CAB39

General Information

Gene Name       : CAB39
Gene ID             : ENSG00000135932.10
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: CAB39)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878CAB39ENSG00000135932.1057.3558.5557.95ENCSR000AEF
HepG2CAB39ENSG00000135932.1023.0632.2727.66ENCSR985KAT
K562CAB39ENSG00000135932.1047.7047.1747.44ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
CAB392716S2Submitted, ENCORE2BGHcLV45-7, Experimented, ENCORE2BGKcLV42-13, Submitted, ENCORE2


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
CAB39K562CRISPRCAB39-BGKcLV42-13,CAB39-BGKcLV42-14NT-BGKcLV42-1,NT-BGKcLV42-257.3,66.1SequencedENCORE2
CAB39HepG2CRISPRBGHcLV45-7,BGHcLV45-8BGHcLV45-1,BGHcLV45-280.9,83.8SequencingENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
CAB39Product_ID: 2716S
Lot_ID: 2
Source: Cell Signaling Technology
Target Name: CAB39-human		 CAB39-HEPG2-CRISPR-2716S.png<br>Caption: Western blot following CRISPR against CAB39 in HepG2 whole cell lysate using CAB39 specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against CAB39. CAB39 protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.
 CST_2716S_2_CAB39.png<br>Caption: IP-WB analysis of 2716S whole cell lysate using the CAB39 specific antibody, 2716S. Lanes 1 and 2 are 2.5% of five million whole cell lysate input and 50% of IP enrichment, respectively, using a normal IgG antibody. Lane 3 is 50% of IP enrichment from five million whole cell lysate using the CAB39-specific antibody, 2716S. The same antibody was used to detect protein levels via Western blot. This antibody passes preliminary validation and will be further pursued for secondary validation. *NOTE* Protein sizes are taken from Genecards.org and are only estimates based on sequence. Actual protein size may differ based on protein characteristics and electrophoresis method used.
 CAB39-K562-CRISPR-2716S.png<br>Caption: Western blot following CRISPR against CAB39 in K562 whole cell lysate using CAB39 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against CAB39. CAB39 protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for CAB39 is not avaliable on ENCORE database.



Proteins bound to RNA
  • CAB39 RNA is bound by 29 proteins.  







eCLIP assay for CAB39 is not avaliable on ENCORE database.





29 proteins are bound to CAB39 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr2231683550231683617+3'-UTR3.981648.26514HepG2U2AF2
chr2231684562231684635+3'-UTR3.5318911.17695K562UPF1
chr2231683980231684072+3'-UTR6.23749400.00000K562PUM2
chr2231685643231685704+3'-UTR5.170227.80881K562PUM2
chr2231685107231685200+3'-UTR3.2694516.17694K562UPF1
chr2231684191231684248+3'-UTR5.0961832.09044K562PUM2
chr2231684153231684181+3'-UTR3.280885.65859K562PUM2
chr2231685200231685270+3'-UTR4.3122117.98472K562UPF1
chr2231684528231684630+3'-UTR3.531237.05065K562TARDBP
chr2231684248231684285+3'-UTR4.4478317.32307K562PUM2
chr2231685734231685763+3'-UTR4.079355.81202K562PUM2
chr2231685130231685263+3'-UTR3.4400922.40580K562FAM120A
chr2231685341231685417+3'-UTR3.425038.00041K562UPF1
chr2231685270231685321+3'-UTR5.0446613.35513K562UPF1
chr2231577741231577949+5'-UTR,intron-Proximal3.556475.53367HepG2SRSF1
chr2231577728231577813+5'-UTR4.6568126.76601HepG2DDX3X
chr2231577602231577716+5'-UTR3.929696.56195HepG2NKRF
chr2231577571231577727+5'-UTR3.6236410.60071HepG2NCBP2
chr2231577598231577774+5'-UTR3.414003.94389K562ZNF800
chr2231577693231577813+5'-UTR4.283363.02371K562EIF3G
chr2231577580231577669+5'-UTR3.043515.18500K562GEMIN5
chr2231577660231577728+5'-UTR4.3511910.34792HepG2DDX3X
chr2231578520231578590+5'-UTR,intron-Distal,intron-Proximal4.034985.84043HepG2NKRF
chr2231577591231577712+5'-UTR3.2227313.20211K562DDX3X
chr2231577599231577706+5'-UTR3.188184.91382K562DDX6
chr2231624616231624697+5'-UTR,intron-Proximal4.785689.13098K562SF3B4
chr2231577587231577642+5'-UTR3.068125.75567K562NCBP2
chr2231578299231578338+5'-UTR,intron-Distal3.677245.34741HepG2NKRF
chr2231663569231663612+CDS3.377678.88089K562YBX3
chr2231678721231678882+CDS,intron-Proximal4.437686.59856K562SF3B4
chr2231624730231624832+CDS,intron-Proximal3.810033.14999HepG2GRWD1
chr2231663314231663412+intron-Distal,intron-Proximal3.170303.93901K562KHSRP
chr2231619184231619274+intron-Distal4.622809.53330K562PTBP1
chr2231619021231619094+intron-Distal5.893089.44534K562PTBP1
chr2231578030231578133+intron-Distal,intron-Proximal4.476457.72433HepG2XRN2
chr2231581423231581530+intron-Distal4.732794.54503HepG2ILF3
chr2231641774231641896+intron-Distal3.225113.68839K562KHSRP
chr2231647546231647622+intron-Distal4.186386.58307HepG2HNRNPC
chr2231619162231619255+intron-Distal4.040863.09122HepG2PTBP1
chr2231583773231583864+intron-Distal3.303765.61499K562QKI
chr2231619130231619214+intron-Distal5.110939.08990HepG2PCBP2
chr2231642899231642981+intron-Distal3.824254.33990HepG2QKI
chr2231655099231655180+intron-Distal3.352543.64762HepG2QKI
chr2231665416231665469+intron-Distal4.344554.72838K562UCHL5
chr2231666688231666749+intron-Distal4.091404.15306K562SAFB2
chr2231654122231654258+intron-Distal4.064403.27946HepG2HNRNPM
chr2231638038231638118+intron-Distal4.485935.08344K562TARDBP
chr2231580095231580186+intron-Distal3.473044.17049K562TARDBP
chr2231619214231619267+intron-Distal5.224639.00303HepG2PCBP2
chr2231624969231625068+intron-Distal3.559205.35459K562KHSRP
chr2231619025231619111+intron-Distal3.679627.02840HepG2PTBP1
chr2231625364231625561+intron-Distal3.835353.34627K562HNRNPK
chr2231652707231652856+intron-Distal3.416464.08064K562KHSRP
chr2231582551231582657+intron-Distal4.663144.66899HepG2HNRNPM
chr2231619209231619299+intron-Distal4.550814.83729K562ILF3
chr2231578041231578086+intron-Distal,intron-Proximal3.694933.82719HepG2RBM22
chr2231584711231584773+intron-Distal4.249744.72162K562KHSRP
chr2231682619231682676+intron-Proximal4.611968.91093K562PRPF8
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for CAB39 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for CAB39 is not available on ENCORE database.

  • 102 RBPs can affect the levels of CAB39.  








The Knockdown/knockout RNA-Seq assay for CAB39 is not available on ENCORE database.





102 RBPs can affect the gene expression of CAB39 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
CAB39ENSG00000135932.61085.26390844.848400.361202.645101.59410HepG2AATF
CAB39ENSG00000135932.61821.193201064.061100.7752022.7570021.39160HepG2ACO1
CAB39ENSG00000135932.61290.297101687.84080-0.387502.453201.94920HepG2AKAP1
CAB39ENSG00000135932.62175.751701653.610600.395806.833205.83100HepG2AUH
CAB39ENSG00000135932.6728.874101176.32010-0.690502.423001.54790HepG2BCCIP
CAB39ENSG00000135932.62399.238801680.419700.513706.318905.45590HepG2BOP1
CAB39ENSG00000135932.61671.145201326.820200.332802.350801.63350HepG2CIRBP
CAB39ENSG00000135932.61844.860301380.506400.418202.033101.38290HepG2CNOT7
CAB39ENSG00000135932.61085.871801542.76210-0.506703.942203.13490HepG2CPSF6
CAB39ENSG00000135932.62350.540901539.867700.6101013.7269012.50890HepG2CELF1
CAB39ENSG00000135932.6507.39480984.18710-0.9558014.9136013.31920HepG2DDX19B
CAB39ENSG00000135932.61264.26040912.222600.470704.937003.70800HepG2DDX24
CAB39ENSG00000135932.62311.068501616.840400.515304.892604.07950HepG2DDX3X
CAB39ENSG00000135932.61472.849901156.469100.348802.369701.64750HepG2DDX55
CAB39ENSG00000135932.62542.423501751.904700.537202.770501.79090HepG2DDX59
CAB39ENSG00000135932.6789.087801008.53850-0.354002.661301.69770HepG2DHX30
CAB39ENSG00000135932.6592.353601045.66820-0.8199014.9408013.42130HepG2DNAJC21
CAB39ENSG00000135932.6892.030601036.40150-0.216402.031101.45590HepG2DNAJC2
CAB39ENSG00000135932.61122.25880765.671600.551504.574303.43310HepG2EIF3D
CAB39ENSG00000135932.61217.52500880.417300.467604.914503.52470HepG2EIF3G
CAB39ENSG00000135932.6788.231601475.55390-0.9046010.516809.29230HepG2EIF4A3
CAB39ENSG00000135932.62015.108701633.484300.302803.800002.84680HepG2EIF4G1
CAB39ENSG00000135932.62653.997501898.444800.483207.496806.58810HepG2ETF1
CAB39ENSG00000135932.61911.187601405.464000.443303.408602.56010HepG2FIP1L1
CAB39ENSG00000135932.6920.613501488.71530-0.693407.673406.56380HepG2FXR1
CAB39ENSG00000135932.61287.073101015.983300.341104.238203.04720HepG2HDGF
CAB39ENSG00000135932.6710.543801055.68570-0.571206.075305.16970HepG2HNRNPA1
CAB39ENSG00000135932.6816.607701174.24410-0.524005.153404.22980HepG2HNRNPC
CAB39ENSG00000135932.61090.084801386.39120-0.346904.289403.41720HepG2HNRNPF
CAB39ENSG00000135932.6905.451201508.24100-0.7362019.8664018.21490HepG2HNRNPL
CAB39ENSG00000135932.61221.64380969.874800.332902.929101.95090HepG2HNRNPM
CAB39ENSG00000135932.6838.763601166.48150-0.475807.225706.28220HepG2HNRNPU
CAB39ENSG00000135932.61088.606201365.20060-0.326602.947402.20190HepG2IGF2BP1
CAB39ENSG00000135932.6841.310501317.36200-0.646902.645801.68540HepG2IGF2BP3
CAB39ENSG00000135932.6908.209401191.52410-0.391706.057505.01610HepG2ILF2
CAB39ENSG00000135932.6815.241201411.96210-0.792407.263505.55470HepG2KHSRP
CAB39ENSG00000135932.61917.576501497.579100.356602.317501.73690HepG2MATR3
CAB39ENSG00000135932.61457.532401137.752700.357203.458102.55390HepG2MSI2
CAB39ENSG00000135932.61463.919501069.782400.452402.472801.48990HepG2PCBP2
CAB39ENSG00000135932.61156.84540891.644700.375604.584303.61500HepG2PRPF4
CAB39ENSG00000135932.61271.15930892.652400.509904.449103.45050HepG2PRPF8
CAB39ENSG00000135932.61830.585501378.999900.408606.337405.57580HepG2PTBP1
CAB39ENSG00000135932.62003.039801567.261000.353803.389802.73890HepG2PUF60
CAB39ENSG00000135932.62102.609101663.718700.337706.300905.48190HepG2PUM1
CAB39ENSG00000135932.61295.951201083.841700.257802.799802.18160HepG2PUS1
CAB39ENSG00000135932.61994.024301493.629300.416805.294504.47160HepG2QKI
CAB39ENSG00000135932.62260.933601032.364801.1309010.265908.97110HepG2RAVER1
CAB39ENSG00000135932.62738.526901586.773900.7872022.0587020.87840HepG2RBM22
CAB39ENSG00000135932.61743.713101355.512300.363203.413502.67100HepG2RBM25
CAB39ENSG00000135932.61811.814301534.748400.239302.303901.80080HepG2NELFE
CAB39ENSG00000135932.61045.20980745.045800.488304.779103.99590HepG2RPS19
CAB39ENSG00000135932.61509.480701159.684200.380203.018902.18290HepG2RPS2
CAB39ENSG00000135932.61539.81800883.070100.8021010.096008.73340HepG2RRP9
CAB39ENSG00000135932.6861.898001038.80990-0.269302.682902.04590HepG2SAFB2
CAB39ENSG00000135932.6946.52400747.747900.340002.225401.37830HepG2SERBP1
CAB39ENSG00000135932.62575.349601372.872700.907509.905808.56860HepG2SF3A3
CAB39ENSG00000135932.61795.596201435.833300.322504.044903.35190HepG2SF3B4
CAB39ENSG00000135932.61252.171501502.76300-0.263203.242202.49300HepG2SLBP
CAB39ENSG00000135932.61382.904401211.438800.190901.914801.36330HepG2SMN1
CAB39ENSG00000135932.63505.352501838.236000.931104.084403.12640HepG2SNRNP70
CAB39ENSG00000135932.62462.609301792.247500.458309.649508.86900HepG2SRFBP1
CAB39ENSG00000135932.62096.993701498.651600.484609.370708.61670HepG2SRSF1
CAB39ENSG00000135932.61862.543901547.444300.267302.704702.08370HepG2SRSF5
CAB39ENSG00000135932.61103.471001362.07990-0.303803.377602.61900HepG2SRSF7
CAB39ENSG00000135932.61576.028501219.192000.370305.322904.60200HepG2SRSF9
CAB39ENSG00000135932.61364.13100964.769600.499602.818701.60460HepG2SUB1
CAB39ENSG00000135932.6758.448801759.86850-1.2143049.7576047.70710HepG2SUCLG1
CAB39ENSG00000135932.61492.415801151.400800.374202.439201.79900HepG2SUPV3L1
CAB39ENSG00000135932.61620.075401346.914600.266302.449101.91760HepG2TAF15
CAB39ENSG00000135932.6846.721701143.58440-0.433606.082605.30440HepG2TRIM56
CAB39ENSG00000135932.62546.766501202.432401.0826019.3192017.60840HepG2U2AF1
CAB39ENSG00000135932.62901.996401567.532400.888502.622301.66230HepG2U2AF2
CAB39ENSG00000135932.62045.896501620.701100.336002.127901.40010HepG2UBE2L3
CAB39ENSG00000135932.61635.940401217.523300.426107.339706.29320HepG2UPF1
CAB39ENSG00000135932.61531.739601175.478400.381805.553004.75290HepG2UTP3
CAB39ENSG00000135932.61434.648601015.177400.498902.882301.59560HepG2XRCC5
CAB39ENSG00000135932.6726.183701133.42320-0.642302.202101.54940HepG2XRN2
CAB39ENSG00000135932.62934.651101339.049501.1319060.3769058.69710HepG2ZNF622
CAB39ENSG00000135932.62450.706401902.594300.365102.617701.47510K562AARS
CAB39ENSG00000135932.62466.199103004.15700-0.284702.385501.77860K562AKAP8L
CAB39ENSG00000135932.63169.244702399.727800.401203.750202.73230K562BOP1
CAB39ENSG00000135932.62856.514803450.26610-0.272502.788901.60760K562CCDC124
CAB39ENSG00000135932.62846.780403629.76440-0.350505.602303.98220K562CPEB4
CAB39ENSG00000135932.62250.703903387.36290-0.589807.882005.45410K562DDX19B
CAB39ENSG00000135932.62445.760301886.369700.374606.134004.16520K562DDX27
CAB39ENSG00000135932.65828.997403756.123700.6339021.4203019.77130K562DDX47
CAB39ENSG00000135932.63694.377503232.723600.192502.045901.30430K562DKC1
CAB39ENSG00000135932.61636.019001007.699100.699004.625203.29240K562EIF3A
CAB39ENSG00000135932.62905.501301951.259100.574305.475103.95350K562EIF3D
CAB39ENSG00000135932.62689.410301958.750000.457303.392702.51760K562EIF3G
CAB39ENSG00000135932.61987.880203007.54290-0.597406.795505.41970K562FIP1L1
CAB39ENSG00000135932.62099.159202462.71280-0.230402.379501.33010K562GLRX3
CAB39ENSG00000135932.62827.906803749.31710-0.406905.031204.01320K562GRSF1
CAB39ENSG00000135932.61940.624302477.11050-0.352103.847802.58410K562HNRNPA1
CAB39ENSG00000135932.61134.454202082.81730-0.876506.625005.74150K562HNRNPC
CAB39ENSG00000135932.62386.573803394.45710-0.508207.389405.58180K562HNRNPL
CAB39ENSG00000135932.61758.390002743.23220-0.6416013.8667011.92680K562HNRNPU
CAB39ENSG00000135932.61922.414602855.50440-0.570806.105404.23120K562IGF2BP3
CAB39ENSG00000135932.62323.206202945.42070-0.342402.806301.87710K562MATR3
CAB39ENSG00000135932.63693.042604720.23340-0.354002.870401.71640K562MSI2
CAB39ENSG00000135932.62414.006602876.95740-0.253104.202403.30400K562NSUN2
CAB39ENSG00000135932.61451.476102050.05770-0.498103.183001.61870K562NUSAP1
CAB39ENSG00000135932.62657.317903413.93690-0.361503.199802.30700K562PPIG
CAB39ENSG00000135932.62448.777201773.276000.465504.905703.90960K562PRPF8
CAB39ENSG00000135932.61215.243501867.34170-0.619703.426502.40580K562PSIP1
CAB39ENSG00000135932.64264.942702867.192000.572807.344006.29940K562PTBP1
CAB39ENSG00000135932.65992.096805138.748700.221502.535401.51540K562PUM1
CAB39ENSG00000135932.62128.629402749.99580-0.369502.420801.63730K562RBM22
CAB39ENSG00000135932.63729.246002893.766800.365802.786901.68960K562NELFE
CAB39ENSG00000135932.62806.095201806.396000.635307.192905.86040K562RPS19
CAB39ENSG00000135932.61886.920401326.891400.507904.960403.56900K562RPS3
CAB39ENSG00000135932.61897.230303086.56430-0.702103.161201.73250K562SFPQ
CAB39ENSG00000135932.62149.999804215.74220-0.9715028.0995024.72950K562SUCLG1
CAB39ENSG00000135932.62208.630001689.419900.386504.751203.66950K562SYNCRIP
CAB39ENSG00000135932.62255.999402844.88170-0.334602.011301.40190K562TARDBP
CAB39ENSG00000135932.62261.851902744.12810-0.278802.128401.41870K562TIA1
CAB39ENSG00000135932.62040.875102692.07090-0.399503.712602.41850K562TRA2A
CAB39ENSG00000135932.61250.809001907.51140-0.608804.429403.17060K562TRIM56
CAB39ENSG00000135932.61301.975001817.25700-0.481104.402903.08760K562UCHL5
CAB39ENSG00000135932.62035.762603020.69920-0.569302.839401.52370K562UTP18
CAB39ENSG00000135932.61647.665702610.22320-0.6637010.907909.11950K562WDR3
CAB39ENSG00000135932.63919.921502714.218700.5302016.5760014.74590K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for CAB39 is not available on ENCORE database.





2 RBPs can affect the splicing of CAB39 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SECAB39ENSG00000135932.6chr2+2316753532316755612316749772316750372316787632316788290.076000.000000.00004includedK562AQR
SECAB39ENSG00000135932.6chr2+231682468231682612231678763231678829231683230231683465-0.075000.000000.00014excludedHepG2SRSF7
A3SSCAB39ENSG00000135932.6chr2+2316824312316826122316824682316826122316787712316788290.066000.000010.00006longerK562AQR
A5SSCAB39ENSG00000135932.6chr2+2316824682316827112316824682316826122316832302316857900.053000.000000.00000longerK562AQR
MXECAB39ENSG00000135932.6chr2+2316753532316755612316787712316788292316749772316750372316824682316826120.076000.000000.000021includedK562AQR
MXECAB39ENSG00000135932.6chr2+231678763231678829231682468231682711231674977231675037231683230231685790-0.091000.000350.003622includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for CAB39 is not avaliable on ENCORE database.