JAK2

General Information

Gene Name       : JAK2
Gene ID             : ENSG00000096968.13
Essential Gene : No

Functions

Localization

Domains (AlphaFold: JAK2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878JAK2ENSG00000096968.1315.3211.7913.55ENCSR000AEF
HepG2JAK2ENSG00000096968.131.141.911.52ENCSR985KAT
K562JAK2ENSG00000096968.139.1510.269.71ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for JAK2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • JAK2 RNA is bound by 29 proteins.  







eCLIP assay for JAK2 is not avaliable on ENCORE database.





29 proteins are bound to JAK2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr951280925128151+3'-UTR5.209617.51195K562TARDBP
chr951271175127185+3'-UTR4.8163115.28381K562PUM2
chr951275185127563+3'-UTR4.117053.26739K562FAM120A
chr951273725127428+3'-UTR5.5241922.65351K562PUM2
chr949853994985623+5'-UTR,intron-Distal3.183099.89870K562FMR1
chr949856284985681+5'-UTR,intron-Distal,intron-Proximal5.035846.04760K562AQR
chr950444165044430+5'-UTR,CDS4.296203.56076K562BUD13
chr950444905044519+5'-UTR,CDS5.419196.36664K562DDX24
chr949858914985963+5'-UTR,intron-Distal,intron-Proximal4.419425.16342K562SF3B4
chr950444215044457+5'-UTR,CDS3.884004.66686K562DDX24
chr950667765066830+CDS,intron-Proximal4.356824.23889K562TIA1
chr950699515070015+CDS3.502385.62120K562ZNF622
chr950666765066731+CDS,intron-Proximal5.3387510.12439K562BUD13
chr950805325080589+CDS,intron-Proximal3.210905.86433K562UCHL5
chr950666625066726+CDS,intron-Proximal4.113604.71174K562U2AF2
chr950898075089857+CDS3.8177710.67158K562LIN28B
chr950801965080249+CDS,intron-Proximal4.743364.65563K562AQR
chr950904445090474+CDS,intron-Proximal3.182075.39816K562LIN28B
chr950896785089774+CDS3.353854.80070K562GRWD1
chr950506855050719+CDS,intron-Proximal3.530754.71060K562BUD13
chr950775295077574+CDS3.103133.26807K562ZNF622
chr950775205077580+CDS4.215073.45943HepG2BCLAF1
chr950784075078441+CDS4.012846.61895K562ZNF622
chr950445165044598+CDS,intron-Proximal3.428164.06013K562PRPF8
chr950817685081830+CDS3.103136.80995K562ZNF622
chr950896745089748+CDS3.7839610.52099K562DDX24
chr950508185050832+CDS,intron-Proximal3.489104.70209K562YBX3
chr950725875072626+CDS3.024834.02508K562DDX24
chr950737525073786+CDS,intron-Proximal3.154285.33841K562DDX24
chr950898575089864+CDS,intron-Proximal3.980417.52193K562LIN28B
chr950198485019917+intron-Distal3.167985.13755K562EXOSC5
chr950450515045076+intron-Distal3.757184.93120K562KHSRP
chr950183455018409+intron-Distal4.439878.51158K562EXOSC5
chr950615685061732+intron-Distal4.405715.32928K562MATR3
chr950571575057238+intron-Distal3.582314.30679K562KHSRP
chr950202435020295+intron-Distal3.694225.57544K562EXOSC5
chr951115785111602+intron-Distal4.123913.75568K562SLTM
chr951011015101144+intron-Distal3.387073.36945K562ZNF622
chr950955045095554+intron-Distal5.4601412.81155K562QKI
chr949949474994996+intron-Distal3.581214.61282K562EXOSC5
chr950030945003149+intron-Distal4.003339.31101K562KHSRP
chr949998564999972+intron-Distal3.119134.99905K562RBFOX2
chr950089045009015+intron-Distal3.499065.28799K562MATR3
chr951001335100182+intron-Distal4.070294.02823K562HNRNPL
chr949918764991942+intron-Distal4.383754.24113K562MATR3
chr950687475068778+intron-Distal3.862908.26817K562KHSRP
chr951257845125834+intron-Distal4.714916.73684K562KHSRP
chr949857004985728+intron-Distal,intron-Proximal3.127683.26275K562BUD13
chr950502085050288+intron-Distal3.660745.83959K562KHSRP
chr950213905021407+intron-Distal3.204383.17919K562KHSRP
chr950765345076586+intron-Distal4.174354.49655K562CSTF2T
chr950687785068823+intron-Distal3.015525.52899K562KHSRP
chr950563865056454+intron-Distal3.162985.62342K562KHSRP
chr949918824991931+intron-Distal3.582343.62418K562PTBP1
chr951258345125913+intron-Distal4.714105.85485K562KHSRP
chr949939554994017+intron-Distal3.630954.57394K562HNRNPM
chr950204665020547+intron-Distal5.701279.21686K562HNRNPM
chr950183415018397+intron-Distal4.460803.23532K562MATR3
chr950427935042837+intron-Distal4.003413.10243K562SLTM
chr950201525020206+intron-Distal4.059274.57394K562HNRNPM
chr950204265020452+intron-Distal4.546025.44508K562EXOSC5
chr949939144993976+intron-Distal4.7189210.79749K562TARDBP
chr950864625086546+intron-Distal3.999803.45817K562MATR3
chr949938034993855+intron-Distal3.506904.81774K562HNRNPM
chr950689195068993+intron-Distal,intron-Proximal3.0870710.53321K562KHSRP
chr950296765029774+intron-Distal,intron-Proximal3.389803.90146K562KHSRP
chr949953234995426+intron-Distal3.559774.73075K562MATR3
chr950254545025523+intron-Distal4.928285.39854K562PTBP1
chr950214465021478+intron-Distal5.157538.24653K562KHSRP
chr950659815066000+intron-Distal4.004469.74134K562KHSRP
chr950177735017841+intron-Distal3.912829.31208K562KHSRP
chr950958955096016+intron-Distal5.6173321.83010K562QKI
chr951002965100419+intron-Distal6.2456224.14083K562QKI
chr951001305100172+intron-Distal6.9077145.39297K562QKI
chr949886534988790+intron-Distal6.254029.99398K562QKI
chr950266845026810+intron-Distal5.3254410.50009K562TARDBP
chr950182515018304+intron-Distal3.708504.02190K562EXOSC5
chr950189245019001+intron-Distal4.248559.86758K562MATR3
chr950213285021390+intron-Distal4.260865.98773K562KHSRP
chr950030925003151+intron-Distal4.793826.65598K562TIA1
chr949939764994045+intron-Distal5.363378.06678K562TARDBP
chr950572565057285+intron-Distal3.927823.66668K562KHSRP
chr950198365019921+intron-Distal5.550949.21686K562HNRNPM
chr950205275020609+intron-Distal4.2122815.09791K562EXOSC5
chr950499685050038+intron-Distal3.361234.76825K562KHSRP
chr950176675017708+intron-Distal3.078693.38150K562KHSRP
chr951010725101136+intron-Distal3.135624.61143K562UCHL5
chr950200015020093+intron-Distal3.385724.77469K562HNRNPM
chr951072665107386+intron-Distal5.037405.58608K562QKI
chr949939234994046+intron-Distal3.783298.17180K562EXOSC5
chr950660005066035+intron-Distal3.492467.81851K562KHSRP
chr950088125008859+intron-Distal4.317083.91475K562PTBP1
chr950564545056515+intron-Distal4.101558.17387K562KHSRP
chr950941285094216+intron-Distal4.191583.83958HepG2QKI
chr951107705110800+intron-Distal4.177373.75568K562SLTM
chr949949364995006+intron-Distal4.133553.87294K562TARDBP
chr951010185101072+intron-Distal4.528925.14565K562UCHL5
chr950407865040851+intron-Distal4.289904.14527K562SLTM
chr950089015008983+intron-Distal3.453928.52685K562PTBP1
chr950501635050208+intron-Distal4.597746.07567K562KHSRP
chr949860814986130+intron-Distal,intron-Proximal4.422064.48623K562EXOSC5
chr950572855057363+intron-Distal4.103928.11138K562KHSRP
chr949889214988970+intron-Distal3.928287.91801K562PTBP1
chr949888144988891+intron-Distal5.153588.85229K562MATR3
chr950496955049828+intron-Distal4.8016714.84917K562KHSRP
chr950658635065912+intron-Distal3.995404.93120K562KHSRP
chr950214785021554+intron-Distal4.305749.41035K562KHSRP
chr950959275096034+intron-Distal5.3032710.09004HepG2QKI
chr950670355067103+intron-Distal4.263614.23889K562TIA1
chr950450765045130+intron-Distal4.123057.69621K562KHSRP
chr950204155020466+intron-Distal5.012664.51309K562HNRNPM
chr950208535020963+intron-Distal4.026357.86844K562EXOSC5
chr950136685013721+intron-Distal4.888315.62258K562KHSRP
chr949888914988981+intron-Distal3.294636.15155K562MATR3
chr951059585106106+intron-Distal4.813525.29868K562UCHL5
chr951108365110918+intron-Distal4.128948.39538K562SLTM
chr950909135091025+intron-Distal,intron-Proximal3.492834.30679K562KHSRP
chr950205235020609+intron-Distal3.995573.52365K562FUS
chr950264735026539+intron-Distal4.329654.76003K562KHSRP
chr949955234995588+intron-Distal3.933246.41110K562EXOSC5
chr951003545100426+intron-Distal3.517193.35377HepG2QKI
chr950495775049663+intron-Distal4.791788.14619K562KHSRP
chr950071805007216+intron-Distal3.610984.10408K562KHSRP
chr950176115017667+intron-Distal3.744467.01633K562KHSRP
chr951112345111269+intron-Distal4.108623.36882K562SLTM
chr950407115040766+intron-Distal3.297883.31097K562SLTM
chr950132655013340+intron-Distal3.980004.02823K562HNRNPL
chr950940825094189+intron-Distal4.6356011.37374K562QKI
chr949881524988243+intron-Distal4.664835.53033K562HNRNPK
chr949953884995427+intron-Distal3.375503.43829K562EXOSC5
chr950659125065981+intron-Distal5.1965614.84917K562KHSRP
chr950957885095892+intron-Distal5.5663914.42007K562QKI
chr949936044993698+intron-Distal4.093895.72424K562MATR3
chr949891374989183+intron-Distal3.290043.79878K562MATR3
chr950199955020119+intron-Distal3.181409.94405K562EXOSC5
chr950650665065137+intron-Proximal3.331495.82594K562KHSRP
chr950219075021960+intron-Proximal5.075184.90235K562SF3B4
chr950689515069021+intron-Proximal4.330986.11702K562SF3B4
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for JAK2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for JAK2 is not available on ENCORE database.

  • 91 RBPs can affect the levels of JAK2.  








The Knockdown/knockout RNA-Seq assay for JAK2 is not available on ENCORE database.





91 RBPs can affect the gene expression of JAK2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
JAK2ENSG00000096968.8371.03190139.366301.4126019.2773017.98790HepG2ACO1
JAK2ENSG00000096968.8542.72660185.875501.5458016.2564015.07770HepG2AKAP1
JAK2ENSG00000096968.8263.40730146.654100.844803.942802.70420HepG2AKAP8
JAK2ENSG00000096968.8369.56990189.828600.961009.645708.49410HepG2AUH
JAK2ENSG00000096968.8200.41630137.285600.545702.305101.59590HepG2CALR
JAK2ENSG00000096968.874.32850137.19660-0.884302.669601.91960HepG2CNOT7
JAK2ENSG00000096968.8232.28780149.901200.631803.452602.75190HepG2CELF1
JAK2ENSG00000096968.8260.70180149.973800.797604.154803.22790HepG2DDX55
JAK2ENSG00000096968.8342.96080222.622400.623302.374901.46940HepG2DDX59
JAK2ENSG00000096968.8223.28520152.927600.545901.953401.42650HepG2DDX6
JAK2ENSG00000096968.8170.5651080.774701.078204.824903.65620HepG2EIF3D
JAK2ENSG00000096968.8228.36340159.015300.522102.454701.65880HepG2EIF4G1
JAK2ENSG00000096968.8368.43680217.936300.757406.808805.93520HepG2ETF1
JAK2ENSG00000096968.8301.43500127.457901.241708.223706.97600HepG2FIP1L1
JAK2ENSG00000096968.8218.81710154.613800.501001.898001.32880HepG2IGF2BP2
JAK2ENSG00000096968.8295.44010103.238901.5168014.3801012.69210HepG2MSI2
JAK2ENSG00000096968.8302.05240125.350201.268704.688403.51000HepG2PABPC1
JAK2ENSG00000096968.8209.22940135.311300.628702.346701.38700HepG2PCBP2
JAK2ENSG00000096968.8204.78480115.770900.822704.059603.10400HepG2PRPF8
JAK2ENSG00000096968.8263.47800137.523000.937906.574905.80220HepG2PTBP1
JAK2ENSG00000096968.8214.18970152.572100.489301.912301.40360HepG2PUF60
JAK2ENSG00000096968.8205.92470141.951900.536602.562301.96340HepG2PUS1
JAK2ENSG00000096968.8267.28610148.991700.843104.998204.19590HepG2QKI
JAK2ENSG00000096968.8617.86110130.584502.2422023.6463021.79090HepG2RAVER1
JAK2ENSG00000096968.8270.27590182.157000.569203.071602.53360HepG2RBM22
JAK2ENSG00000096968.8258.33110135.200300.934005.786604.84350HepG2RBM25
JAK2ENSG00000096968.8217.16040153.069700.504501.846601.38500HepG2NELFE
JAK2ENSG00000096968.8294.67740208.287000.500502.735002.05460HepG2RPLP0
JAK2ENSG00000096968.8133.3962078.599200.763002.600602.00380HepG2RPS19
JAK2ENSG00000096968.8185.34210114.529000.694402.846102.04990HepG2RRP9
JAK2ENSG00000096968.869.98200114.94080-0.715802.459601.84620HepG2SAFB2
JAK2ENSG00000096968.8264.87780174.296400.603702.557901.90930HepG2SF3A3
JAK2ENSG00000096968.8214.05330143.222000.579602.398001.84190HepG2SF3B4
JAK2ENSG00000096968.8471.39980205.744201.1960016.7699015.80980HepG2SRFBP1
JAK2ENSG00000096968.8222.46990149.475300.573602.373801.92680HepG2SRSF1
JAK2ENSG00000096968.8348.26520225.871700.624602.910601.87900HepG2SRSF3
JAK2ENSG00000096968.8174.71360121.591000.522902.012701.52720HepG2SRSF9
JAK2ENSG00000096968.8212.81990122.032700.802302.865601.64140HepG2SUB1
JAK2ENSG00000096968.8256.11290171.321600.580003.284302.61840HepG2SUCLG1
JAK2ENSG00000096968.8226.22050149.319300.599202.502101.85480HepG2SUPV3L1
JAK2ENSG00000096968.8208.68500134.305700.635702.822502.25680HepG2TAF15
JAK2ENSG00000096968.8201.29980125.405800.682603.389602.84650HepG2TIAL1
JAK2ENSG00000096968.8352.15710109.079101.6907016.8047015.20420HepG2U2AF1
JAK2ENSG00000096968.8155.11720104.001900.576602.191601.58350HepG2ZC3H8
JAK2ENSG00000096968.8352.95330170.001901.0538012.1820011.23780HepG2ZNF622
JAK2ENSG00000096968.81409.493401970.24470-0.483205.856303.94490K562APOBEC3C
JAK2ENSG00000096968.81623.030401079.243400.588603.157302.22420K562BOP1
JAK2ENSG00000096968.81539.539101122.881900.455205.357203.23700K562CEBPZ
JAK2ENSG00000096968.84356.185502745.705800.6658014.6226012.51700K562CELF1
JAK2ENSG00000096968.81761.583501290.657900.448706.534604.63760K562DDX21
JAK2ENSG00000096968.81448.61090966.390500.583904.519202.84870K562EEF2
JAK2ENSG00000096968.8708.19060933.69530-0.398802.781901.86670K562EFTUD2
JAK2ENSG00000096968.8847.463901111.54220-0.391304.326703.45560K562EIF2S2
JAK2ENSG00000096968.81646.60870999.658000.719907.105805.33070K562EIF3D
JAK2ENSG00000096968.8805.199801067.79290-0.407204.496603.49240K562EIF3G
JAK2ENSG00000096968.8977.847301426.02400-0.544306.138904.92580K562EIF4A3
JAK2ENSG00000096968.82954.001702232.903100.403706.853705.39530K562EIF4G2
JAK2ENSG00000096968.81559.957001142.359300.449403.586501.74650K562FASTKD2
JAK2ENSG00000096968.81327.88940912.449100.541204.793703.24180K562FKBP4
JAK2ENSG00000096968.81430.11560989.717200.530904.817603.57830K562FTO
JAK2ENSG00000096968.81220.20940943.980400.370203.307201.82750K562FUS
JAK2ENSG00000096968.8875.934501483.00490-0.7596015.9328014.58990K562FXR1
JAK2ENSG00000096968.82551.514901589.610400.682606.259705.09930K562G3BP2
JAK2ENSG00000096968.81229.48360936.096800.393202.727401.32310K562GEMIN5
JAK2ENSG00000096968.81588.511001097.534900.533308.348006.45650K562GLRX3
JAK2ENSG00000096968.81081.756701481.28130-0.453504.825803.82940K562GRSF1
JAK2ENSG00000096968.82233.911601464.827000.608703.460601.43820K562HNRNPA0
JAK2ENSG00000096968.82237.668401244.322700.8465010.018308.13220K562HNRNPA1
JAK2ENSG00000096968.81214.141801584.49500-0.384102.783801.98640K562HSPD1
JAK2ENSG00000096968.82267.419101490.525200.605103.358001.76740K562ILF2
JAK2ENSG00000096968.8639.33090465.752700.456903.006801.46070K562KHDRBS1
JAK2ENSG00000096968.81646.63340935.551900.815508.088406.39670K562KRR1
JAK2ENSG00000096968.8781.729701017.65460-0.380503.083801.60140K562LARP7
JAK2ENSG00000096968.8689.37360937.02130-0.442803.766401.90240K562LSM11
JAK2ENSG00000096968.81324.499801851.58810-0.483302.059701.32960K562MAGOH
JAK2ENSG00000096968.81199.806601848.04310-0.623202.889701.94480K562MATR3
JAK2ENSG00000096968.81505.442601153.912500.383605.442604.33140K562MTPAP
JAK2ENSG00000096968.81998.442301282.113600.6403011.6235010.23750K562NSUN2
JAK2ENSG00000096968.81005.782101326.59600-0.399403.343302.42600K562PPIG
JAK2ENSG00000096968.8711.33080908.59420-0.353102.216801.54160K562PRPF8
JAK2ENSG00000096968.8711.59750941.99030-0.404702.728301.83150K562PSIP1
JAK2ENSG00000096968.81185.147701798.83000-0.602002.822602.15240K562PTBP1
JAK2ENSG00000096968.81779.635802436.24150-0.453105.246204.12570K562PUF60
JAK2ENSG00000096968.82787.386802168.903900.361803.239302.65940K562PUS1
JAK2ENSG00000096968.82332.355401516.708200.620703.904002.18130K562RAVER1
JAK2ENSG00000096968.81109.143001725.62210-0.637702.590301.77850K562RBM22
JAK2ENSG00000096968.82766.298101631.113500.762002.868001.30120K562RBM39
JAK2ENSG00000096968.82334.088201456.280400.680503.057901.38290K562RPS3A
JAK2ENSG00000096968.8954.424601545.34640-0.695202.570301.60840K562RPS3
JAK2ENSG00000096968.81464.25640928.962900.656405.173603.35080K562RRP9
JAK2ENSG00000096968.8497.53680755.49530-0.602605.682804.12980K562SAFB
JAK2ENSG00000096968.81952.447801265.099300.625906.894005.65370K562SF3A3
JAK2ENSG00000096968.81479.249901042.031200.505404.029202.84340K562SF3B1
JAK2ENSG00000096968.81371.447101653.04240-0.269402.356301.56970K562SF3B4
JAK2ENSG00000096968.8826.25120508.070300.701507.155605.14000K562SLBP
JAK2ENSG00000096968.8878.474401763.29720-1.005205.789304.77440K562SRSF1
JAK2ENSG00000096968.81544.481101151.867900.423005.588003.90940K562SRSF7
JAK2ENSG00000096968.81429.987801101.422700.376504.162902.54770K562SSB
JAK2ENSG00000096968.81984.968801533.399300.372303.129301.67050K562SSRP1
JAK2ENSG00000096968.82271.153701402.527300.695306.879804.84370K562STAU1
JAK2ENSG00000096968.81157.38390906.021000.353202.278701.43530K562TIAL1
JAK2ENSG00000096968.82570.339101540.992100.738003.883302.54350K562U2AF1
JAK2ENSG00000096968.82621.797201591.462600.7201015.1638013.25800K562U2AF2
JAK2ENSG00000096968.82551.006401163.241101.1328030.5586027.88600K562WDR3
JAK2ENSG00000096968.82140.133801209.624100.8230028.2396026.02040K562WDR43
JAK2ENSG00000096968.83006.415801851.739900.699107.289105.77230K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for JAK2 is not available on ENCORE database.





5 RBPs can affect the splicing of JAK2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEJAK2ENSG00000096968.8chr9+5056540505660650556685055788506488250650400.084000.003580.05823includedK562SRSF1
SEJAK2ENSG00000096968.8chr9+512633251264465123003512312151266835126814-0.158000.000000.00017excludedK562SF3B4
SEJAK2ENSG00000096968.8chr9+509073850909115090445509057051230035123121-0.053000.002810.04752excludedK562SF3B4
SEJAK2ENSG00000096968.8chr9+498593949860224985244498563050219625022213-0.304000.000250.00539excludedK562PUS1
A5SSJAK2ENSG00000096968.8chr9+505456250548845054562505478950556685055788-0.210000.000050.03183shorterK562CPSF6
A5SSJAK2ENSG00000096968.8chr9+505456250548845054562505478950556685055788-0.139000.003180.09720shorterK562PUS1
A5SSJAK2ENSG00000096968.8chr9+505456250548845054562505478950556685055788-0.710000.000000.00000shorterK562SRSF1
MXEJAK2ENSG00000096968.8chr9+498593949860225021962502221349852444985630502978250299060.136000.002430.040781includedK562HNRNPC

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for JAK2 is not avaliable on ENCORE database.