TFIP11

General Information

Gene Name : TFIP11
Gene ID : ENSG00000100109.16
Essential Gene : Yes

Functions

Splicing regulation
Spliceosome

Localization(RBPImage: TFIP11)

Nuclei
Nucleoplasm
Mutually Exclusive from Nucleolus
Cytoplasm
Compartment/Organelle
Mitochondria
Unknown Cyto Foci
Cytosolic

Domains (AlphaFold: TFIP11)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

Bethyl Labs: A302-548A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	TFIP11	ENSG00000100109.16	17.26	20.00	18.63	ENCSR000AEF
HepG2	TFIP11	ENSG00000100109.16	15.57	13.10	14.34	ENCSR985KAT
K562	TFIP11	ENSG00000100109.16	16.31	17.88	17.09	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	TFIP11-BGKLV19-K562	ENCSR911DGK	TFIP11	K562	Released		ENCSR661HEL	shRNA	KD% = 50.0,46.2
knockdown followed by RNA-seq	TFIP11-BGHLV17-HepG2	ENCSR573UBF	TFIP11	HepG2	Released		ENCSR856ZRV	shRNA	KD% = 97.1,99.6

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
TFIP11	ENCAB593XBQ	A302-548A	1			Released, ENCODE3	BGHLV17-33, Released, ENCODE3	BGKLV19-55, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
TFIP11	K562	shRNA	ENCSR911DGK	ENCSR661HEL	TFIP11_BGKLV19_55B,TFIP11_BGKLV19_56B	NT_BGKLV19_1B,NT_BGKLV19_2B	50.0,46.2	Released	ENCODE3
TFIP11	HepG2	shRNA			BGHLV16-57,BGHLV16-58	BGHLV16-1,BGHLV16-2		NotSatisfied	ENCODE3
TFIP11	HepG2	shRNA	ENCSR573UBF	ENCSR856ZRV	TFIP11_BGHLV17_33,TFIP11_BGHLV17_34	NT_BGHLV17_63,NT_BGHLV17_64	97.1,99.6	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

TFIP11: Click to RBP Image Database

Nuclei

Nucleoplasm

Mutually Exclusive from Nucleolus

Cytoplasm

Compartment/Organelle

Mitochondria

Unknown Cyto Foci

Cytosolic

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
TFIP11	Product_ID: A302-548A Lot_ID: 1 Source: Bethyl Labs Target Name: TFIP11-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for TFIP11 is not avaliable on ENCORE database.

Proteins bound to RNA

TFIP11 RNA is bound by 3 proteins.

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eCLIP assay for TFIP11 is not avaliable on ENCORE database.

3 proteins are bound to TFIP11 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr22	26908060	26908143	-	5'-UTR,intron-Distal,intron-Proximal	3.56737	6.55026	K562	ZNF622
chr22	26902268	26902365	-	CDS,intron-Distal,intron-Proximal	3.67956	4.82082	K562	ZNF622
chr22	26897876	26897953	-	CDS,intron-Distal,intron-Proximal	4.48236	4.78571	K562	UCHL5
chr22	26902271	26902393	-	CDS,intron-Distal,intron-Proximal	3.35980	3.80299	HepG2	GRWD1
chr22	26906158	26906235	-	CDS,intron-Distal	3.20210	3.07653	K562	ZNF622
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 5 of 5 entries

eCLIP assay for TFIP11 is not avaliable on ENCORE database.

Diffrential Expression

3,177 differentially expressed genes after Knockdown/Knockout TFIP11 protein.

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65 RBPs can affect the levels of TFIP11.

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3,177 differentially expressed genes after Knockdown/Knockout TFIP11 protein :

Only display 100 entries as example. Please click "View All" button to see all 3,177 entries.

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Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
ANLN	ENSG00000011426.6	359.62500	1613.63150	-2.16570	51.79360	48.70430	HepG2	TFIP11
CYP24A1	ENSG00000019186.5	1834.77120	480.64250	1.93250	47.10990	44.19670	HepG2	TFIP11
NCAPD2	ENSG00000010292.8	731.54340	2434.13430	-1.73440	42.04030	39.23990	HepG2	TFIP11
TNFRSF12A	ENSG00000006327.9	1153.91710	341.37200	1.75700	33.21160	30.67320	HepG2	TFIP11
DEPDC1	ENSG00000024526.12	95.07330	391.70080	-2.04260	23.51180	21.28450	HepG2	TFIP11
TMSB10	ENSG00000034510.4	6704.65460	3045.07870	1.13860	23.26360	21.03960	HepG2	TFIP11
BRCA1	ENSG00000012048.15	219.71860	658.21260	-1.58290	21.59720	19.42590	HepG2	TFIP11
TFPI	ENSG00000003436.10	7460.68570	3638.36250	1.03590	20.55160	18.42710	HepG2	TFIP11
TACC3	ENSG00000013810.14	213.24460	764.90400	-1.84280	20.38380	18.26460	HepG2	TFIP11
CHPF2	ENSG00000033100.10	943.91870	374.85490	1.33220	16.74950	14.74940	HepG2	TFIP11
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

65 RBPs can affect the gene expression of TFIP11 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
TFIP11	ENSG00000100109.12	3010.21300	1069.38300	1.49300	42.84430	40.78170	K562	AQR
TFIP11	ENSG00000100109.12	1480.09040	560.92340	1.39970	28.46000	26.05890	K562	PRPF8
TFIP11	ENSG00000100109.12	1028.73420	472.01340	1.12390	25.26810	23.55640	K562	FXR1
TFIP11	ENSG00000100109.12	1187.55270	432.85980	1.45590	20.17870	18.31290	HepG2	SF3A3
TFIP11	ENSG00000100109.12	934.65170	382.08680	1.29040	20.04590	18.30640	HepG2	U2AF1
TFIP11	ENSG00000100109.12	743.21300	422.19510	0.81580	14.83060	13.81340	HepG2	ZNF622
TFIP11	ENSG00000100109.12	724.12130	374.10460	0.95270	14.32900	12.27270	K562	SF3B4
TFIP11	ENSG00000100109.12	806.57090	459.38710	0.81200	12.33270	11.48720	HepG2	SRSF1
TFIP11	ENSG00000100109.12	666.14620	370.62170	0.84580	12.32690	11.20130	HepG2	UTP3
TFIP11	ENSG00000100109.12	804.19340	465.02260	0.79010	10.00660	8.67540	K562	SRSF1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 79 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for TFIP11 is not available on ENCORE database.

5 RBPs can affect the splicing of TFIP11 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	TFIP11	ENSG00000100109.12	chr22	-	26907084	26907161	26906582	26906668	26908064	26908141	0.44800	0.00000	0.00003	included	HepG2	U2AF1
SE	TFIP11	ENSG00000100109.12	chr22	-	26907084	26907283	26906582	26906668	26908064	26908141	0.23000	0.00000	0.00001	included	K562	AQR
SE	TFIP11	ENSG00000100109.12	chr22	-	26906582	26906668	26906029	26906247	26908064	26908141	-0.18800	0.00000	0.00004	excluded	K562	AQR
SE	TFIP11	ENSG00000100109.12	chr22	-	26907084	26907283	26906582	26906668	26908064	26908141	0.39200	0.00000	0.00000	included	K562	HNRNPU
A3SS	TFIP11	ENSG00000100109.12	chr22	-	26897865	26898060	26897865	26898018	26899631	26899871	0.10300	0.00000	0.00000	longer	K562	AQR
A3SS	TFIP11	ENSG00000100109.12	chr22	-	26890104	26890326	26890104	26890270	26890762	26890944	0.11200	0.00000	0.00001	longer	K562	AQR
A3SS	TFIP11	ENSG00000100109.12	chr22	-	26890762	26890944	26890762	26890905	26892038	26892282	0.34600	0.00000	0.00000	longer	K562	AQR
A3SS	TFIP11	ENSG00000100109.12	chr22	-	26902740	26902974	26902740	26902894	26906029	26906247	0.09000	0.00000	0.00005	longer	K562	AQR
SE	TFIP11	ENSG00000100109.12	chr22	-	26907084	26907161	26906582	26906668	26908064	26908141	0.40800	0.00001	0.00015	included	HepG2	U2AF2
SE	TFIP11	ENSG00000100109.12	chr22	-	26907084	26907161	26906582	26906668	26908064	26908141	0.52700	0.00001	0.00026	included	K562	U2AF1

Showing 1 to 10 of 14 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

TFIP11

General Information

Functions

Localization(RBPImage: TFIP11)

Domains (AlphaFold: TFIP11)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for TFIP11 is not avaliable on ENCORE database.

3 proteins are bound to TFIP11 RNA:

eCLIP assay for TFIP11 is not avaliable on ENCORE database.

Diffrential Expression

3,177 differentially expressed genes after Knockdown/Knockout TFIP11 protein :

65 RBPs can affect the gene expression of TFIP11 :

The Knockdown/knockout RNA-Seq assay for TFIP11 is not available on ENCORE database.

5 RBPs can affect the splicing of TFIP11 :

The Knockdown/knockout RNA-Seq assay for TFIP11 is not avaliable on ENCORE database.