PSMC6

General Information

Gene Name       : PSMC6
Gene ID             : ENSG00000100519.11
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: PSMC6)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PSMC6ENSG00000100519.11153.72110.22131.97ENCSR000AEF
HepG2PSMC6ENSG00000100519.1185.18183.04134.11ENCSR985KAT
K562PSMC6ENSG00000100519.11129.90140.28135.09ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PSMC6 is not avaliable on ENCORE database.



Proteins bound to RNA
  • PSMC6 RNA is bound by 17 proteins.  







eCLIP assay for PSMC6 is not avaliable on ENCORE database.





17 proteins are bound to PSMC6 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr145317515853175286+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.441499.57774K562EFTUD2
chr145317503153175108+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.039236.45067HepG2BCLAF1
chr145319068453190752+3'-UTR,CDS3.869845.73400HepG2PPIG
chr145317504353175108+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.251646.35635K562UCHL5
chr145317515853175240+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.381288.25232K562BUD13
chr145319439653194489+3'-UTR3.335203.96074HepG2ZC3H11A
chr145317515753175275+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.685689.76099HepG2EFTUD2
chr145317515353175246+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.8357411.78238HepG2BUD13
chr145317515253175253+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal5.194988.52172K562GPKOW
chr145317812453178150+3'-UTR,5'-UTR,CDS,intron-Proximal3.930564.93978HepG2BCLAF1
chr145319434353194399+3'-UTR3.758045.51777K562CPSF6
chr145319452153194594+3'-UTR3.840995.31144HepG2SUB1
chr145319434853194398+3'-UTR4.004725.98925HepG2FUBP3
chr145319433753194399+3'-UTR3.023176.02682HepG2KHSRP
chr145319454353194600+3'-UTR4.3980610.00297K562PUM2
chr145317519753175238+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.448844.59873K562UCHL5
chr145317780053177873+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.7508210.73647HepG2AQR
chr145318492553185009+3'-UTR,CDS,intron-Proximal3.160114.06762HepG2U2AF2
chr145319068853190762+3'-UTR,CDS,intron-Proximal4.647929.30195HepG2BCLAF1
chr145317517853175230+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.7381314.82700K562SF3B4
chr145319439853194453+3'-UTR4.258803.35973HepG2FUBP3
chr145318480253184886+3'-UTR,CDS,intron-Proximal4.4159216.82955HepG2PRPF8
chr145319434353194396+3'-UTR6.3942340.32981K562PUM2
chr145317548053175538+5'-UTR,CDS,intron-Distal,intron-Proximal4.120699.37631HepG2BCLAF1
chr145318782653187910+CDS,intron-Distal,intron-Proximal3.377105.63425HepG2BCLAF1
chr145318569553185757+CDS,intron-Distal,intron-Proximal3.938445.79432HepG2BCLAF1
chr145318568153185742+CDS,intron-Distal,intron-Proximal3.872203.28461K562BUD13
chr145318759853187700+CDS,intron-Distal,intron-Proximal3.824693.11282HepG2G3BP1
chr145319025853190397+intron-Distal3.896566.59336K562KHSRP
chr145317445553174510+intron-Distal3.666843.02234K562KHSRP
chr145317515453175178+intron-Distal,intron-Proximal5.019435.58150K562SF3B4
chr145317645353176514+intron-Distal4.496607.53589K562AQR
chr145317646753176532+intron-Distal3.919625.25185K562PRPF8
chr145319014153190249+intron-Distal4.650475.62025K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PSMC6 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PSMC6 is not available on ENCORE database.

  • 89 RBPs can affect the levels of PSMC6.  








The Knockdown/knockout RNA-Seq assay for PSMC6 is not available on ENCORE database.





89 RBPs can affect the gene expression of PSMC6 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PSMC6ENSG00000100519.71773.618902231.21910-0.331102.923702.31050HepG2BOP1
PSMC6ENSG00000100519.72894.239902347.749000.301803.198002.37450HepG2CALR
PSMC6ENSG00000100519.73020.416902305.216100.389703.504402.64060HepG2CIRBP
PSMC6ENSG00000100519.71463.952801963.06800-0.423208.821107.76330HepG2CKAP4
PSMC6ENSG00000100519.71653.198802048.32700-0.309202.449001.79620HepG2CPSF6
PSMC6ENSG00000100519.72768.047703173.00720-0.197002.992302.22550HepG2DAZAP1
PSMC6ENSG00000100519.71524.169001815.98530-0.252703.373202.46300HepG2DDX19B
PSMC6ENSG00000100519.71436.295901812.78770-0.335904.185803.33610HepG2DNAJC21
PSMC6ENSG00000100519.71243.998801796.77830-0.5304012.7795011.48630HepG2DNAJC2
PSMC6ENSG00000100519.71618.546902319.86620-0.519303.519502.85500HepG2EIF2S1
PSMC6ENSG00000100519.71818.820502563.98000-0.495403.235302.54530HepG2EIF4A3
PSMC6ENSG00000100519.7964.592401190.07170-0.303102.461501.36020HepG2FAM120A
PSMC6ENSG00000100519.71653.892602399.46390-0.536803.827103.04940HepG2G3BP1
PSMC6ENSG00000100519.71854.315702321.79120-0.324402.193501.62010HepG2GPKOW
PSMC6ENSG00000100519.71454.734801830.15460-0.331203.036202.36200HepG2HNRNPA1
PSMC6ENSG00000100519.71522.537802035.70810-0.419104.279503.43130HepG2HNRNPC
PSMC6ENSG00000100519.71725.254902366.34480-0.455907.972106.83110HepG2HNRNPF
PSMC6ENSG00000100519.72523.166702890.41880-0.196003.081602.37290HepG2HNRNPL
PSMC6ENSG00000100519.71770.849302022.24920-0.191501.997501.47250HepG2HNRNPU
PSMC6ENSG00000100519.71669.996702330.19120-0.480606.527105.45790HepG2IGF2BP1
PSMC6ENSG00000100519.71778.345502439.14710-0.455802.852602.16850HepG2IGF2BP2
PSMC6ENSG00000100519.71364.624802065.66080-0.5981018.5432016.83410HepG2ILF2
PSMC6ENSG00000100519.71326.757101791.01350-0.432902.901801.67590HepG2KHDRBS1
PSMC6ENSG00000100519.71409.277301794.90170-0.348906.098004.61080HepG2KIF1C
PSMC6ENSG00000100519.72067.673702663.06720-0.365102.183201.61860HepG2NCBP2
PSMC6ENSG00000100519.72359.405003146.33820-0.415306.497105.33320HepG2NOL12
PSMC6ENSG00000100519.71353.157601803.68480-0.414605.852204.81130HepG2PPIL4
PSMC6ENSG00000100519.72255.989203003.40750-0.412803.258602.61870HepG2PUF60
PSMC6ENSG00000100519.72336.158203188.19370-0.4486013.4626012.36180HepG2PUM1
PSMC6ENSG00000100519.71655.474002000.01040-0.272803.813803.11410HepG2PUS1
PSMC6ENSG00000100519.72456.356001794.427900.452902.158801.53030HepG2RAVER1
PSMC6ENSG00000100519.7925.167201300.01060-0.490703.663701.64890HepG2RBM14
PSMC6ENSG00000100519.71921.197002926.00330-0.6069013.6796012.70200HepG2RBM22
PSMC6ENSG00000100519.72094.035902700.75350-0.367106.135205.38330HepG2NELFE
PSMC6ENSG00000100519.72153.661102515.46150-0.224002.642202.03810HepG2RECQL
PSMC6ENSG00000100519.71187.224401800.90270-0.6011014.6736013.36580HepG2SAFB2
PSMC6ENSG00000100519.73419.992302380.982100.522304.053803.23000HepG2SF3A3
PSMC6ENSG00000100519.72153.673602879.68460-0.4191010.558309.33020HepG2SLBP
PSMC6ENSG00000100519.71520.678802679.98940-0.817502.577501.32940HepG2SNRNP200
PSMC6ENSG00000100519.71750.861302440.19580-0.478902.826102.03710HepG2SNRNP70
PSMC6ENSG00000100519.74260.160103304.794300.366208.568007.81960HepG2SRFBP1
PSMC6ENSG00000100519.73605.594602637.178300.4511011.0811010.27210HepG2SRSF1
PSMC6ENSG00000100519.72365.443202965.36030-0.326105.622304.77620HepG2SRSF5
PSMC6ENSG00000100519.71829.752602324.79650-0.345505.074804.17710HepG2SRSF7
PSMC6ENSG00000100519.72834.034703372.48900-0.251004.479703.72400HepG2SUCLG1
PSMC6ENSG00000100519.71302.576102160.05190-0.7297010.798709.50740HepG2TARDBP
PSMC6ENSG00000100519.71699.149702178.05880-0.358203.017402.14950HepG2TIA1
PSMC6ENSG00000100519.71678.452901964.99520-0.227401.894801.46380HepG2TIAL1
PSMC6ENSG00000100519.71255.684901982.55850-0.6589016.8790015.64510HepG2TRIM56
PSMC6ENSG00000100519.72176.653502934.11050-0.430805.709304.39620HepG2TUFM
PSMC6ENSG00000100519.71483.572103119.37250-1.072203.693402.54730HepG2U2AF2
PSMC6ENSG00000100519.72461.242403105.64960-0.335502.482501.69310HepG2UBE2L3
PSMC6ENSG00000100519.71810.559802111.55980-0.221902.718702.02470HepG2UPF1
PSMC6ENSG00000100519.72571.510602038.639200.334905.454104.66050HepG2UTP3
PSMC6ENSG00000100519.72050.767801669.831600.296404.708503.87120HepG2ZC3H8
PSMC6ENSG00000100519.75478.190702322.321901.23800106.41350104.36020HepG2ZNF622
PSMC6ENSG00000100519.73163.747702399.709800.398708.262207.35430K562AGGF1
PSMC6ENSG00000100519.73185.054202636.993700.272302.399801.49400K562AKAP8
PSMC6ENSG00000100519.73301.265402497.025400.402704.634403.78240K562AKAP8L
PSMC6ENSG00000100519.72560.240304245.28400-0.7296012.3638011.25090K562AQR
PSMC6ENSG00000100519.71993.945902526.40560-0.341505.599404.21890K562BCLAF1
PSMC6ENSG00000100519.71815.111702326.26190-0.358002.948302.04790K562BOP1
PSMC6ENSG00000100519.72401.599403074.40340-0.356302.734901.32890K562BUD13
PSMC6ENSG00000100519.72826.063804020.72980-0.508702.603501.57970K562CNOT7
PSMC6ENSG00000100519.73086.856303757.28270-0.283603.814202.50710K562CPEB4
PSMC6ENSG00000100519.71807.602802473.47260-0.452505.915404.77330K562CPSF6
PSMC6ENSG00000100519.71550.961501916.65490-0.305403.423502.22900K562CSTF2
PSMC6ENSG00000100519.73316.932302686.862000.303804.435303.28930K562DKC1
PSMC6ENSG00000100519.71541.124301880.07270-0.286803.537602.15220K562EIF2S1
PSMC6ENSG00000100519.72173.345803076.95470-0.501608.030606.90200K562EIF2S2
PSMC6ENSG00000100519.71451.149601788.26100-0.301402.452301.67910K562EIF4A3
PSMC6ENSG00000100519.74114.763404761.94380-0.210702.262001.40890K562EIF4G2
PSMC6ENSG00000100519.71588.888702020.52270-0.346703.477502.03560K562EXOSC5
PSMC6ENSG00000100519.71691.904202516.72140-0.572906.951905.57100K562FMR1
PSMC6ENSG00000100519.71600.878902133.15790-0.414103.337202.32610K562FTO
PSMC6ENSG00000100519.72394.381401859.712300.364505.388504.58280K562FXR1
PSMC6ENSG00000100519.73067.941602251.043800.446602.961102.22740K562G3BP2
PSMC6ENSG00000100519.71805.265502361.54860-0.387503.952203.00810K562GPKOW
PSMC6ENSG00000100519.71342.739702185.51320-0.702802.859502.25410K562HNRNPC
PSMC6ENSG00000100519.73388.237002581.518400.392202.736401.51160K562HNRNPK
PSMC6ENSG00000100519.74221.685702609.684000.693804.624403.39280K562HNRNPM
PSMC6ENSG00000100519.73797.333702649.903100.518907.506505.98270K562KIF1C
PSMC6ENSG00000100519.7956.819702016.49160-1.0755013.6733011.46000K562KRR1
PSMC6ENSG00000100519.71700.239102305.13880-0.439105.316604.07870K562METAP2
PSMC6ENSG00000100519.72159.592202767.47960-0.357806.543205.34880K562MTPAP
PSMC6ENSG00000100519.73308.738202080.758200.669103.564802.53430K562NAA15
PSMC6ENSG00000100519.72374.437603074.89370-0.3730010.244008.93050K562NSUN2
PSMC6ENSG00000100519.72500.246201885.634800.406902.631901.90000K562PRPF8
PSMC6ENSG00000100519.74329.875505414.78750-0.322605.074403.75690K562PUM2
PSMC6ENSG00000100519.74741.837302476.231700.9372019.1471017.74850K562PUS1
PSMC6ENSG00000100519.73482.746502412.824400.5294010.795609.64820K562RBM15
PSMC6ENSG00000100519.72057.786702663.18600-0.372103.226302.03640K562NELFE
PSMC6ENSG00000100519.71581.982502020.21310-0.352802.655501.67540K562RPS3
PSMC6ENSG00000100519.72333.499403034.17200-0.378806.153704.97620K562SF3A3
PSMC6ENSG00000100519.71422.216502245.94930-0.659207.127105.51890K562SF3B1
PSMC6ENSG00000100519.72767.816103108.57810-0.167502.148801.31490K562SRPK2
PSMC6ENSG00000100519.71380.017301950.56300-0.499204.170202.83860K562SRSF4
PSMC6ENSG00000100519.72456.864901977.311000.313203.441002.52670K562SYNCRIP
PSMC6ENSG00000100519.71763.606302618.37410-0.570106.843205.68440K562TARDBP
PSMC6ENSG00000100519.71849.745002525.67880-0.449305.927404.66020K562TIA1
PSMC6ENSG00000100519.72085.543403260.37700-0.6446020.3083018.57080K562UPF1
PSMC6ENSG00000100519.71921.319802789.79840-0.538108.106406.56680K562WDR3
PSMC6ENSG00000100519.73915.587604782.71880-0.288602.720601.86540K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PSMC6 is not available on ENCORE database.





19 RBPs can affect the splicing of PSMC6 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPSMC6ENSG00000100519.7chr14+531849465318507053184798531848605318569453185756-0.064000.000170.00448excludedHepG2U2AF1
SEPSMC6ENSG00000100519.7chr14+531750265317510653173939531740225317520053175424-0.060000.000000.00001excludedHepG2U2AF1
SEPSMC6ENSG00000100519.7chr14+531750265317510653173939531740225317520053175424-0.095000.000000.00000excludedHepG2U2AF2
SEPSMC6ENSG00000100519.7chr14+531849465318507053184798531848605318569453185756-0.070000.000000.00000excludedK562AQR
SEPSMC6ENSG00000100519.7chr14+531750265317510653173895531740225317520053175240-0.069000.000000.00000excludedK562AQR
SEPSMC6ENSG00000100519.7chr14+531781025317824253177818531778865318059853180686-0.051000.000010.00018excludedK562AQR
SEPSMC6ENSG00000100519.7chr14+5319052253190592531878275318790853190682531907540.058000.000010.00170includedK562SUPV3L1
SEPSMC6ENSG00000100519.7chr14+531754815317553453173936531740225317781853177886-0.064000.000060.00822excludedK562SUPV3L1
SEPSMC6ENSG00000100519.7chr14+531750265317510653173939531740225317520053175424-0.060000.000000.00000excludedK562U2AF1
A3SSPSMC6ENSG00000100519.7chr14+5317545853175534531754815317553453175200531752400.100000.000000.00000longerK562AQR
A5SSPSMC6ENSG00000100519.7chr14+531753325317553453175332531754245317781853177886-0.054000.000040.00109shorterK562AQR
RIPSMC6ENSG00000100519.7chr14+5319052253190754531905225319059253190682531907540.278000.000000.00000includedK562PUS1
RIPSMC6ENSG00000100519.7chr14+5319052253190754531905225319059253190682531907540.284000.000180.00299includedK562AGGF1
RIPSMC6ENSG00000100519.7chr14+5319052253190754531905225319059253190682531907540.284000.000070.00116includedK562AKAP8L
RIPSMC6ENSG00000100519.7chr14+5319052253190754531905225319059253190682531907540.238000.000580.00801includedK562RBM15
RIPSMC6ENSG00000100519.7chr14+5318477853185020531847785318486053184946531850200.062000.000120.00271includedK562U2AF2
RIPSMC6ENSG00000100519.7chr14+5319052253190754531905225319059253190682531907540.273000.000210.00390includedK562UTP18
MXEPSMC6ENSG00000100519.7chr14+53177818531778865317812753178242531754815317553453180598531806860.085000.004620.068271includedHepG2U2AF1
MXEPSMC6ENSG00000100519.7chr14+5317781853177886531781275317824253175481531755345318059853180686-0.120000.000060.004922includedK562LIN28B
MXEPSMC6ENSG00000100519.7chr14+53177818531778865317810253178242531751755317542453180598531806860.070000.000000.000001includedK562AQR
MXEPSMC6ENSG00000100519.7chr14+53177784531778865318058053180686531754815317553453184798531854060.058000.000000.000001includedK562AQR
MXEPSMC6ENSG00000100519.7chr14+53177784531778865318059853180686531754815317553453184798531854060.054000.000000.000001includedK562AQR
MXEPSMC6ENSG00000100519.7chr14+53177784531778865317810253178242531754815317553453180598531807500.065000.000000.000001includedK562AQR
MXEPSMC6ENSG00000100519.7chr14+53177784531778865317812753178242531754815317553453180598531806860.065000.000000.000001includedK562AQR
MXEPSMC6ENSG00000100519.7chr14+53175458531755345318058053180686531752005317524053184798531848600.165000.000000.000001includedK562AQR
MXEPSMC6ENSG00000100519.7chr14+53185694531857565318782753187908531847985318486053190682531907540.080000.000000.000001includedK562AQR
MXEPSMC6ENSG00000100519.7chr14+53185694531857565318757853187699531847985318486053187827531879080.069000.000000.000001includedK562AQR
MXEPSMC6ENSG00000100519.7chr14+5317781853177886531781275317824253175481531755345318059853180686-0.102000.000500.035492includedK562LARP7
MXEPSMC6ENSG00000100519.7chr14+5317781853177886531781275317824253175481531755345318059853180686-0.256000.000000.000002includedHepG2U2AF2
MXEPSMC6ENSG00000100519.7chr14+5317781853177886531781275317824253175481531755345318059853180686-0.110000.000300.024522includedK562PHF6
MXEPSMC6ENSG00000100519.7chr14+5317781853177886531781275317824253175481531755345318059853180686-0.130000.000010.001152includedK562SBDS
MXEPSMC6ENSG00000100519.7chr14+5317781853177886531781275317824253175481531755345318059853180686-0.109000.000330.008372includedK562HNRNPC
MXEPSMC6ENSG00000100519.7chr14+5317781853177886531781275317824253175481531755345318059853180686-0.092000.001130.033502includedK562PPIL4
MXEPSMC6ENSG00000100519.7chr14+5317781853177886531781275317824253175481531755345318059853180686-0.100000.002810.098972includedK562TIA1
MXEPSMC6ENSG00000100519.7chr14+53177818531778865317812753178242531754815317553453180598531806860.102000.001670.048301includedK562DHX30
MXEPSMC6ENSG00000100519.7chr14+5317781853177886531781275317824253175481531755345318059853180686-0.141000.000000.000262includedK562FXR2
MXEPSMC6ENSG00000100519.7chr14+5317781853177886531781275317824253175481531755345318059853180686-0.198000.000710.019632includedK562HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PSMC6 is not avaliable on ENCORE database.