CHEK2

General Information

Gene Name : CHEK2
Gene ID : ENSG00000183765.21
Essential Gene : No

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: CHEK2)

Not Available

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	CHEK2	ENSG00000183765.21	23.29	18.85	21.07	ENCSR000AEF
HepG2	CHEK2	ENSG00000183765.21	33.06	41.89	37.48	ENCSR985KAT
K562	CHEK2	ENSG00000183765.21	40.83	45.03	42.93	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for CHEK2 is not avaliable on ENCORE database.

Proteins bound to RNA

CHEK2 RNA is bound by 12 proteins.

CanvasJS.com

eCLIP assay for CHEK2 is not avaliable on ENCORE database.

12 proteins are bound to CHEK2 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr22	29137687	29137757	-	intron-Distal	5.10844	21.33558	K562	AQR
chr22	29130660	29130749	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.73482	19.75513	K562	AQR
chr22	29121006	29121112	-	3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal	5.60124	15.02761	K562	PUM2
chr22	29133822	29133865	-	intron-Distal,intron-Proximal	4.42642	10.93035	K562	AQR
chr22	29133865	29133873	-	intron-Distal,intron-Proximal	4.76014	9.85896	K562	AQR
chr22	29130458	29130702	-	5'-UTR,CDS,intron-Distal	3.11910	7.47194	HepG2	GRWD1
chr22	29130504	29130587	-	5'-UTR,CDS,intron-Distal	3.18754	7.37965	K562	YBX3
chr22	29120963	29121115	-	3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal	3.85836	6.39464	HepG2	BCLAF1
chr22	29130647	29130716	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.13069	6.02664	K562	DDX3X
chr22	29089991	29090054	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.74025	5.93840	HepG2	PRPF8
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 23 entries

eCLIP assay for CHEK2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for CHEK2 is not available on ENCORE database.
147 RBPs can affect the levels of CHEK2.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for CHEK2 is not available on ENCORE database.

147 RBPs can affect the gene expression of CHEK2 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
CHEK2	ENSG00000183765.16	138.16320	506.15260	-1.87320	40.71020	39.25080	HepG2	ZNF622
CHEK2	ENSG00000183765.16	396.93100	1033.88400	-1.38110	37.65890	35.91090	HepG2	ETF1
CHEK2	ENSG00000183765.16	405.56110	976.00150	-1.26700	33.38430	32.14710	HepG2	SRFBP1
CHEK2	ENSG00000183765.16	343.75140	886.12160	-1.36610	25.21360	23.65710	HepG2	PUF60
CHEK2	ENSG00000183765.16	405.52670	874.90950	-1.10930	23.71980	22.14430	HepG2	SRSF5
CHEK2	ENSG00000183765.16	410.83300	870.62130	-1.08350	21.78110	20.32660	HepG2	CELF1
CHEK2	ENSG00000183765.16	398.51320	864.13290	-1.11660	21.29230	20.12760	HepG2	RBM22
CHEK2	ENSG00000183765.16	261.71690	579.61340	-1.14710	21.01290	19.56060	HepG2	CKAP4
CHEK2	ENSG00000183765.16	326.72130	788.48930	-1.27100	20.55130	19.00120	K562	HNRNPC
CHEK2	ENSG00000183765.16	522.86680	940.65170	-0.84720	18.81930	17.55260	HepG2	PUM1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 181 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for CHEK2 is not available on ENCORE database.

38 RBPs can affect the splicing of CHEK2 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	CHEK2	ENSG00000183765.16	chr22	-	29092888	29092975	29091697	29091861	29095825	29095925	0.19800	0.00001	included	K562	SRSF1
SE	CHEK2	ENSG00000183765.16	chr22	-	29130390	29130715	29121230	29121355	29137756	29137771	-0.28500	0.00000	excluded	K562	SRSF1
SE	CHEK2	ENSG00000183765.16	chr22	-	29099492	29099554	29095825	29095925	29105993	29106047	-0.21700	0.00002	excluded	K562	SF3B4
SE	CHEK2	ENSG00000183765.16	chr22	-	29092888	29092975	29091697	29091861	29095825	29095925	-0.47100	0.00000	excluded	HepG2	U2AF1
SE	CHEK2	ENSG00000183765.16	chr22	-	29099492	29099554	29095825	29095925	29105993	29106047	-0.47900	0.00000	excluded	HepG2	U2AF1
SE	CHEK2	ENSG00000183765.16	chr22	-	29092888	29092975	29091697	29091861	29095825	29095925	-0.53300	0.00002	excluded	HepG2	U2AF2
SE	CHEK2	ENSG00000183765.16	chr22	-	29099492	29099554	29095825	29095925	29105993	29106047	-0.55900	0.00000	excluded	HepG2	U2AF2
SE	CHEK2	ENSG00000183765.16	chr22	-	29099492	29099554	29095825	29095925	29105993	29106047	-0.15600	0.00000	excluded	K562	AQR
SE	CHEK2	ENSG00000183765.16	chr22	-	29120964	29121112	29107896	29108005	29121230	29121355	-0.19600	0.00000	excluded	K562	AQR
SE	CHEK2	ENSG00000183765.16	chr22	-	29099492	29099554	29095825	29095925	29105993	29106047	-0.42700	0.00044	excluded	HepG2	BCLAF1

Showing 1 to 10 of 77 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

CHEK2

General Information

Functions

Localization

Domains (AlphaFold: CHEK2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for CHEK2 is not avaliable on ENCORE database.

12 proteins are bound to CHEK2 RNA:

eCLIP assay for CHEK2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for CHEK2 is not available on ENCORE database.

147 RBPs can affect the gene expression of CHEK2 :

The Knockdown/knockout RNA-Seq assay for CHEK2 is not available on ENCORE database.

38 RBPs can affect the splicing of CHEK2 :

The Knockdown/knockout RNA-Seq assay for CHEK2 is not avaliable on ENCORE database.