POLE2

General Information

Gene Name       : POLE2
Gene ID             : ENSG00000100479.12
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: POLE2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878POLE2ENSG00000100479.1233.9331.0332.48ENCSR000AEF
HepG2POLE2ENSG00000100479.1220.7434.4427.59ENCSR985KAT
K562POLE2ENSG00000100479.1240.7247.6544.19ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for POLE2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • POLE2 RNA is bound by 13 proteins.  







eCLIP assay for POLE2 is not avaliable on ENCORE database.





13 proteins are bound to POLE2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr145014613750146204-3'-UTR,intron-Distal,intron-Proximal4.382127.69621K562KHSRP
chr145014620750146266-3'-UTR,intron-Distal3.547558.67954K562KHSRP
chr145014637650146423-3'-UTR,CDS,intron-Distal,intron-Proximal4.740674.72162K562KHSRP
chr145015485350154932-5'-UTR,CDS,intron-Distal,intron-Proximal4.406937.55366K562DDX3X
chr145012239650122441-CDS,intron-Distal4.308005.64870K562DDX24
chr145015038950150412-CDS,intron-Distal,intron-Proximal3.694923.86664K562DDX3X
chr145014645250146519-CDS,intron-Distal,intron-Proximal4.150823.79347HepG2GRWD1
chr145013132950131437-CDS,intron-Distal,intron-Proximal3.603315.83621K562AQR
chr145012087250120895-CDS,intron-Distal,intron-Proximal5.566924.75872K562DDX24
chr145013625350136351-CDS,intron-Distal,intron-Proximal3.592855.37841K562SF3B4
chr145012087050120921-CDS,intron-Distal,intron-Proximal3.299455.30777HepG2PPIG
chr145014644150146508-CDS,intron-Distal,intron-Proximal3.023904.94718HepG2PPIG
chr145014643050146518-CDS,intron-Distal,intron-Proximal3.002913.49055K562GRWD1
chr145012087450120917-CDS,intron-Distal,intron-Proximal3.776504.93978HepG2BCLAF1
chr145014644950146518-CDS,intron-Distal3.144367.36535K562ZNF622
chr145012212750122199-intron-Distal4.015383.88340K562TARDBP
chr145014070850140836-intron-Distal,intron-Proximal6.1198519.07774K562EFTUD2
chr145012058050120650-intron-Distal,intron-Proximal4.037814.75425K562EFTUD2
chr145012996750130030-intron-Distal,intron-Proximal4.153076.39176K562AQR
chr145014064050140686-intron-Distal3.647133.69252K562EFTUD2
chr145013524150135362-intron-Distal3.889803.24603K562KHSRP
chr145013656250136710-intron-Distal4.307753.62025K562MATR3
chr145011391650113964-intron-Distal,intron-Proximal4.288114.21433K562PRPF8
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for POLE2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for POLE2 is not available on ENCORE database.

  • 96 RBPs can affect the levels of POLE2.  








The Knockdown/knockout RNA-Seq assay for POLE2 is not available on ENCORE database.





96 RBPs can affect the gene expression of POLE2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
POLE2ENSG00000100479.8114.50470184.53310-0.688503.527502.85590HepG2ACO1
POLE2ENSG00000100479.8120.58610185.40440-0.620602.936302.14690HepG2AKAP8L
POLE2ENSG00000100479.828.8684098.58770-1.771906.744605.54230HepG2ASCC1
POLE2ENSG00000100479.8157.41970296.42450-0.913007.639206.59060HepG2AUH
POLE2ENSG00000100479.869.39670225.36720-1.699302.294601.47820HepG2BCLAF1
POLE2ENSG00000100479.830.09130282.17850-3.2292036.9489035.20400HepG2BOP1
POLE2ENSG00000100479.8134.71630317.41630-1.2365011.107409.72560HepG2CALR
POLE2ENSG00000100479.879.49130184.49820-1.214708.536907.49240HepG2CKAP4
POLE2ENSG00000100479.825.7948064.54810-1.323302.975502.17910HepG2CNOT7
POLE2ENSG00000100479.8111.98440259.04770-1.209908.067706.94490HepG2CPSF6
POLE2ENSG00000100479.8170.61100302.22030-0.824906.092405.20870HepG2CELF1
POLE2ENSG00000100479.8216.88520324.91350-0.583104.065903.19500HepG2DAZAP1
POLE2ENSG00000100479.866.87010172.30090-1.365507.957506.86790HepG2DDX21
POLE2ENSG00000100479.830.40200114.14080-1.908608.417607.37640HepG2DDX3X
POLE2ENSG00000100479.890.28730254.87490-1.497202.245401.54190HepG2DDX55
POLE2ENSG00000100479.8119.70980294.17020-1.297107.168605.63700HepG2DDX59
POLE2ENSG00000100479.8127.85050239.50820-0.905605.313403.95580HepG2DDX5
POLE2ENSG00000100479.816.4029098.03470-2.5793010.448909.33190HepG2DDX6
POLE2ENSG00000100479.872.67300170.46620-1.230006.956505.45950HepG2DHX30
POLE2ENSG00000100479.8115.55890176.74790-0.613102.654401.96190HepG2DNAJC21
POLE2ENSG00000100479.8102.50710175.15740-0.772904.233403.45930HepG2DNAJC2
POLE2ENSG00000100479.874.79420158.73060-1.085604.755303.29860HepG2AGO1
POLE2ENSG00000100479.820.9353094.25760-2.170708.161207.18040HepG2EIF2S1
POLE2ENSG00000100479.865.94670138.30360-1.068504.249403.14560HepG2EIF3D
POLE2ENSG00000100479.8131.50130307.09550-1.223609.677208.19430HepG2EIF4G2
POLE2ENSG00000100479.8145.68890340.32820-1.2240012.2429011.12430HepG2ETF1
POLE2ENSG00000100479.883.75240259.50740-1.631606.941105.34250HepG2FTO
POLE2ENSG00000100479.8200.05890105.084800.928804.383303.52660HepG2FXR1
POLE2ENSG00000100479.8107.47550188.75690-0.812503.627602.45690HepG2GNB2L1
POLE2ENSG00000100479.885.68110293.63020-1.7770015.1021013.72620HepG2GPKOW
POLE2ENSG00000100479.8114.29320176.17940-0.624303.019202.00250HepG2HDGF
POLE2ENSG00000100479.8122.25040178.44080-0.545601.881901.33750HepG2HNRNPA1
POLE2ENSG00000100479.8169.00200298.62780-0.821306.056504.76700HepG2HNRNPA2B1
POLE2ENSG00000100479.895.12780198.47260-1.061005.469504.52140HepG2HNRNPC
POLE2ENSG00000100479.8162.89400268.80630-0.722604.687303.78340HepG2HNRNPF
POLE2ENSG00000100479.8162.5200098.694200.719502.571801.89700HepG2HNRNPK
POLE2ENSG00000100479.8181.57570295.95700-0.704805.033604.14600HepG2HNRNPL
POLE2ENSG00000100479.8109.49890280.21850-1.3556010.051308.93720HepG2HNRNPLL
POLE2ENSG00000100479.8153.13220264.69960-0.789604.976104.03160HepG2IGF2BP1
POLE2ENSG00000100479.845.2546099.10310-1.130903.556802.80100HepG2IGF2BP2
POLE2ENSG00000100479.8147.79040201.39520-0.446502.109501.45990HepG2ILF2
POLE2ENSG00000100479.8157.06280335.80760-1.096307.614306.22160HepG2LARP4
POLE2ENSG00000100479.8135.49310204.78510-0.595902.149001.43110HepG2MSI2
POLE2ENSG00000100479.8241.94910322.18610-0.413202.025101.37020HepG2NOL12
POLE2ENSG00000100479.8150.01220248.48230-0.728103.362402.53790HepG2NSUN2
POLE2ENSG00000100479.818.9866058.98840-1.635403.911102.84180HepG2PABPC1
POLE2ENSG00000100479.850.1188096.37740-0.943302.757102.03670HepG2PABPC4
POLE2ENSG00000100479.895.46310198.05360-1.052905.156203.77010HepG2PCBP2
POLE2ENSG00000100479.851.41760196.84360-1.936703.352202.47110HepG2PRPF8
POLE2ENSG00000100479.8153.22940307.56800-1.005205.240504.45320HepG2PUF60
POLE2ENSG00000100479.8190.32450326.51250-0.778706.689105.85110HepG2PUM1
POLE2ENSG00000100479.8215.39520326.26440-0.599103.482602.73440HepG2PUM2
POLE2ENSG00000100479.869.18410111.02100-0.682301.955601.41610HepG2QKI
POLE2ENSG00000100479.8174.51010283.84430-0.701804.399303.34750HepG2RBM15
POLE2ENSG00000100479.877.10290284.45280-1.8833019.7812018.65710HepG2RBM22
POLE2ENSG00000100479.8120.0524062.333600.945503.107201.48100HepG2RBM47
POLE2ENSG00000100479.8170.94900114.087900.583302.162301.67220HepG2NELFE
POLE2ENSG00000100479.8196.48940106.261800.886704.804904.02190HepG2RECQL
POLE2ENSG00000100479.852.33530289.53890-2.4679027.1872025.52480HepG2RPLP0
POLE2ENSG00000100479.871.62010187.73270-1.390207.321605.84480HepG2RPS10
POLE2ENSG00000100479.848.08070134.60240-1.485206.617305.71250HepG2RPS19
POLE2ENSG00000100479.8119.43790205.67040-0.784103.628402.71600HepG2RPS2
POLE2ENSG00000100479.848.23920194.74150-2.013303.473202.60630HepG2RRP9
POLE2ENSG00000100479.8100.36760175.58650-0.806904.202603.43740HepG2SAFB2
POLE2ENSG00000100479.886.65900277.34910-1.6783014.5955013.11000HepG2SF3B1
POLE2ENSG00000100479.8173.78450294.94140-0.763105.571004.63360HepG2SLBP
POLE2ENSG00000100479.8125.97830194.81680-0.628902.421201.52830HepG2SMNDC1
POLE2ENSG00000100479.8105.81080308.60380-1.5443010.167008.67270HepG2SNRNP70
POLE2ENSG00000100479.886.11120321.28150-1.8996024.2548023.15270HepG2SRFBP1
POLE2ENSG00000100479.8274.85380111.402101.3028011.1876010.37440HepG2SRSF1
POLE2ENSG00000100479.8183.94670303.69710-0.723305.112904.30320HepG2SRSF5
POLE2ENSG00000100479.8107.41320264.08610-1.2978011.7375010.47400HepG2SRSF7
POLE2ENSG00000100479.851.1412090.63340-0.825602.534702.00110HepG2SRSF9
POLE2ENSG00000100479.8104.67250178.62120-0.771002.451601.32240HepG2SUB1
POLE2ENSG00000100479.8246.04000345.37150-0.489302.882702.25090HepG2SUCLG1
POLE2ENSG00000100479.848.00810253.79020-2.402304.055203.26000HepG2SUPV3L1
POLE2ENSG00000100479.8194.78530100.138500.959805.481604.73840HepG2TAF15
POLE2ENSG00000100479.8106.92350273.18100-1.3533010.345209.07550HepG2TARDBP
POLE2ENSG00000100479.858.59340191.61590-1.7094012.9011011.95750HepG2TIAL1
POLE2ENSG00000100479.884.95030193.28900-1.186108.614407.70590HepG2TRIM56
POLE2ENSG00000100479.879.25820192.18320-1.277903.084302.04090HepG2U2AF2
POLE2ENSG00000100479.8212.07840318.09750-0.584902.291201.53500HepG2UBE2L3
POLE2ENSG00000100479.889.41940214.25560-1.260707.589906.52690HepG2UPF1
POLE2ENSG00000100479.859.12330235.64260-1.9948015.0908014.06820HepG2ZNF622
POLE2ENSG00000100479.8372.09580790.81580-1.0877013.9166012.74430K562AQR
POLE2ENSG00000100479.8382.53420578.60440-0.597004.343103.24310K562BOP1
POLE2ENSG00000100479.8429.59690615.21960-0.518104.266603.29160K562CPSF6
POLE2ENSG00000100479.8597.86620815.42950-0.447702.241401.64500K562DDX47
POLE2ENSG00000100479.8417.30770618.85060-0.568505.739804.76030K562EIF2S2
POLE2ENSG00000100479.8467.19990625.97700-0.422102.631801.79830K562FMR1
POLE2ENSG00000100479.8343.46120530.57440-0.627404.514303.32040K562FTO
POLE2ENSG00000100479.8431.67300304.779600.502102.666902.07100K562FXR1
POLE2ENSG00000100479.8608.30250409.168500.572003.402602.60320K562G3BP2
POLE2ENSG00000100479.8363.96730587.38100-0.690506.086804.91050K562GPKOW
POLE2ENSG00000100479.8578.10200824.74440-0.512604.214403.28440K562GRSF1
POLE2ENSG00000100479.8257.78890493.06040-0.935609.098508.06720K562HNRNPC
POLE2ENSG00000100479.8264.70630501.55620-0.922006.539605.03900K562KRR1
POLE2ENSG00000100479.8421.38460573.35040-0.444302.985002.07250K562METAP2
POLE2ENSG00000100479.8335.24200463.65740-0.467902.818401.71490K562NELFE
POLE2ENSG00000100479.8189.89560353.08890-0.894805.516304.36000K562RPS19
POLE2ENSG00000100479.8486.46350638.89980-0.393302.296001.54730K562SF3A3
POLE2ENSG00000100479.8351.08260558.62860-0.670104.570303.30280K562SF3B1
POLE2ENSG00000100479.8290.51150425.78040-0.551503.712902.71820K562SF3B4
POLE2ENSG00000100479.8304.58290425.54720-0.482502.951601.86060K562SRSF5
POLE2ENSG00000100479.8349.96080455.93870-0.381601.991901.38470K562TARDBP
POLE2ENSG00000100479.8307.62370439.81460-0.515703.553002.60780K562TIA1
POLE2ENSG00000100479.8701.69910890.94450-0.344502.509901.69580K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for POLE2 is not available on ENCORE database.





16 RBPs can affect the splicing of POLE2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPOLE2ENSG00000100479.8chr14-501223885012256150121722501218125013003250130105-0.177000.001900.03519excludedK562SF3B4
SEPOLE2ENSG00000100479.8chr14-501215015012155650120872501209325012172250121812-0.284000.000560.01989excludedK562AKAP8L
SEPOLE2ENSG00000100479.8chr14-5014106750141145501408405014093450146442501465180.156000.000420.09091includedK562PUM1
SEPOLE2ENSG00000100479.8chr14-501410675014114550140840501409345014644250146518-0.230000.000620.05915excludedHepG2DDX59
SEPOLE2ENSG00000100479.8chr14-501215015012155650120872501209325012172250121812-0.117000.012310.09571excludedK562AQR
SEPOLE2ENSG00000100479.8chr14-501140105011407850110277501103885011698250117159-0.051000.012800.09868excludedK562AQR
SEPOLE2ENSG00000100479.8chr14-501408405014093450136241501363455014106750141145-0.121000.012290.09560excludedK562AQR
SEPOLE2ENSG00000100479.8chr14-5012150150121556501208725012093250121722501218120.281000.000020.00187includedK562FXR1
SEPOLE2ENSG00000100479.8chr14-5014106750141145501408405014093450146442501465180.283000.000390.01859includedK562FXR1
SEPOLE2ENSG00000100479.8chr14-501410675014117250140840501409345014644250146518-0.212000.000210.05119excludedK562GPKOW
SEPOLE2ENSG00000100479.8chr14-501215015012155650120872501209325012172250121812-0.239000.000170.03594excludedK562LARP4
SEPOLE2ENSG00000100479.8chr14-5014106750141145501408405014093450146442501465180.171000.000480.08023includedK562APOBEC3C
SEPOLE2ENSG00000100479.8chr14-5011371150113810501102815011038850114010501140780.365000.005840.09109includedK562U2AF1
SEPOLE2ENSG00000100479.8chr14-501410675014114550140840501409345014644250146518-0.206000.000220.03989excludedK562SRSF7
SEPOLE2ENSG00000100479.8chr14-501215015012155650120872501209325012172250121812-0.257000.004080.09595excludedK562UTP18
SEPOLE2ENSG00000100479.8chr14-501408405014093450136241501363165014644250146518-0.101000.003360.08319excludedK562UTP18
SEPOLE2ENSG00000100479.8chr14-501410675014114550140840501409345014644250146518-0.194000.002640.05769excludedK562AGGF1
SEPOLE2ENSG00000100479.8chr14-5014106750141145501408405014093450146442501465180.246000.001010.04046includedK562PTBP1
SEPOLE2ENSG00000100479.8chr14-501215015012155650120872501209325012172250121812-0.281000.000150.03558excludedK562NPM1
A3SSPOLE2ENSG00000100479.8chr14-5014084050141012501408405014093450146442501465180.243000.019300.09251longerK562AQR
A3SSPOLE2ENSG00000100479.8chr14-501223885012256150122388501225295013003250130105-0.130000.007230.03993shorterK562AQR
MXEPOLE2ENSG00000100479.8chr14-5014106750141145501464425014651850140840501409345015031050150411-0.236000.000280.012292includedK562UCHL5
MXEPOLE2ENSG00000100479.8chr14-50136241501363455014084050140961501330475013313150141067501411450.084000.008420.055041includedK562AQR
MXEPOLE2ENSG00000100479.8chr14-50122388501225295013003250130143501217225012181250131343501313810.058000.013800.081931includedK562AQR
MXEPOLE2ENSG00000100479.8chr14-50136241501363165014084050140961501330475013313150141067501411450.076000.007150.048261includedK562AQR
MXEPOLE2ENSG00000100479.8chr14-50133047501331315013624150136345501318245013188150140840501409340.097000.016680.095311includedK562AQR
MXEPOLE2ENSG00000100479.8chr14-5013624150136316501408405014093450133047501331315014644250146518-0.109000.000350.036082includedK562PUM1
MXEPOLE2ENSG00000100479.8chr14-5013624150136316501408405014093450133047501331315014644250146518-0.125000.000200.056612includedK562APOBEC3C

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for POLE2 is not avaliable on ENCORE database.