LDB1

General Information

Gene Name       : LDB1
Gene ID             : ENSG00000198728.10
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: LDB1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878LDB1ENSG00000198728.1017.0530.9023.98ENCSR000AEF
HepG2LDB1ENSG00000198728.1037.0119.8228.41ENCSR985KAT
K562LDB1ENSG00000198728.1096.1292.4494.28ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for LDB1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • LDB1 RNA is bound by 33 proteins.  







eCLIP assay for LDB1 is not avaliable on ENCORE database.





33 proteins are bound to LDB1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr10103867503103867539-3'-UTR,intron-Distal3.197286.22806K562PABPC4
chr10103867640103867690-3'-UTR,intron-Distal4.3627314.72879K562RBM15
chr10103867453103867563-3'-UTR,intron-Distal3.8323541.96281K562UPF1
chr10103867695103867749-3'-UTR,intron-Distal4.232864.01763HepG2GRWD1
chr10103867576103867648-3'-UTR,intron-Distal3.174133.18660HepG2PABPN1
chr10103867373103867453-3'-UTR,intron-Distal3.4714220.01085K562UPF1
chr10103867560103867702-3'-UTR,intron-Distal4.453315.14974HepG2UPF1
chr10103867551103867623-3'-UTR,intron-Distal4.0446510.03858K562AKAP1
chr10103867473103867547-3'-UTR,intron-Distal4.626396.51045HepG2LSM11
chr10103867433103867509-3'-UTR,intron-Distal3.487089.76246K562ZC3H11A
chr10103867603103867703-3'-UTR,intron-Distal3.2805722.85032K562UPF1
chr10103867785103867856-3'-UTR,CDS,intron-Distal3.132579.64022K562ZNF800
chr10103867695103867741-3'-UTR,intron-Distal3.171737.46708K562RBM15
chr10103867702103867752-3'-UTR,intron-Distal3.2041710.38787K562UCHL5
chr10103867788103867853-3'-UTR,intron-Distal3.2890316.72749K562UCHL5
chr10103867580103867640-3'-UTR,intron-Distal3.090229.22345K562RBM15
chr10103874335103874371-5'-UTR,intron-Distal3.682676.79943K562RBM15
chr10103880023103880053-5'-UTR,intron-Distal4.462145.95934K562AGGF1
chr10103874148103874164-5'-UTR,intron-Distal3.407517.36655K562AQR
chr10103874604103874671-5'-UTR,intron-Distal3.951663.25631HepG2PRPF4
chr10103874590103874663-5'-UTR,intron-Distal3.0509533.29623K562GEMIN5
chr10103874546103874569-5'-UTR,intron-Distal3.6696710.41546K562BUD13
chr10103874515103874581-5'-UTR,intron-Distal3.1794811.65628K562PRPF8
chr10103871245103871254-5'-UTR,CDS,intron-Distal3.500649.87923K562DDX24
chr10103874343103874377-5'-UTR,intron-Distal3.354978.12187K562GEMIN5
chr10103874531103874595-5'-UTR,intron-Distal4.0925216.41983K562DROSHA
chr10103874537103874571-5'-UTR,intron-Distal6.1077322.42656K562DDX24
chr10103874666103874706-5'-UTR,intron-Distal,intron-Proximal3.1477315.25272K562UCHL5
chr10103874583103874660-5'-UTR,intron-Distal4.6364873.32685K562EIF4G2
chr10103874268103874299-5'-UTR,intron-Distal5.576546.46614K562PCBP1
chr10103874594103874676-5'-UTR,intron-Distal4.4260642.60762K562TARDBP
chr10103874603103874661-5'-UTR,intron-Distal4.1166865.44491K562DDX24
chr10103874608103874660-5'-UTR,intron-Distal3.3476018.90080K562ZNF622
chr10103874539103874571-5'-UTR,intron-Distal3.945206.42469K562XRCC6
chr10103874659103874720-5'-UTR,intron-Distal,intron-Proximal3.256358.93689K562DDX3X
chr10103874595103874660-5'-UTR,intron-Distal3.5457528.39836K562DROSHA
chr10103874663103874722-5'-UTR,intron-Distal,intron-Proximal4.197873.19625HepG2NCBP2
chr10103874478103874576-5'-UTR,intron-Distal3.099676.92561K562CSTF2T
chr10103874530103874579-5'-UTR,intron-Distal4.0919314.77410K562UPF1
chr10103874494103874537-5'-UTR,intron-Distal4.9962428.18877K562DDX24
chr10103880138103880199-5'-UTR,intron-Distal3.368607.80294K562AGGF1
chr10103868032103868078-CDS,intron-Distal5.4260240.70684K562RBM15
chr10103870889103870956-CDS,intron-Distal,intron-Proximal3.377536.71503K562SF3B4
chr10103867995103868032-CDS,intron-Distal3.9568812.18025K562RBM15
chr10103870626103870677-CDS,intron-Distal3.098685.33987HepG2GRWD1
chr10103868888103868918-CDS,intron-Distal4.190594.50960HepG2GRWD1
chr10103870412103870455-CDS,intron-Distal3.332514.06531HepG2GRWD1
chr10103868921103868934-CDS,intron-Distal3.0829314.27058K562ZNF622
chr10103869143103869170-CDS,intron-Distal3.1542813.24655K562DDX24
chr10103870626103870635-CDS,intron-Distal3.6779414.41702K562DDX24
chr10103869403103869438-CDS,intron-Distal3.7965813.59578K562UCHL5
chr10103870626103870634-CDS,intron-Distal3.200266.16987K562UCHL5
chr10103870719103870727-CDS,intron-Distal,intron-Proximal5.0081914.27743K562DDX24
chr10103870827103870853-CDS,intron-Distal,intron-Proximal5.9127318.18706K562DDX24
chr10103868850103868886-CDS,intron-Distal3.0685812.88649K562UCHL5
chr10103870430103870456-CDS,intron-Distal3.278559.43276K562DDX24
chr10103870635103870674-CDS,intron-Distal3.7330925.43274K562DDX24
chr10103868078103868091-CDS,intron-Distal4.5193220.08231K562RBM15
chr10103869360103869391-CDS,intron-Distal,intron-Proximal3.416005.03432K562GRWD1
chr10103869356103869439-CDS,intron-Distal,intron-Proximal3.3095532.55966K562DDX24
chr10103871018103871049-CDS,intron-Distal5.3685319.13447K562DDX24
chr10103869361103869396-CDS,intron-Distal,intron-Proximal4.215895.80295HepG2PPIG
chr10103870723103870726-CDS,intron-Distal3.556799.11524K562UCHL5
chr10103869253103869263-CDS,intron-Distal,intron-Proximal3.6596115.06612K562DDX24
chr10103869139103869188-CDS,intron-Distal,intron-Proximal3.084687.61395HepG2PPIG
chr10103870878103870959-CDS,intron-Distal,intron-Proximal4.5683129.37838K562EFTUD2
chr10103870827103870838-CDS,intron-Distal,intron-Proximal3.346068.15265K562UCHL5
chr10103869356103869400-CDS,intron-Distal,intron-Proximal3.1136716.31022K562UCHL5
chr10103868699103868771-intron-Distal,intron-Proximal3.5090123.04194K562TIA1
chr10103873241103873307-intron-Distal4.590285.74090K562RBFOX2
chr10103868116103868190-intron-Distal3.9655043.90427K562DDX24
chr10103868103103868192-intron-Distal3.849616.23254HepG2PRPF4
chr10103868718103868770-intron-Distal,intron-Proximal3.1069322.58193K562DDX24
chr10103869672103869678-intron-Distal,intron-Proximal4.0578013.66013K562AQR
chr10103873209103873280-intron-Distal4.054053.96304K562CSTF2T
chr10103868238103868293-intron-Distal3.6397819.24938K562UCHL5
chr10103868115103868180-intron-Distal3.5094527.41083K562ZNF622
chr10103873085103873185-intron-Distal4.768836.49093K562TARDBP
chr10103874072103874152-intron-Distal3.384766.69747HepG2PRPF8
chr10103868088103868194-intron-Distal3.7450220.04277K562RBFOX2
chr10103878593103878634-intron-Distal3.922543.80512K562CSTF2T
chr10103868721103868767-intron-Distal,intron-Proximal4.597815.85983HepG2GRWD1
chr10103868098103868166-intron-Distal3.130208.15748K562LSM11
chr10103870733103870802-intron-Distal,intron-Proximal6.1357710.29365K562EFTUD2
chr10103868091103868104-intron-Distal4.3265217.03204K562RBM15
chr10103868300103868321-intron-Distal3.093443.13733K562CPSF6
chr10103868100103868198-intron-Distal3.379603.28107HepG2PABPN1
chr10103869645103869672-intron-Distal,intron-Proximal4.6626310.30697K562AQR
chr10103868103103868188-intron-Distal3.8747131.60871K562UCHL5
chr10103869637103869645-intron-Distal,intron-Proximal6.3325513.72936K562AQR
chr10103868108103868195-intron-Distal3.7090827.03815K562RBM15
chr10103878267103878313-intron-Distal4.211804.27402K562CSTF2T
chr10103873096103873184-intron-Distal3.311525.99853K562EIF4G2
chr10103877367103877436-intron-Distal4.783894.06667K562GTF2F1
chr10103870240103870285-intron-Distal,intron-Proximal4.519639.29543K562AQR
chr10103874115103874148-intron-Distal3.8214610.09391K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for LDB1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for LDB1 is not available on ENCORE database.

  • 97 RBPs can affect the levels of LDB1.  








The Knockdown/knockout RNA-Seq assay for LDB1 is not available on ENCORE database.





97 RBPs can affect the gene expression of LDB1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
LDB1ENSG00000198728.6996.79230776.303400.360604.219403.49850HepG2ACO1
LDB1ENSG00000198728.6953.92590779.906300.290502.625401.87540HepG2AKAP8L
LDB1ENSG00000198728.6874.58100609.243400.521503.877302.95410HepG2ASCC1
LDB1ENSG00000198728.61223.213301011.294100.274402.936802.23300HepG2AUH
LDB1ENSG00000198728.61311.24190906.569500.532305.568104.75480HepG2BOP1
LDB1ENSG00000198728.6616.54080906.33970-0.555905.770004.70910HepG2CALR
LDB1ENSG00000198728.61314.41950776.081300.7600019.2163017.81350HepG2CKAP4
LDB1ENSG00000198728.61121.67450927.640300.273902.742002.10180HepG2CELF1
LDB1ENSG00000198728.6944.13270705.302600.420602.696602.07790HepG2DDX3X
LDB1ENSG00000198728.6930.58540714.532900.381002.058001.38080HepG2DDX55
LDB1ENSG00000198728.6922.45570606.056900.605904.541503.76670HepG2DDX6
LDB1ENSG00000198728.6868.74140702.580600.306202.659502.01830HepG2DNAJC2
LDB1ENSG00000198728.6770.19830582.431300.403002.423401.86700HepG2EIF2S1
LDB1ENSG00000198728.61266.72880936.711900.435304.216602.78250HepG2EIF2S2
LDB1ENSG00000198728.6819.90430634.620100.369502.238201.41720HepG2EIF3D
LDB1ENSG00000198728.61460.66180626.772601.2205014.3834012.88360HepG2EIF4B
LDB1ENSG00000198728.6793.58990984.01720-0.310302.521001.71370HepG2EIF4G1
LDB1ENSG00000198728.61366.718801161.093900.235102.135001.59320HepG2ETF1
LDB1ENSG00000198728.61026.55190649.602300.660106.099805.09810HepG2FXR1
LDB1ENSG00000198728.61048.88660602.458300.799808.228707.11200HepG2G3BP1
LDB1ENSG00000198728.6828.57280639.773700.373002.234901.43920HepG2G3BP2
LDB1ENSG00000198728.6809.08490565.042100.517803.955102.87010HepG2GEMIN5
LDB1ENSG00000198728.61147.05060715.519400.680808.230907.20220HepG2HNRNPA1
LDB1ENSG00000198728.61053.74260795.919700.404703.213402.47310HepG2HNRNPC
LDB1ENSG00000198728.61410.50830610.377801.2083021.9793020.18790HepG2HNRNPK
LDB1ENSG00000198728.6706.90670900.39800-0.349002.078901.52510HepG2HNRNPLL
LDB1ENSG00000198728.6967.29310790.654900.290801.904301.39240HepG2HNRNPU
LDB1ENSG00000198728.61832.567901362.666400.427302.768701.93770HepG2LARP4
LDB1ENSG00000198728.6932.53780653.423100.513003.420202.72500HepG2MATR3
LDB1ENSG00000198728.61025.46570664.175000.626503.435702.26540HepG2METAP2
LDB1ENSG00000198728.61229.89530668.778900.8788010.196809.02440HepG2NCBP2
LDB1ENSG00000198728.6573.37880798.35080-0.477503.433902.59990HepG2NSUN2
LDB1ENSG00000198728.6456.11730652.58500-0.516802.220501.44060HepG2PABPC1
LDB1ENSG00000198728.61135.84870782.567000.537408.197306.86200HepG2PARN
LDB1ENSG00000198728.6872.19690627.784400.474302.458301.47730HepG2PCBP2
LDB1ENSG00000198728.6699.12000524.818200.413603.355101.99660HepG2PKM
LDB1ENSG00000198728.6653.55350871.41100-0.415004.501103.53960HepG2PRPF4
LDB1ENSG00000198728.6750.91120551.184600.446002.793801.98130HepG2PRPF8
LDB1ENSG00000198728.6949.40880670.927700.500806.831706.04770HepG2PTBP1
LDB1ENSG00000198728.6709.14790944.04800-0.412803.142602.51370HepG2PUF60
LDB1ENSG00000198728.61285.756001002.199400.359305.948805.14630HepG2PUM1
LDB1ENSG00000198728.61305.90190970.461100.428205.511204.84280HepG2RBM22
LDB1ENSG00000198728.61035.95110746.664900.472305.757105.02160HepG2NELFE
LDB1ENSG00000198728.6885.71060695.440800.348803.330102.66190HepG2RECQL
LDB1ENSG00000198728.61310.78190617.532601.0857021.1630019.71310HepG2RPS19
LDB1ENSG00000198728.6929.05130721.889000.363902.065701.36820HepG2RPS2
LDB1ENSG00000198728.6793.03800545.233700.540403.613302.73040HepG2RRP9
LDB1ENSG00000198728.6833.77290619.759700.427802.948301.97450HepG2SERBP1
LDB1ENSG00000198728.61007.42330459.779701.131603.747102.12170HepG2SF1
LDB1ENSG00000198728.61514.23100999.140700.599704.411103.54920HepG2SF3A3
LDB1ENSG00000198728.6920.44150698.493900.398004.203703.49900HepG2SF3B4
LDB1ENSG00000198728.6996.78530446.544801.158403.590101.88510HepG2SFPQ
LDB1ENSG00000198728.61067.90990821.053200.379103.342802.64680HepG2SMN1
LDB1ENSG00000198728.6842.72850618.006400.447302.430701.53610HepG2SMNDC1
LDB1ENSG00000198728.6855.20770411.295801.056003.654202.10340HepG2SNRNP200
LDB1ENSG00000198728.61355.276801096.102700.306103.550403.00460HepG2SRFBP1
LDB1ENSG00000198728.61277.67430932.170700.454807.118506.17810HepG2SRSF5
LDB1ENSG00000198728.6780.98930951.68110-0.285202.599802.09720HepG2SSB
LDB1ENSG00000198728.61340.525901001.764500.420202.774401.49010HepG2SSRP1
LDB1ENSG00000198728.61359.152301060.082800.358405.443704.62490HepG2SUCLG1
LDB1ENSG00000198728.61194.01640768.131200.636305.504804.84830HepG2TIAL1
LDB1ENSG00000198728.61024.96380775.145600.402902.871402.30010HepG2TRIM56
LDB1ENSG00000198728.61127.43910922.377800.289502.340101.54360HepG2TUFM
LDB1ENSG00000198728.61345.70520477.915601.493406.180604.64190HepG2U2AF2
LDB1ENSG00000198728.6564.08480420.183300.424802.477401.75880HepG2UCHL5
LDB1ENSG00000198728.61012.10650855.481800.242502.176701.63220HepG2UTP3
LDB1ENSG00000198728.61032.61780666.240500.632104.287902.98170HepG2XRCC6
LDB1ENSG00000198728.62283.677103165.90180-0.471305.903304.11060K562AARS
LDB1ENSG00000198728.65644.360104471.905800.335803.433302.70370K562AKAP8L
LDB1ENSG00000198728.63055.668104141.72930-0.438704.912804.17050K562AQR
LDB1ENSG00000198728.62779.586603662.62780-0.398002.421501.61140K562BOP1
LDB1ENSG00000198728.64327.661503233.554500.420404.429403.03710K562CCAR1
LDB1ENSG00000198728.63010.398903894.20580-0.371404.638903.62530K562CPSF6
LDB1ENSG00000198728.61878.486002255.79110-0.264102.286001.34310K562DDX3X
LDB1ENSG00000198728.67196.302005705.856500.334706.715105.76460K562DDX47
LDB1ENSG00000198728.62564.477304176.14440-0.7035020.9912019.28460K562EIF2S2
LDB1ENSG00000198728.64536.934803289.006700.464002.669801.68590K562EIF3A
LDB1ENSG00000198728.63912.025502897.214200.433102.756401.72220K562EIF3D
LDB1ENSG00000198728.62505.696701359.250500.8823024.2596021.88390K562EIF3G
LDB1ENSG00000198728.63019.029702122.338600.508309.314207.07130K562EIF4B
LDB1ENSG00000198728.62980.088802057.167300.534607.920105.48720K562EWSR1
LDB1ENSG00000198728.64525.261803752.942900.269902.272901.50410K562FIP1L1
LDB1ENSG00000198728.62133.991503008.00740-0.495304.932203.35350K562FKBP4
LDB1ENSG00000198728.62688.760003962.68480-0.559507.609206.15120K562FMR1
LDB1ENSG00000198728.62733.083802223.336800.297703.396001.39730K562FUBP3
LDB1ENSG00000198728.6597.398401323.25410-1.147306.783305.56710K562G3BP2
LDB1ENSG00000198728.63680.288905088.11350-0.467305.649104.52750K562HSPD1
LDB1ENSG00000198728.65610.966304745.932700.241502.352001.60000K562KIF1C
LDB1ENSG00000198728.64823.212903513.360300.457004.716802.69600K562LIN28B
LDB1ENSG00000198728.62544.445602100.949900.276202.191601.38030K562MATR3
LDB1ENSG00000198728.65018.290706692.65470-0.415404.747403.26490K562MSI2
LDB1ENSG00000198728.65956.156905190.446900.198404.437703.51760K562NSUN2
LDB1ENSG00000198728.64402.254303410.537700.368103.168201.60980K562NUSAP1
LDB1ENSG00000198728.64505.838403381.588200.414004.853902.89070K562PHF6
LDB1ENSG00000198728.61866.916002634.18500-0.496702.373801.67710K562PRPF8
LDB1ENSG00000198728.64144.755203105.374100.416405.088203.81260K562PSIP1
LDB1ENSG00000198728.64379.470406850.70200-0.6455011.291909.63370K562PUF60
LDB1ENSG00000198728.65749.152204321.181900.411807.384606.44790K562RBM15
LDB1ENSG00000198728.64077.381602833.696600.524909.078307.27660K562RCC2
LDB1ENSG00000198728.62551.084402063.623100.305802.302501.32630K562NELFE
LDB1ENSG00000198728.61705.742601338.793600.349405.348303.15380K562RPS10
LDB1ENSG00000198728.63294.755902422.655400.443502.815001.80330K562RPS3
LDB1ENSG00000198728.65105.168902849.678800.841103.219901.77750K562SFPQ
LDB1ENSG00000198728.64230.966802686.222500.6553010.926708.52250K562SRFBP1
LDB1ENSG00000198728.63306.941202338.336000.499902.628101.60800K562SRSF4
LDB1ENSG00000198728.63197.622002029.437400.655804.895103.94010K562TARDBP
LDB1ENSG00000198728.62759.237901957.701200.495006.092604.80690K562TIA1
LDB1ENSG00000198728.64443.603802986.796500.573006.752105.23520K562TIAL1
LDB1ENSG00000198728.62470.279601921.805500.362103.055601.89980K562TRA2A
LDB1ENSG00000198728.64928.524903173.581700.6349010.723008.57220K562TRIM56
LDB1ENSG00000198728.69480.205607723.500400.295603.343001.78490K562UBE2L3
LDB1ENSG00000198728.64779.910205503.52750-0.203403.244702.46960K562UPF1
LDB1ENSG00000198728.66770.592104896.889100.4673015.5093013.72320K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for LDB1 is not available on ENCORE database.





2 RBPs can affect the splicing of LDB1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SELDB1ENSG00000198728.6chr10-1038718311038718871038711901038712931038798421038802050.090000.000170.08938includedK562PUM2
A3SSLDB1ENSG00000198728.6chr10-1038693561038695871038693561038694401038696771038698000.084000.000000.00000longerK562AQR
A3SSLDB1ENSG00000198728.6chr10-1038711901038713391038711901038712931038741621038747030.073000.000000.00000longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for LDB1 is not avaliable on ENCORE database.