TMEM74B

General Information

Gene Name       : TMEM74B
Gene ID             : ENSG00000125895.5
Essential Gene : No

Functions

Localization

Domains (AlphaFold: TMEM74B)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878TMEM74BENSG00000125895.50.000.000.00ENCSR000AEF
HepG2TMEM74BENSG00000125895.55.804.275.04ENCSR985KAT
K562TMEM74BENSG00000125895.55.985.045.51ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for TMEM74B is not avaliable on ENCORE database.



Proteins bound to RNA
  • TMEM74B RNA is bound by 33 proteins.  







eCLIP assay for TMEM74B is not avaliable on ENCORE database.





33 proteins are bound to TMEM74B RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr2011652871165412-5'-UTR,intron-Distal,intron-Proximal4.3573415.26304K562HNRNPM
chr2011646971164714-5'-UTR,intron-Distal4.639616.09301K562CSTF2T
chr2011650421165079-5'-UTR,intron-Distal4.5616911.58381K562CSTF2T
chr2011653071165350-5'-UTR,intron-Distal,intron-Proximal4.9131610.08257K562EIF4G2
chr2011652151165273-5'-UTR,intron-Distal,intron-Proximal3.190625.66322K562TBRG4
chr2011650531165079-5'-UTR,intron-Distal4.437243.86024K562EWSR1
chr2011652271165284-5'-UTR,intron-Distal3.342127.75825K562PHF6
chr2011652061165271-5'-UTR,intron-Distal,intron-Proximal3.2206512.08853K562CSTF2T
chr2011651231165180-5'-UTR,intron-Distal,intron-Proximal5.7340015.60039K562CSTF2T
chr2011649671165045-5'-UTR,intron-Distal5.442579.55926K562NONO
chr2011651971165283-5'-UTR,intron-Distal,intron-Proximal6.4482418.07529K562TARDBP
chr2011650411165089-5'-UTR,intron-Distal4.3217314.46975K562EIF4G2
chr2011652321165276-5'-UTR,intron-Distal3.3319511.21695K562GEMIN5
chr2011652171165283-5'-UTR,intron-Distal3.758578.75483K562NONO
chr2011649771165045-5'-UTR,intron-Distal4.311477.47736K562EWSR1
chr2011652021165274-5'-UTR,intron-Distal,intron-Proximal5.0807840.82600K562EIF4G2
chr2011651211165151-5'-UTR,intron-Distal,intron-Proximal4.229263.53896K562NONO
chr2011646941164757-5'-UTR,intron-Distal3.490253.95966K562FUS
chr2011652051165274-5'-UTR,intron-Distal,intron-Proximal3.385344.20072K562IGF2BP1
chr2011651041165197-5'-UTR,intron-Distal,intron-Proximal5.499708.61835K562TARDBP
chr2011652081165286-5'-UTR,intron-Distal,intron-Proximal3.892619.94105K562EWSR1
chr2011649831165034-5'-UTR,intron-Distal4.7502112.42749K562CSTF2T
chr2011652271165294-5'-UTR,intron-Distal3.550395.06214K562FUS
chr2011651391165185-5'-UTR,intron-Distal,intron-Proximal5.0081112.57050K562EIF4G2
chr2011621981162292-CDS,intron-Distal3.396875.28154K562SF3B4
chr2011618241161890-CDS,intron-Distal,intron-Proximal4.408274.48994K562RBM15
chr2011621661162229-CDS,intron-Distal4.373403.89860HepG2PABPN1
chr2011656711165729-intron-Distal3.657025.38546K562RBFOX2
chr2011654661165590-intron-Distal3.6854423.92819K562GEMIN5
chr2011655261165592-intron-Distal4.8235017.71930K562EIF4G2
chr2011656871165739-intron-Distal4.505444.01415K562LSM11
chr2011656881165742-intron-Distal3.398637.24772K562AKAP8L
chr2011659191166008-intron-Distal4.030516.39716K562GEMIN5
chr2011655201165596-intron-Distal3.204954.54235HepG2RBFOX2
chr2011656721165751-intron-Distal5.4133929.65982K562CSTF2T
chr2011655021165553-intron-Distal4.263923.93512K562SMNDC1
chr2011653771165466-intron-Distal,intron-Proximal4.8026711.21374K562GEMIN5
chr2011653681165432-intron-Distal,intron-Proximal5.179957.27892K562EWSR1
chr2011653521165418-intron-Distal,intron-Proximal3.431257.15711K562TIA1
chr2011656761165757-intron-Distal4.6907512.70144K562GTF2F1
chr2011639391164039-intron-Distal6.0816331.33069HepG2HNRNPL
chr2011658951165995-intron-Distal3.0677012.85905K562CSTF2T
chr2011658931166011-intron-Distal4.3886312.64784HepG2PRPF4
chr2011656801165751-intron-Distal3.524654.79053K562FTO
chr2011658891165984-intron-Distal4.441299.21100K562GTF2F1
chr2011656741165742-intron-Distal4.961099.80960K562NONO
chr2011659111165999-intron-Distal4.617738.87808K562DDX51
chr2011656821165773-intron-Distal4.7269313.07947HepG2PRPF4
chr2011636421163694-intron-Distal4.019673.64859K562AGGF1
chr2011654591165588-intron-Distal4.9701937.86325K562CSTF2T
chr2011656831165755-intron-Distal4.1539912.95456K562EIF4G2
chr2011655061165589-intron-Distal3.312516.62714K562XRN2
chr2011656731165781-intron-Distal3.0365311.77173K562TIA1
chr2011654931165582-intron-Distal5.0302117.70806K562DROSHA
chr2011654861165585-intron-Distal3.718796.78741K562RBFOX2
chr2011656801165764-intron-Distal4.3964314.38196K562EWSR1
chr2011655081165610-intron-Distal3.927978.59703HepG2PRPF4
chr2011655111165575-intron-Distal3.267118.15780K562AKAP8L
chr2011655111165585-intron-Distal3.464216.27848K562DDX6
chr2011656831165760-intron-Distal4.1800112.97258K562FASTKD2
chr2011658781165970-intron-Distal3.629617.69813K562NONO
chr2011654951165572-intron-Distal4.8417719.18632K562NONO
chr2011654981165568-intron-Distal5.405848.56872K562TBRG4
chr2011656901165721-intron-Distal3.701803.50054K562TBRG4
chr2011656831165726-intron-Distal3.840968.57093K562DROSHA
chr2011655351165586-intron-Distal3.598188.65148K562FASTKD2
chr2011656861165738-intron-Distal3.277915.75319K562DDX52
chr2011655111165590-intron-Distal3.456438.03852HepG2FAM120A
chr2011639481163994-intron-Distal4.9249918.04756K562AGGF1
chr2011658771166011-intron-Distal3.7877115.02229HepG2CSTF2T
chr2011656761165753-intron-Distal3.363536.52705HepG2FAM120A
chr2011656631165751-intron-Distal3.535895.04221K562XRN2
chr2011653841165431-intron-Distal,intron-Proximal4.3235010.61026K562EIF4G2
chr2011654761165592-intron-Distal4.2056614.68325K562EWSR1
chr2011633231163355-intron-Distal3.038703.51990K562AGGF1
chr2011655061165574-intron-Distal3.674266.32781K562PHF6
chr2011653201165444-intron-Distal,intron-Proximal5.3950821.65425K562NONO
chr2011657031165791-intron-Distal3.461275.83933K562FUS
chr2011655201165578-intron-Distal5.084477.78167HepG2FASTKD2
chr2011653821165448-intron-Distal,intron-Proximal4.2667813.13888K562CSTF2T
chr2011656411165771-intron-Distal5.5591217.82135HepG2CSTF2T
chr2011654781165584-intron-Distal3.489166.66573HepG2GTF2F1
chr2011656931165746-intron-Distal4.390725.71515K562SLTM
chr2011656721165741-intron-Distal4.419095.97891K562FAM120A
chr2011639361164014-intron-Distal5.7415811.41394K562HNRNPL
chr2011655071165591-intron-Distal4.0539215.24811HepG2CSTF2T
chr2011653201165367-intron-Distal,intron-Proximal3.816439.41808K562CSTF2T
chr2011656681165719-intron-Distal3.848435.66718K562DHX30
chr2011655101165601-intron-Distal3.408388.55909K562FAM120A
chr2011654631165585-intron-Distal4.7500918.25664K562GTF2F1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for TMEM74B is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for TMEM74B is not available on ENCORE database.

  • 104 RBPs can affect the levels of TMEM74B.  








The Knockdown/knockout RNA-Seq assay for TMEM74B is not available on ENCORE database.





104 RBPs can affect the gene expression of TMEM74B :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
TMEM74BENSG00000125895.5259.87010353.28090-0.443002.940002.31580HepG2ACO1
TMEM74BENSG00000125895.5142.85390219.26750-0.618202.771001.77290HepG2ADAR
TMEM74BENSG00000125895.535.4854067.76660-0.933301.936401.42840HepG2BOP1
TMEM74BENSG00000125895.5426.43240265.031600.686103.789902.63570HepG2CCAR1
TMEM74BENSG00000125895.548.92280260.15010-2.410806.266705.13320HepG2CIRBP
TMEM74BENSG00000125895.5225.53290353.21320-0.647205.474604.59890HepG2CKAP4
TMEM74BENSG00000125895.5128.00980293.23330-1.195806.899005.69140HepG2CNOT7
TMEM74BENSG00000125895.558.18960124.17730-1.093604.768503.40580HepG2CSTF2
TMEM74BENSG00000125895.5259.23950417.01760-0.685803.202702.52080HepG2CELF1
TMEM74BENSG00000125895.5152.62980225.17520-0.561002.643601.51350HepG2DDX1
TMEM74BENSG00000125895.5166.53670249.04940-0.580602.696502.02610HepG2DDX21
TMEM74BENSG00000125895.5151.78310243.92760-0.684403.532102.49080HepG2DDX24
TMEM74BENSG00000125895.5111.71020175.04920-0.648002.485201.52250HepG2DDX5
TMEM74BENSG00000125895.5638.69840272.473801.2289010.930809.79800HepG2DDX6
TMEM74BENSG00000125895.5129.87570337.99650-1.3799015.5079014.18020HepG2DKC1
TMEM74BENSG00000125895.5308.94930220.802100.484502.782602.07810HepG2DNAJC21
TMEM74BENSG00000125895.5117.61240216.81060-0.882404.217803.10240HepG2EEF2
TMEM74BENSG00000125895.5571.74280261.736401.127206.141605.27710HepG2EIF2S1
TMEM74BENSG00000125895.5123.80180289.15310-1.223802.742702.10630HepG2EIF4A3
TMEM74BENSG00000125895.5243.43940345.22660-0.504002.118601.39000HepG2EWSR1
TMEM74BENSG00000125895.5281.00050157.307300.836905.932704.17860HepG2FAM120A
TMEM74BENSG00000125895.565.93120222.91720-1.7575012.8472011.62240HepG2HNRNPA1
TMEM74BENSG00000125895.5200.66630133.560600.587201.913901.30990HepG2HNRNPF
TMEM74BENSG00000125895.5312.12110246.307600.341501.811101.31130HepG2HNRNPU
TMEM74BENSG00000125895.5153.50280292.13830-0.928402.027401.46210HepG2MAGOH
TMEM74BENSG00000125895.5457.01320300.606200.604302.215801.64680HepG2NCBP2
TMEM74BENSG00000125895.5163.61920243.81220-0.575403.165602.26570HepG2PARN
TMEM74BENSG00000125895.5290.56290219.688100.403302.049601.40670HepG2PPIL4
TMEM74BENSG00000125895.593.33620152.45560-0.707902.663401.87040HepG2PRPF8
TMEM74BENSG00000125895.5354.23050270.540900.388702.203301.70420HepG2PTBP1
TMEM74BENSG00000125895.5235.63620450.51870-0.935009.056008.11450HepG2PUM1
TMEM74BENSG00000125895.5741.49100450.165300.719909.170307.98480HepG2PUM2
TMEM74BENSG00000125895.5230.21520359.84090-0.644405.451304.63960HepG2PUS1
TMEM74BENSG00000125895.580.38280247.25160-1.621008.806307.59480HepG2RAVER1
TMEM74BENSG00000125895.5415.54170288.133900.528203.421502.47700HepG2RBM15
TMEM74BENSG00000125895.5153.73390394.78560-1.3606016.6837015.62940HepG2RBM22
TMEM74BENSG00000125895.5126.76430258.59380-1.028505.419103.92900HepG2RCC2
TMEM74BENSG00000125895.596.93270143.92580-0.570302.024801.42940HepG2RPLP0
TMEM74BENSG00000125895.5102.33330243.00500-1.247707.179405.71300HepG2RPS10
TMEM74BENSG00000125895.598.57540171.25830-0.796903.565902.87740HepG2RPS19
TMEM74BENSG00000125895.5194.39390299.79730-0.625003.067301.93440HepG2RPS5
TMEM74BENSG00000125895.551.41340150.80070-1.552407.774906.54030HepG2RRP9
TMEM74BENSG00000125895.597.03300171.87570-0.824803.567202.49530HepG2SERBP1
TMEM74BENSG00000125895.579.80190199.32360-1.320607.224606.09930HepG2SF3A3
TMEM74BENSG00000125895.5161.24400255.80990-0.665804.292003.52230HepG2SMN1
TMEM74BENSG00000125895.5338.51750445.88420-0.397402.769902.26820HepG2SRFBP1
TMEM74BENSG00000125895.563.84280293.99330-2.2032026.3432025.20850HepG2SRSF1
TMEM74BENSG00000125895.5191.70120419.04310-1.1282010.359709.25110HepG2SRSF5
TMEM74BENSG00000125895.5323.07450239.183200.433702.648202.10570HepG2SRSF9
TMEM74BENSG00000125895.573.83560387.11280-2.3904041.2984039.87740HepG2SSB
TMEM74BENSG00000125895.5373.27340253.151300.560102.956901.63170HepG2SSRP1
TMEM74BENSG00000125895.5361.56360476.52730-0.398302.332701.75210HepG2SUCLG1
TMEM74BENSG00000125895.5122.36790196.83300-0.685702.866202.17910HepG2SUPV3L1
TMEM74BENSG00000125895.5125.22630248.65190-0.989603.802602.56230HepG2TBRG4
TMEM74BENSG00000125895.5473.50400242.810400.9634010.957809.32800HepG2TIA1
TMEM74BENSG00000125895.5348.14690241.471400.527703.838503.19690HepG2TRIM56
TMEM74BENSG00000125895.575.76120225.39510-1.572903.335902.65210HepG2U2AF1
TMEM74BENSG00000125895.594.07930170.66430-0.859204.399803.67290HepG2UTP3
TMEM74BENSG00000125895.5175.82880271.97990-0.629302.688601.64860HepG2XRCC6
TMEM74BENSG00000125895.582.18150158.19820-0.944804.819803.97430HepG2ZC3H8
TMEM74BENSG00000125895.5142.02460194.41290-0.453001.968101.48550HepG2ZNF622
TMEM74BENSG00000125895.5155.44890247.15090-0.669002.942201.59980HepG2ZRANB2
TMEM74BENSG00000125895.5115.38260184.21710-0.675002.786401.60260K562AARS
TMEM74BENSG00000125895.5355.02650226.854700.646103.810302.35050K562ABCF1
TMEM74BENSG00000125895.5669.80850386.589300.7928010.844009.81370K562AGGF1
TMEM74BENSG00000125895.5625.29980424.798400.557704.475703.15230K562AKAP8
TMEM74BENSG00000125895.5654.21260402.262500.701506.790305.73050K562AKAP8L
TMEM74BENSG00000125895.5373.54010495.03890-0.406302.016501.50030K562AQR
TMEM74BENSG00000125895.5409.83190275.287700.574003.851902.53880K562CPEB4
TMEM74BENSG00000125895.5522.81900339.964500.620805.733303.94830K562DDX21
TMEM74BENSG00000125895.5451.30290301.078000.583904.500503.12460K562DDX3X
TMEM74BENSG00000125895.5504.17390284.728100.824208.008606.97690K562DDX47
TMEM74BENSG00000125895.5453.78880330.722000.456303.573002.17900K562EIF2S1
TMEM74BENSG00000125895.5236.45300170.904000.468302.112501.40950K562EIF3G
TMEM74BENSG00000125895.5921.83990584.790200.656508.908907.25830K562EIF4G2
TMEM74BENSG00000125895.5239.58590163.080700.554902.552401.73960K562FIP1L1
TMEM74BENSG00000125895.5188.62390327.12730-0.794306.163405.31340K562FXR1
TMEM74BENSG00000125895.579.63980177.33060-1.154904.921503.91540K562G3BP2
TMEM74BENSG00000125895.5731.37680473.806800.626205.657704.57270K562GRSF1
TMEM74BENSG00000125895.5555.59960349.663800.668006.465504.86850K562HNRNPA1
TMEM74BENSG00000125895.5265.41480179.930900.560702.585301.48580K562HNRNPF
TMEM74BENSG00000125895.5203.10910134.141600.598402.296901.45220K562HNRNPM
TMEM74BENSG00000125895.5385.89460259.871600.570302.896201.83960K562IGF2BP2
TMEM74BENSG00000125895.5380.70140264.252900.526603.151001.85830K562IGF2BP3
TMEM74BENSG00000125895.5604.56610426.905200.501903.357802.43890K562KIF1C
TMEM74BENSG00000125895.5418.83100272.356900.620804.773703.52730K562MATR3
TMEM74BENSG00000125895.5842.33070623.312700.434303.022901.84130K562MSI2
TMEM74BENSG00000125895.5338.25910228.412300.566402.752401.94570K562MTPAP
TMEM74BENSG00000125895.5404.51220253.782600.672506.132805.08140K562NSUN2
TMEM74BENSG00000125895.5398.25430258.821500.621602.202301.33980K562PABPN1
TMEM74BENSG00000125895.5614.96920383.174100.682404.356802.32910K562PKM
TMEM74BENSG00000125895.5306.24890185.136600.726004.584603.49180K562PPIG
TMEM74BENSG00000125895.5332.00650180.606300.878306.475104.99820K562PSIP1
TMEM74BENSG00000125895.5179.29690265.18920-0.564703.163502.45850K562PTBP1
TMEM74BENSG00000125895.5426.78240638.03770-0.580104.480303.44780K562PUF60
TMEM74BENSG00000125895.5896.55230664.942200.431103.983602.82810K562PUM2
TMEM74BENSG00000125895.5555.86330398.942400.478403.094802.52620K562PUS1
TMEM74BENSG00000125895.5503.82540388.702300.374202.396301.83790K562RBM15
TMEM74BENSG00000125895.5128.34040201.05460-0.647602.753201.67380K562SAFB
TMEM74BENSG00000125895.5382.36500250.424600.610504.604303.57560K562SF3A3
TMEM74BENSG00000125895.5490.65430288.761200.764703.117101.70020K562SFPQ
TMEM74BENSG00000125895.5409.53450256.565900.674606.095304.77040K562SRPK2
TMEM74BENSG00000125895.5289.17770195.693100.563302.603301.39630K562STAU1
TMEM74BENSG00000125895.5547.98950325.199200.752703.053501.53110K562SUPT6H
TMEM74BENSG00000125895.5127.47650226.32530-0.828204.864603.76870K562SYNCRIP
TMEM74BENSG00000125895.5435.53140263.087700.727105.548204.52840K562TARDBP
TMEM74BENSG00000125895.5420.48080253.789100.728305.908704.64390K562TIA1
TMEM74BENSG00000125895.5330.57370173.701700.928306.246704.78620K562TIAL1
TMEM74BENSG00000125895.5361.67790249.144100.537602.887701.76650K562TRA2A
TMEM74BENSG00000125895.5328.42650190.742000.783804.938302.97070K562TRIP6
TMEM74BENSG00000125895.5355.80310269.091400.402902.462001.78310K562UPF1
TMEM74BENSG00000125895.5286.18700196.068500.545502.687301.50490K562UTP3
TMEM74BENSG00000125895.5346.92890230.252500.591303.840202.80330K562WDR3
TMEM74BENSG00000125895.5401.02980239.439400.743907.574806.23850K562WDR43
TMEM74BENSG00000125895.5905.84540586.754700.626407.149105.08150K562WRN
TMEM74BENSG00000125895.5821.93130557.567100.559804.404703.27570K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for TMEM74B is not available on ENCORE database.





1 RBPs can affect the splicing of TMEM74B :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SETMEM74BENSG00000125895.5chr20-116441411645921161800116223111660341166059-0.525000.001590.03035excludedK562SRSF1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for TMEM74B is not avaliable on ENCORE database.