SEH1L

General Information

Gene Name       : SEH1L
Gene ID             : ENSG00000085415.15
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: SEH1L)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SEH1LENSG00000085415.1537.5836.2136.89ENCSR000AEF
HepG2SEH1LENSG00000085415.1529.8238.6634.24ENCSR985KAT
K562SEH1LENSG00000085415.1563.8172.5868.19ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SEH1L is not avaliable on ENCORE database.



Proteins bound to RNA
  • SEH1L RNA is bound by 20 proteins.  







eCLIP assay for SEH1L is not avaliable on ENCORE database.





20 proteins are bound to SEH1L RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr181298714112987268+3'-UTR3.494665.20689K562IGF2BP1
chr181298614412986207+3'-UTR,intron-Distal3.382164.46783HepG2FUBP3
chr181298682912986868+3'-UTR,CDS,intron-Proximal3.712074.46957K562TIA1
chr181298630512986363+3'-UTR,intron-Distal3.355707.83495K562KHSRP
chr181298691012987022+3'-UTR,CDS4.3670910.39320HepG2PCBP2
chr181298683112986933+3'-UTR,CDS,intron-Proximal3.911817.54025HepG2U2AF1
chr181298617012986200+3'-UTR,intron-Distal3.051073.77257K562FAM120A
chr181298735812987431+3'-UTR3.999787.55138K562KHSRP
chr181298613712986227+3'-UTR,intron-Distal3.290269.83419K562KHSRP
chr181298641012986459+3'-UTR,intron-Distal3.472628.31323K562YBX3
chr181298708212987135+3'-UTR5.1525213.21799K562PUM2
chr181298681912986922+3'-UTR,CDS,intron-Proximal3.4685215.28508HepG2U2AF2
chr181298681312986952+3'-UTR,CDS,intron-Proximal3.005205.93908K562U2AF2
chr181298636512986410+3'-UTR,intron-Distal4.359704.32914K562YBX3
chr181298716012987197+3'-UTR3.961076.24385K562PUM2
chr181298573912985800+3'-UTR,intron-Distal3.027403.66774HepG2CSTF2
chr181298520712985263+3'-UTR,CDS,intron-Distal,intron-Proximal4.579376.86842HepG2U2AF2
chr181298673912986789+3'-UTR,intron-Distal,intron-Proximal3.063604.41351K562PTBP1
chr181298649312986532+3'-UTR,intron-Distal3.898066.62754K562PUM2
chr181298636312986430+3'-UTR,intron-Distal3.224418.00700K562KHSRP
chr181298631412986417+3'-UTR,intron-Distal3.420825.39573HepG2KHSRP
chr181298526112985318+3'-UTR,intron-Distal4.8007452.89959K562PABPC4
chr181298683512986896+3'-UTR,CDS,intron-Proximal3.145724.89227HepG2KHSRP
chr181298730512987380+3'-UTR4.7900815.01495K562PUM2
chr181298681912986943+3'-UTR,CDS,intron-Proximal3.660408.04171K562U2AF1
chr181294801412948086+5'-UTR,intron-Distal,intron-Proximal3.8110010.65333K562DDX3X
chr181294803012948122+5'-UTR,CDS,intron-Distal,intron-Proximal5.7196816.03443HepG2DDX3X
chr181294808612948162+5'-UTR,CDS,intron-Proximal5.0311319.79992K562DDX3X
chr181294799212948142+5'-UTR,CDS,intron-Distal,intron-Proximal3.083463.90007HepG2NCBP2
chr181295553112955609+CDS,intron-Distal,intron-Proximal4.097327.39306HepG2PPIG
chr181298411412984231+CDS,intron-Proximal4.059105.36555HepG2BCLAF1
chr181294820712948268+CDS,intron-Proximal3.911557.29769HepG2PRPF8
chr181297113412971195+CDS,intron-Proximal3.076844.21310K562U2AF1
chr181297113312971221+CDS,intron-Proximal3.7146210.46234K562U2AF2
chr181298403412984114+CDS,intron-Proximal3.176663.55800HepG2BCLAF1
chr181297124112971304+CDS,intron-Proximal3.890143.19904K562TIA1
chr181296859812968680+intron-Distal4.350193.62025K562MATR3
chr181298481712984863+intron-Distal3.512785.40624K562KHSRP
chr181298473012984783+intron-Distal4.593916.93191K562KHSRP
chr181298436912984442+intron-Distal3.863006.89441K562KHSRP
chr181296345112963572+intron-Distal,intron-Proximal3.534244.66077K562U2AF2
chr181298481412984876+intron-Distal3.458524.79415HepG2KHSRP
chr181298497512985022+intron-Distal4.360354.79379K562KHSRP
chr181298517112985226+intron-Distal,intron-Proximal3.487973.78824HepG2KHSRP
chr181296345112963579+intron-Distal,intron-Proximal5.3056315.60330HepG2U2AF2
chr181297132012971415+intron-Distal,intron-Proximal3.462787.20875K562KHSRP
chr181297389012973944+intron-Distal3.791163.39866K562LSM11
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SEH1L is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SEH1L is not available on ENCORE database.

  • 99 RBPs can affect the levels of SEH1L.  








The Knockdown/knockout RNA-Seq assay for SEH1L is not available on ENCORE database.





99 RBPs can affect the gene expression of SEH1L :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SEH1LENSG00000085415.11649.09690856.89580-0.400702.765901.76890HepG2ADAR
SEH1LENSG00000085415.11810.444301031.56620-0.348102.123501.43030HepG2ASCC1
SEH1LENSG00000085415.11563.94920851.85740-0.595004.241303.14950HepG2BCLAF1
SEH1LENSG00000085415.11747.441601192.40640-0.673805.314303.94520HepG2CCAR1
SEH1LENSG00000085415.11697.88350956.77310-0.455206.425205.48780HepG2CKAP4
SEH1LENSG00000085415.11852.809101424.37430-0.7400019.6262017.98890HepG2DAZAP1
SEH1LENSG00000085415.11617.89620885.07870-0.518407.862006.57770HepG2DDX19B
SEH1LENSG00000085415.11594.63500879.97540-0.565506.782405.06840HepG2DDX1
SEH1LENSG00000085415.11432.74610733.92630-0.762108.302907.19480HepG2DDX21
SEH1LENSG00000085415.11271.33690730.22970-1.4283019.7436016.90610HepG2DDX28
SEH1LENSG00000085415.11732.84510963.83320-0.395302.042901.36850HepG2DDX55
SEH1LENSG00000085415.11574.84240832.23180-0.533804.872203.58830HepG2DHX30
SEH1LENSG00000085415.11743.06620915.58400-0.301202.623601.96140HepG2DKC1
SEH1LENSG00000085415.11639.47140862.87850-0.432304.472503.59490HepG2DNAJC21
SEH1LENSG00000085415.11561.52020855.19960-0.6069010.042308.89250HepG2DNAJC2
SEH1LENSG00000085415.11610.29390986.23290-0.692406.586405.69540HepG2EIF2S1
SEH1LENSG00000085415.111045.830501405.15910-0.426106.316405.14250HepG2EIF4G1
SEH1LENSG00000085415.111087.873501346.06570-0.307202.215101.48060HepG2EIF4G2
SEH1LENSG00000085415.111419.849901785.38340-0.330502.233801.68400HepG2ETF1
SEH1LENSG00000085415.11490.52900763.85000-0.639002.197901.30130HepG2FTO
SEH1LENSG00000085415.11647.824501020.09970-0.655005.773504.82610HepG2G3BP1
SEH1LENSG00000085415.11581.68750827.02670-0.507703.459902.31350HepG2GNB2L1
SEH1LENSG00000085415.11359.03560864.44400-1.2676016.4316014.99410HepG2GPKOW
SEH1LENSG00000085415.11383.91210871.14450-1.1821018.3020016.87800HepG2HNRNPA1
SEH1LENSG00000085415.11596.52980968.96750-0.699907.749206.63670HepG2HNRNPC
SEH1LENSG00000085415.11674.879501013.21140-0.586209.340308.11990HepG2HNRNPF
SEH1LENSG00000085415.111086.431401297.52180-0.256203.042602.33830HepG2HNRNPL
SEH1LENSG00000085415.11512.40430824.95280-0.687006.243305.33990HepG2HNRNPLL
SEH1LENSG00000085415.11597.60370962.56270-0.6877010.970109.82990HepG2HNRNPU
SEH1LENSG00000085415.11687.97810997.71730-0.536304.102003.23540HepG2IGF2BP1
SEH1LENSG00000085415.11695.74730983.22930-0.499007.800606.63580HepG2ILF2
SEH1LENSG00000085415.11725.12520874.80590-0.270702.591301.60250HepG2KIF1C
SEH1LENSG00000085415.11824.600001100.03260-0.415802.856402.19140HepG2MAGOH
SEH1LENSG00000085415.11431.75530841.29510-0.962407.533805.90410HepG2MTPAP
SEH1LENSG00000085415.11540.99460731.46200-0.435202.916902.14840HepG2NSUN2
SEH1LENSG00000085415.11692.38000952.79690-0.460605.667604.51530HepG2PARN
SEH1LENSG00000085415.111209.57640959.679000.333803.831203.14150HepG2PCBP1
SEH1LENSG00000085415.11517.16190858.53240-0.7313010.983309.56610HepG2PPIL4
SEH1LENSG00000085415.11568.84770749.05120-0.397003.889902.98800HepG2PRPF4
SEH1LENSG00000085415.11840.460201348.23760-0.681809.389108.38030HepG2PUF60
SEH1LENSG00000085415.11779.172201430.15790-0.8762017.1551015.57600HepG2PUM2
SEH1LENSG00000085415.11438.53310974.76280-1.1524030.5299028.88740HepG2PUS1
SEH1LENSG00000085415.11785.44170992.53440-0.337602.713001.86240HepG2RBM15
SEH1LENSG00000085415.11697.187101091.57580-0.646807.672306.62240HepG2RPLP0
SEH1LENSG00000085415.11356.70970502.66120-0.494803.327602.66160HepG2RPS19
SEH1LENSG00000085415.11663.36090900.99280-0.441703.066402.22440HepG2RPS2
SEH1LENSG00000085415.11525.80900890.13660-0.759505.931004.76230HepG2RPS3A
SEH1LENSG00000085415.11459.20540857.21620-0.9005018.1462016.70380HepG2SAFB2
SEH1LENSG00000085415.11483.77470918.63000-0.925102.657801.34270HepG2SF1
SEH1LENSG00000085415.111008.469601292.69270-0.358205.150204.24090HepG2SLBP
SEH1LENSG00000085415.11719.97530999.67860-0.473507.304406.33600HepG2SMN1
SEH1LENSG00000085415.11566.35330842.98260-0.573803.745401.85930HepG2SND1
SEH1LENSG00000085415.112160.253501685.517000.357905.616404.97220HepG2SRFBP1
SEH1LENSG00000085415.111511.988401061.185000.510708.772908.03730HepG2SRSF1
SEH1LENSG00000085415.111136.759901331.15500-0.227802.219901.65220HepG2SRSF5
SEH1LENSG00000085415.11717.80040995.46950-0.471806.527505.53110HepG2SRSF7
SEH1LENSG00000085415.111076.16260863.338300.317803.558302.94950HepG2SRSF9
SEH1LENSG00000085415.111030.824201463.50810-0.505604.239403.63340HepG2SSB
SEH1LENSG00000085415.111173.133301513.91840-0.367905.803404.96190HepG2SUCLG1
SEH1LENSG00000085415.11484.74710959.51400-0.9851010.269509.10400HepG2SUPV3L1
SEH1LENSG00000085415.11603.94730804.01340-0.412802.818502.08820HepG2TARDBP
SEH1LENSG00000085415.11388.77920935.38340-1.2666026.7103025.45240HepG2TIAL1
SEH1LENSG00000085415.11645.40240943.66570-0.548107.920807.04400HepG2TRIM56
SEH1LENSG00000085415.111010.570901317.12570-0.382203.606002.59550HepG2TUFM
SEH1LENSG00000085415.11965.814601394.12700-0.529504.144403.10930HepG2UBE2L3
SEH1LENSG00000085415.11569.15440878.70780-0.626603.398802.28000HepG2UPF2
SEH1LENSG00000085415.11616.44720944.53530-0.615604.905403.94860HepG2XRN2
SEH1LENSG00000085415.11588.67240739.22800-0.328603.072402.37270HepG2ZC3H8
SEH1LENSG00000085415.112123.477601694.178900.325702.947201.72220K562AARS
SEH1LENSG00000085415.112144.673701740.594900.301104.259103.58130K562AGGF1
SEH1LENSG00000085415.112813.902301811.171100.635509.810808.48420K562AKAP8L
SEH1LENSG00000085415.112517.000604053.66720-0.687508.445007.51000K562AQR
SEH1LENSG00000085415.112382.720701900.360500.326204.202303.05360K562ATP5C1
SEH1LENSG00000085415.112011.688702477.88380-0.300704.573303.32100K562BCLAF1
SEH1LENSG00000085415.111272.451601678.33320-0.399403.309702.35440K562BOP1
SEH1LENSG00000085415.111321.567001784.55270-0.433304.994503.94660K562CPSF6
SEH1LENSG00000085415.111692.497802423.10100-0.517705.338902.51580K562DDX28
SEH1LENSG00000085415.112759.660601948.929800.501707.123705.60640K562DKC1
SEH1LENSG00000085415.111510.770102269.09050-0.586806.875605.38420K562EFTUD2
SEH1LENSG00000085415.111677.241802072.93690-0.305603.945102.47710K562EIF2S1
SEH1LENSG00000085415.112105.926103058.19490-0.5382011.6172010.29410K562EIF2S2
SEH1LENSG00000085415.111329.106101971.60980-0.568907.183305.86570K562EIF4A3
SEH1LENSG00000085415.111349.884901815.73430-0.427703.956302.93030K562FMR1
SEH1LENSG00000085415.111000.294501538.99610-0.621606.461205.00740K562FTO
SEH1LENSG00000085415.112561.899802050.397700.321204.578703.82740K562FXR1
SEH1LENSG00000085415.11892.144301703.81100-0.9334017.0680015.02570K562GPKOW
SEH1LENSG00000085415.113451.730204075.40480-0.239602.148801.47750K562GRSF1
SEH1LENSG00000085415.111214.658401854.18620-0.610208.673407.66690K562HNRNPC
SEH1LENSG00000085415.111290.655201655.60820-0.359303.204901.97000K562HNRNPF
SEH1LENSG00000085415.113343.236202488.313000.426003.998702.47690K562HNRNPK
SEH1LENSG00000085415.112371.506101922.094000.303002.327401.57980K562KIF1C
SEH1LENSG00000085415.111018.131301454.83590-0.514903.506002.44060K562KRR1
SEH1LENSG00000085415.111299.438101652.92950-0.347103.117301.46630K562LSM11
SEH1LENSG00000085415.112110.983402618.10770-0.310602.915002.05180K562MAGOH
SEH1LENSG00000085415.111337.023201663.10870-0.314902.563101.72440K562METAP2
SEH1LENSG00000085415.111879.643702360.83770-0.328805.296704.20250K562MTPAP
SEH1LENSG00000085415.112337.534801509.260900.631005.395604.02350K562NAA15
SEH1LENSG00000085415.112100.067402623.11030-0.320807.199406.07780K562NSUN2
SEH1LENSG00000085415.111357.616301825.34310-0.427103.505101.82960K562NUSAP1
SEH1LENSG00000085415.111507.143302272.38280-0.592406.272205.01580K562PCBP3
SEH1LENSG00000085415.111370.159201810.12110-0.401703.790202.07860K562PHF6
SEH1LENSG00000085415.111104.937601743.02670-0.6576010.642509.11800K562POLR2G
SEH1LENSG00000085415.111096.598101662.42140-0.600307.280605.68590K562PSIP1
SEH1LENSG00000085415.113927.441704910.83420-0.322404.596703.35000K562PUM2
SEH1LENSG00000085415.112380.143501796.162100.406003.645503.03430K562PUS1
SEH1LENSG00000085415.112410.346801750.108200.461707.451406.50940K562RBM15
SEH1LENSG00000085415.111549.479702249.33730-0.537704.563603.51170K562RPS19
SEH1LENSG00000085415.111578.732702588.32900-0.7133018.2648016.31870K562SF3A3
SEH1LENSG00000085415.111114.758501437.62630-0.367003.043301.95550K562SRFBP1
SEH1LENSG00000085415.113004.898602493.462400.269102.587601.90070K562SRSF1
SEH1LENSG00000085415.11962.923301225.47410-0.347802.815901.75110K562SRSF4
SEH1LENSG00000085415.111789.312802354.63550-0.396102.958001.86540K562SRSF5
SEH1LENSG00000085415.111743.561602082.76770-0.256502.813301.63590K562SRSF7
SEH1LENSG00000085415.111660.005502063.02070-0.313603.738902.22070K562SSB
SEH1LENSG00000085415.111376.622502138.18280-0.635306.131604.57470K562SUPV3L1
SEH1LENSG00000085415.112166.632701748.257600.309403.211902.32690K562SYNCRIP
SEH1LENSG00000085415.111896.550702523.76590-0.412203.859903.01830K562TARDBP
SEH1LENSG00000085415.111775.536702434.39960-0.455306.026904.74900K562TIA1
SEH1LENSG00000085415.111081.917401599.00110-0.563605.394304.04500K562TIAL1
SEH1LENSG00000085415.111289.905401698.45880-0.397003.776202.63890K562TRIM56
SEH1LENSG00000085415.112757.272203177.17820-0.204502.726701.46730K562TROVE2
SEH1LENSG00000085415.111489.912702262.86140-0.602906.917805.22190K562UCHL5
SEH1LENSG00000085415.111824.755802781.33890-0.6081017.3182015.68650K562UPF1
SEH1LENSG00000085415.111837.914102379.90480-0.372804.112503.03760K562WDR3
SEH1LENSG00000085415.111710.854602304.00180-0.429403.774902.28450K562XRN2
SEH1LENSG00000085415.113791.757404566.90240-0.268302.420801.62170K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SEH1L is not available on ENCORE database.





5 RBPs can affect the splicing of SEH1L :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESEH1LENSG00000085415.11chr18+129554611295569112951853129519041296315812963370-0.222000.005090.07515excludedK562SF3B4
SESEH1LENSG00000085415.11chr18+1296346012963556129631581296337012971151129712510.099000.000000.00000includedK562HNRNPC
A3SSSEH1LENSG00000085415.11chr18+129852381298753512986860129875351298403812984189-0.649000.000000.00000shorterHepG2PTBP1
A3SSSEH1LENSG00000085415.11chr18+129852381298753512986860129875351298403812984189-0.285000.000010.00417shorterHepG2MATR3
A3SSSEH1LENSG00000085415.11chr18+1298249612982674129825161298267412976286129788910.058000.000000.00002longerK562AQR
A3SSSEH1LENSG00000085415.11chr18+129852381298753512986860129875351298403812984189-0.642000.000000.00000shorterK562PTBP1
MXESEH1LENSG00000085415.11chr18+12963460129635561296443412964494129631581296337012971151129712500.581000.003800.028541includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SEH1L is not avaliable on ENCORE database.