DNASE1

General Information

Gene Name       : DNASE1
Gene ID             : ENSG00000213918.10
Essential Gene : No

Functions

Localization

Domains (AlphaFold: DNASE1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878DNASE1ENSG00000213918.102.904.983.94ENCSR000AEF
HepG2DNASE1ENSG00000213918.108.754.566.65ENCSR985KAT
K562DNASE1ENSG00000213918.104.905.125.01ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for DNASE1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • DNASE1 RNA is bound by 4 proteins.  







eCLIP assay for DNASE1 is not avaliable on ENCORE database.





4 proteins are bound to DNASE1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr1637044773704537+5'-UTR,intron-Distal4.136719.24023HepG2DKC1
chr1636618523661973+5'-UTR3.302663.42164K562UPF1
chr1637043293704477+5'-UTR,intron-Distal6.7109133.58639HepG2DKC1
chr1637113383711432+intron-Distal4.136053.85494HepG2HLTF
chr1636997253699783+intron-Distal4.419644.64592HepG2HNRNPM
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for DNASE1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for DNASE1 is not available on ENCORE database.

  • 116 RBPs can affect the levels of DNASE1.  








The Knockdown/knockout RNA-Seq assay for DNASE1 is not available on ENCORE database.





116 RBPs can affect the gene expression of DNASE1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
DNASE1ENSG00000213918.6444.43780332.518200.418402.865702.24880HepG2ACO1
DNASE1ENSG00000213918.6219.04350328.78550-0.585902.581802.06660HepG2AKAP1
DNASE1ENSG00000213918.6319.08500194.831700.711602.878901.92130HepG2BCCIP
DNASE1ENSG00000213918.6447.22380332.541600.427403.025602.33720HepG2CKAP4
DNASE1ENSG00000213918.6431.66090221.074300.965308.875207.73120HepG2DDX21
DNASE1ENSG00000213918.6342.58530487.65530-0.509403.309301.89630HepG2DDX47
DNASE1ENSG00000213918.6296.37170191.576300.629402.260401.55480HepG2DDX55
DNASE1ENSG00000213918.6390.48610270.568800.529202.460901.87580HepG2DDX6
DNASE1ENSG00000213918.6252.82840187.991600.427402.261101.65870HepG2DNAJC2
DNASE1ENSG00000213918.6373.15550260.074900.520702.579002.00640HepG2EIF2S1
DNASE1ENSG00000213918.6148.60610213.50840-0.522802.226601.40720HepG2EIF3D
DNASE1ENSG00000213918.6571.18670287.399000.990808.936707.79320HepG2EIF4A3
DNASE1ENSG00000213918.6643.99850408.817200.655507.209806.31560HepG2ETF1
DNASE1ENSG00000213918.6195.76670325.01460-0.731403.644002.68580HepG2EWSR1
DNASE1ENSG00000213918.6411.00280189.209401.119104.564503.26850HepG2FTO
DNASE1ENSG00000213918.6309.20420197.740700.644903.764202.85570HepG2FUBP3
DNASE1ENSG00000213918.6406.44660269.010400.595303.381702.64990HepG2G3BP1
DNASE1ENSG00000213918.6327.05790210.064100.638603.038701.96800HepG2GNB2L1
DNASE1ENSG00000213918.6369.90140191.477300.949907.487606.50180HepG2HNRNPA1
DNASE1ENSG00000213918.6415.76760212.985200.964908.017006.88280HepG2HNRNPC
DNASE1ENSG00000213918.6377.17130242.722400.635805.057004.12410HepG2HNRNPF
DNASE1ENSG00000213918.6466.12140287.128100.698908.184107.08050HepG2HNRNPL
DNASE1ENSG00000213918.6327.46000204.296800.680603.713502.99500HepG2HNRNPLL
DNASE1ENSG00000213918.6361.07330211.576900.771005.642404.80200HepG2HNRNPU
DNASE1ENSG00000213918.6369.56970239.010700.628704.265803.38340HepG2IGF2BP1
DNASE1ENSG00000213918.6400.06050273.435100.548903.045302.34210HepG2IGF2BP2
DNASE1ENSG00000213918.6497.35180290.118200.777505.760204.82450HepG2MAGOH
DNASE1ENSG00000213918.694.07630223.44660-1.248005.060403.66440HepG2METAP2
DNASE1ENSG00000213918.6324.99880208.406300.640902.421301.52020HepG2MTPAP
DNASE1ENSG00000213918.6391.29140312.590900.323901.950201.30730HepG2NOL12
DNASE1ENSG00000213918.684.45400159.59520-0.918203.166901.45860HepG2PA2G4
DNASE1ENSG00000213918.6189.23270311.76580-0.720302.477101.64630HepG2PABPC1
DNASE1ENSG00000213918.6379.66650265.897600.513802.668701.95910HepG2PABPC4
DNASE1ENSG00000213918.6298.11280147.697901.013105.758904.64020HepG2PRPF8
DNASE1ENSG00000213918.6412.28840253.761300.700106.053405.30670HepG2PTBP1
DNASE1ENSG00000213918.6475.83910338.705300.490304.043203.32390HepG2PUS1
DNASE1ENSG00000213918.6284.10450411.58570-0.534803.332002.40000HepG2RBM15
DNASE1ENSG00000213918.6438.99500341.692300.361401.965401.50900HepG2RBM22
DNASE1ENSG00000213918.6163.81670248.22470-0.599602.893801.87820HepG2RBM27
DNASE1ENSG00000213918.6394.89690282.427100.483502.917102.36350HepG2NELFE
DNASE1ENSG00000213918.6354.20320263.015100.429302.322101.75060HepG2RECQL
DNASE1ENSG00000213918.6481.41960261.495500.880407.696806.64520HepG2RPLP0
DNASE1ENSG00000213918.6326.89230228.915200.513902.211601.49210HepG2RPS2
DNASE1ENSG00000213918.6143.81160208.50480-0.535902.160801.32650HepG2SERBP1
DNASE1ENSG00000213918.6318.80410202.200200.656803.661302.85860HepG2SF3B1
DNASE1ENSG00000213918.6355.96020264.230900.429802.329301.78070HepG2SF3B4
DNASE1ENSG00000213918.6381.04790286.196600.412903.080502.34570HepG2SLBP
DNASE1ENSG00000213918.6306.34580219.724500.479403.020402.35190HepG2SMN1
DNASE1ENSG00000213918.6764.90560385.923100.9869017.7798016.80110HepG2SRFBP1
DNASE1ENSG00000213918.6337.15350238.472300.499503.084402.35530HepG2SRSF7
DNASE1ENSG00000213918.6332.43580224.355600.567203.936503.30180HepG2SRSF9
DNASE1ENSG00000213918.6466.79250335.062600.478303.340602.78880HepG2SSB
DNASE1ENSG00000213918.6316.28010190.685800.729902.933602.24000HepG2SUPV3L1
DNASE1ENSG00000213918.6642.49130205.578801.6439031.6737030.31330HepG2TIAL1
DNASE1ENSG00000213918.6282.99780207.424800.448102.502201.96010HepG2TRIM56
DNASE1ENSG00000213918.6394.96230291.590000.437702.147101.38450HepG2TUFM
DNASE1ENSG00000213918.6433.35260308.674100.489402.376601.60580HepG2UBE2L3
DNASE1ENSG00000213918.6185.91300349.31270-0.909908.335607.38650HepG2UTP3
DNASE1ENSG00000213918.6282.06420187.710100.587402.061301.42710HepG2XRN2
DNASE1ENSG00000213918.6493.87050207.205001.2530019.9918018.48150HepG2ZC3H8
DNASE1ENSG00000213918.6133.32950216.97700-0.702503.217001.93050K562AARS
DNASE1ENSG00000213918.6459.30050281.197400.707805.204703.51690K562ABCF1
DNASE1ENSG00000213918.6340.39430600.63680-0.819306.463905.64890K562AGGF1
DNASE1ENSG00000213918.6434.61670624.96670-0.524003.607302.85780K562AKAP8L
DNASE1ENSG00000213918.61050.23050411.198301.3527023.7861022.25260K562AQR
DNASE1ENSG00000213918.6336.25490239.225500.491102.758501.44960K562BCCIP
DNASE1ENSG00000213918.6373.84860231.184000.693305.622404.23580K562BCLAF1
DNASE1ENSG00000213918.6470.15270177.599901.404405.975704.68260K562BOP1
DNASE1ENSG00000213918.6335.86830195.876300.777904.768702.83030K562BUD13
DNASE1ENSG00000213918.6222.50730152.880800.541302.286201.34430K562CCAR1
DNASE1ENSG00000213918.6511.75070337.744100.599405.358203.23700K562CEBPZ
DNASE1ENSG00000213918.6426.32290289.052800.560503.673602.18650K562CIRBP
DNASE1ENSG00000213918.61049.03280404.111801.3761013.2224010.94540K562CNOT7
DNASE1ENSG00000213918.6421.61510188.827501.1588012.1928010.53580K562CPSF6
DNASE1ENSG00000213918.6250.30660175.387500.513002.323901.37160K562CSTF2
DNASE1ENSG00000213918.6649.73930388.175600.743109.188406.97080K562DDX21
DNASE1ENSG00000213918.6440.47660672.65390-0.610803.768702.72450K562DKC1
DNASE1ENSG00000213918.6292.29480164.395500.830205.388503.50590K562DNAJC21
DNASE1ENSG00000213918.6678.45990232.703101.5437022.2848019.34180K562EFTUD2
DNASE1ENSG00000213918.6788.51540246.372801.6782040.4991038.38520K562EIF2S2
DNASE1ENSG00000213918.6428.51650249.003300.783103.844302.60100K562EIF3D
DNASE1ENSG00000213918.689.39000146.28280-0.710602.614501.83930K562EIF3G
DNASE1ENSG00000213918.6651.90680509.970200.354202.164301.32830K562EIF4G2
DNASE1ENSG00000213918.6479.70190192.151101.3198014.6812012.63060K562FMR1
DNASE1ENSG00000213918.6583.77600162.875601.8415027.6693024.73220K562FTO
DNASE1ENSG00000213918.6199.70450346.79540-0.796206.486405.61630K562FXR1
DNASE1ENSG00000213918.663.66660164.79260-1.372007.018305.77850K562G3BP2
DNASE1ENSG00000213918.6410.57280275.364800.576204.481803.03510K562GLRX3
DNASE1ENSG00000213918.6422.58420180.274001.2289012.6573010.94330K562GPKOW
DNASE1ENSG00000213918.6454.07600302.767800.584604.583603.20920K562HNRNPA1
DNASE1ENSG00000213918.6586.63170378.128100.633503.233901.51510K562HNRNPAB
DNASE1ENSG00000213918.6886.16670237.303101.9007042.3529040.10940K562HNRNPC
DNASE1ENSG00000213918.6405.90270211.961900.937208.159806.11470K562HNRNPF
DNASE1ENSG00000213918.6553.31490398.105400.474903.508001.38800K562HNRNPH1
DNASE1ENSG00000213918.6758.22620335.288001.1771021.7713019.43720K562HNRNPU
DNASE1ENSG00000213918.6374.56120274.059400.450602.305601.57470K562HSPD1
DNASE1ENSG00000213918.6584.38810388.318600.589604.046201.81080K562IGF2BP1
DNASE1ENSG00000213918.6377.55540269.737400.485002.267501.36510K562IGF2BP2
DNASE1ENSG00000213918.6587.09170368.689900.671103.118501.59820K562ILF2
DNASE1ENSG00000213918.6242.71480154.345000.653003.263801.64470K562KHDRBS1
DNASE1ENSG00000213918.6464.04250663.32690-0.515502.550801.76320K562KIF1C
DNASE1ENSG00000213918.6288.61010153.957100.906504.687703.43340K562KRR1
DNASE1ENSG00000213918.6198.60270282.86260-0.510202.701801.79150K562MATR3
DNASE1ENSG00000213918.6486.72150743.08240-0.610403.834902.73590K562MBNL1
DNASE1ENSG00000213918.6356.47450175.971701.018408.654307.04190K562METAP2
DNASE1ENSG00000213918.6950.99320543.546200.806906.354204.65650K562MSI2
DNASE1ENSG00000213918.6560.14630289.512300.9521013.3257011.71470K562MTPAP
DNASE1ENSG00000213918.6330.11290520.83980-0.657903.727702.66550K562NAA15
DNASE1ENSG00000213918.6709.01620321.662001.1402023.8712022.00470K562NSUN2
DNASE1ENSG00000213918.6728.41490388.231900.907705.950504.12270K562PABPC1
DNASE1ENSG00000213918.6395.28660252.187400.648304.369403.13500K562PCBP2
DNASE1ENSG00000213918.61189.34710481.171901.3054020.7700018.57860K562PCBP3
DNASE1ENSG00000213918.6469.17200331.769600.499802.926701.32580K562PKM
DNASE1ENSG00000213918.6916.89700369.097201.3127026.3758024.13520K562POLR2G
DNASE1ENSG00000213918.6934.97380579.848100.689208.647606.92390K562PUM2
DNASE1ENSG00000213918.6411.11350619.96090-0.592603.811703.18820K562PUS1
DNASE1ENSG00000213918.6297.43850603.92140-1.021808.183307.19280K562RBM15
DNASE1ENSG00000213918.6183.91420328.80580-0.838205.860704.29020K562SAFB
DNASE1ENSG00000213918.6759.77010317.416501.2591022.4114020.29890K562SF3A3
DNASE1ENSG00000213918.6477.47620171.482501.4773014.3557012.07280K562SF3B1
DNASE1ENSG00000213918.6634.94260393.749800.689202.742901.45310K562SFPQ
DNASE1ENSG00000213918.6309.41470168.369200.877804.355502.73730K562SLBP
DNASE1ENSG00000213918.6559.31500346.373500.691207.959505.97820K562SRSF7
DNASE1ENSG00000213918.6416.72880242.570900.780604.639702.94530K562STAU1
DNASE1ENSG00000213918.6630.75000360.217300.808103.623701.73360K562STIP1
DNASE1ENSG00000213918.6501.59680219.057101.195107.783906.02250K562SUPV3L1
DNASE1ENSG00000213918.6158.76550370.18380-1.2213012.9802011.20490K562SYNCRIP
DNASE1ENSG00000213918.6435.30370273.222500.671804.861803.91070K562TARDBP
DNASE1ENSG00000213918.6374.62080263.556500.507203.053702.18560K562TIA1
DNASE1ENSG00000213918.6340.03230204.651600.732404.352203.15960K562TIAL1
DNASE1ENSG00000213918.6405.03210236.430500.776505.656103.54600K562TRIP6
DNASE1ENSG00000213918.6243.72060164.878700.563702.852502.03650K562U2AF2
DNASE1ENSG00000213918.6903.13110627.467800.525304.221902.48950K562UBE2L3
DNASE1ENSG00000213918.6477.11880231.943101.040508.147406.33610K562UCHL5
DNASE1ENSG00000213918.61126.64040341.066001.7238059.7629057.11110K562UPF1
DNASE1ENSG00000213918.6507.33700322.786600.652304.582803.02770K562UTP3
DNASE1ENSG00000213918.6598.46380291.837801.0360013.6722011.67840K562WDR3
DNASE1ENSG00000213918.6468.51380303.488300.626406.457305.21570K562WDR43
DNASE1ENSG00000213918.6906.09000463.211800.9679014.2759012.16710K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for DNASE1 is not available on ENCORE database.





6 RBPs can affect the splicing of DNASE1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEDNASE1ENSG00000213918.6chr16+3705849370593837053733705521370610237061860.518000.000170.07821includedHepG2GRSF1
SEDNASE1ENSG00000213918.6chr16+370584937059673705373370552137061023706186-0.591000.000130.00887excludedHepG2PCBP1
SEDNASE1ENSG00000213918.6chr16+370584937059673705373370552137061023706186-0.564000.000430.02373excludedHepG2SF3B4
SEDNASE1ENSG00000213918.6chr16+3705849370593837053733705521370610237061860.387000.003060.07765includedK562UTP18
SEDNASE1ENSG00000213918.6chr16+3705849370593837053733705521370610237061860.571000.000560.02863includedK562HNRNPK
RIDNASE1ENSG00000213918.6chr16+3706999370734237069993707112370718737073420.581000.003950.03808includedK562EFTUD2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for DNASE1 is not avaliable on ENCORE database.