LARS2

General Information

Gene Name       : LARS2
Gene ID             : ENSG00000011376.10
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: LARS2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878LARS2ENSG00000011376.1015.1120.9718.04ENCSR000AEF
HepG2LARS2ENSG00000011376.1025.0524.8424.95ENCSR985KAT
K562LARS2ENSG00000011376.1026.7828.6127.70ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for LARS2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • LARS2 RNA is bound by 17 proteins.  







eCLIP assay for LARS2 is not avaliable on ENCORE database.





17 proteins are bound to LARS2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr34559008545590184+3'-UTR5.510189.83131K562UPF1
chr34558994745590043+3'-UTR4.513453.64119HepG2UPF1
chr34558960345589735+3'-UTR5.7787111.00768HepG2UPF1
chr34558912245589198+3'-UTR4.227573.34655HepG2AKAP1
chr34558915445589424+3'-UTR5.1009121.44569K562UPF1
chr34558981045589875+3'-UTR4.593295.17229HepG2UPF1
chr34558965645589734+3'-UTR4.962277.01394HepG2AKAP1
chr34558981445589867+3'-UTR3.644194.24288K562UPF1
chr34558909345589182+3'-UTR5.164739.50783HepG2UPF1
chr34558997645590046+3'-UTR3.126523.52299HepG2AKAP1
chr34558923245589341+3'-UTR4.5980611.60568HepG2UPF1
chr34558958945589770+3'-UTR5.4089016.93141K562UPF1
chr34543013645430165+5'-UTR4.187843.71570HepG2BCLAF1
chr34543310645433140+5'-UTR,intron-Distal3.734973.02060K562LIN28B
chr34543592245435966+5'-UTR,CDS,intron-Proximal4.019203.90287K562LIN28B
chr34554195545542022+CDS5.9287914.06811K562PUM2
chr34544181545441912+CDS,intron-Distal,intron-Proximal3.482467.02084HepG2PRPF8
chr34555759745557652+CDS3.867413.34184HepG2GRWD1
chr34543603545436094+CDS4.059105.36555HepG2BCLAF1
chr34543601345436083+CDS4.174033.59941K562UCHL5
chr34551579645515842+CDS3.760343.34184HepG2GRWD1
chr34551796445517993+CDS4.261623.38968HepG2BCLAF1
chr34555472545554759+CDS,intron-Proximal3.964544.49024K562AQR
chr34550672745506852+intron-Distal3.351333.30286HepG2PTBP1
chr34547712245477197+intron-Distal6.3930814.59132K562PTBP1
chr34546437545464451+intron-Distal3.827803.45805K562KHSRP
chr34547707845477122+intron-Distal3.978053.76275K562PTBP1
chr34549488645494927+intron-Distal3.846053.01445K562EXOSC5
chr34557721745577350+intron-Distal4.078896.22491K562AGGF1
chr34547712045477174+intron-Distal5.326018.82480HepG2PTBP1
chr34555032345550444+intron-Distal4.3432710.00855HepG2PCBP2
chr34557727945577338+intron-Distal3.190453.51804HepG2HNRNPL
chr34547707645477120+intron-Distal3.152053.30286HepG2PTBP1
chr34555776845557887+intron-Distal,intron-Proximal5.9645412.46873K562AQR
chr34555777445557892+intron-Distal,intron-Proximal3.223463.20886K562PRPF8
chr34546680045466884+intron-Distal3.348023.10883HepG2SUGP2
chr34547707645477192+intron-Distal3.912043.06015K562MATR3
chr34549392145493980+intron-Distal4.258273.89080K562EXOSC5
chr34557720445577273+intron-Distal3.044765.84692HepG2HNRNPL
chr34555475945554769+intron-Proximal5.012856.22530K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for LARS2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for LARS2 is not available on ENCORE database.

  • 102 RBPs can affect the levels of LARS2.  








The Knockdown/knockout RNA-Seq assay for LARS2 is not available on ENCORE database.





102 RBPs can affect the gene expression of LARS2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
LARS2ENSG00000011376.5559.83780747.42810-0.416902.963501.85930HepG2AATF
LARS2ENSG00000011376.5818.994601196.94210-0.547404.014003.39040HepG2AKAP1
LARS2ENSG00000011376.5900.611501400.01560-0.6365012.2723011.00770HepG2AUH
LARS2ENSG00000011376.5413.72040940.91210-1.1854016.7988015.09190HepG2CIRBP
LARS2ENSG00000011376.51176.42610979.077900.264802.948802.26670HepG2CKAP4
LARS2ENSG00000011376.5758.51300457.672200.728804.383103.41630HepG2CNOT7
LARS2ENSG00000011376.5803.29090578.852200.472603.282702.11770HepG2CSTF2
LARS2ENSG00000011376.51633.738501249.163900.387106.743105.66040HepG2DAZAP1
LARS2ENSG00000011376.51542.787701146.557000.428103.283202.60910HepG2DDX3X
LARS2ENSG00000011376.5631.88860921.58070-0.544404.128603.20420HepG2DDX55
LARS2ENSG00000011376.5565.05690919.67120-0.702703.778402.64200HepG2DDX59
LARS2ENSG00000011376.5755.86900984.97030-0.381902.135801.58610HepG2DDX6
LARS2ENSG00000011376.51182.64350936.985500.335802.524801.87360HepG2DKC1
LARS2ENSG00000011376.51100.89200802.504000.456003.467502.44250HepG2EEF2
LARS2ENSG00000011376.5489.11940759.35550-0.634604.418303.00510HepG2AGO1
LARS2ENSG00000011376.5641.00030946.82210-0.562804.500503.75470HepG2EIF2S1
LARS2ENSG00000011376.5404.36690651.43210-0.687905.632704.37430HepG2EIF3D
LARS2ENSG00000011376.51459.493701046.323800.480003.528602.80910HepG2EIF4A3
LARS2ENSG00000011376.5779.598001018.79260-0.386101.876401.30210HepG2EIF4B
LARS2ENSG00000011376.51111.133701607.38720-0.532709.562708.55480HepG2ETF1
LARS2ENSG00000011376.5438.85100582.26260-0.407903.045601.80830HepG2FAM120A
LARS2ENSG00000011376.5674.19730979.34520-0.538604.102103.30120HepG2G3BP1
LARS2ENSG00000011376.51319.370801039.754500.343502.280301.47550HepG2G3BP2
LARS2ENSG00000011376.51468.15140918.001000.677306.702305.73420HepG2GPKOW
LARS2ENSG00000011376.5585.40490801.56960-0.453403.485102.77020HepG2HNRNPA1
LARS2ENSG00000011376.5910.148401148.02890-0.335003.122202.13730HepG2HNRNPA2B1
LARS2ENSG00000011376.5610.64870891.63580-0.546104.838903.94040HepG2HNRNPC
LARS2ENSG00000011376.5759.80870991.77230-0.384402.686701.99760HepG2HNRNPK
LARS2ENSG00000011376.5932.157701137.88540-0.287703.334402.60010HepG2HNRNPL
LARS2ENSG00000011376.5478.89540876.06960-0.871309.695608.59660HepG2HNRNPLL
LARS2ENSG00000011376.5531.169401328.45520-1.3225018.4228016.28250HepG2LARP4
LARS2ENSG00000011376.51536.289101056.144400.540504.927804.06040HepG2MAGOH
LARS2ENSG00000011376.51072.10680776.838300.464703.897303.01350HepG2NSUN2
LARS2ENSG00000011376.5257.87190418.26640-0.697803.213202.25170HepG2PABPC1
LARS2ENSG00000011376.5675.44590876.68180-0.376203.505102.56270HepG2PARN
LARS2ENSG00000011376.5503.45140881.63470-0.808306.040604.55150HepG2PCBP2
LARS2ENSG00000011376.5650.47050790.00100-0.280402.013801.37600HepG2PPIL4
LARS2ENSG00000011376.5813.93820997.55810-0.293502.995802.36150HepG2PUS1
LARS2ENSG00000011376.5528.52790850.81890-0.686903.585802.78560HepG2RAVER1
LARS2ENSG00000011376.5752.098101121.95510-0.577007.312706.00930HepG2RBM15
LARS2ENSG00000011376.5694.22190985.91090-0.506105.231904.33180HepG2RBM25
LARS2ENSG00000011376.5569.23650769.88040-0.435602.744901.68830HepG2RCC2
LARS2ENSG00000011376.5814.235201116.26920-0.455205.422004.70480HepG2NELFE
LARS2ENSG00000011376.5514.54640874.34760-0.764908.429507.08470HepG2RPS2
LARS2ENSG00000011376.5648.22370459.430900.496502.623001.84470HepG2RPS3A
LARS2ENSG00000011376.5434.76570703.03820-0.693405.572504.49240HepG2RRP9
LARS2ENSG00000011376.51231.500801044.339700.237701.927201.41860HepG2SF3B4
LARS2ENSG00000011376.51319.431001133.777100.218702.314401.66340HepG2SLBP
LARS2ENSG00000011376.5615.76820964.81970-0.647903.977803.03270HepG2SNRNP70
LARS2ENSG00000011376.51933.607301090.019500.8268023.1072022.02870HepG2SRSF1
LARS2ENSG00000011376.5656.71050933.09040-0.506803.066902.00480HepG2SRSF3
LARS2ENSG00000011376.5607.74820886.75020-0.545106.769805.97520HepG2SRSF9
LARS2ENSG00000011376.52284.789201317.491600.7942025.5110024.30580HepG2SSB
LARS2ENSG00000011376.5265.57320399.60600-0.589503.213302.02100HepG2STIP1
LARS2ENSG00000011376.5618.94060917.36240-0.567704.481103.65160HepG2SUPV3L1
LARS2ENSG00000011376.5595.93980854.02460-0.519104.301003.42330HepG2TARDBP
LARS2ENSG00000011376.5356.06980541.87520-0.605804.592803.61100HepG2UCHL5
LARS2ENSG00000011376.5529.95000833.02910-0.6525010.486209.31940HepG2ZC3H8
LARS2ENSG00000011376.51135.976202235.62030-0.9767017.7210016.40310K562AQR
LARS2ENSG00000011376.51216.894001486.89680-0.289103.466702.38680K562BCLAF1
LARS2ENSG00000011376.5716.920201001.23000-0.481903.072302.15060K562BOP1
LARS2ENSG00000011376.5486.874801121.81250-1.2042021.8679019.09990K562CIRBP
LARS2ENSG00000011376.5809.879401064.65290-0.394602.245701.53220K562CPSF6
LARS2ENSG00000011376.5873.032601128.03280-0.369703.513702.30300K562CSTF2
LARS2ENSG00000011376.52785.513003552.36180-0.350804.180302.97380K562CELF1
LARS2ENSG00000011376.51779.841802075.06780-0.221402.416401.80200K562DDX47
LARS2ENSG00000011376.5851.190501348.08810-0.663407.658106.07140K562EFTUD2
LARS2ENSG00000011376.51594.721801960.99350-0.298303.530702.73320K562EIF2S2
LARS2ENSG00000011376.5649.65450911.76340-0.489002.318901.40660K562EIF3A
LARS2ENSG00000011376.51046.09900832.693300.329103.267302.40530K562EIF3G
LARS2ENSG00000011376.51234.60810981.309800.331202.454101.68070K562EIF4A3
LARS2ENSG00000011376.5792.072301186.97030-0.583605.245903.60270K562FKBP4
LARS2ENSG00000011376.5771.518701083.14660-0.489503.132602.21830K562FMR1
LARS2ENSG00000011376.5637.18310918.01560-0.526803.701702.63050K562FTO
LARS2ENSG00000011376.51644.845501020.514000.6886013.8452012.59650K562FXR1
LARS2ENSG00000011376.5441.53150752.10630-0.768405.925604.80400K562G3BP2
LARS2ENSG00000011376.51280.622001699.99280-0.408705.369003.80830K562GLRX3
LARS2ENSG00000011376.51856.097102613.23120-0.493606.621305.44590K562GRSF1
LARS2ENSG00000011376.51211.365201786.74160-0.560707.827806.10620K562HNRNPA1
LARS2ENSG00000011376.5779.749101231.11830-0.658902.858901.61700K562HNRNPA2B1
LARS2ENSG00000011376.5855.420001367.65100-0.677009.243108.20220K562HNRNPC
LARS2ENSG00000011376.51508.742401978.74640-0.391205.185303.94800K562HNRNPU
LARS2ENSG00000011376.51749.480602187.54530-0.322402.626201.84970K562HSPD1
LARS2ENSG00000011376.5672.31890905.07030-0.428903.109201.53190K562KHDRBS1
LARS2ENSG00000011376.5515.29500867.86630-0.752104.613403.37190K562KRR1
LARS2ENSG00000011376.5699.953101403.72090-1.003905.690602.62170K562LARP4
LARS2ENSG00000011376.51648.389501100.044800.583407.902306.45300K562MAGOH
LARS2ENSG00000011376.52286.295403079.86230-0.429904.246702.85030K562MSI2
LARS2ENSG00000011376.51415.048701787.31620-0.336904.786103.74590K562MTPAP
LARS2ENSG00000011376.5766.21210979.95180-0.355003.060801.76940K562NCBP2
LARS2ENSG00000011376.51417.791101985.89450-0.4861012.6708011.23410K562NSUN2
LARS2ENSG00000011376.51385.334101929.84670-0.478302.627701.43210K562PABPC1
LARS2ENSG00000011376.5681.304901077.20210-0.660902.836101.83020K562PABPN1
LARS2ENSG00000011376.51284.258701859.01070-0.533605.003303.88460K562PCBP3
LARS2ENSG00000011376.51172.103601425.90440-0.282802.302801.57250K562POLR2G
LARS2ENSG00000011376.5995.428601311.84540-0.398203.026202.24130K562PRPF8
LARS2ENSG00000011376.5999.978201226.21080-0.294202.086601.31180K562PSIP1
LARS2ENSG00000011376.51310.687201068.777500.294302.425401.79700K562PTBP1
LARS2ENSG00000011376.52567.940903152.59130-0.295902.372401.61780K562PUF60
LARS2ENSG00000011376.52693.245303352.94030-0.316103.407402.21670K562PUM1
LARS2ENSG00000011376.52589.379003285.55970-0.343504.735103.46810K562PUM2
LARS2ENSG00000011376.5485.71810717.57930-0.563002.719501.32020K562RAVER1
LARS2ENSG00000011376.5787.756801118.60600-0.505905.276303.90060K562RCC2
LARS2ENSG00000011376.5932.097301336.24810-0.519603.919402.94310K562RPS19
LARS2ENSG00000011376.51627.936801959.53290-0.267502.711801.90490K562SF3A3
LARS2ENSG00000011376.5750.99640987.30160-0.394702.941601.63660K562SLBP
LARS2ENSG00000011376.5797.411601060.42440-0.411203.357902.20070K562SRFBP1
LARS2ENSG00000011376.51324.502001047.780900.338002.946202.21970K562SRSF1
LARS2ENSG00000011376.5633.16300858.95960-0.440002.643401.39750K562SSB
LARS2ENSG00000011376.51467.051001936.23880-0.400303.168801.81580K562STAU1
LARS2ENSG00000011376.5749.986501353.39100-0.851604.076502.19800K562SUPT6H
LARS2ENSG00000011376.5867.051401270.12470-0.550804.612603.27410K562SUPV3L1
LARS2ENSG00000011376.51752.269101430.247200.292902.719201.90750K562SYNCRIP
LARS2ENSG00000011376.5815.085501179.42810-0.533104.500803.28460K562TIAL1
LARS2ENSG00000011376.5941.564901252.81980-0.412003.527702.43460K562TRIM56
LARS2ENSG00000011376.5526.95720752.85940-0.514705.058103.97690K562U2AF2
LARS2ENSG00000011376.5861.705601344.28320-0.641606.927805.22940K562UCHL5
LARS2ENSG00000011376.51698.854002105.68400-0.309704.747603.83240K562UPF1
LARS2ENSG00000011376.51238.130401801.77060-0.541307.323405.85900K562WDR3
LARS2ENSG00000011376.51015.627201368.87590-0.430603.481602.06820K562XRN2
LARS2ENSG00000011376.51474.568602518.66020-0.7724013.6586011.59630K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for LARS2 is not available on ENCORE database.





9 RBPs can affect the splicing of LARS2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SELARS2ENSG00000011376.5chr3+455157344551584245500234455003784551795945518119-0.242000.000250.00666excludedK562SRSF1
SELARS2ENSG00000011376.5chr3+4556118445561282455594544555956445561710455617880.215000.000340.03858includedHepG2DDX59
SELARS2ENSG00000011376.5chr3+455611844556128245559454455595644556171045561788-0.343000.000000.00014excludedHepG2U2AF2
SELARS2ENSG00000011376.5chr3+455157344551584245500234455003784551795945518119-0.116000.000740.00952excludedK562AQR
SELARS2ENSG00000011376.5chr3+455611844556128245559454455595644556171045561788-0.301000.000150.01104excludedHepG2SFPQ
SELARS2ENSG00000011376.5chr3+455833204558344845565488455656004558884245589101-0.200000.000710.03975excludedK562EFTUD2
SELARS2ENSG00000011376.5chr3+4543052445430598454301104543017245433074454331400.211000.000100.00262includedK562HNRNPC
SELARS2ENSG00000011376.5chr3+4556118445561282455594544555956445561710455617880.160000.001420.02573includedK562HNRNPC
MXELARS2ENSG00000011376.5chr3+4556548845565600455833204558344845561710455617884558884245590329-0.223000.003860.084442includedK562DHX30
MXELARS2ENSG00000011376.5chr3+45541933455420714555462645554727455377664553786545557585455577680.211000.002990.046151includedK562HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for LARS2 is not avaliable on ENCORE database.