DNAJC2

General Information

Gene Name : DNAJC2
Gene ID : ENSG00000105821.14
Essential Gene : No

Functions

Novel RBP

Localization(RBPImage: DNAJC2)

Nuclei
Nucleoplasm
Unknown Nuclear Foci
Cytoplasm
Compartment/Organelle
Mitochondria
Cytosolic

Domains (AlphaFold: DNAJC2)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

View validation images for all DNAJC2 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	DNAJC2	ENSG00000105821.14	49.05	37.04	43.05	ENCSR000AEF
HepG2	DNAJC2	ENSG00000105821.14	28.23	50.53	39.38	ENCSR985KAT
K562	DNAJC2	ENSG00000105821.14	87.12	105.71	96.41	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	DNAJC2-BGKLV24-K562	ENCSR577OVP	DNAJC2	K562	Released		ENCSR667PLJ	shRNA	KD% = 71.4,59.8
knockdown followed by RNA-seq	DNAJC2-BGHLV20-HepG2	ENCSR004OSI	DNAJC2	HepG2	Released		ENCSR305XWT	shRNA	KD% = 54.6,50.8

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
DNAJC2	ENCAB425OIO	A303-721A	1	Released, ENCODE3	Released, ENCODE3	BGHLV20-21, Released, ENCODE3	BGKLV24-17, Released, ENCODE3
DNAJC2		A303-722A	1	Released, ENCODE3		BGHLV20-21, Released, ENCODE3	BGKcLV38-21, Submitted, ENCORE2
DNAJC2		12844S	1	Released, ENCODE3	Submitted, ENCORE2	BGHLV20-21, Released, ENCODE3	BGKcLV38-21, Submitted, ENCORE2

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
DNAJC2	K562	shRNA	ENCSR577OVP	ENCSR667PLJ	DNAJC2_BGKLV24_17_17608,DNAJC2_BGKLV24_18_17609	non-target_BGKLV24_1_17594,non-target_BGKLV24_2_17595	71.4,59.8	Released	ENCODE3
DNAJC2	HepG2	shRNA			BGHLV18-7,BGHLV18-8	BGHLV18-1,BGHLV18-2		NotSatisfied	ENCODE3
DNAJC2	HepG2	shRNA	ENCSR004OSI	ENCSR305XWT	DNAJC2-57-BGHLV20-21_17716,DNAJC2-57-BGHLV20-22_17717	non-target-BGHLV20-1_17706,non-target-BGHLV20-2_17707	54.6,50.8	Released	ENCODE3
DNAJC2	K562	CRISPR			DNAJC2-BGKcLV38-21,DNAJC2-BGKcLV38-22	NT-BGKcLV38-1,NT-BGKcLV38-2	71.0,79.7	Submitting	ENCORE2
DNAJC2	HepG2	CRISPR			BGHcLV39-29,BGHcLV39-30	BGHcLV39-1,BGHcLV39-2	39.1,47.3	NotSatisfied	ENCORE2
DNAJC2	HepG2	CRISPR			BGHcLV41-13,BGHcLV41-14	BGHcLV41-1,BGHcLV41-2	0.0,0.0	NotSatisfied	ENCORE2

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

DNAJC2: Click to RBP Image Database

Nuclei

Nucleoplasm

Unknown Nuclear Foci

Cytoplasm

Compartment/Organelle

Mitochondria

Cytosolic

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
DNAJC2	Product_ID: A303-721A Lot_ID: 1 Source: Bethyl Labs Target Name: DNAJC2-human
DNAJC2	Product_ID: 12844S Lot_ID: 1 Source: Cell Signaling Technology Target Name: DNAJC2-human
DNAJC2	Product_ID: A303-722A Lot_ID: 1 Source: Bethyl Labs Target Name: DNAJC2-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for DNAJC2 is not avaliable on ENCORE database.

Proteins bound to RNA

DNAJC2 RNA is bound by 19 proteins.

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eCLIP assay for DNAJC2 is not avaliable on ENCORE database.

19 proteins are bound to DNAJC2 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr7	102962407	102962525	-	CDS,intron-Distal	4.33009	32.08638	K562	UCHL5
chr7	102962372	102962525	-	CDS,intron-Distal,intron-Proximal	4.14716	30.77859	K562	ZNF622
chr7	102962960	102963049	-	CDS,intron-Distal,intron-Proximal	4.63216	20.86047	K562	UCHL5
chr7	102963173	102963225	-	CDS,intron-Distal,intron-Proximal	4.60736	20.84920	K562	ZNF622
chr7	102962418	102962500	-	CDS,intron-Distal	3.08908	20.55471	K562	ZNF800
chr7	102957372	102957455	-	CDS,intron-Distal	4.83178	20.20015	K562	UCHL5
chr7	102957310	102957369	-	CDS,intron-Distal	4.70783	17.57985	K562	ZNF622
chr7	102953393	102953472	-	CDS,intron-Distal,intron-Proximal	3.81327	17.39147	K562	UCHL5
chr7	102982210	102982360	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.17908	17.23002	K562	ZNF622
chr7	102962991	102963081	-	CDS,intron-Distal,intron-Proximal	3.48513	15.85918	K562	ZNF622
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 102 entries

eCLIP assay for DNAJC2 is not avaliable on ENCORE database.

Diffrential Expression

6,812 differentially expressed genes after Knockdown/Knockout DNAJC2 protein.

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108 RBPs can affect the levels of DNAJC2.

CanvasJS.com

6,812 differentially expressed genes after Knockdown/Knockout DNAJC2 protein :

Only display 100 entries as example. Please click "View All" button to see all 6,812 entries.

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
IL32	ENSG00000008517.12	3190.11910	1404.55800	1.18340	73.49280	70.38080	HepG2	DNAJC2
NCAPD2	ENSG00000010292.8	2135.88050	3663.09690	-0.77820	36.59480	34.47550	HepG2	DNAJC2
PKD1	ENSG00000008710.13	708.58590	276.77220	1.35610	33.76530	31.72850	HepG2	DNAJC2
SPAG9	ENSG00000008294.16	1701.54130	2880.12480	-0.75930	31.47130	29.50200	HepG2	DNAJC2
RECQL	ENSG00000004700.11	293.04700	650.87900	-1.15130	24.02400	22.28100	HepG2	DNAJC2
RANBP9	ENSG00000010017.9	787.74330	1346.57630	-0.77350	20.99110	19.34890	HepG2	DNAJC2
MLXIPL	ENSG00000009950.11	2229.97070	1164.52430	0.93720	20.73360	19.10190	HepG2	DNAJC2
DBNDD1	ENSG00000003249.9	1054.39210	574.69710	0.87540	20.07310	18.47080	HepG2	DNAJC2
RHBDD2	ENSG00000005486.12	628.40230	306.00770	1.03800	19.83490	18.23920	HepG2	DNAJC2
TMEM132A	ENSG00000006118.10	724.84050	375.34660	0.94930	19.21810	17.64950	HepG2	DNAJC2
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

108 RBPs can affect the gene expression of DNAJC2 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
DNAJC2	ENSG00000105821.10	157.50720	526.00100	-1.73960	38.08560	35.93050	HepG2	DNAJC2
DNAJC2	ENSG00000105821.10	8195.27510	4664.05170	0.81310	36.75980	34.65380	K562	DDX47
DNAJC2	ENSG00000105821.10	530.55140	1114.84100	-1.07130	26.48150	24.76190	HepG2	SRSF7
DNAJC2	ENSG00000105821.10	4941.57170	3309.55920	0.57820	20.97140	18.98380	K562	WDR43
DNAJC2	ENSG00000105821.10	644.79530	1464.96570	-1.18400	20.24770	18.78930	HepG2	HNRNPLL
DNAJC2	ENSG00000105821.10	1037.03250	535.78890	0.95260	20.08530	18.72960	HepG2	SF3B4
DNAJC2	ENSG00000105821.10	1411.03700	570.86210	1.30540	19.95210	18.38450	HepG2	MATR3
DNAJC2	ENSG00000105821.10	3851.45620	2132.83580	0.85250	18.03690	15.43610	K562	PCBP2
DNAJC2	ENSG00000105821.10	7590.39270	4352.91340	0.80210	16.40690	15.13690	K562	AQR
DNAJC2	ENSG00000105821.10	3019.44100	1809.45740	0.73860	16.41950	14.44620	K562	SYNCRIP
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 133 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for DNAJC2 is not available on ENCORE database.

30 RBPs can affect the splicing of DNAJC2 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	is_included	Cell Line	Affected by RBP
SE	DNAJC2	ENSG00000105821.10	chr7	-	102967778	102967825	102966989	102967131	102968102	102968201	0.31000	included	K562	SRSF1
SE	DNAJC2	ENSG00000105821.10	chr7	-	102967778	102967825	102966989	102967131	102968102	102968201	0.35500	included	HepG2	HNRNPK
SE	DNAJC2	ENSG00000105821.10	chr7	-	102967778	102967825	102966989	102967131	102968102	102968201	0.17700	included	K562	AQR
SE	DNAJC2	ENSG00000105821.10	chr7	-	102960202	102960291	102960055	102960125	102962378	102962575	-0.07300	excluded	K562	AQR
SE	DNAJC2	ENSG00000105821.10	chr7	-	102967778	102967825	102966989	102967131	102968102	102968201	0.18800	included	K562	TARDBP
A3SS	DNAJC2	ENSG00000105821.10	chr7	-	102964928	102965153	102964928	102965009	102966989	102967207	0.06800	longer	K562	AQR
A3SS	DNAJC2	ENSG00000105821.10	chr7	-	102956210	102956342	102956210	102956318	102956434	102956535	0.12200	longer	K562	AQR
A3SS	DNAJC2	ENSG00000105821.10	chr7	-	102963149	102963291	102963149	102963241	102964044	102964245	0.13100	longer	K562	AQR
A3SS	DNAJC2	ENSG00000105821.10	chr7	-	102952965	102953148	102952965	102953090	102953393	102953536	0.06100	longer	K562	AQR
RI	DNAJC2	ENSG00000105821.10	chr7	-	102962957	102963241	102962957	102963079	102963149	102963241	0.25300	included	HepG2	PCBP2

Showing 1 to 10 of 56 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

DNAJC2

General Information

Functions

Localization(RBPImage: DNAJC2)

Domains (AlphaFold: DNAJC2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for DNAJC2 is not avaliable on ENCORE database.

19 proteins are bound to DNAJC2 RNA:

eCLIP assay for DNAJC2 is not avaliable on ENCORE database.

Diffrential Expression

6,812 differentially expressed genes after Knockdown/Knockout DNAJC2 protein :

108 RBPs can affect the gene expression of DNAJC2 :

The Knockdown/knockout RNA-Seq assay for DNAJC2 is not available on ENCORE database.

30 RBPs can affect the splicing of DNAJC2 :

The Knockdown/knockout RNA-Seq assay for DNAJC2 is not avaliable on ENCORE database.