NEDD4

General Information

Gene Name       : NEDD4
Gene ID             : ENSG00000069869.16
Essential Gene : No

Functions

Localization

Domains (AlphaFold: NEDD4)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878NEDD4ENSG00000069869.164.514.034.27ENCSR000AEF
HepG2NEDD4ENSG00000069869.166.3012.999.64ENCSR985KAT
K562NEDD4ENSG00000069869.1613.5315.9414.73ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
NEDD4HepG2CRISPRBGHcLV41-87,BGHcLV41-88BGHcLV41-1,BGHcLV41-20.0,0.0NotSatisfiedENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for NEDD4 is not avaliable on ENCORE database.



Proteins bound to RNA
  • NEDD4 RNA is bound by 13 proteins.  







eCLIP assay for NEDD4 is not avaliable on ENCORE database.





13 proteins are bound to NEDD4 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr155615511056155203-3'-UTR,CDS,intron-Distal,intron-Proximal5.242597.04013HepG2BCLAF1
chr155612628356126342-3'-UTR,CDS,intron-Distal,intron-Proximal3.650844.51739HepG2BCLAF1
chr155613412956134312-3'-UTR,CDS,intron-Distal,intron-Proximal3.534195.52031HepG2GRWD1
chr155615520556155276-3'-UTR,CDS,intron-Distal,intron-Proximal4.603135.24929K562ZNF622
chr155621683856216896-3'-UTR,CDS,intron-Distal,intron-Proximal3.333623.07653K562ZNF622
chr155613265256132716-3'-UTR,CDS,intron-Distal,intron-Proximal3.158663.58206K562LIN28B
chr155614469656144742-3'-UTR,CDS,intron-Distal,intron-Proximal3.559403.95301K562ZNF622
chr155613423456134292-3'-UTR,CDS,intron-Distal4.128153.11168K562ZNF622
chr155613417856134295-3'-UTR,CDS,intron-Distal4.318783.36385K562UCHL5
chr155614056356140629-3'-UTR,CDS,intron-Distal,intron-Proximal3.395613.61259K562ZNF622
chr155615260656152664-3'-UTR,CDS,intron-Distal3.008143.55800HepG2BCLAF1
chr155621683256216876-3'-UTR,CDS,intron-Distal,intron-Proximal3.630114.09885HepG2BCLAF1
chr155620901356209059-5'-UTR,CDS,intron-Distal4.039733.55983HepG2HLTF
chr155628570756285821-5'-UTR,CDS,intron-Distal,intron-Proximal4.213724.52089HepG2NCBP2
chr155625867056258726-CDS,intron-Distal,intron-Proximal4.463084.10264K562ZNF622
chr155620591256206048-intron-Distal4.162204.37030K562KHSRP
chr155617637556176471-intron-Distal4.346024.78128HepG2SUGP2
chr155617981656179884-intron-Distal3.465794.02190K562EXOSC5
chr155614565856145688-intron-Distal6.038076.37906K562DDX42
chr155620013956200273-intron-Distal3.909933.08314K562TARDBP
chr155617980956179905-intron-Distal3.651734.33009HepG2SUGP2
chr155621424756214324-intron-Distal3.731485.14864K562KHSRP
chr155621391756214018-intron-Distal3.285923.46531K562KHSRP
chr155614565956145677-intron-Distal5.9644816.48436HepG2SF3B4
chr155614567956145688-intron-Distal5.9644816.48436HepG2SF3B4
chr155621417756214247-intron-Distal3.820136.19377K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for NEDD4 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for NEDD4 is not available on ENCORE database.

  • 93 RBPs can affect the levels of NEDD4.  








The Knockdown/knockout RNA-Seq assay for NEDD4 is not available on ENCORE database.





93 RBPs can affect the gene expression of NEDD4 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
NEDD4ENSG00000069869.11846.82500600.625500.495504.084802.80590HepG2AATF
NEDD4ENSG00000069869.11421.76500666.65150-0.660505.730004.36290HepG2ADAR
NEDD4ENSG00000069869.111972.375901134.499500.7978010.623009.15540HepG2ASCC1
NEDD4ENSG00000069869.111308.082801049.133200.318203.584802.82020HepG2AUH
NEDD4ENSG00000069869.11403.14500668.26280-0.729104.950303.69330HepG2BCCIP
NEDD4ENSG00000069869.111072.45950811.962400.401303.667102.79640HepG2CALR
NEDD4ENSG00000069869.11792.49170653.637400.277802.481401.84460HepG2CKAP4
NEDD4ENSG00000069869.11378.49130848.26520-1.164305.779204.67500HepG2CNOT7
NEDD4ENSG00000069869.11528.90840683.63980-0.370202.975701.91970HepG2YBX3
NEDD4ENSG00000069869.111023.19800827.650400.305902.619101.99170HepG2CELF1
NEDD4ENSG00000069869.11409.56270662.91340-0.694706.730305.72040HepG2DDX21
NEDD4ENSG00000069869.11330.49220497.79520-0.590903.535901.95740HepG2DDX28
NEDD4ENSG00000069869.111625.53660815.715100.994707.579306.00140HepG2DDX59
NEDD4ENSG00000069869.11875.25910671.290600.382703.662402.85950HepG2DNAJC21
NEDD4ENSG00000069869.11481.24820665.35200-0.467304.120803.35610HepG2DNAJC2
NEDD4ENSG00000069869.11852.24370610.277300.481702.858901.73230HepG2AGO1
NEDD4ENSG00000069869.11652.969601084.67080-0.732207.412706.47730HepG2EIF2S1
NEDD4ENSG00000069869.11892.22480625.205000.513005.188003.61570HepG2EIF2S2
NEDD4ENSG00000069869.11828.534001167.01690-0.494202.869302.16930HepG2EIF4B
NEDD4ENSG00000069869.111233.49650877.985300.490406.639705.44360HepG2EIF4G1
NEDD4ENSG00000069869.111239.89740832.103900.575304.258903.32050HepG2FIP1L1
NEDD4ENSG00000069869.11836.657301209.26530-0.531404.518403.64930HepG2FXR1
NEDD4ENSG00000069869.111154.41940814.329400.503403.826103.08390HepG2GPKOW
NEDD4ENSG00000069869.11758.73230624.158400.281602.384301.47070HepG2HDGF
NEDD4ENSG00000069869.11516.37750677.72160-0.392302.655902.02080HepG2HNRNPA1
NEDD4ENSG00000069869.11967.21110753.836400.359502.139601.52060HepG2HNRNPC
NEDD4ENSG00000069869.11845.535601135.72630-0.425703.311102.54910HepG2HNRNPK
NEDD4ENSG00000069869.111275.15240777.125700.714308.108207.09400HepG2HNRNPLL
NEDD4ENSG00000069869.11908.85750748.852700.279302.475601.90120HepG2HNRNPU
NEDD4ENSG00000069869.11584.143801039.33970-0.831306.900504.94950HepG2KRR1
NEDD4ENSG00000069869.11848.628101156.87410-0.447002.724401.90130HepG2LARP4
NEDD4ENSG00000069869.11856.748501209.68640-0.497703.902003.12390HepG2MAGOH
NEDD4ENSG00000069869.11830.475701216.49630-0.550704.245403.47980HepG2MATR3
NEDD4ENSG00000069869.11886.98350673.578800.397003.258802.38380HepG2MSI2
NEDD4ENSG00000069869.11928.364201245.18360-0.423602.937902.28670HepG2NCBP2
NEDD4ENSG00000069869.11876.77890689.039600.347502.216901.54500HepG2NSUN2
NEDD4ENSG00000069869.111415.521901109.064300.351902.349301.67960HepG2PABPC4
NEDD4ENSG00000069869.11479.268301061.11990-1.1467029.5269027.90510HepG2PCBP1
NEDD4ENSG00000069869.11539.00490667.91740-0.309402.257201.58470HepG2PPIL4
NEDD4ENSG00000069869.111075.77510687.790700.6452010.714309.33550HepG2PRPF4
NEDD4ENSG00000069869.11909.13260506.937900.842609.167907.79430HepG2PRPF8
NEDD4ENSG00000069869.11488.91770796.57220-0.704203.260301.33940HepG2PSIP1
NEDD4ENSG00000069869.111244.33010842.461500.562603.622802.95240HepG2PUF60
NEDD4ENSG00000069869.111536.42550894.265000.7807022.2696020.91840HepG2PUM1
NEDD4ENSG00000069869.11888.61310665.882200.416204.989204.20560HepG2PUS1
NEDD4ENSG00000069869.11856.037301169.39960-0.450005.119004.30950HepG2QKI
NEDD4ENSG00000069869.111270.98970881.616100.527606.744705.48200HepG2RBM15
NEDD4ENSG00000069869.11932.044101201.62780-0.366504.227303.58410HepG2NELFE
NEDD4ENSG00000069869.11883.028601119.11520-0.341803.751803.04890HepG2RECQL
NEDD4ENSG00000069869.11345.06940510.14900-0.564004.229803.48470HepG2RPS19
NEDD4ENSG00000069869.11913.52410501.476100.865208.755107.46050HepG2RRP9
NEDD4ENSG00000069869.11500.08840666.88860-0.415304.090803.33420HepG2SAFB2
NEDD4ENSG00000069869.11974.99060807.696800.271502.424201.76150HepG2SLBP
NEDD4ENSG00000069869.11557.97170777.70840-0.479006.320005.41090HepG2SMN1
NEDD4ENSG00000069869.111868.76640855.889401.1265011.8689010.26430HepG2SNRNP70
NEDD4ENSG00000069869.111508.074001137.095600.407306.750806.06390HepG2SRFBP1
NEDD4ENSG00000069869.111380.486901173.357400.234402.157101.72520HepG2SRSF1
NEDD4ENSG00000069869.111364.34700954.572900.515209.019008.12480HepG2SRSF9
NEDD4ENSG00000069869.111083.44400703.274200.623403.868002.43690HepG2SUB1
NEDD4ENSG00000069869.111684.95040654.084901.3651023.4152021.79130HepG2SUPV3L1
NEDD4ENSG00000069869.111078.71430757.344000.510204.381003.49610HepG2TARDBP
NEDD4ENSG00000069869.11634.966201017.71930-0.680602.521201.49820HepG2TBRG4
NEDD4ENSG00000069869.11599.26190727.66390-0.280101.850601.42380HepG2TIAL1
NEDD4ENSG00000069869.111331.97400711.883900.9038012.5101011.14130HepG2U2AF1
NEDD4ENSG00000069869.111595.93150871.058400.873509.721108.11200HepG2UBE2L3
NEDD4ENSG00000069869.11307.53040599.01600-0.961906.351704.78750HepG2UPF2
NEDD4ENSG00000069869.11441.38070643.87400-0.544803.288402.50290HepG2XRN2
NEDD4ENSG00000069869.111032.21210678.788000.604606.273005.32860HepG2ZC3H8
NEDD4ENSG00000069869.111403.46880867.469900.6940017.9472016.85600HepG2ZNF622
NEDD4ENSG00000069869.111224.076101854.47910-0.599305.921005.14030K562AGGF1
NEDD4ENSG00000069869.111501.749902037.61710-0.440204.918003.51770K562AKAP8
NEDD4ENSG00000069869.11966.310201929.62650-0.9978020.0217017.94170K562AKAP8L
NEDD4ENSG00000069869.11652.079401186.48110-0.8636011.6455010.56280K562AQR
NEDD4ENSG00000069869.111375.753702024.56130-0.5574010.355308.45500K562ATP5C1
NEDD4ENSG00000069869.111728.365102216.34420-0.358804.386002.86260K562CCDC124
NEDD4ENSG00000069869.11741.798201166.17580-0.652703.684902.42690K562CNOT7
NEDD4ENSG00000069869.111004.313001186.76210-0.240802.280901.68000K562DDX47
NEDD4ENSG00000069869.111766.535902076.68640-0.233402.488201.66380K562DKC1
NEDD4ENSG00000069869.111634.09100795.278901.0389028.8890027.00720K562EIF2S2
NEDD4ENSG00000069869.11560.55770814.86480-0.539703.861102.93000K562EIF3G
NEDD4ENSG00000069869.11494.33710624.41290-0.337002.433801.37330K562EIF4B
NEDD4ENSG00000069869.111335.33600792.859200.752006.735905.52670K562G3BP2
NEDD4ENSG00000069869.11735.630001059.74990-0.526704.158903.23530K562GRSF1
NEDD4ENSG00000069869.11498.76590734.71580-0.558803.869002.75650K562HNRNPM
NEDD4ENSG00000069869.112322.756401210.869500.9397017.3057015.44060K562HSPD1
NEDD4ENSG00000069869.111394.069002047.96690-0.554907.408005.89450K562KIF1C
NEDD4ENSG00000069869.111868.044802294.21920-0.296503.170702.18570K562MBNL1
NEDD4ENSG00000069869.11587.96030775.15990-0.398802.975402.06500K562METAP2
NEDD4ENSG00000069869.111140.656401608.06820-0.495503.473702.46110K562NAA15
NEDD4ENSG00000069869.11727.478901416.90730-0.961805.613304.06470K562PABPN1
NEDD4ENSG00000069869.11774.89840995.47360-0.361403.095001.66520K562PCBP1
NEDD4ENSG00000069869.11395.14150559.91900-0.502802.235301.43010K562PSIP1
NEDD4ENSG00000069869.111004.634101913.96820-0.9299012.4784011.37150K562PUS1
NEDD4ENSG00000069869.111027.235401864.61830-0.860108.029007.04960K562RBM15
NEDD4ENSG00000069869.11656.53800948.78440-0.531205.021203.84960K562RBM22
NEDD4ENSG00000069869.11711.19950467.345700.605703.454201.68810K562SERBP1
NEDD4ENSG00000069869.11654.84550824.91030-0.333102.446901.64450K562SF3B4
NEDD4ENSG00000069869.111015.92550769.073800.401502.603101.54570K562U2AF1
NEDD4ENSG00000069869.111105.83790794.110600.477605.468504.34360K562U2AF2
NEDD4ENSG00000069869.11717.43720979.81670-0.449705.856004.85480K562UPF1
NEDD4ENSG00000069869.111294.875901940.25250-0.583402.790601.48860K562UTP18
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for NEDD4 is not available on ENCORE database.





8 RBPs can affect the splicing of NEDD4 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SENEDD4ENSG00000069869.11chr15-561391665613923256134131561343615614056956140628-0.368000.000010.00030excludedK562SF3B4
SENEDD4ENSG00000069869.11chr15-561264245612648456126235561263435612998656130047-0.111000.003720.03650excludedK562AQR
SENEDD4ENSG00000069869.11chr15-561391665613923256134131561343615614056956140628-0.291000.000000.00001excludedK562PUS1
SENEDD4ENSG00000069869.11chr15-561391665613923256134131561343615614056956140628-0.067000.000060.00888excludedK562HNRNPUL1
SENEDD4ENSG00000069869.11chr15-561391665613923256134131561343615614056956140628-0.158000.000220.01076excludedK562UTP18
SENEDD4ENSG00000069869.11chr15-561391665613923256134131561343615614056956140628-0.270000.000410.00958excludedK562U2AF2
SENEDD4ENSG00000069869.11chr15-561391665613923256134131561343615614056956140628-0.117000.004260.08120excludedK562RBM15
SENEDD4ENSG00000069869.11chr15-561391665613923256134131561343615614056956140628-0.107000.000640.01954excludedK562AGGF1
A3SSNEDD4ENSG00000069869.11chr15-5612642456126484561264245612646056129986561300470.055000.000740.02074longerHepG2U2AF2
A3SSNEDD4ENSG00000069869.11chr15-5612642456126594561264245612648456129986561302090.079000.016640.08166longerK562AQR
A3SSNEDD4ENSG00000069869.11chr15-5621684356216913562168435621689756243573562435980.163000.007850.04292longerK562AQR
A5SSNEDD4ENSG00000069869.11chr15-562447795624494356244851562449435624370856243787-0.647000.000140.00781shorterHepG2U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for NEDD4 is not avaliable on ENCORE database.