PABPC1

General Information

Gene Name : PABPC1
Gene ID : ENSG00000070756.15
Essential Gene : Yes

Functions

RNA stability & decay
RNA export
Translation regulation
Viral RNA regulation
Other

Localization

Not Available

Domains (AlphaFold: PABPC1)

RRM

Antibody Validation

Cell Signaling Technology: 3505S

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	PABPC1	ENSG00000070756.15	1649.82	1455.92	1552.87	ENCSR000AEF
HepG2	PABPC1	ENSG00000070756.15	1064.06	700.52	882.29	ENCSR985KAT
K562	PABPC1	ENSG00000070756.15	1304.34	1462.38	1383.36	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	PABPC1-BGKLV24-K562	ENCSR192GBD	PABPC1	K562	Released		ENCSR419JMU	shRNA	KD% = no AB,no AB
knockdown followed by RNA-seq	PABPC1-BGHLV22-HepG2	ENCSR910YNJ	PABPC1	HepG2	Released		ENCSR279HMU	shRNA	KD% = NO AB,NO AB

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
PABPC1		3505S	2			Submitted, ENCORE2	BGHcLV43-37, Submitted, ENCORE2	BGKcLV42-61, Submitted, ENCORE2

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
PABPC1	K562	shRNA	ENCSR192GBD	ENCSR419JMU	PABPC1_BGKLV24_41B,PABPC1_BGKLV24_42B	non-target_BGKLV24_1B,non-target_BGKLV24_2B	no AB,no AB	Released	ENCODE3
PABPC1	HepG2	shRNA	ENCSR910YNJ	ENCSR279HMU	PABPC1-BGHLV22-33,PABPC1-BGHLV22-34	non-target-BGHLV22-1_17746,non-target-BGHLV22-2_17747	NO AB,NO AB	Released	ENCODE3
PABPC1	K562	CRISPR			PABPC1-BGKcLV42-61,PABPC1-BGKcLV42-62	NT-BGKcLV42-1,NT-BGKcLV42-2	82.1,85.7	Submitting	ENCORE2
PABPC1	HepG2	CRISPR			PABPC1-BGHcLV43-37,PABPC1-BGHcLV43-38	NT-BGHcLV43-1,NT-BGHcLV43-2	67.7,73.7	Submitting	ENCORE2

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
PABPC1	Product_ID: 3505S Lot_ID: 2 Source: Cell Signaling Technology Target Name: PABPC1-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for PABPC1 is not avaliable on ENCORE database.

Proteins bound to RNA

PABPC1 RNA is bound by 39 proteins.

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eCLIP assay for PABPC1 is not avaliable on ENCORE database.

39 proteins are bound to PABPC1 RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr8	101721413	101721451	-	3'-UTR,CDS,intron-Distal	5.64171	400.00000	K562	IGF2BP2
chr8	101734073	101734137	-	3'-UTR,5'-UTR,intron-Distal,intron-Proximal	4.33627	400.00000	HepG2	TIAL1
chr8	101734098	101734130	-	3'-UTR,5'-UTR,intron-Distal,intron-Proximal	4.71403	400.00000	K562	TIA1
chr8	101715517	101715539	-	3'-UTR,intron-Distal	4.24795	400.00000	K562	CPEB4
chr8	101715433	101715441	-	3'-UTR,intron-Distal,intron-Proximal	4.58673	400.00000	K562	PABPC4
chr8	101734099	101734103	-	3'-UTR,5'-UTR,intron-Distal	3.39081	400.00000	K562	APOBEC3C
chr8	101721414	101721448	-	3'-UTR,CDS,intron-Distal	4.79532	400.00000	HepG2	IGF2BP1
chr8	101715356	101715392	-	3'-UTR,intron-Distal,intron-Proximal	5.76469	400.00000	K562	PABPC4
chr8	101715471	101715475	-	3'-UTR,intron-Distal,intron-Proximal	5.65398	400.00000	K562	PABPC4
chr8	101734040	101734057	-	3'-UTR,5'-UTR,intron-Distal	5.05995	400.00000	K562	PABPC4
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 396 entries

eCLIP assay for PABPC1 is not avaliable on ENCORE database.

Diffrential Expression

5,948 differentially expressed genes after Knockdown/Knockout PABPC1 protein.

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134 RBPs can affect the levels of PABPC1.

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5,948 differentially expressed genes after Knockdown/Knockout PABPC1 protein :

Only display 100 entries as example. Please click "View All" button to see all 5,948 entries.

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
GCLC	ENSG00000001084.6	13289.14580	1600.94820	3.05310	42.32940	39.28990	HepG2	PABPC1
PLAUR	ENSG00000011422.7	309.90430	52.12450	2.57170	22.39710	19.91630	HepG2	PABPC1
TNFRSF12A	ENSG00000006327.9	2794.74010	926.33840	1.59300	19.55640	17.17700	HepG2	PABPC1
ACSM3	ENSG00000005187.7	357.79010	1111.09000	-1.63480	17.84150	15.56260	HepG2	PABPC1
BAIAP3	ENSG00000007516.9	680.46100	203.39610	1.74210	17.27400	15.01610	HepG2	PABPC1
PKD1	ENSG00000008710.13	1570.36020	506.27860	1.63300	15.27910	13.14270	HepG2	PABPC1
CYP51A1	ENSG00000001630.11	6961.78740	2872.43780	1.27710	13.95650	11.92520	HepG2	PABPC1
FAM214B	ENSG00000005238.15	324.77280	91.45850	1.82810	13.78790	11.76670	HepG2	PABPC1
SOX8	ENSG00000005513.9	84.12530	9.04710	3.21690	11.99800	10.11630	HepG2	PABPC1
ZC3H3	ENSG00000014164.6	526.56400	179.43830	1.55300	10.81190	9.02660	HepG2	PABPC1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

134 RBPs can affect the gene expression of PABPC1 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
PABPC1	ENSG00000070756.9	11054.19290	37405.39510	-1.75870	190.42270	187.50350	HepG2	PTBP1
PABPC1	ENSG00000070756.9	7219.95230	20412.56880	-1.49940	166.41900	163.29460	HepG2	PUS1
PABPC1	ENSG00000070756.9	5039.18290	20155.25720	-1.99990	141.98420	139.42590	HepG2	TIAL1
PABPC1	ENSG00000070756.9	16407.79270	40648.53970	-1.30880	140.55910	138.51290	HepG2	SRSF1
PABPC1	ENSG00000070756.9	6758.49030	106946.00710	-3.98400	115.55370	111.14730	K562	PABPC1
PABPC1	ENSG00000070756.9	1905.39250	22332.15540	-3.55100	87.79670	83.73600	HepG2	PABPC1
PABPC1	ENSG00000070756.9	20093.35000	41628.31990	-1.05080	77.67910	75.80550	HepG2	NELFE
PABPC1	ENSG00000070756.9	18489.06650	44420.86270	-1.26460	53.24330	50.47120	K562	PTBP1
PABPC1	ENSG00000070756.9	17066.79790	29958.34980	-0.81180	50.20970	48.69300	HepG2	SSB
PABPC1	ENSG00000070756.9	12360.18570	37001.92690	-1.58190	47.88410	45.41400	HepG2	MAGOH
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 156 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for PABPC1 is not available on ENCORE database.

9 RBPs can affect the splicing of PABPC1 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
RI	PABPC1	ENSG00000070756.9	chr8	-	101730000	101730508			101730000	101730142	101730314	101730508	-0.49500	0.00000	0.00000	excluded	K562	AQR
MXE	PABPC1	ENSG00000070756.9	chr8	-	101717153	101717284	101717816	101717901	101716341	101716618	101718878	101719033	0.07000	0.00000	0.00000	1included	HepG2	U2AF2
MXE	PABPC1	ENSG00000070756.9	chr8	-	101727689	101727829	101730000	101730508	101725365	101725409	101733618	101733811	0.13200	0.00000	0.00000	1included	K562	SUPV3L1
MXE	PABPC1	ENSG00000070756.9	chr8	-	101724879	101725017	101725314	101725409	101724589	101724685	101727689	101727724	-0.11000	0.00001	0.00066	2included	HepG2	HNRNPUL1
A3SS	PABPC1	ENSG00000070756.9	chr8	-	101717816	101717992			101717816	101717901	101721360	101721451	0.37300	0.00022	0.00180	longer	K562	AQR
SE	PABPC1	ENSG00000070756.9	chr8	-	101721773	101721901			101721360	101721451	101724589	101724685	-0.28100	0.00023	0.01195	excluded	K562	TARDBP
MXE	PABPC1	ENSG00000070756.9	chr8	-	101725314	101725409	101727689	101727829	101724879	101725017	101730000	101730116	0.06800	0.00100	0.01817	1included	K562	DROSHA
MXE	PABPC1	ENSG00000070756.9	chr8	-	101725314	101725409	101727689	101727829	101724879	101725017	101730000	101730116	0.07100	0.00335	0.05542	1included	HepG2	FTO
MXE	PABPC1	ENSG00000070756.9	chr8	-	101725314	101725409	101727689	101727829	101724879	101725017	101730000	101730116	0.05500	0.00531	0.08805	1included	K562	PPIL4
MXE	PABPC1	ENSG00000070756.9	chr8	-	101724879	101725017	101725314	101725409	101724589	101724685	101727689	101727724	-0.08400	0.00619	0.09992	2included	K562	SBDS

Showing 1 to 10 of 11 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

PABPC1

General Information

Functions

Localization

Domains (AlphaFold: PABPC1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for PABPC1 is not avaliable on ENCORE database.

39 proteins are bound to PABPC1 RNA:

eCLIP assay for PABPC1 is not avaliable on ENCORE database.

Diffrential Expression

5,948 differentially expressed genes after Knockdown/Knockout PABPC1 protein :

134 RBPs can affect the gene expression of PABPC1 :

The Knockdown/knockout RNA-Seq assay for PABPC1 is not available on ENCORE database.

9 RBPs can affect the splicing of PABPC1 :

The Knockdown/knockout RNA-Seq assay for PABPC1 is not avaliable on ENCORE database.