74900K562AKAP8L
PSMB4ENSG00000159377.63348.742302797.096900.259603.112902.14070K562ATP5C1
PSMB4ENSG00000159377.63037.442203623.01400-0.254304.065602.88520K562BCLAF1
PSMB4ENSG00000159377.61310.435501755.49960-0.421803.699202.44390K562CCAR1
PSMB4ENSG00000159377.61551.367401967.48370-0.342803.618002.72240K562CPSF6
PSMB4ENSG00000159377.62304.831002748.59600-0.254002.681201.64070K562CSTF2
PSMB4ENSG00000159377.65929.681007488.46910-0.336704.938003.62610K562CELF1
PSMB4ENSG00000159377.62879.480503379.27190-0.230902.742901.53590K562DDX21
PSMB4ENSG00000159377.62861.440703474.05770-0.279904.229903.44730K562DDX47
PSMB4ENSG00000159377.61490.805401965.19810-0.398603.381801.89850K562DHX30
PSMB4ENSG00000159377.63538.945202868.599100.302904.238803.12230K562DKC1
PSMB4ENSG00000159377.61417.271601887.78920-0.413603.934002.31160K562DNAJC21
PSMB4ENSG00000159377.62257.836503108.31340-0.461205.073003.81760K562EFTUD2
PSMB4ENSG00000159377.61164.005101785.67970-0.617404.034502.79410K562EIF3A
PSMB4ENSG00000159377.62318.306701984.745700.224002.034501.34380K562EIF3G
PSMB4ENSG00000159377.63129.180302349.558100.413304.464903.36900K562FIP1L1
PSMB4ENSG00000159377.61910.618102400.79150-0.329502.412001.37160K562FKBP4
PSMB4ENSG00000159377.61302.166901696.73620-0.381802.824101.89990K562FTO
PSMB4ENSG00000159377.64120.663102751.220700.5827015.0524013.75410K562FXR1
PSMB4ENSG00000159377.61080.840901947.56250-0.849508.913407.49810K562G3BP2
PSMB4ENSG00000159377.67338.112205966.377300.298503.358702.52820K562GRSF1
PSMB4ENSG00000159377.63418.221404306.39970-0.333203.874702.60610K562HNRNPA1
PSMB4ENSG00000159377.61789.532802763.70510-0.6270010.568009.46270K562HNRNPC
PSMB4ENSG00000159377.61995.528402468.38910-0.306802.768301.62450K562HNRNPF
PSMB4ENSG00000159377.62890.796301932.678500.580806.143404.68100K562HNRNPM
PSMB4ENSG00000159377.63859.140904769.23430-0.305504.182703.07620K562HNRNPU
PSMB4ENSG00000159377.64166.052003185.314700.387104.060603.10290K562HSPD1
PSMB4ENSG00000159377.61257.812401772.60540-0.495004.766002.82260K562KHDRBS1
PSMB4ENSG00000159377.63565.095702829.095300.333503.310202.39920K562KIF1C
PSMB4ENSG00000159377.63854.103203169.302800.282102.670501.78130K562MBNL1
PSMB4ENSG00000159377.61363.197601833.59410-0.427704.451103.32130K562METAP2
PSMB4ENSG00000159377.65360.934706491.45720-0.276102.390201.34410K562MSI2
PSMB4ENSG00000159377.63195.692602221.452600.524504.195103.04360K562NAA15
PSMB4ENSG00000159377.62882.987203221.77370-0.160302.498501.78560K562NSUN2
PSMB4ENSG00000159377.63399.847601948.454800.803004.421603.09270K562PABPN1
PSMB4ENSG00000159377.62072.742402806.88840-0.437404.654503.37940K562PCBP2
PSMB4ENSG00000159377.62685.000603422.35820-0.350102.687101.86860K562PCBP3
PSMB4ENSG00000159377.63806.980802667.405700.513106.369305.03530K562PPIG
PSMB4ENSG00000159377.63703.487503065.418100.272702.547101.90570K562PTBP1
PSMB4ENSG00000159377.65891.486106925.00660-0.233203.156802.13350K562PUM2
PSMB4ENSG00000159377.66060.786802643.745001.1968016.0042014.73920K562PUS1
PSMB4ENSG00000159377.63950.392702575.948700.6168014.4953013.12770K562RBM15
PSMB4ENSG00000159377.62177.631103080.92350-0.500604.447803.40880K562RPS19
PSMB4ENSG00000159377.61508.247901933.65570-0.358503.050301.71950K562SLBP
PSMB4ENSG00000159377.62363.833502988.09050-0.338104.072302.21670K562SRSF9
PSMB4ENSG00000159377.61693.722202047.27530-0.273503.139601.75590K562SSB
PSMB4ENSG00000159377.62299.273002928.38760-0.348902.558801.58550K562SUPV3L1
PSMB4ENSG00000159377.63353.088702632.987600.348704.393203.35330K562SYNCRIP
PSMB4ENSG00000159377.62185.867003099.45040-0.503805.577904.08440K562UCHL5
PSMB4ENSG00000159377.62899.864503416.11040-0.236403.553702.74720K562UPF1
PSMB4ENSG00000159377.62453.727602923.06530-0.252502.276701.48160K562WDR3
PSMB4ENSG00000159377.62413.978603156.28470-0.386803.476302.06530K562XRN2
PSMB4ENSG00000159377.64796.808206557.39190-0.451006.043004.68610K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PSMB4 is not available on ENCORE database.





14 RBPs can affect the splicing of PSMB4 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
RIPSMB4ENSG00000159377.6chr1+1513737141513741061513737141513738311513740171513741060.085000.000000.00000includedK562SF3B4
RIPSMB4ENSG00000159377.6chr1+1513737141513741061513737141513738311513740171513741060.130000.000000.00000includedK562PUS1
RIPSMB4ENSG00000159377.6chr1+1513737141513741061513737141513738311513740171513741060.070000.000000.00000includedK562AGGF1
RIPSMB4ENSG00000159377.6chr1+1513737141513741061513737141513738311513740171513741060.093000.000000.00000includedK562PRPF8
RIPSMB4ENSG00000159377.6chr1+1513737141513741061513737141513738311513740171513741060.058000.000000.00000includedK562RBM22
RIPSMB4ENSG00000159377.6chr1+1513737141513741061513737141513738311513740171513741060.091000.000000.00000includedK562AKAP8L
RIPSMB4ENSG00000159377.6chr1+1513737141513741061513737141513738311513740171513741060.079000.000000.00000includedK562RBM15
RIPSMB4ENSG00000159377.6chr1+1513737141513741061513737141513738311513740171513741060.087000.000000.00000includedK562U2AF1
RIPSMB4ENSG00000159377.6chr1+1513737141513741061513737141513738311513740171513741060.114000.000000.00000includedK562U2AF2
RIPSMB4ENSG00000159377.6chr1+1513737141513741061513737141513738311513740171513741060.088000.000000.00000includedK562UTP18
RIPSMB4ENSG00000159377.6chr1+1513737141513741061513737141513738311513740171513741060.095000.000000.00000includedK562EFTUD2
RIPSMB4ENSG00000159377.6chr1+1513737141513741061513737141513738311513740171513741060.269000.000000.00000includedK562AQR
MXEPSMB4ENSG00000159377.6chr1+151373239151373321151373714151373831151372917151373064151374017151374106-0.085000.000610.058202includedK562ZNF800
MXEPSMB4ENSG00000159377.6chr1+151373239151373321151373714151373831151372917151373064151374017151374106-0.085000.000570.024622includedK562DDX55

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PSMB4 is not avaliable on ENCORE database.