CCS

General Information

Gene Name       : CCS
Gene ID             : ENSG00000173992.8
Essential Gene : No

Functions

Localization

Domains (AlphaFold: CCS)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878CCSENSG00000173992.84.4413.989.21ENCSR000AEF
HepG2CCSENSG00000173992.834.4815.8125.14ENCSR985KAT
K562CCSENSG00000173992.817.0912.5914.84ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for CCS is not avaliable on ENCORE database.



Proteins bound to RNA
  • CCS RNA is bound by 19 proteins.  







eCLIP assay for CCS is not avaliable on ENCORE database.





19 proteins are bound to CCS RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr116637303766373063+3'-UTR,CDS3.587308.57574HepG2PPIG
chr116637286766372940+3'-UTR,CDS,intron-Proximal3.732676.46344HepG2PRPF8
chr116637318066373240+3'-UTR,CDS3.843684.47485K562DDX55
chr116637298466373032+3'-UTR,CDS3.925956.57824K562ZC3H11A
chr116637297966373055+3'-UTR,CDS4.863218.08515K562DDX24
chr116637307966373186+3'-UTR,CDS,intron-Proximal4.5580510.43503HepG2EFTUD2
chr116637296366373064+3'-UTR,CDS,intron-Proximal3.420068.21421HepG2PABPN1
chr116637299966373051+3'-UTR,CDS5.130414.22122K562DDX55
chr116637283866372880+3'-UTR,CDS3.671884.20387K562ZNF622
chr116637282466372883+3'-UTR,CDS5.288098.25598HepG2PPIG
chr116637297266373046+3'-UTR,CDS4.635697.01471HepG2GRWD1
chr116637303266373063+3'-UTR,CDS3.844204.44313K562ZC3H11A
chr116637296166373028+3'-UTR,CDS3.581608.21285K562ZNF622
chr116636787566367940+5'-UTR,intron-Proximal4.245057.84250HepG2AQR
chr116636111766361185+5'-UTR,CDS,intron-Distal3.164369.89337HepG2PPIG
chr116636793666368014+5'-UTR,CDS,intron-Proximal3.9082018.95928K562BUD13
chr116636785466367958+5'-UTR,intron-Distal,intron-Proximal4.811706.49093K562TARDBP
chr116636793266367975+5'-UTR,CDS,intron-Proximal4.5735653.27149K562AQR
chr116636799466368078+5'-UTR,CDS,intron-Proximal3.645609.73349HepG2EFTUD2
chr116636111366361180+5'-UTR,CDS,intron-Distal3.043195.99542K562ZNF622
chr116636792566367946+5'-UTR,intron-Proximal3.472359.64125K562PRPF8
chr116636787366367932+5'-UTR,intron-Proximal4.4541731.52266K562AQR
chr116636112066361184+5'-UTR,CDS,intron-Distal3.513065.39086K562UCHL5
chr116636788766367946+5'-UTR,intron-Proximal4.525693.72755K562EIF4G2
chr116636794766368001+5'-UTR,CDS,intron-Proximal4.007524.57180HepG2AQR
chr116636066966360743+5'-UTR,CDS4.342584.08283K562DDX3X
chr116636793566368054+5'-UTR,CDS,intron-Proximal3.463746.34474K562EFTUD2
chr116636797566368025+5'-UTR,CDS,intron-Proximal4.9858342.65076K562AQR
chr116636073766360768+5'-UTR,CDS3.236685.30095HepG2PPIG
chr116636794666367968+5'-UTR,CDS,intron-Proximal3.254978.81217K562PRPF8
chr116636700966367088+CDS3.018975.06946K562SRSF1
chr116636672366366729+CDS,intron-Proximal5.1401418.07708K562AQR
chr116636691766366932+CDS,intron-Proximal4.622377.53589K562AQR
chr116636668466366760+CDS,intron-Proximal3.434103.62863K562SRSF1
chr116636690366366961+CDS,intron-Proximal5.233378.88638HepG2AQR
chr116636692466366988+CDS,intron-Proximal3.722429.87984K562BUD13
chr116636708666367141+CDS,intron-Proximal3.458237.92114K562BUD13
chr116636669266366778+CDS,intron-Proximal4.1232616.04525HepG2PRPF8
chr116636710666367113+CDS,intron-Proximal5.3291635.97527K562AQR
chr116636664566366725+CDS,intron-Proximal3.269823.76985K562MTPAP
chr116636703666367077+CDS4.015935.52342HepG2PPIG
chr116636655666366611+CDS,intron-Proximal4.493244.62947HepG2AQR
chr116636699166367031+CDS3.203215.45873K562BUD13
chr116636658766366695+CDS3.0374612.98780HepG2PPIG
chr116636710466367147+CDS,intron-Proximal3.733473.56873HepG2PRPF8
chr116636690466366999+CDS,intron-Proximal3.068945.43614HepG2PRPF8
chr116636715266367214+intron-Distal,intron-Proximal4.4145314.61250K562RBM22
chr116636715266367220+intron-Distal,intron-Proximal3.897986.05828HepG2RBM22
chr116636714466367223+intron-Distal,intron-Proximal3.3469215.01867K562PRPF8
chr116636085966360960+intron-Distal,intron-Proximal4.285134.35952HepG2PRPF4
chr116636672566366773+intron-Proximal3.611696.20926HepG2PPIG
chr116636672966366768+intron-Proximal5.0676623.95513K562AQR
chr116636715266367202+intron-Proximal4.7187116.09791K562BUD13
chr116636685166366891+intron-Proximal3.146215.54603K562PRPF8
chr116636715166367197+intron-Proximal5.4649330.37721K562AQR
chr116636672466366764+intron-Proximal5.104434.28193HepG2AQR
chr116636711366367151+intron-Proximal6.7046255.53041K562AQR
chr116636684966366895+intron-Proximal3.617364.40383K562UCHL5
chr116636673266366773+intron-Proximal3.073683.55660K562BUD13
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for CCS is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for CCS is not available on ENCORE database.

  • 96 RBPs can affect the levels of CCS.  








The Knockdown/knockout RNA-Seq assay for CCS is not available on ENCORE database.





96 RBPs can affect the gene expression of CCS :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
CCSENSG00000173992.4369.65370503.59440-0.446103.808503.11620HepG2ACO1
CCSENSG00000173992.4507.87110336.428000.594102.608101.70060HepG2BCCIP
CCSENSG00000173992.4373.02650503.41490-0.432503.719102.96950HepG2CKAP4
CCSENSG00000173992.4488.80980316.529600.626802.933802.14510HepG2CNOT7
CCSENSG00000173992.4280.94380376.59470-0.422702.121501.51080HepG2CPSF6
CCSENSG00000173992.4616.47180498.352200.306802.158001.57900HepG2CELF1
CCSENSG00000173992.4374.35270465.72040-0.315102.198201.44880HepG2DDX19B
CCSENSG00000173992.4537.78190241.635301.1541017.3166015.70510HepG2DNAJC21
CCSENSG00000173992.4201.16720334.73290-0.734602.398501.55250HepG2EIF3D
CCSENSG00000173992.4439.40710775.99290-0.8205013.2419012.08900HepG2ETF1
CCSENSG00000173992.4282.64660492.03950-0.799807.748706.35740HepG2EWSR1
CCSENSG00000173992.4370.20060578.69020-0.644505.592404.48620HepG2FUBP3
CCSENSG00000173992.4399.32190243.950300.710903.434502.72360HepG2HNRNPA1
CCSENSG00000173992.4260.88210395.91600-0.601804.112902.97330HepG2HNRNPM
CCSENSG00000173992.4474.27390269.557800.815009.754408.67060HepG2HNRNPU
CCSENSG00000173992.4501.51910365.572100.456002.704301.98870HepG2IGF2BP1
CCSENSG00000173992.4555.94120303.930400.871103.895502.58240HepG2NONO
CCSENSG00000173992.4371.50560727.89260-0.9703016.8171015.52460HepG2PCBP1
CCSENSG00000173992.4357.22780240.423600.571204.125103.24190HepG2PPIL4
CCSENSG00000173992.4205.23210352.54780-0.780606.660305.51980HepG2PRPF4
CCSENSG00000173992.4177.57330255.02240-0.522202.481101.71430HepG2PRPF8
CCSENSG00000173992.4538.36130740.68910-0.460304.424003.76720HepG2PTBP1
CCSENSG00000173992.4680.41870507.215200.423703.045302.42520HepG2PUF60
CCSENSG00000173992.4831.86150538.038700.628504.471303.62980HepG2PUM2
CCSENSG00000173992.4120.61430291.82350-1.274702.467301.80010HepG2RAVER1
CCSENSG00000173992.4410.77870648.57980-0.658907.180606.43760HepG2RBM22
CCSENSG00000173992.4391.91430727.99890-0.893409.455208.26500HepG2RBM25
CCSENSG00000173992.4669.89150824.29000-0.299202.294901.79270HepG2NELFE
CCSENSG00000173992.4621.82830767.76110-0.304102.316401.74560HepG2RECQL
CCSENSG00000173992.4543.34550399.807600.442502.518701.86210HepG2RPLP0
CCSENSG00000173992.4443.35310325.776500.444502.186701.63320HepG2RPS19
CCSENSG00000173992.4560.10330382.939300.548503.015402.18020HepG2RPS2
CCSENSG00000173992.4480.88300318.124500.596003.202402.34340HepG2RPS3A
CCSENSG00000173992.4174.45600252.25310-0.532002.379001.64380HepG2RRP9
CCSENSG00000173992.4414.91340240.051800.789408.318507.29040HepG2SAFB2
CCSENSG00000173992.4287.62950588.20980-1.032108.098606.90130HepG2SF3A3
CCSENSG00000173992.4228.41530403.22000-0.819906.243405.21900HepG2SF3B1
CCSENSG00000173992.4424.71470771.09710-0.8604013.3795012.23190HepG2SF3B4
CCSENSG00000173992.4617.76250486.344100.345002.918102.19860HepG2SLBP
CCSENSG00000173992.4422.69010279.938600.594405.417704.56880HepG2SMN1
CCSENSG00000173992.4270.76270732.53520-1.4359032.9284031.69890HepG2SRFBP1
CCSENSG00000173992.4465.11670804.88130-0.7912011.8144010.98290HepG2SRSF1
CCSENSG00000173992.4534.87060364.705500.552406.107005.13710HepG2SRSF7
CCSENSG00000173992.4450.07370654.83340-0.541006.013505.25630HepG2SRSF9
CCSENSG00000173992.4949.51850635.993300.578108.702807.89320HepG2SSB
CCSENSG00000173992.4294.49350723.52190-1.2968023.9057022.48070HepG2TAF15
CCSENSG00000173992.4669.19930261.917001.3532023.6524022.45900HepG2TIAL1
CCSENSG00000173992.4252.03190490.87280-0.961708.455307.35430HepG2U2AF1
CCSENSG00000173992.4287.31000194.474300.562902.298501.60580HepG2UCHL5
CCSENSG00000173992.4557.19080301.377000.886502.852601.83290HepG2UPF2
CCSENSG00000173992.4356.84870503.63470-0.497104.383103.65720HepG2UTP3
CCSENSG00000173992.4480.95070284.960500.755004.858303.39350HepG2XPO5
CCSENSG00000173992.4633.79690324.128800.967407.851406.64200HepG2XRN2
CCSENSG00000173992.4604.77900419.325700.528203.684202.24830K562ABCF1
CCSENSG00000173992.4964.07620773.872700.317003.044202.45300K562AGGF1
CCSENSG00000173992.41072.14250805.251000.412903.529802.78850K562AKAP8L
CCSENSG00000173992.4566.07730414.856800.448303.800302.66560K562BCLAF1
CCSENSG00000173992.4431.59510291.467600.566203.288902.33580K562BOP1
CCSENSG00000173992.4714.03730543.413300.393803.311301.64980K562CEBPZ
CCSENSG00000173992.4445.69580309.887800.524203.583702.69180K562CPSF6
CCSENSG00000173992.4414.76890314.730700.398102.258101.32260K562CSTF2
CCSENSG00000173992.4852.56590624.554400.448904.943603.29860K562DDX21
CCSENSG00000173992.4613.34680441.064100.475604.284402.54630K562DDX6
CCSENSG00000173992.4705.56810866.49950-0.296402.391001.58500K562DKC1
CCSENSG00000173992.4435.07950317.241800.455602.603501.30650K562DNAJC21
CCSENSG00000173992.4627.55890477.820100.393203.241801.91800K562EIF2S1
CCSENSG00000173992.4691.47930447.352900.628207.347606.25780K562EIF2S2
CCSENSG00000173992.4457.48020301.422400.601804.204103.14440K562FIP1L1
CCSENSG00000173992.4406.59770267.312500.605003.715102.64240K562FTO
CCSENSG00000173992.4259.95200472.65450-0.862509.539808.49720K562FXR1
CCSENSG00000173992.4111.24810240.44020-1.111903.033802.28750K562G3BP2
CCSENSG00000173992.4429.72510295.845800.538502.887102.07580K562GPKOW
CCSENSG00000173992.4891.37450596.124000.580305.557504.48260K562GRSF1
CCSENSG00000173992.4739.28820588.808600.328202.464501.62110K562HNRNPU
CCSENSG00000173992.4609.62610408.667300.576903.313902.44550K562HSPD1
CCSENSG00000173992.4523.30200335.814800.639904.029802.69460K562IGF2BP2
CCSENSG00000173992.4451.87510297.857600.601204.044502.24400K562KHDRBS1
CCSENSG00000173992.41071.24330854.567900.325902.765801.94010K562KIF1C
CCSENSG00000173992.4261.79820352.84310-0.430602.437801.64580K562MAGOH
CCSENSG00000173992.4407.96480288.787300.498302.950802.04390K562METAP2
CCSENSG00000173992.4635.66800523.105400.281102.071501.36640K562MTPAP
CCSENSG00000173992.4887.31420581.158200.6104010.259208.94420K562NSUN2
CCSENSG00000173992.4584.87600392.167700.576604.239402.29310K562NUSAP1
CCSENSG00000173992.4731.46820513.981100.509003.480002.54680K562PCBP3
CCSENSG00000173992.4545.38860394.243900.468103.264702.38960K562POLR2G
CCSENSG00000173992.4489.26880342.171600.515803.391502.46780K562PPIG
CCSENSG00000173992.4141.15030286.68100-1.022202.761602.01380K562PRPF8
CCSENSG00000173992.4628.40720357.042200.815508.392106.63790K562PSIP1
CCSENSG00000173992.4613.14090897.65630-0.549902.901902.06660K562PUF60
CCSENSG00000173992.4988.61960798.578700.307901.967201.49440K562PUS1
CCSENSG00000173992.4466.99550324.921100.523203.449602.02180K562SLBP
CCSENSG00000173992.4202.94270336.08310-0.727705.051704.10040K562SRSF1
CCSENSG00000173992.4492.91310373.357600.400702.238501.31050K562SRSF4
CCSENSG00000173992.4493.65030317.428800.637004.941303.46290K562SRSF5
CCSENSG00000173992.4765.75950557.295700.458304.973503.38880K562SRSF7
CCSENSG00000173992.4429.45820277.332200.630802.681901.68100K562SUPV3L1
CCSENSG00000173992.4254.40280395.43290-0.636304.779803.69390K562SYNCRIP
CCSENSG00000173992.4496.45040340.117500.545503.004002.26710K562TARDBP
CCSENSG00000173992.4538.88710328.087100.715806.783305.41550K562TIA1
CCSENSG00000173992.4487.88880343.403600.506502.874501.92100K562TIAL1
CCSENSG00000173992.4521.28260321.999700.694905.857404.12770K562TRA2A
CCSENSG00000173992.4540.36480364.926500.566204.180502.96720K562TRIM56
CCSENSG00000173992.4511.12750352.612500.535503.476601.88980K562TRIP6
CCSENSG00000173992.4520.95670293.640500.827004.662403.30470K562UCHL5
CCSENSG00000173992.4728.84360527.271600.467004.012202.95260K562WDR3
CCSENSG00000173992.41029.83850741.799400.473202.696001.84590K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for CCS is not available on ENCORE database.





14 RBPs can affect the splicing of CCS :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSCCSENSG00000173992.4chr11+6637262466372887663728096637288766367959663680200.332000.000060.00382longerK562U2AF2
A3SSCCSENSG00000173992.4chr11+663726246637288766372809663728876636795966368020-0.103000.000270.03610shorterK562HNRNPC
RICCSENSG00000173992.4chr11+663665866636710766366586663667246636692966367107-0.277000.000270.01976excludedHepG2SFPQ
RICCSENSG00000173992.4chr11+663665866636710766366586663667246636692966367107-0.432000.000000.00021excludedK562NONO
RICCSENSG00000173992.4chr11+663665866636710766366586663667246636692966367107-0.257000.002270.04690excludedK562HNRNPC
RICCSENSG00000173992.4chr11+6636658666367107663665866636672466366929663671070.172000.001180.04148includedHepG2TIA1
RICCSENSG00000173992.4chr11+663665866636710766366586663667246636692966367107-0.384000.000000.00102excludedK562UCHL5
RICCSENSG00000173992.4chr11+663665866636710766366586663667246636692966367107-0.356000.000450.00757excludedK562PRPF8
RICCSENSG00000173992.4chr11+6636658666367107663665866636672466366929663671070.189000.000960.01299includedHepG2QKI
RICCSENSG00000173992.4chr11+663665866636710766366586663667246636692966367107-0.371000.000010.00344excludedK562XRN2
RICCSENSG00000173992.4chr11+6636658666367107663665866636672466366929663671070.252000.000080.00145includedHepG2TAF15
RICCSENSG00000173992.4chr11+6636658666367107663665866636672466366929663671070.146000.009700.06046includedHepG2SF3B4
RICCSENSG00000173992.4chr11+6636658666367107663665866636672466366929663671070.289000.000000.00000includedHepG2FUBP3
RICCSENSG00000173992.4chr11+6636658666367107663665866636672466366929663671070.248000.000330.00531includedHepG2HNRNPK
RICCSENSG00000173992.4chr11+6636658666367107663665866636672466366929663671070.138000.000490.01552includedHepG2PTBP1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for CCS is not avaliable on ENCORE database.