SLBP

General Information

Gene Name : SLBP
Gene ID : ENSG00000163950.12
Essential Gene : No

Functions

3' end processing
Viral RNA regulation

Localization(RBPImage: SLBP)

Nuclei
Nucleoplasm
Nucleolus
Variable Nuclear Intensity
Cytoplasm
Compartment/Organelle
Golgi
Cytosolic
Nuclear release mitosis

Domains (AlphaFold: SLBP)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

MBLI: RN045P

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	SLBP	ENSG00000163950.12	143.51	140.40	141.95	ENCSR000AEF
HepG2	SLBP	ENSG00000163950.12	61.76	109.23	85.50	ENCSR985KAT
K562	SLBP	ENSG00000163950.12	123.66	144.04	133.85	ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 262	ENCSR483NOP	SLBP	K562	Released	ENCAB000BGB	ENCSR950WBG
knockdown followed by RNA-seq	SLBP-BGKLV24-K562	ENCSR112YTD	SLBP	K562	Released		ENCSR667PLJ	shRNA	KD% = 96.5,95.2
knockdown followed by RNA-seq	SLBP-BGHLV23-HepG2	ENCSR519KXM	SLBP	HepG2	Released		ENCSR042QTH	shRNA	KD% = 89.2,93.8

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
SLBP	262	K562	ENCSR483NOP	ENCSR950WBG	ENCAB000BGB	RN045P	1	Released	ENCODE3

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
SLBP	ENCAB000BGB	RN045P	1			Released, ENCODE3	BGHLV23-41, Released, ENCODE3	BGKLV24-57, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
SLBP	K562	shRNA	ENCSR112YTD	ENCSR667PLJ	SLBP_BGKLV24_57_17626,SLBP_BGKLV24_58_17627	non-target_BGKLV24_1_17594,non-target_BGKLV24_2_17595	96.5,95.2	Released	ENCODE3
SLBP	HepG2	shRNA	ENCSR519KXM	ENCSR042QTH	SLBP-BGHLV23-41,SLBP-BGHLV23-42	non-target-BGHLV23-1,non-target-BGHLV23-2	89.2,93.8	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

SLBP: Click to RBP Image Database

Nuclei

Nucleoplasm

Nucleolus

Variable Nuclear Intensity

Cytoplasm

Compartment/Organelle

Golgi

Cytosolic

Nuclear release mitosis

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
SLBP	Product_ID: RN045P Lot_ID: 1 Source: MBLI Target Name: SLBP-human

RNA Targets

SLBP protein binds to 151 RNA regions.

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Proteins bound to RNA

SLBP RNA is bound by 19 proteins.

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SLBP protein has 151 RNA targets:

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
SLBP	chr6	27114140	27114150	-	12.35523	400.00000	K562	HIST1H2BK	intron-Distal
SLBP	chr6	26056017	26056027	-	9.48938	400.00000	K562	HIST1H1C	CDS
SLBP	chr6	26104448	26104500	+	6.90516	400.00000	K562	HIST1H4C	3'-UTR,CDS
SLBP	chr6	26157267	26157341	+	10.02017	400.00000	K562	HIST1H1E	3'-UTR,CDS
SLBP	chr6	27101287	27101314	+	11.48241	400.00000	K562	HIST1H2AG	3'-UTR
SLBP	chr6	26104195	26104249	+	4.68453	400.00000	K562	HIST1H4C	CDS
SLBP	chr6	26200204	26200215	+	11.85023	400.00000	K562	HIST1H2BF	3'-UTR
SLBP	chr6	26056032	26056052	-	8.51256	400.00000	K562	HIST1H1C	CDS
SLBP	chr6	26199077	26199146	-	6.29208	400.00000	K562	HIST1H3D, HIST1H2AD	3'-UTR,5'-UTR,CDS,intron-Distal
SLBP	chr6	27792218	27792255	+	12.41346	400.00000	K562	HIST1H4J	3'-UTR

Showing 1 to 10 of 100 entries

19 proteins are bound to SLBP RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr4	1694680	1694789	-	3'-UTR,intron-Distal	3.72307	54.67056	K562	PUM2
chr4	1713682	1713805	-	CDS,intron-Distal,intron-Proximal	5.35609	28.44810	HepG2	AQR
chr4	1694561	1694604	-	3'-UTR,intron-Distal,intron-Proximal	4.29575	18.97391	K562	PUM2
chr4	1713691	1713778	-	CDS,intron-Distal,intron-Proximal	5.17517	18.63887	HepG2	BUD13
chr4	1695076	1695132	-	3'-UTR,intron-Distal,intron-Proximal	3.01487	17.72976	K562	PUM2
chr4	1713633	1713719	-	CDS,intron-Distal,intron-Proximal	4.44054	17.02861	K562	AQR
chr4	1701308	1701403	-	CDS,intron-Distal	3.15636	16.72749	K562	UCHL5
chr4	1713719	1713748	-	CDS,intron-Distal,intron-Proximal	4.39771	16.67977	K562	AQR
chr4	1694604	1694663	-	3'-UTR,intron-Distal	4.21424	16.00523	K562	PUM2
chr4	1701736	1701797	-	CDS,intron-Distal,intron-Proximal	3.47371	15.97490	K562	ZNF622
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 53 entries

No autoregularoty interactions between protein SLBP and its RNA.

Diffrential Expression

7,488 differentially expressed genes after Knockdown/Knockout SLBP protein.

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111 RBPs can affect the levels of SLBP.

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7,488 differentially expressed genes after Knockdown/Knockout SLBP protein :

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
PKD1	ENSG00000008710.13	1266.12050	384.15300	1.72060	74.72950	72.26940	HepG2	SLBP
MLXIPL	ENSG00000009950.11	5705.43030	2782.70970	1.03570	72.05570	69.63380	HepG2	SLBP
CX3CL1	ENSG00000006210.6	3562.30660	1812.74480	0.97450	53.62900	51.38970	HepG2	SLBP
SEMA3G	ENSG00000010319.2	1621.90000	703.36680	1.20520	48.83670	46.67240	HepG2	SLBP
TSPAN9	ENSG00000011105.7	2147.83630	1104.26810	0.95970	39.76690	37.77160	HepG2	SLBP
TFPI	ENSG00000003436.10	15533.29860	9858.97800	0.65580	25.75540	24.03230	HepG2	SLBP
IL32	ENSG00000008517.12	3811.98380	2476.48190	0.62210	24.21300	22.53890	HepG2	SLBP
NISCH	ENSG00000010322.11	2094.45550	1279.81870	0.71050	22.95230	21.32210	HepG2	SLBP
CLCN6	ENSG00000011021.17	2692.24840	1610.39500	0.74130	21.84110	20.24230	HepG2	SLBP
UPF1	ENSG00000005007.8	2689.54260	1724.60620	0.64100	21.74610	20.14870	HepG2	SLBP
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

111 RBPs can affect the gene expression of SLBP :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
SLBP	ENSG00000163950.8	243.85690	1370.85850	-2.49100	127.87330	124.90920	HepG2	SLBP
SLBP	ENSG00000163950.8	291.51320	1215.35520	-2.05970	54.08920	50.02630	K562	SLBP
SLBP	ENSG00000163950.8	401.04980	1293.06000	-1.68890	35.46910	33.61480	HepG2	HNRNPLL
SLBP	ENSG00000163950.8	812.14890	1510.46470	-0.89520	28.34390	26.45120	HepG2	DAZAP1
SLBP	ENSG00000163950.8	516.07410	1277.59400	-1.30780	27.08660	25.42670	HepG2	RPLP0
SLBP	ENSG00000163950.8	486.16860	1260.17700	-1.37410	26.90840	25.09930	HepG2	TARDBP
SLBP	ENSG00000163950.8	1528.87020	816.84790	0.90420	23.74290	22.65410	HepG2	SRSF1
SLBP	ENSG00000163950.8	591.28750	1165.14650	-0.97860	24.12730	22.46840	HepG2	SRSF7
SLBP	ENSG00000163950.8	564.12260	1301.90910	-1.20650	22.67220	21.22210	HepG2	BOP1
SLBP	ENSG00000163950.8	519.82780	1195.24500	-1.20120	20.10000	18.46030	HepG2	CPSF6
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 134 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

44 alternative splicing events after Knockdown/Knockout SLBP protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	ZNF207	ENSG00000010244.12	chr17	+	30693683	30693776	30692348	30692506	30694790	30694962	0.19200	0.00001	included	K562	SLBP
SE	SNHG6	ENSG00000245910.4	chr8	-	67834848	67834960	67834558	67834627	67837671	67837831	0.13200	0.00113	included	K562	SLBP
SE	UQCRH	ENSG00000173660.7	chr1	+	46775568	46775716	46774772	46774799	46775826	46775988	0.15600	0.00040	included	K562	SLBP
SE	RFC5	ENSG00000111445.9	chr12	+	118455494	118455620	118454505	118454697	118456876	118456941	0.06000	0.00254	included	K562	SLBP
SE	GUK1	ENSG00000143774.12	chr1	+	228332261	228332453	228328832	228328989	228333211	228333325	0.24400	0.00004	included	K562	SLBP
SE	SRRM1	ENSG00000133226.12	chr1	+	24973569	24973699	24973157	24973280	24975349	24975520	0.31100	0.00010	included	K562	SLBP
SE	HIST1H2AC	ENSG00000180573.8	chr6	+	26127925	26127989	26124430	26124861	26138281	26139344	0.13300	0.00010	included	K562	SLBP
SE	SRSF3	ENSG00000112081.12	chr6	+	36567597	36568053	36566603	36566760	36568928	36568967	0.07500	0.00017	included	K562	SLBP
SE	RPS24	ENSG00000138326.14	chr10	+	79799961	79799983	79796951	79797062	79800372	79800455	0.15400	0.00000	included	K562	SLBP
SE	SNRNP70	ENSG00000104852.10	chr19	+	49605370	49606844	49604646	49604728	49607890	49607992	0.05900	0.00040	included	K562	SLBP

Showing 1 to 10 of 44 entries

10 RBPs can affect the splicing of SLBP :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	SLBP	ENSG00000163950.8	chr4	-	1713600	1713717			1705322	1705427	1713856	1714282	-0.12500	0.00000	0.00003	excluded	HepG2	U2AF2
A3SS	SLBP	ENSG00000163950.8	chr4	-	1701737	1701818			1701737	1701797	1705322	1705508	0.16100	0.00000	0.00000	longer	K562	AQR
SE	SLBP	ENSG00000163950.8	chr4	-	1705322	1705427			1701737	1701818	1713600	1713739	-0.08400	0.00001	0.00014	excluded	K562	AQR
SE	SLBP	ENSG00000163950.8	chr4	-	1705322	1705427			1701737	1701797	1713600	1713717	-0.08000	0.00002	0.00145	excluded	K562	SF3B1
SE	SLBP	ENSG00000163950.8	chr4	-	1705322	1705427			1701737	1701797	1713600	1713717	-0.05800	0.00046	0.02050	excluded	K562	TARDBP
MXE	SLBP	ENSG00000163950.8	chr4	-	1696500	1696567	1697928	1698078	1694584	1695440	1701290	1701428	0.09100	0.00103	0.02067	1included	K562	PUS1
MXE	SLBP	ENSG00000163950.8	chr4	-	1701290	1701428	1705322	1705427	1698021	1698078	1713600	1713654	-0.08900	0.00155	0.04055	2included	K562	PPIL4
SE	SLBP	ENSG00000163950.8	chr4	-	1705322	1705427			1701737	1701797	1713600	1713717	-0.07300	0.00232	0.04101	excluded	K562	SF3B4
SE	SLBP	ENSG00000163950.8	chr4	-	1713600	1713717			1705322	1705427	1713856	1714282	-0.12100	0.00437	0.06816	excluded	K562	SRSF1
MXE	SLBP	ENSG00000163950.8	chr4	-	1701737	1701797	1705322	1705427	1701290	1701428	1713600	1713717	-0.10000	0.00486	0.05409	2included	K562	DROSHA

Showing 1 to 10 of 11 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

SLBP

General Information

Functions

Localization(RBPImage: SLBP)

Domains (AlphaFold: SLBP)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

SLBP protein has 151 RNA targets:

19 proteins are bound to SLBP RNA:

No autoregularoty interactions between protein SLBP and its RNA.

Diffrential Expression

7,488 differentially expressed genes after Knockdown/Knockout SLBP protein :

111 RBPs can affect the gene expression of SLBP :

44 alternative splicing events after Knockdown/Knockout SLBP protein :

10 RBPs can affect the splicing of SLBP :

No autoregularoty alternative splicing events between protein SLBP and its RNA.