POLE3

General Information

Gene Name       : POLE3
Gene ID             : ENSG00000148229.12
Essential Gene : No

Functions

Localization

Domains (AlphaFold: POLE3)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878POLE3ENSG00000148229.1279.9079.1279.51ENCSR000AEF
HepG2POLE3ENSG00000148229.1260.1969.5464.87ENCSR985KAT
K562POLE3ENSG00000148229.12115.08120.51117.80ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for POLE3 is not avaliable on ENCORE database.



Proteins bound to RNA
  • POLE3 RNA is bound by 23 proteins.  







eCLIP assay for POLE3 is not avaliable on ENCORE database.





23 proteins are bound to POLE3 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr9116171039116171105-3'-UTR,CDS,intron-Distal3.583276.37848K562CPSF6
chr9116170055116170206-3'-UTR,intron-Distal4.4934318.02669K562MATR3
chr9116170055116170194-3'-UTR,intron-Distal4.304518.08110HepG2UPF1
chr9116169710116169737-3'-UTR,intron-Distal3.741357.13548K562UPF1
chr9116170050116170143-3'-UTR,intron-Distal5.4488131.61209HepG2PTBP1
chr9116169540116169608-3'-UTR,intron-Distal5.033714.77410HepG2SUB1
chr9116170043116170166-3'-UTR,intron-Distal3.1855612.48410HepG2PCBP2
chr9116170975116171047-3'-UTR,intron-Distal5.107184.69071HepG2GRWD1
chr9116169524116169617-3'-UTR,intron-Distal3.826843.69826K562TARDBP
chr9116171038116171109-3'-UTR,CDS,intron-Distal3.496149.86835K562PUM1
chr9116170444116170462-3'-UTR,intron-Distal3.993333.67607K562YBX3
chr9116169956116169998-3'-UTR,intron-Distal3.6776510.16051K562UPF1
chr9116170989116171129-3'-UTR,CDS,intron-Distal,intron-Proximal3.4676017.85564K562ZNF800
chr9116171023116171179-3'-UTR,CDS,intron-Distal,intron-Proximal5.1188729.82545K562UCHL5
chr9116170819116170850-3'-UTR,intron-Distal4.205058.79526K562YBX3
chr9116170850116170854-3'-UTR,intron-Distal5.563618.74043K562YBX3
chr9116171035116171188-3'-UTR,CDS,intron-Distal,intron-Proximal3.427473.77542K562SRSF7
chr9116170002116170074-3'-UTR,intron-Distal4.3891229.46846K562UPF1
chr9116170075116170182-3'-UTR,intron-Distal3.7220317.19479K562PCBP1
chr9116170107116170183-3'-UTR,intron-Distal4.156613.08342HepG2AKAP1
chr9116170069116170204-3'-UTR,intron-Distal3.392616.77715HepG2MATR3
chr9116171010116171104-3'-UTR,CDS,intron-Distal3.1036510.17820K562ZNF622
chr9116171032116171106-3'-UTR,CDS,intron-Distal3.217196.16392K562GRWD1
chr9116171033116171178-3'-UTR,CDS,intron-Distal,intron-Proximal4.842786.10084K562SRSF1
chr9116170962116171077-3'-UTR,intron-Distal3.481667.66871HepG2BCLAF1
chr9116169571116169684-3'-UTR,intron-Distal6.0301931.57043K562UPF1
chr9116170351116170402-3'-UTR,intron-Distal3.221647.04063K562YBX3
chr9116170854116170888-3'-UTR,intron-Distal6.1767217.48226K562YBX3
chr9116170143116170192-3'-UTR,intron-Distal3.8319711.19030HepG2PTBP1
chr9116170155116170201-3'-UTR,intron-Distal3.7784429.06662K562PTBP1
chr9116170050116170155-3'-UTR,intron-Distal4.90197400.00000K562PTBP1
chr9116170013116170050-3'-UTR,intron-Distal4.536755.04769HepG2PTBP1
chr9116170002116170044-3'-UTR,intron-Distal4.2203413.16736K562PTBP1
chr9116169606116169687-3'-UTR,intron-Distal3.511994.72143K562TIA1
chr9116172520116172631-5'-UTR,CDS,intron-Distal,intron-Proximal4.009509.06301K562DDX3X
chr9116172347116172419-CDS,intron-Distal,intron-Proximal4.365253.67707K562METAP2
chr9116171209116171265-CDS,intron-Distal,intron-Proximal4.992747.31591K562UCHL5
chr9116171124116171235-CDS,intron-Distal,intron-Proximal4.095213.48757K562TRA2A
chr9116171104116171163-CDS,intron-Distal,intron-Proximal4.503169.27525K562ZNF622
chr9116171129116171209-CDS,intron-Distal,intron-Proximal3.1902711.14150K562ZNF800
chr9116172350116172513-CDS,intron-Distal,intron-Proximal3.8974913.83580HepG2PRPF8
chr9116172365116172379-CDS,intron-Distal3.9299716.28196K562YBX3
chr9116171105116171167-CDS,intron-Distal,intron-Proximal4.151654.97883K562CPSF6
chr9116172259116172336-CDS,intron-Distal,intron-Proximal3.854224.71457HepG2PRPF8
chr9116171109116171175-CDS,intron-Distal,intron-Proximal3.969357.17255K562PUM1
chr9116172379116172409-CDS,intron-Distal,intron-Proximal3.4758817.60196K562YBX3
chr9116172236116172333-intron-Distal,intron-Proximal4.788114.58968K562PRPF8
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for POLE3 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for POLE3 is not available on ENCORE database.

  • 114 RBPs can affect the levels of POLE3.  








The Knockdown/knockout RNA-Seq assay for POLE3 is not available on ENCORE database.





114 RBPs can affect the gene expression of POLE3 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
POLE3ENSG00000148229.81932.123601500.609700.364502.974301.99460HepG2ABCF1
POLE3ENSG00000148229.81027.01710883.462400.217101.878601.35990HepG2ACO1
POLE3ENSG00000148229.8970.199201543.95960-0.6703013.4412012.12890HepG2AUH
POLE3ENSG00000148229.8599.64630975.12630-0.701505.929204.66860HepG2BCLAF1
POLE3ENSG00000148229.81309.683602229.79710-0.7677012.2728011.13500HepG2BOP1
POLE3ENSG00000148229.8564.906701517.46270-1.4256039.7754037.58900HepG2CALR
POLE3ENSG00000148229.8467.62450883.30660-0.9176020.1782018.74590HepG2CKAP4
POLE3ENSG00000148229.8355.049002047.11340-2.5275074.2958071.56290HepG2CPSF6
POLE3ENSG00000148229.8679.52110917.70410-0.433504.522703.22120HepG2YBX3
POLE3ENSG00000148229.81001.79270693.220900.531105.033603.64190HepG2CSTF2
POLE3ENSG00000148229.8634.425501283.23750-1.0163025.2589023.71920HepG2CELF1
POLE3ENSG00000148229.8923.025201379.91130-0.5801012.6878011.29090HepG2DAZAP1
POLE3ENSG00000148229.81256.364802324.63500-0.887706.356104.90300HepG2DDX59
POLE3ENSG00000148229.8826.792801128.48710-0.448802.576701.59460HepG2DDX5
POLE3ENSG00000148229.8450.60980743.39020-0.722205.613004.76040HepG2DDX6
POLE3ENSG00000148229.8543.89790869.15770-0.676304.407503.18180HepG2DHX30
POLE3ENSG00000148229.8410.61990901.16690-1.1340023.7193021.87770HepG2DNAJC21
POLE3ENSG00000148229.8540.63210783.79420-0.535803.394702.15880HepG2AGO1
POLE3ENSG00000148229.8325.25160714.79360-1.1360011.039509.90320HepG2EIF2S1
POLE3ENSG00000148229.8562.87630790.00570-0.489002.996602.33110HepG2EIF4A3
POLE3ENSG00000148229.81009.102201361.26730-0.431906.427205.24390HepG2EIF4G1
POLE3ENSG00000148229.8730.325101304.02490-0.8364011.8569010.24560HepG2EIF4G2
POLE3ENSG00000148229.81341.624701772.57440-0.401905.937205.11250HepG2ETF1
POLE3ENSG00000148229.81069.65470863.332700.309102.336601.56990HepG2EWSR1
POLE3ENSG00000148229.8624.39340811.18440-0.377602.848901.68880HepG2FASTKD2
POLE3ENSG00000148229.81135.37660796.856500.510704.152703.31680HepG2FXR1
POLE3ENSG00000148229.81117.33510818.460200.449003.147502.05800HepG2GNB2L1
POLE3ENSG00000148229.81351.602802320.66710-0.779909.598608.45460HepG2GPKOW
POLE3ENSG00000148229.8957.829901268.12210-0.404905.339204.11530HepG2HNRNPA2B1
POLE3ENSG00000148229.8526.679601011.95950-0.9422013.1442011.73840HepG2HNRNPC
POLE3ENSG00000148229.81084.028201831.83850-0.7569015.6869014.16230HepG2HNRNPF
POLE3ENSG00000148229.81152.31850748.350900.622706.459505.42320HepG2HNRNPK
POLE3ENSG00000148229.8769.095701257.02870-0.7088016.6856015.15500HepG2HNRNPL
POLE3ENSG00000148229.8977.448602214.64590-1.1800015.3988014.07940HepG2HNRNPLL
POLE3ENSG00000148229.81033.860301803.85570-0.8030015.1403013.59200HepG2IGF2BP1
POLE3ENSG00000148229.8550.96270751.54510-0.447902.812702.13270HepG2IGF2BP2
POLE3ENSG00000148229.8629.497101026.85500-0.7060015.3999013.83080HepG2ILF2
POLE3ENSG00000148229.8314.71100489.77540-0.638103.450501.95040HepG2ILF3
POLE3ENSG00000148229.8666.59530807.61790-0.276902.554801.57320HepG2KIF1C
POLE3ENSG00000148229.8651.41960841.90290-0.370102.645501.46300HepG2LIN28B
POLE3ENSG00000148229.81032.53420797.133600.373202.363701.75620HepG2MAGOH
POLE3ENSG00000148229.81452.10940801.631900.857009.736508.61060HepG2MATR3
POLE3ENSG00000148229.81438.497802258.42230-0.650804.642003.36790HepG2MTPAP
POLE3ENSG00000148229.8727.864601030.01800-0.500904.561903.00290HepG2NAA15
POLE3ENSG00000148229.81314.229501963.63120-0.579306.913805.76510HepG2NSUN2
POLE3ENSG00000148229.8866.74060509.814900.765504.868802.78800HepG2PA2G4
POLE3ENSG00000148229.8521.76510730.88600-0.486203.189702.41600HepG2PABPC4
POLE3ENSG00000148229.8984.90070761.272100.371503.928303.23190HepG2PCBP1
POLE3ENSG00000148229.8746.43330564.015100.404203.306101.95610HepG2PKM
POLE3ENSG00000148229.8695.24120896.62550-0.367003.492202.67430HepG2PPIL4
POLE3ENSG00000148229.8653.29060851.23500-0.381802.107501.39790HepG2PRPF8
POLE3ENSG00000148229.81012.96940774.592800.387004.299703.65030HepG2PTBP1
POLE3ENSG00000148229.8981.652401306.14040-0.412003.983303.28290HepG2PUF60
POLE3ENSG00000148229.8616.665901386.48800-1.1689043.6960041.91780HepG2PUM1
POLE3ENSG00000148229.8876.848701385.49870-0.6600010.399409.14420HepG2PUM2
POLE3ENSG00000148229.8683.57680838.96720-0.295502.227401.65650HepG2QKI
POLE3ENSG00000148229.8854.050001481.56460-0.7947015.8921014.85800HepG2RBM22
POLE3ENSG00000148229.8516.68630761.39240-0.559405.385504.47310HepG2RBM25
POLE3ENSG00000148229.81034.57130785.266300.397702.381801.39890HepG2RCC2
POLE3ENSG00000148229.81137.86690862.072400.400404.463703.80620HepG2NELFE
POLE3ENSG00000148229.8999.48340802.857900.315902.880602.25320HepG2RECQL
POLE3ENSG00000148229.81019.236501973.07420-0.9530017.2505015.83250HepG2RPLP0
POLE3ENSG00000148229.8510.26650889.49480-0.801705.750004.41710HepG2RPS10
POLE3ENSG00000148229.8862.64660663.662800.378201.876701.36180HepG2RPS19
POLE3ENSG00000148229.81177.56650910.387700.371202.469701.45590HepG2RPS5
POLE3ENSG00000148229.8492.07480842.05930-0.775006.535505.38350HepG2RRP9
POLE3ENSG00000148229.8373.25870895.25240-1.2621032.8345030.96960HepG2SAFB2
POLE3ENSG00000148229.8955.27730666.038500.520204.283303.12180HepG2SERBP1
POLE3ENSG00000148229.81315.225002192.12230-0.737005.628604.65080HepG2SF3B1
POLE3ENSG00000148229.8848.183301252.30760-0.5621010.948309.70680HepG2SLBP
POLE3ENSG00000148229.81342.035401673.40880-0.318402.955202.44280HepG2SRFBP1
POLE3ENSG00000148229.81797.35760841.794601.0942036.2727034.99060HepG2SRSF1
POLE3ENSG00000148229.8977.816401799.65970-0.8801022.5580020.93040HepG2SRSF7
POLE3ENSG00000148229.8901.024701452.97790-0.6894013.5963012.63290HepG2SSB
POLE3ENSG00000148229.8585.724301012.44120-0.789506.983005.12870HepG2STAU1
POLE3ENSG00000148229.8549.43860846.15390-0.623003.441302.09150HepG2SUB1
POLE3ENSG00000148229.8766.464201023.50580-0.417202.643001.72220HepG2SUPT6H
POLE3ENSG00000148229.8497.571601098.36470-1.1424014.2850012.95190HepG2SUPV3L1
POLE3ENSG00000148229.81113.39870756.576700.557307.502706.65530HepG2TAF15
POLE3ENSG00000148229.81254.911202158.31670-0.7823012.1192010.76550HepG2TARDBP
POLE3ENSG00000148229.8471.29580736.21630-0.643504.977103.69810HepG2TFIP11
POLE3ENSG00000148229.8450.81440695.25570-0.625006.671905.37730HepG2TIA1
POLE3ENSG00000148229.8782.34190976.89930-0.320402.253101.79240HepG2TIAL1
POLE3ENSG00000148229.81581.787901296.453900.286902.101601.54610HepG2U2AF1
POLE3ENSG00000148229.8796.541301350.56660-0.761708.053306.59810HepG2UBE2L3
POLE3ENSG00000148229.8402.56070648.86140-0.688705.658804.56460HepG2UCHL5
POLE3ENSG00000148229.8851.805601103.72260-0.373803.142802.40770HepG2UPF1
POLE3ENSG00000148229.8910.983901213.88860-0.414106.655205.90320HepG2ZNF622
POLE3ENSG00000148229.8522.51240904.68590-0.792006.501204.40660HepG2ZRANB2
POLE3ENSG00000148229.83185.941602587.710800.299904.629703.92880K562AGGF1
POLE3ENSG00000148229.81619.588102084.22310-0.363903.807902.67070K562BCLAF1
POLE3ENSG00000148229.82801.063005282.95510-0.915408.088506.22990K562CNOT7
POLE3ENSG00000148229.81779.022305072.68630-1.511705.473004.37640K562CPSF6
POLE3ENSG00000148229.81320.354301581.19430-0.260102.502701.50560K562CSTF2
POLE3ENSG00000148229.84506.761805700.92130-0.339102.203501.33380K562CELF1
POLE3ENSG00000148229.86910.325704445.818100.6362012.9938011.69090K562DDX47
POLE3ENSG00000148229.83648.422302897.610800.332304.941603.71960K562DKC1
POLE3ENSG00000148229.82497.116301488.577600.746205.709304.22750K562EIF3A
POLE3ENSG00000148229.82528.159201772.647000.512108.944407.51640K562EIF3G
POLE3ENSG00000148229.81506.810901896.43080-0.331802.987801.32540K562FASTKD2
POLE3ENSG00000148229.82832.788705160.27570-0.865202.481201.67130K562FMR1
POLE3ENSG00000148229.82921.583901521.214400.9414017.9662016.53360K562FXR1
POLE3ENSG00000148229.82421.284902891.73890-0.256202.943701.76680K562GLRX3
POLE3ENSG00000148229.82047.699502470.97020-0.271102.516601.49110K562HNRNPA1
POLE3ENSG00000148229.81451.123302054.95270-0.501902.407401.84510K562HNRNPC
POLE3ENSG00000148229.82522.331401852.012300.445603.877302.38500K562HNRNPK
POLE3ENSG00000148229.85938.018704016.685600.563903.636102.55660K562HNRNPM
POLE3ENSG00000148229.82285.534802736.46650-0.259802.870601.96100K562HNRNPU
POLE3ENSG00000148229.82045.249804134.68480-1.015502.766201.83350K562KRR1
POLE3ENSG00000148229.82420.979701944.840100.315803.098202.11880K562MATR3
POLE3ENSG00000148229.82410.021503378.16100-0.4872011.8192010.42440K562NSUN2
POLE3ENSG00000148229.82869.326201622.774200.8221014.0952012.39220K562PRPF8
POLE3ENSG00000148229.82695.597101893.344400.509607.560106.49810K562PTBP1
POLE3ENSG00000148229.83167.597605381.01060-0.764509.259007.24160K562PUM1
POLE3ENSG00000148229.83409.360002670.525800.352303.323502.73690K562PUS1
POLE3ENSG00000148229.83081.044602601.856500.243802.558001.98460K562RBM15
POLE3ENSG00000148229.82842.418501653.269900.7817010.395608.78480K562RPS19
POLE3ENSG00000148229.82719.599502020.431700.428603.930602.71010K562RPS3
POLE3ENSG00000148229.84273.257402690.680000.667306.206204.58530K562SAFB
POLE3ENSG00000148229.83591.948402781.748800.368703.583001.92820K562SDAD1
POLE3ENSG00000148229.82406.762003333.14200-0.469809.601508.15170K562SF3A3
POLE3ENSG00000148229.82782.139303414.85420-0.295606.028904.71080K562SRPK2
POLE3ENSG00000148229.82966.145801856.093300.6762012.7428011.22160K562SRSF1
POLE3ENSG00000148229.83262.061505862.33750-0.845703.545602.09720K562STAU1
POLE3ENSG00000148229.85397.940403028.741800.833608.456407.01840K562SYNCRIP
POLE3ENSG00000148229.81437.601401812.03670-0.333903.330702.42130K562TIA1
POLE3ENSG00000148229.83342.787303924.35610-0.231403.222301.84640K562TROVE2
POLE3ENSG00000148229.82094.914701573.456800.412903.159701.97940K562U2AF1
POLE3ENSG00000148229.82087.661301624.823300.361504.203803.21700K562U2AF2
POLE3ENSG00000148229.82205.240003064.95930-0.474906.709405.31030K562WDR3
POLE3ENSG00000148229.83081.760504343.50290-0.495102.517701.70220K562ZC3H8
POLE3ENSG00000148229.84126.911503220.213200.357804.100301.88810K562ZNF800
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for POLE3 is not available on ENCORE database.





4 RBPs can affect the splicing of POLE3 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSPOLE3ENSG00000148229.8chr9-1161719211161721601161719211161720081161723341161724200.084000.000000.00000longerK562AQR
RIPOLE3ENSG00000148229.8chr9-1161718891161724201161718891161720081161723341161724200.128000.000000.00011includedHepG2RBM22
RIPOLE3ENSG00000148229.8chr9-1161718891161724201161718891161720081161723341161724200.117000.000000.00000includedK562AQR
MXEPOLE3ENSG00000148229.8chr9-1161718891161720081161723341161724201161695141161712631161725071161726880.125000.000000.000001includedK562DROSHA
MXEPOLE3ENSG00000148229.8chr9-1161718891161720081161723341161724201161695141161712631161725071161726880.081000.000090.022381includedK562NPM1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for POLE3 is not avaliable on ENCORE database.