CDK4

General Information

Gene Name       : CDK4
Gene ID             : ENSG00000135446.16
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: CDK4)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878CDK4ENSG00000135446.16134.45163.18148.81ENCSR000AEF
HepG2CDK4ENSG00000135446.16215.07194.04204.56ENCSR985KAT
K562CDK4ENSG00000135446.16308.72233.62271.17ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for CDK4 is not avaliable on ENCORE database.



Proteins bound to RNA
  • CDK4 RNA is bound by 21 proteins.  







eCLIP assay for CDK4 is not avaliable on ENCORE database.





21 proteins are bound to CDK4 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr125814300358143066-3'-UTR,CDS,intron-Distal,intron-Proximal3.970784.02740K562PCBP1
chr125814300758143090-3'-UTR,CDS,intron-Distal,intron-Proximal3.638228.60819HepG2LARP4
chr125814203358142106-3'-UTR,intron-Distal,intron-Proximal4.4721313.74647K562TIA1
chr125814205858142161-3'-UTR,intron-Distal,intron-Proximal3.356145.98230K562HNRNPK
chr125814505658145125-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.202903.67092HepG2G3BP1
chr125814206758142153-3'-UTR,intron-Distal,intron-Proximal3.007304.17463HepG2PTBP1
chr125814204458142094-3'-UTR,intron-Distal,intron-Proximal4.718214.41043K562APOBEC3C
chr125814206758142172-3'-UTR,intron-Distal,intron-Proximal6.110309.47433HepG2PCBP1
chr125814205658142183-3'-UTR,intron-Distal,intron-Proximal4.345999.39239HepG2LARP4
chr125814293358142992-3'-UTR,CDS,intron-Distal,intron-Proximal3.455845.50267HepG2PRPF8
chr125814298958143101-3'-UTR,CDS,intron-Distal,intron-Proximal4.3777915.66174K562RPS3
chr125814296858143080-3'-UTR,CDS,intron-Distal,intron-Proximal3.8849917.89100HepG2RPS3
chr125814206058142170-3'-UTR,intron-Distal,intron-Proximal6.6095840.95634K562PCBP1
chr125814320758143275-3'-UTR,CDS,intron-Distal,intron-Proximal5.815227.36776HepG2PRPF8
chr125814542758145521-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.726196.63166HepG2DDX3X
chr125814296458143007-3'-UTR,CDS,intron-Distal,intron-Proximal4.932487.56355HepG2LARP4
chr125814206658142101-3'-UTR,intron-Distal,intron-Proximal7.5836822.28433HepG2PCBP2
chr125814541358145519-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.0827325.51093K562DDX3X
chr125814544058145513-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.828504.08867HepG2LARP4
chr125814210158142169-3'-UTR,intron-Distal,intron-Proximal5.8938144.26726HepG2PCBP2
chr125814598658146085-5'-UTR,intron-Distal,intron-Proximal3.252915.64888HepG2RPS3
chr125814600558146078-5'-UTR,intron-Distal,intron-Proximal5.4621227.83502HepG2DDX3X
chr125814596158146005-5'-UTR,intron-Distal,intron-Proximal4.385967.30480HepG2DDX3X
chr125814444958144518-5'-UTR,CDS,intron-Distal,intron-Proximal3.039289.61156K562YBX3
chr125814595658145974-5'-UTR,intron-Distal,intron-Proximal3.1159111.73000K562DDX3X
chr125814470558144722-5'-UTR,CDS,intron-Distal,intron-Proximal3.284403.69775K562YBX3
chr125814597458146038-5'-UTR,intron-Distal,intron-Proximal3.1312922.76023K562DDX3X
chr125814599458146061-5'-UTR,intron-Distal,intron-Proximal5.334428.04156K562GEMIN5
chr125814598058146055-5'-UTR,intron-Distal,intron-Proximal3.109616.46536K562FTO
chr125814533458145427-5'-UTR,CDS,intron-Distal,intron-Proximal4.312797.94128HepG2DDX3X
chr125814502358145061-CDS,intron-Distal,intron-Proximal3.0930610.64090K562YBX3
chr125814506158145065-CDS,intron-Distal,intron-Proximal3.659128.63185K562YBX3
chr125814496058145028-CDS,intron-Distal,intron-Proximal4.241628.17589HepG2PRPF8
chr125814439458144438-intron-Distal,intron-Proximal3.639914.65388K562PRPF8
chr125814874358148792-intron-Distal4.185064.19345HepG2CSTF2T
chr125814943758149482-intron-Distal3.911833.60408HepG2XPO5
chr125814918358149267-intron-Distal4.778115.35385HepG2PRPF4
chr125814903158149080-intron-Distal4.585395.60609HepG2CSTF2T
chr125814312458143189-intron-Distal,intron-Proximal3.759783.05889HepG2SF3B4
chr125814517358145265-intron-Distal,intron-Proximal4.452833.19125K562GTF2F1
chr125814916258149271-intron-Distal5.304649.42984HepG2NKRF
chr125814948658149526-intron-Distal5.072795.31214HepG2XPO5
chr125814889758148962-intron-Distal4.960264.82195HepG2XPO5
chr125814936558149411-intron-Distal4.780314.75034HepG2XPO5
chr125814917958149237-intron-Distal3.486854.21158HepG2CSTF2T
chr125814284258142923-intron-Distal,intron-Proximal4.789836.46853K562EFTUD2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for CDK4 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for CDK4 is not available on ENCORE database.

  • 107 RBPs can affect the levels of CDK4.  








The Knockdown/knockout RNA-Seq assay for CDK4 is not available on ENCORE database.





107 RBPs can affect the gene expression of CDK4 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
CDK4ENSG00000135446.122227.221201389.288700.680808.054206.56310HepG2ABCF1
CDK4ENSG00000135446.122120.730503237.56730-0.6103017.1712015.72730HepG2AUH
CDK4ENSG00000135446.121003.704501704.44490-0.764009.583908.04220HepG2BCLAF1
CDK4ENSG00000135446.12971.12380699.284800.473703.980403.27660HepG2BOP1
CDK4ENSG00000135446.12828.904701040.82870-0.328502.560201.37740HepG2BUD13
CDK4ENSG00000135446.12653.18250950.07760-0.540605.795404.73270HepG2CALR
CDK4ENSG00000135446.121595.544701211.484700.397203.015201.89440HepG2CSTF2
CDK4ENSG00000135446.121804.731202369.63770-0.392904.012503.26460HepG2CELF1
CDK4ENSG00000135446.121901.797501512.030800.330802.512001.71430HepG2DDX19B
CDK4ENSG00000135446.121401.414002088.19870-0.575405.780704.90730HepG2DDX3X
CDK4ENSG00000135446.121261.091101928.98910-0.613205.452204.41170HepG2DDX55
CDK4ENSG00000135446.12865.556701361.95360-0.654005.485703.93280HepG2AGO1
CDK4ENSG00000135446.12761.115301724.42840-1.1799019.7795018.29560HepG2EIF2S1
CDK4ENSG00000135446.122743.364701855.472000.564104.237003.39560HepG2EIF4B
CDK4ENSG00000135446.122003.764902513.66200-0.327103.829602.87400HepG2EIF4G1
CDK4ENSG00000135446.122118.658301597.395800.407303.405302.47730HepG2EWSR1
CDK4ENSG00000135446.121124.675501409.62620-0.325802.773301.62820HepG2FASTKD2
CDK4ENSG00000135446.121237.429601605.45560-0.375603.110901.76530HepG2FKBP4
CDK4ENSG00000135446.12291.49060643.09660-1.141605.466804.04570HepG2FTO
CDK4ENSG00000135446.12590.946601206.66690-1.0299018.1964016.26420HepG2FUBP3
CDK4ENSG00000135446.121193.69430796.733000.583205.471304.20700HepG2GEMIN5
CDK4ENSG00000135446.12957.898601437.41540-0.585503.112501.63970HepG2HLTF
CDK4ENSG00000135446.121620.845902341.49410-0.5307010.583908.97470HepG2HNRNPA2B1
CDK4ENSG00000135446.121441.169502122.34450-0.5584012.1857010.82750HepG2HNRNPF
CDK4ENSG00000135446.121470.010001806.14610-0.297102.140101.52100HepG2HNRNPK
CDK4ENSG00000135446.12330.25310694.44520-1.0723012.3217011.11630HepG2HNRNPLL
CDK4ENSG00000135446.12707.376301506.05710-1.0902026.3030024.59060HepG2HNRNPU
CDK4ENSG00000135446.121692.914202089.90000-0.303903.023102.26850HepG2IGF2BP1
CDK4ENSG00000135446.121039.843601538.39560-0.5651011.272909.90250HepG2ILF2
CDK4ENSG00000135446.123838.759801934.219600.9888015.4394014.03870HepG2MATR3
CDK4ENSG00000135446.12870.570001135.29260-0.383003.208702.33970HepG2MSI2
CDK4ENSG00000135446.12415.95100708.32510-0.768003.074902.04890HepG2MTPAP
CDK4ENSG00000135446.121506.565901979.77730-0.394102.901002.25380HepG2NCBP2
CDK4ENSG00000135446.122059.963602526.23820-0.294403.063202.26180HepG2NOL12
CDK4ENSG00000135446.12820.844901771.89370-1.110109.854407.75820HepG2NONO
CDK4ENSG00000135446.12401.57550615.78550-0.616804.681003.71710HepG2NSUN2
CDK4ENSG00000135446.121193.233201763.10230-0.563205.373704.37800HepG2PABPC4
CDK4ENSG00000135446.122169.457501877.937400.208102.207101.65410HepG2PCBP1
CDK4ENSG00000135446.121040.936601418.49910-0.446502.407101.43570HepG2PCBP2
CDK4ENSG00000135446.12574.207601395.30050-1.2809037.8054035.63940HepG2PRPF4
CDK4ENSG00000135446.121042.155301487.44200-0.513305.117204.05390HepG2PRPF8
CDK4ENSG00000135446.122882.221702560.125400.170902.660202.07580HepG2PUM1
CDK4ENSG00000135446.12601.776702069.55250-1.7820073.0534070.69940HepG2QKI
CDK4ENSG00000135446.124080.048503106.985800.393003.891303.30450HepG2RBM22
CDK4ENSG00000135446.121254.216901878.22780-0.582608.368607.24560HepG2RBM25
CDK4ENSG00000135446.122794.891902126.608100.394106.903806.11750HepG2NELFE
CDK4ENSG00000135446.121705.996402286.33700-0.422404.357003.52890HepG2RPLP0
CDK4ENSG00000135446.12974.541301344.89180-0.464702.491601.59430HepG2RPS10
CDK4ENSG00000135446.121283.617001833.54340-0.514405.773604.64340HepG2RPS2
CDK4ENSG00000135446.121025.619201471.32740-0.520604.722303.72650HepG2RRP9
CDK4ENSG00000135446.12516.49950687.34210-0.412302.659701.96830HepG2SF3B1
CDK4ENSG00000135446.121681.312101989.48650-0.242802.867502.26730HepG2SF3B4
CDK4ENSG00000135446.121838.769002312.56140-0.330803.681802.89150HepG2SLBP
CDK4ENSG00000135446.12546.97920764.79630-0.483602.273901.56880HepG2SNRNP70
CDK4ENSG00000135446.121968.389103509.15120-0.8341033.5650032.32450HepG2SRFBP1
CDK4ENSG00000135446.122637.266602076.571200.344705.908005.28210HepG2SRSF1
CDK4ENSG00000135446.121954.117302381.22930-0.285203.646502.94600HepG2SRSF5
CDK4ENSG00000135446.121398.430802085.14530-0.5763013.2617011.93360HepG2SRSF7
CDK4ENSG00000135446.122125.396703046.64320-0.519507.394906.63450HepG2SSB
CDK4ENSG00000135446.12817.738401279.07480-0.645404.088102.61130HepG2SUB1
CDK4ENSG00000135446.123367.762602708.008700.314504.916204.12810HepG2SUCLG1
CDK4ENSG00000135446.12739.68530947.20120-0.356802.758301.81900HepG2SUPT6H
CDK4ENSG00000135446.121485.022001920.09990-0.370703.062802.35570HepG2SUPV3L1
CDK4ENSG00000135446.121264.13650845.027200.581002.274601.30740HepG2TBRG4
CDK4ENSG00000135446.12892.781601286.86660-0.527504.805103.54410HepG2TFIP11
CDK4ENSG00000135446.121367.592501715.07080-0.326603.230502.33180HepG2TIA1
CDK4ENSG00000135446.121119.002601463.59230-0.387304.328803.73220HepG2TIAL1
CDK4ENSG00000135446.12881.268001476.48640-0.7445017.5813016.32070HepG2TRIM56
CDK4ENSG00000135446.12610.104601199.99320-0.9759014.0280012.57810HepG2U2AF1
CDK4ENSG00000135446.12859.104101134.13980-0.400703.238302.41820HepG2UCHL5
CDK4ENSG00000135446.12683.237401159.40150-0.7629016.6118015.18170HepG2UPF1
CDK4ENSG00000135446.121730.397501119.359400.6283014.2637013.06560HepG2UTP3
CDK4ENSG00000135446.12930.260001346.30010-0.533303.290501.90160HepG2XRCC5
CDK4ENSG00000135446.121141.503801377.03310-0.270603.341002.61440HepG2ZC3H8
CDK4ENSG00000135446.12837.188301275.12230-0.6070013.3401012.36520HepG2ZNF622
CDK4ENSG00000135446.12648.570801367.84560-1.0766012.219209.43490HepG2ZRANB2
CDK4ENSG00000135446.121684.456102077.92640-0.302902.559701.42900K562AARS
CDK4ENSG00000135446.121954.680802680.02430-0.455302.939401.91720K562AKAP8
CDK4ENSG00000135446.123469.807904871.11110-0.489406.273605.44940K562AQR
CDK4ENSG00000135446.122594.370703001.87990-0.210502.777801.81620K562BCLAF1
CDK4ENSG00000135446.121055.586301418.71490-0.426503.551602.32570K562CCAR1
CDK4ENSG00000135446.121450.827301799.19040-0.310502.636801.62020K562DDX3X
CDK4ENSG00000135446.121186.260001588.16870-0.420903.183901.75050K562DHX30
CDK4ENSG00000135446.121111.397301525.63130-0.457004.391602.66980K562DNAJC21
CDK4ENSG00000135446.121864.384902655.50770-0.510305.848604.49030K562EFTUD2
CDK4ENSG00000135446.122367.810301779.295600.412106.235105.05840K562EIF3G
CDK4ENSG00000135446.123083.776102082.517300.566307.830306.33050K562FIP1L1
CDK4ENSG00000135446.121359.825501974.58940-0.538103.338102.07940K562FKBP4
CDK4ENSG00000135446.121013.538001309.16850-0.369302.808901.94850K562FMR1
CDK4ENSG00000135446.12736.635001109.68070-0.591105.323104.01070K562FTO
CDK4ENSG00000135446.122974.814301954.740900.6057014.2273012.96090K562FXR1
CDK4ENSG00000135446.12886.297901414.05380-0.674005.494504.42250K562G3BP2
CDK4ENSG00000135446.121831.203702272.73730-0.311603.013602.39410K562HNRNPC
CDK4ENSG00000135446.123240.328002462.607500.395903.124901.99490K562HNRNPL
CDK4ENSG00000135446.122980.946004358.94470-0.5482011.8243010.00000K562HNRNPU
CDK4ENSG00000135446.124198.528102823.210200.572408.163306.81230K562HSPD1
CDK4ENSG00000135446.122117.676002693.55040-0.347004.010302.99270K562KIF1C
CDK4ENSG00000135446.12635.877001048.94880-0.722103.195102.18290K562KRR1
CDK4ENSG00000135446.123108.578802247.522400.467805.268003.94040K562MATR3
CDK4ENSG00000135446.122374.071403017.43560-0.346003.895502.78640K562MBNL1
CDK4ENSG00000135446.121414.009901877.02700-0.408704.986703.33110K562NCBP2
CDK4ENSG00000135446.121226.171402121.60030-0.791004.440901.70980K562NFX1
CDK4ENSG00000135446.122073.398702616.49350-0.335602.517201.30150K562NONO
CDK4ENSG00000135446.121445.771102003.73200-0.470903.070502.04050K562PCBP2
CDK4ENSG00000135446.122265.228802834.08510-0.323202.340501.57570K562PCBP3
CDK4ENSG00000135446.123202.313004313.26930-0.429704.039802.11180K562PKM
CDK4ENSG00000135446.123408.768202364.317000.527706.633705.26660K562PPIG
CDK4ENSG00000135446.121429.236502037.86130-0.511806.223404.78610K562PSIP1
CDK4ENSG00000135446.121730.253502517.25950-0.540906.040805.27610K562PUS1
CDK4ENSG00000135446.121131.180601581.84420-0.483806.637603.79880K562QKI
CDK4ENSG00000135446.121972.171602452.43300-0.314403.933703.24350K562RBM15
CDK4ENSG00000135446.12789.657801686.06960-1.094406.337603.76100K562RBM39
CDK4ENSG00000135446.12696.193301168.33500-0.746907.300405.67310K562SF3B1
CDK4ENSG00000135446.121208.541201469.88780-0.282402.572601.75120K562SF3B4
CDK4ENSG00000135446.122515.720201527.802200.719403.240601.78970K562SFPQ
CDK4ENSG00000135446.122249.209202773.04590-0.302104.120302.66870K562SRSF7
CDK4ENSG00000135446.121908.055502474.40120-0.375004.692602.68520K562SRSF9
CDK4ENSG00000135446.121812.967802502.00570-0.464703.982102.74800K562SUPV3L1
CDK4ENSG00000135446.123042.215402180.410500.480407.465806.10350K562SYNCRIP
CDK4ENSG00000135446.121575.647102082.87620-0.402604.009202.82680K562TRIM56
CDK4ENSG00000135446.123441.145703975.09410-0.208102.613201.38440K562TROVE2
CDK4ENSG00000135446.12929.524501370.13850-0.559804.827003.30030K562U2AF1
CDK4ENSG00000135446.121091.444201415.23130-0.374803.949802.99190K562U2AF2
CDK4ENSG00000135446.121866.208802648.05260-0.504805.361303.90020K562UCHL5
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for CDK4 is not available on ENCORE database.





10 RBPs can affect the splicing of CDK4 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SECDK4ENSG00000135446.12chr12-581452825814551958144438581445485814595758146078-0.053000.000000.00003excludedK562AQR
SECDK4ENSG00000135446.12chr12-581429645814312058142373581424005814323658143287-0.052000.000000.00005excludedK562AQR
SECDK4ENSG00000135446.12chr12-581452825814551958144989581451255814595758146304-0.052000.000000.00083excludedHepG2NCBP2
SECDK4ENSG00000135446.12chr12-581452825814551958143236581432875814595758146116-0.115000.000200.00839excludedHepG2SF3A3
SECDK4ENSG00000135446.12chr12-581452825814547958144989581451255814595758146132-0.052000.000130.00794excludedK562PTBP1
A3SSCDK4ENSG00000135446.12chr12-5814498958145157581449895814512558145282581455190.057000.000000.00000longerK562AQR
A3SSCDK4ENSG00000135446.12chr12-5814296458143135581429645814310058143236581434130.055000.000000.00000longerK562AQR
A5SSCDK4ENSG00000135446.12chr12-581449895814551958145282581455195814469058144873-0.094000.000000.00002shorterK562SRSF1
RICDK4ENSG00000135446.12chr12-5814498958145519581449895814512558145282581455190.117000.000000.00000includedK562AQR
MXECDK4ENSG00000135446.12chr12-58144438581445485814528258145519581432365814328758145957581461090.109000.002000.046101includedK562TARDBP
MXECDK4ENSG00000135446.12chr12-58144705581448735814528258145519581444385814454858145957581461090.109000.000340.014241includedK562EFTUD2
MXECDK4ENSG00000135446.12chr12-58144438581445485814528258145442581432365814328758145957581460590.054000.003350.048011includedK562SF3B4
MXECDK4ENSG00000135446.12chr12-58144705581448735814528258145519581444385814454858145957581461090.108000.000270.008471includedK562PRPF8
MXECDK4ENSG00000135446.12chr12-5814443858144548581447055814487358143236581432875814498958145125-0.166000.000000.000022includedK562PRPF8
MXECDK4ENSG00000135446.12chr12-5814443858144548581449895814512558143236581432875814528258145442-0.150000.000000.000022includedK562PRPF8
MXECDK4ENSG00000135446.12chr12-5814470558144873581449895814512558144438581445485814528258145519-0.080000.007010.095952includedK562PRPF8
MXECDK4ENSG00000135446.12chr12-58144705581448735814528258145519581444385814454858145957581461090.127000.000240.008611includedK562SUPV3L1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for CDK4 is not avaliable on ENCORE database.