HLCS

General Information

Gene Name       : HLCS
Gene ID             : ENSG00000159267.14
Essential Gene : No

Functions

Localization

Domains (AlphaFold: HLCS)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878HLCSENSG00000159267.146.936.746.83ENCSR000AEF
HepG2HLCSENSG00000159267.145.988.437.21ENCSR985KAT
K562HLCSENSG00000159267.1410.9711.5011.23ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for HLCS is not avaliable on ENCORE database.



Proteins bound to RNA
  • HLCS RNA is bound by 11 proteins.  







eCLIP assay for HLCS is not avaliable on ENCORE database.





11 proteins are bound to HLCS RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr213812545638125529-3'-UTR,intron-Distal3.634623.02250K562YBX3
chr213826913338269204-CDS,intron-Distal,intron-Proximal3.710314.80676K562RBM15
chr213824045838240519-intron-Distal5.0443712.49273K562PTBP1
chr213824053038240569-intron-Distal3.461843.27944K562PTBP1
chr213822912138229202-intron-Distal4.228644.62276K562TARDBP
chr213823507238235151-intron-Distal3.720273.01412K562SAFB2
chr213822985938229913-intron-Distal3.934663.10243K562SLTM
chr213820170338201879-intron-Distal3.977584.14103K562KHSRP
chr213824066938240718-intron-Distal5.450829.27567K562PTBP1
chr213824041038240458-intron-Distal4.130059.00412K562PTBP1
chr213815894538159026-intron-Distal4.023714.06464HepG2CSTF2
chr213816471338164819-intron-Distal4.743624.86763HepG2PCBP2
chr213822951338229621-intron-Distal4.073754.37667K562SAFB2
chr213819415038194228-intron-Distal4.121416.43614HepG2PCBP2
chr213824042738240530-intron-Distal5.1715518.07577HepG2PTBP1
chr213819416238194227-intron-Distal3.792113.09122HepG2PTBP1
chr213823572838235811-intron-Distal4.500905.14122HepG2PCBP2
chr213821056138210621-intron-Distal4.287374.38266K562TARDBP
chr213818432038184382-intron-Distal3.908933.53569K562LIN28B
chr213815604438156171-intron-Distal3.432133.71972K562TARDBP
chr213826132738261390-intron-Distal4.397455.02084HepG2HNRNPM
chr213823116338231218-intron-Distal3.317433.12654K562SLTM
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for HLCS is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for HLCS is not available on ENCORE database.

  • 90 RBPs can affect the levels of HLCS.  








The Knockdown/knockout RNA-Seq assay for HLCS is not available on ENCORE database.





90 RBPs can affect the gene expression of HLCS :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
HLCSENSG00000159267.10498.35660333.368500.580004.133902.85070HepG2AATF
HLCSENSG00000159267.10641.16610451.767100.505005.515804.71580HepG2ACO1
HLCSENSG00000159267.10273.52000420.78010-0.621404.114302.92560HepG2ADAR
HLCSENSG00000159267.101610.56290501.558101.6830030.9396029.40240HepG2AKAP1
HLCSENSG00000159267.10947.03920706.165100.423304.794403.93190HepG2AUH
HLCSENSG00000159267.10875.35960457.099100.9373014.6461013.11700HepG2CALR
HLCSENSG00000159267.10552.29130375.693800.555803.866902.56440HepG2CPSF7
HLCSENSG00000159267.10860.37620569.661500.594807.875506.89440HepG2CELF1
HLCSENSG00000159267.10700.32630480.529700.543302.154401.59550HepG2DDX3X
HLCSENSG00000159267.10657.82300436.283700.592304.169003.24120HepG2DDX55
HLCSENSG00000159267.10701.61980476.521300.558002.409101.49630HepG2DDX59
HLCSENSG00000159267.10709.53230412.608400.782005.871205.00080HepG2DDX6
HLCSENSG00000159267.10450.21890301.965500.576103.652802.36870HepG2EFTUD2
HLCSENSG00000159267.10461.20150294.038800.649304.379803.26160HepG2EIF3D
HLCSENSG00000159267.10659.11400438.623800.587403.489802.77360HepG2EIF4A3
HLCSENSG00000159267.10695.49660426.900000.704003.400902.64090HepG2EIF4B
HLCSENSG00000159267.10809.42590604.294400.421504.371903.36280HepG2EIF4G1
HLCSENSG00000159267.101178.89060810.787400.539907.983607.05340HepG2ETF1
HLCSENSG00000159267.10355.42070262.784400.435502.512901.40050HepG2FAM120A
HLCSENSG00000159267.10569.61940350.441400.700706.486004.86290HepG2FASTKD2
HLCSENSG00000159267.10757.48790460.816200.716904.657303.67920HepG2FIP1L1
HLCSENSG00000159267.10579.35760431.342900.425503.899502.75440HepG2HDGF
HLCSENSG00000159267.10674.67550445.578100.598402.822101.43740HepG2HLTF
HLCSENSG00000159267.10747.96060562.928500.409903.917002.83480HepG2HNRNPA2B1
HLCSENSG00000159267.10569.43450415.282300.455302.304701.66350HepG2HNRNPK
HLCSENSG00000159267.10620.73160417.240900.573003.405602.66400HepG2IGF2BP2
HLCSENSG00000159267.10879.52590391.369301.168105.496604.13560HepG2IGF2BP3
HLCSENSG00000159267.10576.58630482.809600.256001.970401.33900HepG2ILF2
HLCSENSG00000159267.10243.28950349.94710-0.524502.471701.36250HepG2KHDRBS1
HLCSENSG00000159267.10545.25220307.742800.825104.826203.46050HepG2METAP2
HLCSENSG00000159267.10525.67020372.810900.495603.032302.18580HepG2MSI2
HLCSENSG00000159267.10854.54150405.793401.074309.919108.57060HepG2PABPC4
HLCSENSG00000159267.10608.24500467.855400.378503.074702.18550HepG2PARN
HLCSENSG00000159267.10623.67980400.135800.640207.416006.50090HepG2PCBP1
HLCSENSG00000159267.10321.50270421.57760-0.391002.491901.78860HepG2PPIL4
HLCSENSG00000159267.10712.30100407.144500.8068011.6478010.67820HepG2PTBP1
HLCSENSG00000159267.10891.83370615.479700.535008.287007.37490HepG2PUM1
HLCSENSG00000159267.10715.61070440.966000.698407.833406.86380HepG2QKI
HLCSENSG00000159267.101055.64240556.617100.923307.004605.72460HepG2RBM15
HLCSENSG00000159267.101147.44130677.665100.7597012.9850012.02840HepG2RBM22
HLCSENSG00000159267.10611.50630400.198000.611605.343604.43500HepG2RBM25
HLCSENSG00000159267.10565.14990453.119900.318601.962101.48900HepG2NELFE
HLCSENSG00000159267.10540.83160333.062100.699305.100104.06680HepG2RRP9
HLCSENSG00000159267.10408.52690287.161800.508502.850001.89600HepG2SERBP1
HLCSENSG00000159267.10588.71820423.905500.473704.017503.32650HepG2SF3B4
HLCSENSG00000159267.10453.24270555.93480-0.294602.054001.43260HepG2SLBP
HLCSENSG00000159267.101709.97690765.392101.1596042.0038040.65740HepG2SRFBP1
HLCSENSG00000159267.10850.20600442.459200.9422016.6668015.71350HepG2SRSF1
HLCSENSG00000159267.10871.51330572.464700.606208.602607.57710HepG2SRSF5
HLCSENSG00000159267.10567.34150359.958700.656307.763806.92410HepG2SRSF9
HLCSENSG00000159267.10999.88470651.049900.6189010.659209.57210HepG2SUCLG1
HLCSENSG00000159267.10288.78380434.35020-0.588902.689002.02090HepG2SUPV3L1
HLCSENSG00000159267.10635.36400463.386000.455304.611003.92050HepG2TRIM56
HLCSENSG00000159267.10524.65190394.116500.412601.962401.42350HepG2U2AF1
HLCSENSG00000159267.10980.23930599.564700.709105.840504.59370HepG2UBE2L3
HLCSENSG00000159267.10369.00830515.49910-0.482304.262803.42600HepG2UPF1
HLCSENSG00000159267.10635.92950417.528200.606903.162301.80660HepG2XRCC5
HLCSENSG00000159267.10304.01330427.56910-0.492002.065801.43070HepG2XRN2
HLCSENSG00000159267.10322.65590422.57680-0.389202.701302.03690HepG2ZC3H8
HLCSENSG00000159267.10953.63870566.951400.7501015.5647014.53120HepG2ZNF622
HLCSENSG00000159267.10451.306101435.94710-1.6698062.9652060.34790K562AGGF1
HLCSENSG00000159267.101120.589501577.77950-0.493605.473403.97810K562AKAP8
HLCSENSG00000159267.10606.998201494.14120-1.2996016.0730014.26600K562AKAP8L
HLCSENSG00000159267.101359.546101080.698500.331102.980101.69160K562APOBEC3C
HLCSENSG00000159267.10624.397001116.15670-0.838009.893208.88780K562AQR
HLCSENSG00000159267.10799.250001567.66290-0.9719024.1958021.31710K562ATP5C1
HLCSENSG00000159267.101306.978801684.75700-0.366303.166801.59640K562DDX19B
HLCSENSG00000159267.10339.71770449.23460-0.403102.823101.49930K562DDX6
HLCSENSG00000159267.101185.900901607.97160-0.439303.614502.59640K562DKC1
HLCSENSG00000159267.10417.88190599.17610-0.519903.473902.44580K562EFTUD2
HLCSENSG00000159267.101203.76130832.530800.531907.643906.53620K562EIF2S2
HLCSENSG00000159267.10624.38300461.079200.437302.653801.55490K562FKBP4
HLCSENSG00000159267.10398.11630530.34720-0.413702.867801.50160K562FUS
HLCSENSG00000159267.10691.03350481.403000.521405.136104.34740K562FXR1
HLCSENSG00000159267.10520.271901042.99790-1.003404.312902.68450K562HNRNPA2B1
HLCSENSG00000159267.10717.24720531.509300.432303.310402.66510K562HNRNPC
HLCSENSG00000159267.10752.62380946.14890-0.330102.467301.47590K562HNRNPL
HLCSENSG00000159267.10457.89240635.55400-0.473002.834301.89140K562HNRNPM
HLCSENSG00000159267.101449.901301047.658500.468704.247303.26710K562HSPD1
HLCSENSG00000159267.10820.352501585.75150-0.950907.437005.92070K562KIF1C
HLCSENSG00000159267.10954.669901517.87790-0.669004.751003.22670K562MAK16
HLCSENSG00000159267.101107.679801776.42910-0.6814011.084409.06550K562MBNL1
HLCSENSG00000159267.10919.72900702.790500.388004.213303.23330K562MTPAP
HLCSENSG00000159267.10528.354301245.13980-1.236708.723606.81040K562NAA15
HLCSENSG00000159267.10327.92080912.85810-1.477006.628904.89660K562PABPN1
HLCSENSG00000159267.10345.41800476.52470-0.464202.797801.88810K562PSIP1
HLCSENSG00000159267.10467.693601481.97050-1.6639039.4122037.31280K562PUS1
HLCSENSG00000159267.10559.312001443.79750-1.3681039.5558037.22030K562RBM15
HLCSENSG00000159267.10628.008001123.13170-0.838703.160201.48830K562RBM39
HLCSENSG00000159267.10898.85200646.873700.474503.704802.41930K562NELFE
HLCSENSG00000159267.10442.78970593.95330-0.423702.030401.33670K562RPS19
HLCSENSG00000159267.10462.16960835.13740-0.853602.678401.50280K562SF1
HLCSENSG00000159267.10332.24760484.14560-0.543204.260803.19470K562SF3B4
HLCSENSG00000159267.10511.83820958.62930-0.905303.554402.09780K562SNRNP200
HLCSENSG00000159267.10858.43610628.418600.449903.986503.14400K562SRSF1
HLCSENSG00000159267.10777.09700606.039200.358602.756501.93820K562SYNCRIP
HLCSENSG00000159267.10819.843801502.36900-0.873802.608601.36680K562UTP18
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for HLCS is not available on ENCORE database.





6 RBPs can affect the splicing of HLCS :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEHLCSENSG00000159267.10chr21-383196323832058738311131383112943833433538334470-0.172000.001070.02169excludedHepG2U2AF1
SEHLCSENSG00000159267.10chr21-3813731238137473381320273813214238139518381395860.139000.000560.03850includedHepG2AKAP1
SEHLCSENSG00000159267.10chr21-383204653832058738311131383112943833433538334470-0.139000.000410.07930excludedK562METAP2
A3SSHLCSENSG00000159267.10chr21-3812884238129088381288423812905638132027381321420.134000.002340.01481longerK562AQR
MXEHLCSENSG00000159267.10chr21-3831830838318454383204653832058738311131383112943833433538334470-0.803000.000420.038762includedK562CPSF6
MXEHLCSENSG00000159267.10chr21-3831830838318454383204653832058738311131383112943833433538334470-0.790000.000090.032202includedK562GPKOW

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for HLCS is not avaliable on ENCORE database.