MAPK8

General Information

Gene Name       : MAPK8
Gene ID             : ENSG00000107643.16
Essential Gene : No

Functions

Localization

Domains (AlphaFold: MAPK8)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878MAPK8ENSG00000107643.1646.7041.7844.24ENCSR000AEF
HepG2MAPK8ENSG00000107643.1618.9633.1526.05ENCSR985KAT
K562MAPK8ENSG00000107643.1665.7762.8264.30ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for MAPK8 is not avaliable on ENCORE database.



Proteins bound to RNA
  • MAPK8 RNA is bound by 32 proteins.  







eCLIP assay for MAPK8 is not avaliable on ENCORE database.





32 proteins are bound to MAPK8 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr104964370749643792+3'-UTR3.192893.68829K562YBX3
chr104964324049643440+3'-UTR4.5288511.09782K562DDX6
chr104964330349643376+3'-UTR4.652529.17735K562PUM2
chr104964445849644554+3'-UTR,polyA_site4.888067.24177K562CSTF2T
chr104964348049643521+3'-UTR3.799227.28182K562PABPC4
chr104951472749514820+5'-UTR4.671505.88953K562DDX3X
chr104951504649515123+5'-UTR,intron-Distal3.544644.01575K562NONO
chr104951517649515307+5'-UTR,intron-Distal,intron-Proximal3.575763.73797K562CSTF2T
chr104951513649515171+5'-UTR,intron-Distal3.795893.31905K562NONO
chr104963506049635196+CDS,intron-Proximal4.2397212.81671K562SF3B4
chr104963504849635150+CDS,intron-Proximal4.875115.56788K562SMNDC1
chr104961807349618141+CDS4.372824.04372HepG2BCLAF1
chr104956047949560574+intron-Distal5.1618310.39744K562SAFB2
chr104962797149628044+intron-Distal7.4174826.65922K562QKI
chr104962792749628075+intron-Distal4.213773.06005HepG2QKI
chr104956973849569836+intron-Distal4.814495.37222HepG2MATR3
chr104962309149623186+intron-Distal3.689603.06150K562KHSRP
chr104954866549548717+intron-Distal3.032523.75707K562SAFB2
chr104960103549601135+intron-Distal4.888327.06647K562MATR3
chr104963524449635316+intron-Distal,intron-Proximal4.283837.46973K562KHSRP
chr104951496349515058+intron-Distal,intron-Proximal4.201323.02324K562XRN2
chr104956626749566309+intron-Distal4.618215.76606K562EXOSC5
chr104961984249619907+intron-Distal3.944533.09122HepG2PTBP1
chr104951542849515537+intron-Distal4.475035.04680K562HNRNPM
chr104956268149562732+intron-Distal4.464006.25977K562SAFB2
chr104954761149547686+intron-Distal4.570496.44435K562SAFB2
chr104956966949569731+intron-Distal4.442835.20135HepG2QKI
chr104954533249545388+intron-Distal3.992434.16015K562SAFB2
chr104962846349628492+intron-Distal4.606596.13339K562KHSRP
chr104963275749632878+intron-Distal3.412995.83938K562KHSRP
chr104955933449559393+intron-Distal3.562294.48636K562SAFB2
chr104956149149561565+intron-Distal3.371116.34609K562SAFB2
chr104951527049515328+intron-Distal,intron-Proximal4.569966.13283K562NONO
chr104954885349548954+intron-Distal4.019574.22415K562PTBP1
chr104960739249607510+intron-Distal4.098754.02846K562HNRNPM
chr104962788749627948+intron-Distal3.477589.48651K562KHSRP
chr104952675149526822+intron-Distal3.617363.94496K562RBFOX2
chr104956222249562297+intron-Distal4.384764.97094K562SAFB2
chr104961837549618479+intron-Distal3.113843.71638K562CSTF2T
chr104951492449514970+intron-Distal,intron-Proximal4.285724.58989K562NONO
chr104956967949569805+intron-Distal3.173593.45713HepG2PTBP1
chr104954642049546453+intron-Distal3.605533.01412K562SAFB2
chr104956639349566432+intron-Distal3.677544.61282K562EXOSC5
chr104962774049627880+intron-Distal4.209079.20471K562KHSRP
chr104951536649515421+intron-Distal3.981523.28572K562HNRNPM
chr104961987249619926+intron-Distal3.861475.38389HepG2PCBP2
chr104956128849561363+intron-Distal3.623956.36646K562SAFB2
chr104962222549622326+intron-Distal3.051784.35941K562KHSRP
chr104956188549562008+intron-Distal3.257157.17195K562SAFB2
chr104961992649619979+intron-Distal4.920033.39700HepG2PCBP2
chr104954440949544497+intron-Distal4.259005.20871K562SAFB2
chr104954483049544908+intron-Distal3.893166.96497K562SAFB2
chr104958086749580985+intron-Distal4.111724.37667K562SAFB2
chr104956194549562046+intron-Distal4.075814.13866K562PPIL4
chr104954684649546907+intron-Distal4.008893.14791K562HNRNPL
chr104956020249560260+intron-Distal4.347584.51328K562SAFB2
chr104951493049515016+intron-Distal,intron-Proximal3.344186.20453K562TIA1
chr104955716349557270+intron-Distal4.147804.95197K562SAFB2
chr104956651549566564+intron-Distal3.646844.61282K562EXOSC5
chr104956972049569845+intron-Distal4.2471412.07253K562MATR3
chr104956682349566894+intron-Distal3.133515.41777K562EXOSC5
chr104954864049548710+intron-Distal4.115854.24478HepG2CSTF2
chr104958880849588949+intron-Distal3.188413.90716K562KHDRBS1
chr104961984649619943+intron-Distal5.073034.90095K562PTBP1
chr104951878349518868+intron-Distal5.130488.14280K562TARDBP
chr104958584949585900+intron-Distal4.073754.58306K562SAFB2
chr104956630949566334+intron-Distal3.258273.43875K562EXOSC5
chr104958023049580317+intron-Distal4.202324.07072K562UCHL5
chr104953948349539584+intron-Distal3.200595.05821K562MATR3
chr104956972449569836+intron-Distal4.797629.46053K562PTBP1
chr104956376049563841+intron-Distal3.152183.67498K562SAFB2
chr104963416649634222+intron-Distal,intron-Proximal4.245663.49003K562PRPF8
chr104963667449636770+intron-Distal3.391496.18396K562KHSRP
chr104958595249586044+intron-Distal4.292554.97094K562SAFB2
chr104951520049515319+intron-Distal,intron-Proximal3.748756.14554K562DROSHA
chr104955986849559921+intron-Distal3.591404.48017K562SAFB2
chr104951555149515591+intron-Distal3.277474.09779K562NONO
chr104960738049607450+intron-Distal4.006983.16028HepG2SUGP2
chr104951523749515294+intron-Distal,intron-Proximal4.188265.08521K562GEMIN5
chr104956692949567002+intron-Distal3.956073.45817K562MATR3
chr104956678949566929+intron-Distal3.348206.21509K562MATR3
chr104962792249627971+intron-Distal6.8185217.00261K562QKI
chr104960122149601310+intron-Distal3.922023.04224HepG2SUGP2
chr104951658749516660+intron-Distal3.388063.20331K562CSTF2T
chr104956139149561462+intron-Distal3.276386.55120K562SAFB2
chr104954819949548275+intron-Distal3.498475.13780K562SAFB2
chr104963459449634644+intron-Proximal4.261544.36481K562EFTUD2
chr104962843449628463+intron-Proximal3.459324.35650K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for MAPK8 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for MAPK8 is not available on ENCORE database.

  • 90 RBPs can affect the levels of MAPK8.  








The Knockdown/knockout RNA-Seq assay for MAPK8 is not available on ENCORE database.





90 RBPs can affect the gene expression of MAPK8 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
MAPK8ENSG00000107643.11524.88140774.65220-0.561603.402402.36210HepG2ABCF1
MAPK8ENSG00000107643.11370.92530664.59370-0.841305.947704.97420HepG2CPSF6
MAPK8ENSG00000107643.11588.93050860.70700-0.547406.761705.84140HepG2CELF1
MAPK8ENSG00000107643.11706.70140546.800300.370002.471001.61120HepG2DDX24
MAPK8ENSG00000107643.11417.67750550.64910-0.398703.651402.92170HepG2DNAJC2
MAPK8ENSG00000107643.11294.63060769.39060-1.3848019.0763017.62000HepG2EIF2S1
MAPK8ENSG00000107643.11440.48270587.85080-0.416402.460901.36110HepG2EIF2S2
MAPK8ENSG00000107643.111211.19860827.865500.548903.136802.40710HepG2EIF4B
MAPK8ENSG00000107643.11627.10200874.63610-0.480003.865102.91300HepG2EIF4G2
MAPK8ENSG00000107643.111430.638001190.865100.264502.587002.00240HepG2ETF1
MAPK8ENSG00000107643.11559.40440438.349000.351702.094301.40270HepG2FUBP3
MAPK8ENSG00000107643.11592.97130857.90800-0.532904.099703.26890HepG2FXR1
MAPK8ENSG00000107643.11509.36960753.43540-0.564801.968801.42260HepG2GPKOW
MAPK8ENSG00000107643.11684.80620850.54700-0.312702.690301.76560HepG2HNRNPA2B1
MAPK8ENSG00000107643.11456.87280571.73790-0.323602.342301.67880HepG2HNRNPF
MAPK8ENSG00000107643.11582.83270805.88070-0.467503.388902.61820HepG2HNRNPK
MAPK8ENSG00000107643.11717.56240843.06780-0.232501.990401.40710HepG2HNRNPL
MAPK8ENSG00000107643.11665.08470858.20770-0.367802.171801.58850HepG2MAGOH
MAPK8ENSG00000107643.11706.55330917.72190-0.377303.475902.62240HepG2NOL12
MAPK8ENSG00000107643.11447.28610719.66980-0.686109.490908.47580HepG2PCBP1
MAPK8ENSG00000107643.11430.04940606.92260-0.497005.016404.00680HepG2PRPF4
MAPK8ENSG00000107643.11748.01990929.27030-0.313002.416401.78920HepG2PUM2
MAPK8ENSG00000107643.11961.15070793.104600.277201.983101.44050HepG2QKI
MAPK8ENSG00000107643.111559.39650995.332600.6476011.6127010.70490HepG2RBM22
MAPK8ENSG00000107643.11984.37890719.781500.451604.072403.26810HepG2RBM25
MAPK8ENSG00000107643.111090.58270814.965400.420204.767704.09240HepG2NELFE
MAPK8ENSG00000107643.11911.44590759.007300.263902.074201.53040HepG2RECQL
MAPK8ENSG00000107643.11668.28200438.762500.606904.079603.14680HepG2RRP9
MAPK8ENSG00000107643.11954.20760762.420400.323602.917302.31320HepG2SF3B4
MAPK8ENSG00000107643.11457.03490651.63840-0.511802.835301.86680HepG2SMNDC1
MAPK8ENSG00000107643.111225.22500795.791100.6225010.529409.73860HepG2SRSF1
MAPK8ENSG00000107643.111113.04310765.701200.539603.101202.03220HepG2SRSF3
MAPK8ENSG00000107643.11378.23050528.44630-0.482502.286301.42610HepG2SUPT6H
MAPK8ENSG00000107643.11938.33500715.258300.391503.650403.02130HepG2TAF15
MAPK8ENSG00000107643.11331.41240602.24250-0.8617010.471309.60680HepG2TIAL1
MAPK8ENSG00000107643.11446.73160607.59850-0.443704.293703.62160HepG2TRIM56
MAPK8ENSG00000107643.11942.00090669.327700.492904.207803.44140HepG2U2AF1
MAPK8ENSG00000107643.11439.90190598.96190-0.445304.332903.52270HepG2ZC3H8
MAPK8ENSG00000107643.111701.543902369.09030-0.477505.194903.51010K562ABCF1
MAPK8ENSG00000107643.112391.871901982.435100.270803.652503.01680K562AGGF1
MAPK8ENSG00000107643.111895.383602571.64120-0.440204.520603.80430K562AQR
MAPK8ENSG00000107643.111156.716601430.48610-0.306503.579802.48250K562BCLAF1
MAPK8ENSG00000107643.111137.440201611.18210-0.502304.856803.68800K562BOP1
MAPK8ENSG00000107643.111689.211302163.26160-0.356903.213101.81760K562CIRBP
MAPK8ENSG00000107643.111906.973902239.93240-0.232202.410501.38480K562CPEB4
MAPK8ENSG00000107643.11847.323501713.14080-1.0157022.0416019.79590K562CPSF6
MAPK8ENSG00000107643.113177.347203761.16890-0.243402.287901.40110K562CELF1
MAPK8ENSG00000107643.111127.238501421.22660-0.334303.896802.44800K562DDX21
MAPK8ENSG00000107643.111035.198401254.34770-0.277002.783801.45700K562DDX27
MAPK8ENSG00000107643.111514.860402317.76920-0.6136014.8483013.45420K562DDX47
MAPK8ENSG00000107643.111068.531901627.60730-0.6071012.099709.52950K562EIF2S1
MAPK8ENSG00000107643.11437.12810728.43360-0.736704.427803.12750K562EIF3A
MAPK8ENSG00000107643.11987.098601462.88040-0.567509.176307.73180K562EIF3G
MAPK8ENSG00000107643.111043.854901548.05400-0.568506.719505.45280K562EIF4A3
MAPK8ENSG00000107643.112489.299003059.12070-0.297403.966202.84500K562EIF4G2
MAPK8ENSG00000107643.11959.129101351.30980-0.494606.442504.28950K562EWSR1
MAPK8ENSG00000107643.111421.391001120.927000.342502.325701.30330K562FKBP4
MAPK8ENSG00000107643.111341.541301743.09570-0.377803.165402.24560K562FMR1
MAPK8ENSG00000107643.111236.319901609.91550-0.380904.864304.09290K562FXR1
MAPK8ENSG00000107643.112270.990401678.429600.436102.764202.05680K562G3BP2
MAPK8ENSG00000107643.11999.229701635.62150-0.7110010.456708.89480K562GPKOW
MAPK8ENSG00000107643.111431.134702177.51730-0.605508.966107.58340K562GRSF1
MAPK8ENSG00000107643.111373.244201661.34960-0.274802.332101.35210K562HNRNPA1
MAPK8ENSG00000107643.111010.372701291.80510-0.354502.930702.31850K562HNRNPC
MAPK8ENSG00000107643.111055.514301400.67260-0.408202.881201.92930K562HNRNPM
MAPK8ENSG00000107643.111436.029901839.75080-0.357404.391603.25550K562HNRNPU
MAPK8ENSG00000107643.111799.968902308.85990-0.359203.252402.39180K562HSPD1
MAPK8ENSG00000107643.111050.818001396.63360-0.410402.328701.48050K562KRR1
MAPK8ENSG00000107643.111456.669502121.25700-0.542207.223305.83810K562MAGOH
MAPK8ENSG00000107643.111611.738202117.03750-0.393404.359703.17820K562MATR3
MAPK8ENSG00000107643.113101.226502452.427900.338503.621502.55950K562MBNL1
MAPK8ENSG00000107643.111126.733001596.55180-0.502805.677504.39490K562METAP2
MAPK8ENSG00000107643.112435.484203260.75880-0.421004.132502.75200K562MSI2
MAPK8ENSG00000107643.11996.701801639.94630-0.7184017.4464015.66110K562MTPAP
MAPK8ENSG00000107643.112602.882101718.972300.598505.077103.76270K562NAA15
MAPK8ENSG00000107643.111357.990601822.10510-0.424109.160807.90990K562NSUN2
MAPK8ENSG00000107643.111611.528602073.26240-0.363503.972202.34010K562PCBP1
MAPK8ENSG00000107643.111492.156901887.49410-0.339103.016601.99770K562PCBP2
MAPK8ENSG00000107643.11815.943401049.34580-0.362903.081702.23440K562POLR2G
MAPK8ENSG00000107643.111585.347001933.14500-0.286202.101301.39010K562PPIG
MAPK8ENSG00000107643.111600.890002060.89280-0.364403.938903.15940K562PTBP1
MAPK8ENSG00000107643.112602.828003478.53770-0.418407.119405.55430K562PUM2
MAPK8ENSG00000107643.112616.881802045.785900.355103.186602.61090K562PUS1
MAPK8ENSG00000107643.112405.963701993.270900.271402.950902.34220K562RBM15
MAPK8ENSG00000107643.111569.658901976.45130-0.332502.802501.95640K562RBM22
MAPK8ENSG00000107643.111435.013801926.43240-0.424903.677502.00410K562RBM34
MAPK8ENSG00000107643.111182.646901440.68530-0.284703.662301.84460K562RPS10
MAPK8ENSG00000107643.11710.493901157.08540-0.703606.271305.03410K562RPS19
MAPK8ENSG00000107643.11869.969301261.35360-0.535904.530903.21080K562RPS3
MAPK8ENSG00000107643.111426.128901797.98620-0.334304.185303.19650K562SF3A3
MAPK8ENSG00000107643.111410.658502020.30020-0.518207.124305.99770K562SRSF1
MAPK8ENSG00000107643.11936.422101217.78800-0.379003.253502.09510K562SRSF4
MAPK8ENSG00000107643.111544.809601907.86810-0.304502.372001.41160K562SRSF5
MAPK8ENSG00000107643.11785.864501099.93610-0.485103.428202.28550K562SUPV3L1
MAPK8ENSG00000107643.111004.411702044.80890-1.0256018.7102016.55140K562TARDBP
MAPK8ENSG00000107643.111511.739701972.41410-0.383804.174403.13730K562TIA1
MAPK8ENSG00000107643.11843.724701114.01410-0.400902.688701.76770K562TIAL1
MAPK8ENSG00000107643.11909.991701164.04210-0.355202.288801.37090K562UCHL5
MAPK8ENSG00000107643.111603.831601932.01840-0.268603.550202.74400K562UPF1
MAPK8ENSG00000107643.111344.033801653.16420-0.298702.583901.73630K562WDR3
MAPK8ENSG00000107643.111323.064301719.11900-0.377806.287605.06340K562WDR43
MAPK8ENSG00000107643.112411.715603047.10560-0.337403.547802.07480K562WRN
MAPK8ENSG00000107643.11832.500501185.15490-0.509604.277302.65600K562XRN2
MAPK8ENSG00000107643.112386.444202896.94840-0.279702.355801.56930K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for MAPK8 is not available on ENCORE database.





15 RBPs can affect the splicing of MAPK8 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEMAPK8ENSG00000107643.11chr10+4953393949534008495161374951633149609654496098250.238000.002770.04734includedK562SRSF1
SEMAPK8ENSG00000107643.11chr10+496180724961821149617921496179804962819749628289-0.053000.000810.01021excludedK562AQR
SEMAPK8ENSG00000107643.11chr10+496344224963454749634086496341134963923549639313-0.071000.001590.02503excludedK562PUS1
SEMAPK8ENSG00000107643.11chr10+495339394953400849516137495163314960965449609825-0.210000.000010.00038excludedK562PUS1
SEMAPK8ENSG00000107643.11chr10+4953393949534008495161374951633149609654496098250.505000.000040.00371includedHepG2SFPQ
SEMAPK8ENSG00000107643.11chr10+4951614549516331495147224951486449609654496098250.475000.000000.00006includedK562LARP4
SEMAPK8ENSG00000107643.11chr10+496344224963454749633930496341134963512249635186-0.067000.000230.00687excludedK562U2AF1
SEMAPK8ENSG00000107643.11chr10+4962819749628363496180724961821149639235496393130.353000.000480.07881includedK562FXR2
SEMAPK8ENSG00000107643.11chr10+496351224963518649618072496182114963923549639313-0.052000.000120.00678excludedK562UTP18
SEMAPK8ENSG00000107643.11chr10+495339394953400849516137495163314960965449609825-0.173000.000470.01505excludedK562RBM15
SEMAPK8ENSG00000107643.11chr10+495339394953400849516137495163314960965449609825-0.170000.000440.01444excludedK562AGGF1
MXEMAPK8ENSG00000107643.11chr10+4963213049632202496325564963262849628197496283634963393049634113-0.186000.010880.092832includedK562DROSHA
MXEMAPK8ENSG00000107643.11chr10+4963213049632202496325564963262849628197496283634963393049634113-0.194000.000470.022762includedK562LIN28B
MXEMAPK8ENSG00000107643.11chr10+4963213049632202496325564963262849628197496283634963393049634113-0.187000.000920.048002includedK562PHF6
MXEMAPK8ENSG00000107643.11chr10+49632130496322024963255649632628496281974962836349633930496341130.085000.001930.032241includedK562SF3B4
MXEMAPK8ENSG00000107643.11chr10+49628197496283634963512249635186496180724961821149639235496393130.116000.000200.007791includedK562HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for MAPK8 is not avaliable on ENCORE database.