SFPQ

General Information

Gene Name : SFPQ
Gene ID : ENSG00000116560.10
Essential Gene : Yes

Functions

Splicing regulation
Spliceosome

Localization(RBPImage: SFPQ)

Nuclei
Nucleoplasm
Mutually Exclusive from Nucleolus
Speckles
Nuclear release mitosis

Domains (AlphaFold: SFPQ)

RRM

Antibody Validation

View validation images for all SFPQ antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	SFPQ	ENSG00000116560.10	454.18	380.44	417.31	ENCSR000AEF
HepG2	SFPQ	ENSG00000116560.10	360.00	341.75	350.88	ENCSR985KAT
K562	SFPQ	ENSG00000116560.10	361.85	377.90	369.88	ENCSR000AEO

Assays

4 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 437	ENCSR965DLL	SFPQ	HepG2	Released	ENCAB692IKS	ENCSR506EIW
knockdown followed by RNA-seq	SFPQ-BGKLV28-K562	ENCSR535YPK	SFPQ	K562	Released		ENCSR164MUK	shRNA	KD% = 50.0,60.7
knockdown followed by RNA-seq	SFPQ-BGHLV26-HepG2	ENCSR782MXN	SFPQ	HepG2	Released		ENCSR104ABF	shRNA	KD% = 52.3,62.1
RNA Bind-n-Seq	RBNS: SFPQ	ENCSR951YCV	SFPQ	cell-free sample	Released		ENCSR265XUT

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
SFPQ	437	HepG2	ENCSR965DLL	ENCSR506EIW	ENCAB692IKS	A301-321A	1	Released	ENCODE3

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
SFPQ	ENCAB692IKS	A301-321A	1		Released, ENCODE3	Released, ENCODE3	BGHLV26-55, Released, ENCODE3	BGKLV28-51, Released, ENCODE3
SFPQ		71992S	1		Released, ENCODE3	Submitted, ENCORE2	BGHLV26-55, Released, ENCODE3	BGKLV28-51, Submitted, ENCORE2

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
SFPQ	K562	shRNA			BGKLV08-53,BGKLV08-54	BGKLV08-1,BGKLV08-2		NotSatisfied	ENCODE3
SFPQ	K562	shRNA	ENCSR535YPK	ENCSR164MUK	SFPQ_BGKLV28-51,SFPQ_BGKLV28-52	non-target_BGKLV28-1,non-target_BGKLV28-2	50.0,60.7	Released	ENCODE3
SFPQ	HepG2	shRNA	ENCSR782MXN	ENCSR104ABF	SFPQ_BGHLV26_55,SFPQ_BGHLV26_56	non-target_BGHLV26-1,non-target_BGHLV26-2	52.3,62.1	Released	ENCODE3
SFPQ	293T	shRNA			BG293LV04-75,BG293LV04-76	BG293LV04-1,BG293LV04-2		NotSatisfied	ENCORE2
SFPQ	293T	shRNA			BG293LV05-107,BG293LV05-108	BG293LV05-1,BG293LV05-2		NotSatisfied	ENCORE2

RNA Bind-n-Seqn

GeneName	gene_aliases	Status	Project	Note
SFPQ	SFPQ		Released	ENCODE3

Localization Image in HepG2

SFPQ: Click to RBP Image Database

Nuclei

Nucleoplasm

Mutually Exclusive from Nucleolus

Speckles

Nuclear release mitosis

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
SFPQ	Product_ID: A301-321A Lot_ID: 1 Source: Bethyl Labs Target Name: SFPQ-human
SFPQ	Product_ID: 71992S Lot_ID: 1 Source: Cell Signaling Technology Target Name: SFPQ-human

RNA Targets

SFPQ protein binds to 2,489 RNA regions.

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The binding motifs of SFPQ

Proteins bound to RNA

SFPQ RNA is bound by 55 proteins.

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SFPQ protein has 2,489 RNA targets:

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
SFPQ	chr16	50606504	50606620	+	3.56777	38.23461	HepG2	NKD1	intron-Distal
SFPQ	chr17	79963080	79963100	+	3.44926	30.08245	HepG2	ASPSCR1	intron-Distal
SFPQ	chr1	8085555	8085619	-	3.00329	17.06038	HepG2	ERRFI1	intron-Distal
SFPQ	chr6	158986887	158986966	+	3.48112	13.49093	HepG2	TMEM181	intron-Distal
SFPQ	chr17	80192314	80192367	+	3.00400	12.61484	HepG2	SLC16A3	5'-UTR,intron-Distal
SFPQ	chr2	42434941	42435025	+	3.23497	10.38305	HepG2	EML4	intron-Distal,intron-Proximal
SFPQ	chr1	1821662	1821705	-	5.53989	9.48646	HepG2	GNB1	intron-Distal
SFPQ	chr15	69110135	69110207	-	3.89658	8.92853	HepG2	ANP32A	intron-Distal,intron-Proximal
SFPQ	chr2	178128928	178128971	-	3.28075	8.59993	HepG2	NFE2L2	intron-Distal
SFPQ	chr6	157351683	157351750	+	4.03664	8.18864	HepG2	ARID1B	intron-Distal

Showing 1 to 10 of 100 entries

55 proteins are bound to SFPQ RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr1	35653577	35653635	-	CDS,intron-Distal	5.11329	400.00000	K562	UCHL5
chr1	35652805	35652840	-	CDS,intron-Distal,intron-Proximal	6.46640	400.00000	K562	ZNF622
chr1	35650255	35650352	-	intron-Distal	4.62945	400.00000	HepG2	U2AF2
chr1	35652803	35652813	-	CDS,intron-Distal,intron-Proximal	6.46984	88.23100	K562	UCHL5
chr1	35652835	35652849	-	CDS,intron-Distal	6.17813	86.12660	K562	UCHL5
chr1	35653608	35653634	-	CDS,intron-Distal	4.05839	84.03642	K562	PUM1
chr1	35653610	35653664	-	CDS,intron-Distal,intron-Proximal	4.72134	84.02855	K562	ZNF622
chr1	35650298	35650340	-	intron-Distal	5.20411	80.71956	K562	U2AF2
chr1	35653586	35653610	-	CDS,intron-Distal	5.17619	80.39987	K562	ZNF622
chr1	35653572	35653577	-	CDS,intron-Distal,intron-Proximal	5.61206	78.52259	K562	UCHL5
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 417 entries

No autoregularoty interactions between protein SFPQ and its RNA.

Diffrential Expression

2,280 differentially expressed genes after Knockdown/Knockout SFPQ protein.

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113 RBPs can affect the levels of SFPQ.

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2,280 differentially expressed genes after Knockdown/Knockout SFPQ protein :

Only display 100 entries as example. Please click "View All" button to see all 2,280 entries.

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
HAL	ENSG00000084110.6	36.90550	735.08470	-4.31600	28.65820	24.29900	HepG2	SFPQ
ITGA3	ENSG00000005884.13	356.97290	33.43620	3.41620	16.53940	12.65730	HepG2	SFPQ
TNFRSF12A	ENSG00000006327.9	659.74610	116.70980	2.49890	12.14600	8.56490	HepG2	SFPQ
NGFR	ENSG00000064300.4	385.59050	70.26380	2.45610	10.40670	7.34850	HepG2	SFPQ
ACSM2B	ENSG00000066813.10	62.24130	332.10810	-2.41570	9.85290	6.94090	HepG2	SFPQ
BCAR1	ENSG00000050820.12	2530.57950	663.02210	1.93220	9.16490	6.37390	HepG2	SFPQ
MCAM	ENSG00000076706.10	2148.08250	581.38860	1.88540	8.72590	6.00010	HepG2	SFPQ
CLEC2D	ENSG00000069493.10	14.29680	109.95850	-2.94320	8.13960	5.47060	HepG2	SFPQ
IL11	ENSG00000095752.2	205.16540	40.23500	2.35020	7.84140	5.20640	HepG2	SFPQ
FBXL19	ENSG00000099364.12	504.10810	138.81850	1.86040	7.14770	4.62740	HepG2	SFPQ
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

113 RBPs can affect the gene expression of SFPQ :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
SFPQ	ENSG00000116560.6	7418.75100	3609.59310	1.03920	67.13130	65.50960	HepG2	SRSF1
SFPQ	ENSG00000116560.6	6763.66590	3696.61450	0.87150	41.45510	39.91740	HepG2	NELFE
SFPQ	ENSG00000116560.6	6110.61000	3443.01660	0.82750	38.06280	36.28600	HepG2	RECQL
SFPQ	ENSG00000116560.6	9713.40480	13720.36520	-0.49830	32.78290	30.68870	K562	NSUN2
SFPQ	ENSG00000116560.6	11094.43150	6434.86080	0.78580	31.74110	29.82690	K562	FXR1
SFPQ	ENSG00000116560.6	3787.57200	7841.72840	-1.04990	28.62820	26.93990	HepG2	RPLP0
SFPQ	ENSG00000116560.6	2986.62230	4841.61620	-0.69700	26.29560	24.58420	HepG2	HNRNPU
SFPQ	ENSG00000116560.6	2754.22930	4311.65970	-0.64660	25.44180	23.75860	HepG2	SAFB2
SFPQ	ENSG00000116560.6	7418.82800	3378.41020	1.13470	26.07950	23.50810	HepG2	G3BP2
SFPQ	ENSG00000116560.6	5239.92930	10324.52590	-0.97850	24.97740	23.47260	HepG2	BOP1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 134 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

1,451 alternative splicing events after Knockdown/Knockout SFPQ protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	SPRED2	ENSG00000198369.5	chr2	-	65611807	65612039	65571852	65572030	65659095	65659218	0.06500	0.00055	included	HepG2	SFPQ
SE	METAP1	ENSG00000164024.7	chr4	+	99969883	99970027	99966329	99966461	99978903	99978969	0.10400	0.00041	included	HepG2	SFPQ
SE	DDX18	ENSG00000088205.8	chr2	+	118580328	118580421	118579722	118579837	118582144	118582284	0.15500	0.00000	included	HepG2	SFPQ
SE	ADD1	ENSG00000087274.12	chr4	+	2869698	2869856	2845671	2845751	2877622	2877837	0.07100	0.00012	included	HepG2	SFPQ
SE	GOLGA8A	ENSG00000175265.13	chr15	-	34720815	34720905	34699776	34699936	34727583	34727672	0.09600	0.00018	included	HepG2	SFPQ
SE	STX2	ENSG00000111450.9	chr12	-	131280539	131280665	131275378	131276522	131283069	131283180	0.49100	0.00000	included	HepG2	SFPQ
SE	RNF34	ENSG00000170633.12	chr12	+	121840544	121840610	121837921	121838021	121853961	121854180	0.28100	0.00001	included	HepG2	SFPQ
SE	MYL6	ENSG00000092841.14	chr12	+	56553406	56553514	56552467	56552495	56553758	56553932	0.09700	0.00046	included	HepG2	SFPQ
SE	CIZ1	ENSG00000148337.15	chr9	-	130950141	130950213	130947825	130948055	130952607	130952723	0.15600	0.00029	included	HepG2	SFPQ
SE	SREK1	ENSG00000153914.11	chr5	+	65451892	65454760	65449290	65449424	65455046	65455162	0.27700	0.00000	included	HepG2	SFPQ

Showing 1 to 10 of 100 entries

9 RBPs can affect the splicing of SFPQ :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	SFPQ	ENSG00000116560.6	chr1	-	35656538	35656596			35656294	35656448	35656941	35657130	-0.18100	0.00000	excluded	HepG2	U2AF1
SE	SFPQ	ENSG00000116560.6	chr1	-	35643589	35643637			35642919	35643000	35652601	35652723	-0.05200	0.00001	excluded	K562	AQR
SE	SFPQ	ENSG00000116560.6	chr1	-	35642919	35643000			35641978	35642075	35643589	35643637	0.08500	0.00166	included	K562	PPIL4
A3SS	SFPQ	ENSG00000116560.6	chr1	-	35641978	35642150			35641978	35642075	35642919	35643040	0.11100	0.00000	longer	K562	AQR
A3SS	SFPQ	ENSG00000116560.6	chr1	-	35642919	35643147			35642919	35643000	35643589	35643637	0.08500	0.00000	longer	K562	AQR
A3SS	SFPQ	ENSG00000116560.6	chr1	-	35653573	35653789			35653573	35653691	35654603	35654671	0.06000	0.00000	longer	K562	AQR
A3SS	SFPQ	ENSG00000116560.6	chr1	-	35656941	35657170			35656941	35657130	35657822	35658749	0.22900	0.00000	longer	K562	AQR
A3SS	SFPQ	ENSG00000116560.6	chr1	-	35656294	35656596			35656294	35656448	35656941	35657098	-0.09700	0.00000	shorter	HepG2	U2AF1
MXE	SFPQ	ENSG00000116560.6	chr1	-	35643589	35643637	35652601	35652723	35642919	35643000	35652803	35652852	-0.29700	0.00000	2included	K562	RBM15
MXE	SFPQ	ENSG00000116560.6	chr1	-	35643589	35643637	35652547	35652723	35642919	35643000	35652803	35652852	-0.29700	0.00000	2included	K562	RBM15

Showing 1 to 10 of 29 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

SFPQ

General Information

Functions

Localization(RBPImage: SFPQ)

Domains (AlphaFold: SFPQ)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

SFPQ protein has 2,489 RNA targets:

55 proteins are bound to SFPQ RNA:

No autoregularoty interactions between protein SFPQ and its RNA.

Diffrential Expression

2,280 differentially expressed genes after Knockdown/Knockout SFPQ protein :

113 RBPs can affect the gene expression of SFPQ :

1,451 alternative splicing events after Knockdown/Knockout SFPQ protein :

9 RBPs can affect the splicing of SFPQ :

No autoregularoty alternative splicing events between protein SFPQ and its RNA.