WBP11

General Information

Gene Name       : WBP11
Gene ID             : ENSG00000084463.7
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: WBP11)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878WBP11ENSG00000084463.751.1041.0246.06ENCSR000AEF
HepG2WBP11ENSG00000084463.729.9337.3533.64ENCSR985KAT
K562WBP11ENSG00000084463.735.4738.2436.86ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
knockdown followed by RNA-seq WBP11-BGKcLV23-K562ENCSR070AYAWBP11K562ReleasedENCSR877JEM   CRISPRKD% = 57.1,53.1
knockdown followed by RNA-seq WBP11-BGHcLV22-HepG2ENCSR484QEXWBP11HepG2ReleasedENCSR704VPL   CRISPRKD% = 56.1,64.4






  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
WBP11ENCAB949LDWA304-855A1BGHcLV22-63, Released, ENCODE4BGKcLV23-65, Released, ENCODE4


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
WBP11K562CRISPRBGKcLV21-51,BGKcLV21-52BGKcLV21-1,BGKcLV21-229.6,24.5NotSatisfiedENCODE4
WBP11K562CRISPRENCSR070AYAENCSR877JEMWBP11-BGKcLV23-65,WBP11-BGKcLV23-66NT-BGKcLV23-1,NT-BGKcLV23-257.1,53.1ReleasedENCODE4
WBP11HepG2CRISPRBGHcLV22-61,BGHcLV22-62BGHcLV22-1,BGHcLV22-2NotSatisfiedENCODE4
WBP11HepG2CRISPRENCSR484QEXENCSR704VPLWBP11-BGHcLV22-63,WBP11-BGHcLV22-64NT-BGHcLV22-1,NT-BGHcLV22-256.1,64.4ReleasedENCODE4


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
WBP11Product_ID: A304-855A
Lot_ID: 1
Source: Bethyl Labs
Target Name: WBP11-human		 WBP11-HEPG2-CRISPR-A304-855A.png<br>Caption: Western blot following CRISPR against WBP11 in HepG2 whole cell lysate using WBP11 specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against WBP11. WBP11 protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.
 WBP11-K562-CRISPR-A304-855A.png<br>Caption: Western blot following CRISPR against WBP11 in K562 whole cell lysate using WBP11 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against WBP11. WBP11 protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for WBP11 is not avaliable on ENCORE database.



Proteins bound to RNA
  • WBP11 RNA is bound by 15 proteins.  







eCLIP assay for WBP11 is not avaliable on ENCORE database.





15 proteins are bound to WBP11 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr121494406814944119-3'-UTR,CDS,intron-Distal,intron-Proximal3.253895.28960K562AQR
chr121495427314954349-3'-UTR,5'-UTR,CDS,intron-Distal3.796374.71502HepG2GRWD1
chr121493948014939552-3'-UTR,intron-Distal3.918385.51877K562PUM2
chr121494411014944199-3'-UTR,CDS,intron-Distal3.243378.19608K562ZNF800
chr121494365714943679-3'-UTR,CDS,intron-Distal3.400533.73423K562UCHL5
chr121494974314949751-CDS,intron-Distal3.241323.12941K562UCHL5
chr121494339914943457-CDS,intron-Distal4.477525.82083HepG2GRWD1
chr121494791414947987-CDS,intron-Distal3.851556.15459HepG2GRWD1
chr121494748614947549-CDS,intron-Distal4.190616.65960HepG2BCLAF1
chr121494748414947539-CDS,intron-Distal3.107183.99689HepG2GRWD1
chr121494666614946754-CDS,intron-Distal4.9755313.00315K562ZNF622
chr121494974014949813-CDS,intron-Distal,intron-Proximal3.147216.33024HepG2BCLAF1
chr121494759114947648-CDS,intron-Distal3.810297.89598HepG2GRWD1
chr121494195814942020-CDS,intron-Distal4.048893.15006K562RBM15
chr121494194314942004-CDS,intron-Distal3.310803.85853K562IGF2BP2
chr121494753914947591-CDS,intron-Distal3.914168.07380HepG2GRWD1
chr121495358914953743-CDS,intron-Distal,intron-Proximal3.073449.01163K562AQR
chr121494801914948036-CDS,intron-Distal3.294783.73423K562UCHL5
chr121495258214952646-CDS,intron-Distal,intron-Proximal3.545145.76104HepG2BCLAF1
chr121494801514948039-CDS,intron-Distal,intron-Proximal4.203684.23351K562BUD13
chr121495261714952662-CDS,intron-Distal3.932716.33304K562BUD13
chr121494748914947552-CDS,intron-Distal4.138814.25199K562GRWD1
chr121495257114952656-CDS,intron-Distal,intron-Proximal3.021063.53928K562ZNF800
chr121495257314952634-CDS,intron-Distal,intron-Proximal3.654203.67894HepG2AQR
chr121494748914947545-CDS,intron-Distal3.801978.61219K562UCHL5
chr121494667414946723-CDS,intron-Distal4.924595.70640HepG2BCLAF1
chr121494756814947646-CDS,intron-Distal3.137507.63960K562UCHL5
chr121494192314942017-CDS,intron-Distal3.975518.12409K562PCBP1
chr121494033014940384-CDS,intron-Distal4.310804.29122K562IGF2BP2
chr121494976714949925-CDS,intron-Distal3.4322510.09563K562PUM1
chr121494642714946511-intron-Distal3.191833.90146K562KHSRP
chr121495574914955850-intron-Distal4.313804.10688K562KHSRP
chr121495607314956162-intron-Distal3.515954.35635K562PRPF8
chr121495360714953652-intron-Distal,intron-Proximal3.884433.02181K562PRPF8
chr121495617314956260-intron-Distal3.752594.71867K562TIA1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for WBP11 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for WBP11 is not available on ENCORE database.

  • 106 RBPs can affect the levels of WBP11.  








The Knockdown/knockout RNA-Seq assay for WBP11 is not available on ENCORE database.





106 RBPs can affect the gene expression of WBP11 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
WBP11ENSG00000084463.31529.159901843.20160-0.269503.604902.92740HepG2ACO1
WBP11ENSG00000084463.31614.453902047.55540-0.342902.111801.64030HepG2AKAP1
WBP11ENSG00000084463.31453.757401851.85950-0.349205.023104.01460HepG2AKAP8L
WBP11ENSG00000084463.31130.995301694.14420-0.583005.819404.70380HepG2ASCC1
WBP11ENSG00000084463.31668.900502814.22490-0.7538023.7837022.13670HepG2AUH
WBP11ENSG00000084463.3918.656401505.71520-0.712907.920306.49610HepG2BCLAF1
WBP11ENSG00000084463.31513.322103259.30670-1.1068026.4854024.94750HepG2BOP1
WBP11ENSG00000084463.31851.067302881.78610-0.6386012.2823010.84930HepG2CALR
WBP11ENSG00000084463.32677.103403675.70860-0.457303.289802.21970HepG2CCAR1
WBP11ENSG00000084463.31295.817401842.79860-0.5080011.7579010.57990HepG2CKAP4
WBP11ENSG00000084463.31426.211902992.19370-1.0690022.2174020.50710HepG2CPSF6
WBP11ENSG00000084463.32210.001602834.23470-0.358903.528302.28380HepG2CPSF7
WBP11ENSG00000084463.3706.044501070.31000-0.600206.403204.86800HepG2CSTF2
WBP11ENSG00000084463.31860.768402495.13610-0.423207.084606.14540HepG2CELF1
WBP11ENSG00000084463.31194.488801586.36660-0.409303.942603.14670HepG2DDX21
WBP11ENSG00000084463.31270.887801551.84840-0.288202.483301.62100HepG2DDX24
WBP11ENSG00000084463.31041.555401961.32590-0.9131012.9597011.69890HepG2DDX3X
WBP11ENSG00000084463.3882.871501703.89910-0.9486012.4809010.98460HepG2DDX55
WBP11ENSG00000084463.32280.585903038.96070-0.414204.083502.86370HepG2DDX5
WBP11ENSG00000084463.31301.084701685.00150-0.373002.429701.84710HepG2DDX6
WBP11ENSG00000084463.31321.272501605.46610-0.281101.930001.33120HepG2DNAJC21
WBP11ENSG00000084463.31022.250801619.65220-0.663907.175706.25350HepG2EIF2S1
WBP11ENSG00000084463.31053.433601610.84470-0.612705.575504.32350HepG2EIF3D
WBP11ENSG00000084463.31147.874001789.81870-0.640806.079105.13510HepG2EIF4A3
WBP11ENSG00000084463.32022.208702646.81140-0.388306.703705.50310HepG2EIF4G1
WBP11ENSG00000084463.31332.001502535.45340-0.9286016.9575015.07100HepG2EIF4G2
WBP11ENSG00000084463.32247.765703231.14260-0.5236012.7773011.64200HepG2ETF1
WBP11ENSG00000084463.31002.048601801.13520-0.8460015.7664013.87100HepG2EWSR1
WBP11ENSG00000084463.31107.300101418.18700-0.357002.697701.44630HepG2FKBP4
WBP11ENSG00000084463.31502.644702997.37940-0.996205.522504.09390HepG2FTO
WBP11ENSG00000084463.31259.143401675.29870-0.412003.007302.31470HepG2G3BP1
WBP11ENSG00000084463.31119.076203391.80970-1.5997038.2436036.18300HepG2GPKOW
WBP11ENSG00000084463.31476.451702465.58350-0.7398020.3376018.27270HepG2HNRNPA2B1
WBP11ENSG00000084463.32051.274202647.27640-0.368006.556705.51660HepG2HNRNPF
WBP11ENSG00000084463.32081.872102443.72480-0.231203.328202.59420HepG2HNRNPL
WBP11ENSG00000084463.32093.150303236.87330-0.628908.222007.19920HepG2HNRNPLL
WBP11ENSG00000084463.31969.101102606.80130-0.404705.386604.40930HepG2IGF2BP1
WBP11ENSG00000084463.31080.480601702.85510-0.656307.247406.20640HepG2IGF2BP2
WBP11ENSG00000084463.31594.967801829.45500-0.197902.554501.84770HepG2ILF2
WBP11ENSG00000084463.32710.545803882.81180-0.518504.240603.20700HepG2LARP4
WBP11ENSG00000084463.31948.233102812.63630-0.529807.338706.08010HepG2MSI2
WBP11ENSG00000084463.32519.619903301.35400-0.389902.159201.31230HepG2MTPAP
WBP11ENSG00000084463.31143.523001859.57860-0.701507.795806.75840HepG2NCBP2
WBP11ENSG00000084463.31961.817302870.16170-0.548907.017405.86200HepG2NSUN2
WBP11ENSG00000084463.31127.683701655.91530-0.554305.191804.21540HepG2PABPC4
WBP11ENSG00000084463.3893.436301314.18050-0.556705.225804.15120HepG2PRPF8
WBP11ENSG00000084463.31454.331901751.22950-0.268002.920002.36090HepG2PTBP1
WBP11ENSG00000084463.31812.558902539.43920-0.486506.140405.29900HepG2PUF60
WBP11ENSG00000084463.32252.776702695.77400-0.259004.334103.62770HepG2PUM1
WBP11ENSG00000084463.31405.161002693.77560-0.9389024.5299022.65320HepG2PUM2
WBP11ENSG00000084463.31273.192001877.42000-0.5603013.0263011.85960HepG2PUS1
WBP11ENSG00000084463.3837.800201891.57270-1.1749010.557709.24730HepG2RAVER1
WBP11ENSG00000084463.32634.823903491.18010-0.406005.930104.73400HepG2RBM15
WBP11ENSG00000084463.31710.826502700.62980-0.6586015.2475014.23100HepG2RBM22
WBP11ENSG00000084463.31192.665301721.26640-0.529306.726505.71600HepG2RBM25
WBP11ENSG00000084463.32014.711702851.91910-0.501406.581505.59150HepG2RPLP0
WBP11ENSG00000084463.31135.589501858.48190-0.710705.313504.02860HepG2RPS10
WBP11ENSG00000084463.31304.184501567.46510-0.265302.098001.55590HepG2RPS19
WBP11ENSG00000084463.31290.158601807.20130-0.486204.822503.78420HepG2RPS2
WBP11ENSG00000084463.34374.645002860.875600.612605.010204.08390HepG2SF3A3
WBP11ENSG00000084463.32166.137103203.82180-0.564707.661806.53860HepG2SF3B1
WBP11ENSG00000084463.31569.651101823.18850-0.216002.132301.60320HepG2SF3B4
WBP11ENSG00000084463.31842.176702435.02320-0.402508.587207.45800HepG2SLBP
WBP11ENSG00000084463.31334.293301929.80720-0.532403.718202.59480HepG2SMNDC1
WBP11ENSG00000084463.32547.949103564.82910-0.484502.994102.18020HepG2SNRNP70
WBP11ENSG00000084463.31962.007703050.24880-0.6366020.5903019.55410HepG2SRFBP1
WBP11ENSG00000084463.32994.967001903.041600.6541020.1370019.10810HepG2SRSF1
WBP11ENSG00000084463.31913.367302507.38290-0.390106.786705.86500HepG2SRSF5
WBP11ENSG00000084463.31937.056402600.89710-0.425108.478407.37520HepG2SRSF7
WBP11ENSG00000084463.31252.118001548.24940-0.306303.935303.30080HepG2SRSF9
WBP11ENSG00000084463.32168.685602648.31500-0.288304.495403.87350HepG2SSB
WBP11ENSG00000084463.31742.508302346.66470-0.429404.801103.57930HepG2SUPT6H
WBP11ENSG00000084463.3937.183001696.13570-0.8558010.658209.47280HepG2SUPV3L1
WBP11ENSG00000084463.31699.996003155.14820-0.8922016.9983015.46430HepG2TARDBP
WBP11ENSG00000084463.3692.466901136.81790-0.715207.365005.87840HepG2TFIP11
WBP11ENSG00000084463.31360.490601740.14020-0.355103.778603.21390HepG2TIAL1
WBP11ENSG00000084463.31942.576002481.00160-0.353003.694602.67000HepG2TUFM
WBP11ENSG00000084463.31873.149302626.15190-0.487504.273603.22120HepG2UBE2L3
WBP11ENSG00000084463.3677.330201001.91200-0.564805.120004.07910HepG2UCHL5
WBP11ENSG00000084463.31536.847102537.15620-0.7232023.1674021.53720HepG2UPF1
WBP11ENSG00000084463.3879.050201552.95750-0.821007.707105.97960HepG2UPF2
WBP11ENSG00000084463.32088.436502607.86450-0.320404.672103.34900HepG2UTP18
WBP11ENSG00000084463.33044.339602449.529300.313505.539004.73990HepG2UTP3
WBP11ENSG00000084463.31364.805901669.66170-0.290902.030401.40120HepG2XRN2
WBP11ENSG00000084463.32418.205502698.85020-0.158401.931201.35480HepG2ZC3H8
WBP11ENSG00000084463.32048.750602790.39040-0.4457012.2881011.34160HepG2ZNF622
WBP11ENSG00000084463.34504.965603057.463800.5591016.4743015.21170K562AGGF1
WBP11ENSG00000084463.33852.529903181.399800.276002.351201.74740K562AKAP8L
WBP11ENSG00000084463.35214.862303317.259500.6525010.596009.55840K562AQR
WBP11ENSG00000084463.31682.171302015.73320-0.261003.491702.40800K562BCLAF1
WBP11ENSG00000084463.32320.732603555.90300-0.615608.256406.71240K562BOP1
WBP11ENSG00000084463.32764.949703780.99490-0.451506.601105.38450K562CPSF6
WBP11ENSG00000084463.31109.708201529.23440-0.462606.099804.44750K562CSTF2
WBP11ENSG00000084463.34101.993503423.601700.260703.369002.38990K562DKC1
WBP11ENSG00000084463.32563.041903011.16160-0.232502.659801.95180K562EIF2S2
WBP11ENSG00000084463.31986.356101644.223400.272602.113801.39210K562EIF4A3
WBP11ENSG00000084463.32835.004803846.97640-0.440404.928603.77860K562FMR1
WBP11ENSG00000084463.32287.002503260.61770-0.511705.304103.99500K562FTO
WBP11ENSG00000084463.32428.097401709.927700.505809.815308.75760K562FXR1
WBP11ENSG00000084463.31941.136003609.95930-0.8951019.5070017.29050K562GPKOW
WBP11ENSG00000084463.32939.708604012.69940-0.448906.266505.12360K562GRSF1
WBP11ENSG00000084463.34162.784805364.72670-0.366003.806702.87790K562HSPD1
WBP11ENSG00000084463.34209.764403376.365200.318203.262402.35920K562KIF1C
WBP11ENSG00000084463.31987.701903082.35090-0.632905.716904.31640K562KRR1
WBP11ENSG00000084463.32836.210302267.991700.322403.061001.58770K562LARP7
WBP11ENSG00000084463.35266.622103782.367200.477507.078805.49770K562MBNL1
WBP11ENSG00000084463.32743.179703523.70640-0.361203.870302.82290K562METAP2
WBP11ENSG00000084463.32480.969003490.33160-0.4925010.064108.62570K562MTPAP
WBP11ENSG00000084463.33871.567802651.156300.546204.487103.27840K562NAA15
WBP11ENSG00000084463.33337.779903878.32620-0.216502.646401.91370K562NSUN2
WBP11ENSG00000084463.32335.045401863.309200.325502.923701.91920K562PCBP2
WBP11ENSG00000084463.33605.413604491.47190-0.317002.827901.99710K562PPIG
WBP11ENSG00000084463.32833.625301748.709300.6963010.219308.77250K562PRPF8
WBP11ENSG00000084463.34307.897705274.69970-0.292104.095902.92020K562PUM2
WBP11ENSG00000084463.35200.241003155.290000.7207012.2940011.19680K562PUS1
WBP11ENSG00000084463.34567.325903074.177100.571009.070908.02090K562RBM15
WBP11ENSG00000084463.33310.512002667.811700.311302.533501.49960K562SAFB
WBP11ENSG00000084463.32016.639001627.101300.309503.098902.19140K562SF3B4
WBP11ENSG00000084463.34826.673402573.702400.907104.677502.95140K562SNRNP200
WBP11ENSG00000084463.32232.691401816.448200.297602.484201.52400K562SRFBP1
WBP11ENSG00000084463.32726.503501994.803600.450706.051805.01470K562SRSF1
WBP11ENSG00000084463.33976.116603003.044100.404802.189001.45810K562SYNCRIP
WBP11ENSG00000084463.32658.785502146.011300.309002.771501.82490K562TRIM56
WBP11ENSG00000084463.32906.313804112.25140-0.500707.652306.53130K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for WBP11 is not available on ENCORE database.





1 RBPs can affect the splicing of WBP11 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEWBP11ENSG00000084463.3chr12-149479041494809314947463149476701494974014949937-0.080000.000010.00015excludedK562AQR
SEWBP11ENSG00000084463.3chr12-149536851495374914952490149526621495425314954451-0.061000.000000.00007excludedK562AQR
A3SSWBP11ENSG00000084463.3chr12-1495425314954437149542531495436214956285149564740.072000.000000.00000longerK562AQR
A3SSWBP11ENSG00000084463.3chr12-1495368514953749149536851495371714954253149543980.200000.000000.00000longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for WBP11 is not avaliable on ENCORE database.