DKC1

General Information

Gene Name : DKC1
Gene ID : ENSG00000130826.17
Essential Gene : Yes

Functions

RNA modification
rRNA processing
snoRNA / snRNA / telomerase

Localization(RBPImage: DKC1)

Nuclei
Nucleolus

Domains (AlphaFold: DKC1)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

GeneTex: GTX109000

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	DKC1	ENSG00000130826.17	91.84	96.42	94.13	ENCSR000AEF
HepG2	DKC1	ENSG00000130826.17	87.01	103.75	95.38	ENCSR985KAT
K562	DKC1	ENSG00000130826.17	180.87	175.19	178.03	ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 544	ENCSR301TFY	DKC1	HepG2	Released	ENCAB174DOV	ENCSR197LHH
knockdown followed by RNA-seq	DKC1-BGKLV32-K562	ENCSR494UDF	DKC1	K562	Released		ENCSR143COQ	shRNA	KD% = 87.2,89.9
knockdown followed by RNA-seq	DKC1-BGHLV31-HepG2	ENCSR118KUN	DKC1	HepG2	Released		ENCSR538QOG	shRNA	KD% = 93.2,88.3

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
DKC1	544	HepG2	ENCSR301TFY	ENCSR197LHH	ENCAB174DOV	GTX109000	40583	Released	ENCODE3

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
DKC1	ENCAB174DOV	GTX109000	40583		Released, ENCODE3		BGHLV31-33, Released, ENCODE3	BGKLV32-29, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
DKC1	K562	shRNA			BGKLV29-25,BGKLV29-26	BGKLV29-1,BGKLV29-2		NotSatisfied	ENCODE3
DKC1	K562	shRNA	ENCSR494UDF	ENCSR143COQ	DKC1_BGKLV32-29,DKC1_BGKLV32-30	NT_BGKLV32-1,NT_BGKLV32-2	87.2,89.9	Released	ENCODE3
DKC1	HepG2	shRNA	ENCSR118KUN	ENCSR538QOG	DKC1_BGHLV31-33,DKC1_BGHLV31-34	NT-BGHLV31-1,NT-BGHLV31-2	93.2,88.3	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

DKC1: Click to RBP Image Database

Nuclei

Nucleolus

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
DKC1	Product_ID: GTX109000 Lot_ID: 40583 Source: GeneTex Target Name: DKC1-human

RNA Targets

DKC1 protein binds to 2,590 RNA regions.

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Proteins bound to RNA

DKC1 RNA is bound by 46 proteins.

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DKC1 protein has 2,590 RNA targets:

Only display 100 entries as example. Please click "View All" button to see all 2,590 entries.

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
DKC1	chr14	103804302	103804307	+	5.11939	400.00000	HepG2	EIF5	intron-Distal
DKC1	chr12	49048225	49048229	-	5.26776	400.00000	HepG2	KANSL2	intron-Distal
DKC1	chr19	17973449	17973454	+	4.14877	400.00000	HepG2	RPL18A	intron-Distal
DKC1	chr9	95054842	95054872	-	6.03614	400.00000	HepG2	IARS	intron-Distal
DKC1	chr1	28906974	28906984	-	4.38293	400.00000	HepG2	SNHG12	intron-Distal,intron-Proximal
DKC1	chr8	99054405	99054419	-	3.82854	400.00000	HepG2	RPL30	intron-Distal
DKC1	chr20	47895480	47895492	+	3.38975	400.00000	HepG2	ZFAS1	intron-Distal
DKC1	chr3	39450009	39450019	+	6.27735	400.00000	HepG2	RPSA	intron-Proximal
DKC1	chr1	173836015	173836029	-	5.85841	400.00000	HepG2	GAS5	intron-Distal,intron-Proximal
DKC1	chr15	66795203	66795231	-	5.17651	400.00000	HepG2	RPL4	intron-Distal,intron-Proximal

Showing 1 to 10 of 100 entries

46 proteins are bound to DKC1 RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chrX	153996803	153996808	+	intron-Distal,intron-Proximal	5.44027	400.00000	HepG2	DKC1
chrX	153996856	153996858	+	intron-Distal	6.39647	400.00000	HepG2	DKC1
chrX	153996858	153996863	+	intron-Distal	6.48568	400.00000	HepG2	DKC1
chrX	154003368	154003401	+	intron-Distal,intron-Proximal	5.98425	400.00000	HepG2	DKC1
chrX	154003346	154003368	+	intron-Distal	5.75995	400.00000	HepG2	DKC1
chrX	153996863	153996873	+	intron-Distal	5.11486	400.00000	HepG2	DKC1
chrX	154003279	154003317	+	intron-Distal	6.05366	400.00000	HepG2	DKC1
chrX	153996847	153996853	+	intron-Distal	5.82321	400.00000	HepG2	DKC1
chrX	154003329	154003336	+	intron-Distal	6.11266	400.00000	HepG2	DKC1
chrX	154003365	154003391	+	intron-Distal,intron-Proximal	5.09490	400.00000	HepG2	NOLC1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 186 entries

The DKC1 protein binds to its own RNA.

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
DKC1	chrX	153996803	153996808	+	5.44027	400.00000	HepG2	DKC1	intron-Distal,intron-Proximal
DKC1	chrX	153996856	153996858	+	6.39647	400.00000	HepG2	DKC1	intron-Distal
DKC1	chrX	153996858	153996863	+	6.48568	400.00000	HepG2	DKC1	intron-Distal
DKC1	chrX	154003368	154003401	+	5.98425	400.00000	HepG2	DKC1	intron-Distal,intron-Proximal
DKC1	chrX	154003346	154003368	+	5.75995	400.00000	HepG2	DKC1	intron-Distal
DKC1	chrX	153996863	153996873	+	5.11486	400.00000	HepG2	DKC1	intron-Distal
DKC1	chrX	154003279	154003317	+	6.05366	400.00000	HepG2	DKC1	intron-Distal
DKC1	chrX	153996847	153996853	+	5.82321	400.00000	HepG2	DKC1	intron-Distal
DKC1	chrX	154003329	154003336	+	6.11266	400.00000	HepG2	DKC1	intron-Distal
DKC1	chrX	153996808	153996847	+	5.59779	400.00000	HepG2	DKC1	intron-Distal

Showing 1 to 10 of 12 entries

Diffrential Expression

10,800 differentially expressed genes after Knockdown/Knockout DKC1 protein.

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114 RBPs can affect the levels of DKC1.

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10,800 differentially expressed genes after Knockdown/Knockout DKC1 protein :

Only display 100 entries as example. Please click "View All" button to see all 10,800 entries.

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
CRLF1	ENSG00000006016.6	924.06670	4768.23980	-2.36740	215.63160	212.62230	HepG2	DKC1
SLC7A2	ENSG00000003989.12	2080.13350	7005.48890	-1.75180	149.01150	146.33060	HepG2	DKC1
JHDM1D	ENSG00000006459.6	521.21800	2311.24760	-2.14870	128.87960	126.30790	HepG2	DKC1
MLXIPL	ENSG00000009950.11	9980.07260	3518.66090	1.50390	105.78250	103.32530	HepG2	DKC1
ZFX	ENSG00000005889.11	2636.16650	965.60440	1.44880	72.06070	69.87440	HepG2	DKC1
PLXND1	ENSG00000004399.8	1021.22570	2736.92200	-1.42230	71.85360	69.67570	HepG2	DKC1
TFPI	ENSG00000003436.10	5485.64120	10281.19840	-0.90630	48.71800	46.79720	HepG2	DKC1
ST3GAL1	ENSG00000008513.10	2536.87920	1160.90680	1.12770	45.86600	43.97780	HepG2	DKC1
SPAG9	ENSG00000008294.16	2212.63880	4326.30380	-0.96740	43.73860	41.88740	HepG2	DKC1
CROT	ENSG00000005469.7	645.45510	220.80400	1.54750	31.49460	29.85190	HepG2	DKC1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

114 RBPs can affect the gene expression of DKC1 :

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
DKC1	ENSG00000130826.11	378.63350	1786.98170	-2.23870	117.91650	115.37790	HepG2	DKC1
DKC1	ENSG00000130826.11	1721.73070	3371.43560	-0.96950	43.40670	41.96460	HepG2	SSB
DKC1	ENSG00000130826.11	16315.66750	9205.26650	0.82560	41.73200	39.48780	K562	DDX47
DKC1	ENSG00000130826.11	1235.50990	2821.07980	-1.19110	31.76730	30.03840	HepG2	PUF60
DKC1	ENSG00000130826.11	1085.47520	2699.45270	-1.31430	28.32110	26.65350	HepG2	HNRNPLL
DKC1	ENSG00000130826.11	780.17190	1772.34430	-1.18380	26.34200	24.55870	HepG2	DDX21
DKC1	ENSG00000130826.11	868.98600	1744.53280	-1.00540	24.07580	22.87430	HepG2	TIAL1
DKC1	ENSG00000130826.11	2178.71120	3582.64630	-0.71760	23.73860	22.09430	HepG2	AUH
DKC1	ENSG00000130826.11	2853.02520	5393.90880	-0.91880	23.46770	21.80930	K562	HNRNPC
DKC1	ENSG00000130826.11	1630.91560	2992.55680	-0.87570	22.00940	20.23500	HepG2	PUM2
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 139 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

241 alternative splicing events after Knockdown/Knockout DKC1 protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	MICU1	ENSG00000107745.12	chr10	-	74283559	74283640	74267912	74268027	74293503	74293547	0.24700	0.00029	included	HepG2	DKC1
SE	IVNS1ABP	ENSG00000116679.11	chr1	-	185275616	185275757	185274667	185274775	185276145	185276271	0.28600	0.00043	included	HepG2	DKC1
SE	APOC1	ENSG00000130208.5	chr19	+	45417928	45417990	45417503	45417746	45418128	45418206	0.12500	0.00000	included	HepG2	DKC1
SE	SREK1	ENSG00000153914.11	chr5	+	65451892	65454760	65449290	65449424	65455046	65455162	0.34500	0.00008	included	HepG2	DKC1
SE	UGP2	ENSG00000169764.10	chr2	+	64069672	64069733	64068990	64069338	64083439	64083567	0.23400	0.00072	included	HepG2	DKC1
SE	HNRNPA2B1	ENSG00000122566.16	chr7	-	26231041	26231270	26230612	26230748	26232114	26232197	0.29300	0.00008	included	HepG2	DKC1
SE	RWDD1	ENSG00000111832.8	chr6	+	116894020	116894148	116892582	116892818	116895220	116895334	0.30400	0.00017	included	HepG2	DKC1
SE	KHK	ENSG00000138030.8	chr2	+	27317667	27317802	27315199	27315316	27319596	27319669	0.41900	0.00235	included	HepG2	DKC1
SE	EXOC1	ENSG00000090989.13	chr4	+	56755053	56755098	56749988	56750094	56756388	56756552	0.45700	0.00210	included	HepG2	DKC1
SE	SLC35D2	ENSG00000130958.7	chr9	-	99113384	99113453	99107580	99107683	99122435	99122503	0.12600	0.00039	included	HepG2	DKC1

Showing 1 to 10 of 100 entries

10 RBPs can affect the splicing of DKC1 :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	DKC1	ENSG00000130826.11	chrX	+	153995271	153995336	153994490	153994675	153995530	153995657	0.05200	0.00000	included	K562	FMR1
SE	DKC1	ENSG00000130826.11	chrX	+	153993718	153993949	153993199	153993241	153994181	153994273	-0.08300	0.00000	excluded	K562	AQR
SE	DKC1	ENSG00000130826.11	chrX	+	153996526	153996707	153995563	153995657	153997441	153997485	-0.05700	0.00000	excluded	K562	AQR
SE	DKC1	ENSG00000130826.11	chrX	+	153994181	153994199	153993718	153993805	153994539	153994675	-0.22200	0.00002	excluded	K562	SUPV3L1
SE	DKC1	ENSG00000130826.11	chrX	+	153995271	153995336	153994490	153994675	153995530	153995657	-0.05300	0.00004	excluded	K562	PUS1
SE	DKC1	ENSG00000130826.11	chrX	+	153995271	153995336	153994490	153994675	153995530	153995657	-0.16300	0.00000	excluded	K562	U2AF1
SE	DKC1	ENSG00000130826.11	chrX	+	153993173	153993241	153991165	153991256	153993718	153993805	-0.09400	0.00000	excluded	K562	U2AF2
SE	DKC1	ENSG00000130826.11	chrX	+	153995271	153995336	153994490	153994675	153995530	153995657	-0.16600	0.00000	excluded	K562	U2AF2
SE	DKC1	ENSG00000130826.11	chrX	+	153995271	153995336	153994490	153994675	153995530	153995657	-0.06500	0.00000	excluded	K562	RBM15
A5SS	DKC1	ENSG00000130826.11	chrX	+	154003469	154003682	154003469	154003548	154004461	154004540	0.06700	0.00000	longer	K562	PUS1

Showing 1 to 10 of 23 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

DKC1

General Information

Functions

Localization(RBPImage: DKC1)

Domains (AlphaFold: DKC1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

DKC1 protein has 2,590 RNA targets:

46 proteins are bound to DKC1 RNA:

The DKC1 protein binds to its own RNA.

Diffrential Expression

10,800 differentially expressed genes after Knockdown/Knockout DKC1 protein :

114 RBPs can affect the gene expression of DKC1 :

241 alternative splicing events after Knockdown/Knockout DKC1 protein :

10 RBPs can affect the splicing of DKC1 :

No autoregularoty alternative splicing events between protein DKC1 and its RNA.