GRK6

General Information

Gene Name       : GRK6
Gene ID             : ENSG00000198055.10
Essential Gene : No

Functions

Localization

Domains (AlphaFold: GRK6)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878GRK6ENSG00000198055.105.4021.1913.30ENCSR000AEF
HepG2GRK6ENSG00000198055.1034.269.0921.67ENCSR985KAT
K562GRK6ENSG00000198055.1050.0726.3838.23ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for GRK6 is not avaliable on ENCORE database.



Proteins bound to RNA
  • GRK6 RNA is bound by 34 proteins.  







eCLIP assay for GRK6 is not avaliable on ENCORE database.





34 proteins are bound to GRK6 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr5176869516176869589+3'-UTR3.061453.85957K562IGF2BP2
chr5176862109176862209+3'-UTR,CDS,intron-Proximal3.745669.14595K562PRPF8
chr5176869036176869124+3'-UTR,polyA_site4.8547211.96832K562PUM2
chr5176857915176857969+3'-UTR,CDS,intron-Proximal4.031785.24452HepG2PPIG
chr5176869054176869133+3'-UTR,polyA_site3.857376.23998K562PUM1
chr5176863541176863574+3'-UTR,CDS,intron-Proximal4.199637.30031K562AQR
chr5176869058176869119+3'-UTR,polyA_site3.421743.27682HepG2LARP4
chr5176863051176863098+3'-UTR,CDS,intron-Proximal3.501076.69182K562AQR
chr5176868323176868388+3'-UTR,intron-Distal4.681377.92018K562AQR
chr5176869633176869681+3'-UTR3.756985.16186K562NONO
chr5176861966176862035+3'-UTR,CDS,intron-Proximal5.585696.41139HepG2EFTUD2
chr5176869268176869312+3'-UTR3.094413.38183K562NONO
chr5176869681176869747+3'-UTR4.831385.42636K562NONO
chr5176863552176863628+3'-UTR,intron-Proximal3.854655.29694K562EFTUD2
chr5176868241176868295+3'-UTR,CDS,intron-Distal,intron-Proximal3.711925.46476K562AQR
chr5176863560176863588+3'-UTR,intron-Proximal3.533164.77019K562BUD13
chr5176857749176857806+3'-UTR,intron-Distal,intron-Proximal6.0226412.80845K562SF3B4
chr5176869066176869155+3'-UTR4.041743.07786HepG2UPF1
chr5176869677176869784+3'-UTR3.870606.28005HepG2XPO5
chr5176869005176869036+3'-UTR5.940284.20717K562PUM2
chr5176868854176868903+3'-UTR4.397203.15006K562RBM15
chr5176863028176863104+3'-UTR,CDS,intron-Proximal3.884476.26407K562SF3B4
chr5176861878176861931+3'-UTR,CDS,intron-Proximal4.395796.77156K562AQR
chr5176862120176862154+3'-UTR,CDS,intron-Proximal4.4249610.30697K562AQR
chr5176860844176860949+5'-UTR,CDS,intron-Distal,intron-Proximal3.769419.08133K562BUD13
chr5176861002176861101+5'-UTR,CDS,intron-Proximal3.123683.91443HepG2PPIG
chr5176860935176860953+5'-UTR,CDS,intron-Proximal4.1992120.07395K562YBX3
chr5176853784176853842+5'-UTR,intron-Distal5.216468.88833HepG2DDX3X
chr5176860598176860670+5'-UTR,CDS4.476216.83823K562DDX24
chr5176860966176860990+5'-UTR,CDS,intron-Proximal4.016856.82724K562YBX3
chr5176860661176860677+5'-UTR,CDS4.161998.34856K562YBX3
chr5176861071176861149+5'-UTR,CDS,intron-Proximal4.0707415.45005HepG2PRPF8
chr5176853690176853782+5'-UTR,intron-Distal,intron-Proximal6.7707316.47004HepG2DDX3X
chr5176860990176861021+5'-UTR,CDS,intron-Proximal3.257127.65028K562YBX3
chr5176861104176861110+5'-UTR,CDS,intron-Proximal5.4645414.99196K562AQR
chr5176860925176860935+5'-UTR,CDS,intron-Proximal4.0779819.48629K562YBX3
chr5176860953176860957+5'-UTR,CDS,intron-Proximal3.9297915.26119K562YBX3
chr5176860894176860973+5'-UTR,CDS,intron-Distal,intron-Proximal3.169964.65103K562METAP2
chr5176860508176860570+5'-UTR,CDS,intron-Proximal4.7529411.56048K562EFTUD2
chr5176860914176860925+5'-UTR,CDS,intron-Distal,intron-Proximal4.0278418.83118K562YBX3
chr5176868053176868059+CDS,intron-Proximal5.4796018.01578K562AQR
chr5176863531176863535+CDS,intron-Proximal3.707604.88100K562AQR
chr5176859215176859255+CDS,intron-Proximal5.1641819.61217K562SF3B4
chr5176859236176859334+CDS,intron-Proximal3.902903.45590K562GRWD1
chr5176859706176859741+CDS,intron-Distal,intron-Proximal3.433243.69775K562YBX3
chr5176860382176860412+CDS,intron-Proximal4.523903.49905HepG2PPIG
chr5176868044176868141+CDS,intron-Proximal3.200816.29405HepG2PRPF8
chr5176868048176868101+CDS,intron-Proximal4.832274.97857HepG2AQR
chr5176867919176867940+CDS,intron-Proximal3.308413.05161HepG2PPIG
chr5176860515176860554+CDS,intron-Proximal3.531115.34337K562AQR
chr5176857918176857965+CDS4.004505.74136K562DDX24
chr5176863462176863525+CDS3.690926.74842K562ZNF622
chr5176860288176860357+CDS,intron-Proximal3.9973512.17288K562EFTUD2
chr5176859179176859260+CDS,intron-Proximal3.648265.24441K562SMNDC1
chr5176860347176860394+CDS,intron-Proximal4.200847.39346K562DDX24
chr5176860304176860371+CDS,intron-Proximal3.128216.45164K562BUD13
chr5176859256176859304+CDS4.744184.97342HepG2PPIG
chr5176868686176868763+CDS,intron-Proximal4.7433610.93035K562AQR
chr5176854159176854207+intron-Distal4.614134.79919K562GEMIN5
chr5176856417176856532+intron-Distal4.301963.85108HepG2GTF2F1
chr5176856490176856548+intron-Distal4.2138111.64762K562GTF2F1
chr5176855759176855849+intron-Distal3.972483.84029K562DROSHA
chr5176863944176864011+intron-Distal6.7169323.43457K562PTBP1
chr5176856015176856071+intron-Distal4.226796.48623K562RBFOX2
chr5176854352176854410+intron-Distal3.998543.80512K562CSTF2T
chr5176858290176858338+intron-Distal3.808094.83721K562EFTUD2
chr5176856424176856477+intron-Distal3.212083.27165HepG2RBFOX2
chr5176856438176856510+intron-Distal3.594414.48585K562NONO
chr5176857064176857095+intron-Distal3.192723.36199K562EWSR1
chr5176856477176856558+intron-Distal5.0828814.34609K562RBFOX2
chr5176856010176856060+intron-Distal3.442574.34865K562NONO
chr5176860777176860836+intron-Distal,intron-Proximal4.1309510.40403K562PRPF8
chr5176856480176856549+intron-Distal3.022665.22851K562CSTF2T
chr5176860790176860841+intron-Distal,intron-Proximal3.242253.18634K562MTPAP
chr5176856416176856527+intron-Distal3.154453.00054HepG2PRPF4
chr5176858222176858306+intron-Distal3.768019.96904K562SF3B4
chr5176868636176868683+intron-Distal,intron-Proximal5.159486.91748K562SF3B4
chr5176856413176856490+intron-Distal5.1716513.72268K562GTF2F1
chr5176854887176854931+intron-Distal4.044703.27618K562RBFOX2
chr5176868558176868616+intron-Distal4.119355.09344HepG2XPO5
chr5176868371176868502+intron-Distal3.285583.98966K562HNRNPK
chr5176860846176860861+intron-Distal,intron-Proximal3.630084.22460K562RBM15
chr5176856435176856545+intron-Distal4.4053215.31003K562DROSHA
chr5176856477176856541+intron-Distal4.292584.43116HepG2RBFOX2
chr5176856017176856066+intron-Distal3.187154.61081K562GTF2F1
chr5176863887176863944+intron-Distal5.8335912.39591K562PTBP1
chr5176854782176854887+intron-Distal3.033183.91816K562RBFOX2
chr5176854154176854268+intron-Distal3.000033.18404K562FUS
chr5176856407176856531+intron-Distal3.853934.88931HepG2FAM120A
chr5176856286176856342+intron-Distal3.855218.63667K562GTF2F1
chr5176860776176860844+intron-Distal,intron-Proximal4.133986.60685K562BUD13
chr5176856262176856343+intron-Distal4.560244.50934HepG2RBFOX2
chr5176855995176856080+intron-Distal3.884038.29689K562EWSR1
chr5176856611176856687+intron-Distal3.741698.15232K562RBFOX2
chr5176856071176856131+intron-Distal3.442555.01300K562RBFOX2
chr5176856081176856139+intron-Distal3.321693.38183K562NONO
chr5176856296176856331+intron-Distal4.614405.44484K562RBFOX2
chr5176856424176856477+intron-Distal4.6797210.84076K562RBFOX2
chr5176856442176856537+intron-Distal4.090183.37800K562HNRNPU
chr5176868067176868184+intron-Distal,intron-Proximal4.563334.24431HepG2RBFOX2
chr5176855174176855235+intron-Distal3.361244.20405K562EWSR1
chr5176860861176860895+intron-Distal,intron-Proximal3.667483.93112K562RBM15
chr5176861967176862020+intron-Proximal5.464547.63570K562AQR
chr5176860441176860508+intron-Proximal6.3302912.75970K562EFTUD2
chr5176868086176868133+intron-Proximal3.585915.66421K562PRPF8
chr5176860103176860140+intron-Proximal4.343425.16342K562SF3B4
chr5176860286176860346+intron-Proximal6.1739214.59522K562SF3B4
chr5176860480176860532+intron-Proximal4.203226.10653K562SF3B4
chr5176859320176859361+intron-Proximal4.784594.65563K562AQR
chr5176868059176868099+intron-Proximal5.7286320.15911K562AQR
chr5176868064176868136+intron-Proximal3.811915.85504K562SF3B4
chr5176857968176858009+intron-Proximal4.721835.17615K562AQR
chr5176861110176861179+intron-Proximal6.1348124.24524K562AQR
chr5176862154176862169+intron-Proximal4.839559.56266K562AQR
chr5176859183176859215+intron-Proximal5.3152422.13577K562SF3B4
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for GRK6 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for GRK6 is not available on ENCORE database.

  • 84 RBPs can affect the levels of GRK6.  








The Knockdown/knockout RNA-Seq assay for GRK6 is not available on ENCORE database.





84 RBPs can affect the gene expression of GRK6 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
GRK6ENSG00000198055.6333.36930510.27570-0.614206.172205.06910HepG2AKAP8L
GRK6ENSG00000198055.6299.49170523.95520-0.806904.153303.19970HepG2ASCC1
GRK6ENSG00000198055.6557.04290748.55390-0.426304.096303.29090HepG2AUH
GRK6ENSG00000198055.6190.55100277.94550-0.544602.421501.58200HepG2BCLAF1
GRK6ENSG00000198055.6164.36090301.55700-0.875603.402702.55830HepG2CALR
GRK6ENSG00000198055.6353.75810507.77200-0.521405.087504.23620HepG2CKAP4
GRK6ENSG00000198055.6297.41180201.533100.561303.306502.04300HepG2DDX1
GRK6ENSG00000198055.6163.56670243.75230-0.575502.699801.79930HepG2DDX24
GRK6ENSG00000198055.6367.61660197.613500.895408.589607.40500HepG2DNAJC21
GRK6ENSG00000198055.6311.44710195.873900.669005.452204.58230HepG2DNAJC2
GRK6ENSG00000198055.6111.51840229.36450-1.040405.699404.11830HepG2AGO1
GRK6ENSG00000198055.6348.98760500.88500-0.521302.801402.20410HepG2EIF2S1
GRK6ENSG00000198055.6192.63720269.85520-0.486302.116001.31750HepG2EIF3D
GRK6ENSG00000198055.6285.13800423.14670-0.569504.065903.08650HepG2EIF4G1
GRK6ENSG00000198055.6618.90140859.47390-0.473706.051905.22130HepG2ETF1
GRK6ENSG00000198055.6424.76230575.26850-0.437602.211201.51930HepG2FIP1L1
GRK6ENSG00000198055.6135.04150261.82110-0.955204.910103.25500HepG2FKBP4
GRK6ENSG00000198055.6285.60210394.15670-0.464802.902601.94860HepG2HNRNPA2B1
GRK6ENSG00000198055.6297.13860396.88180-0.417602.281901.41910HepG2HNRNPM
GRK6ENSG00000198055.6375.05310220.448900.766607.283406.33650HepG2HNRNPU
GRK6ENSG00000198055.6545.25090323.798500.751703.071201.79990HepG2KHDRBS1
GRK6ENSG00000198055.6358.46470561.98180-0.648703.141602.47240HepG2MATR3
GRK6ENSG00000198055.6533.80100425.244900.327902.258801.57010HepG2NOL12
GRK6ENSG00000198055.6317.70080218.204400.541903.471102.53360HepG2PARN
GRK6ENSG00000198055.6413.82660512.72590-0.309202.077501.53920HepG2PCBP1
GRK6ENSG00000198055.6374.30940196.622500.928704.211403.32270HepG2PPIL4
GRK6ENSG00000198055.6142.16460242.52150-0.770604.041403.08770HepG2PRPF8
GRK6ENSG00000198055.6291.17760405.95460-0.479402.616302.03430HepG2PUF60
GRK6ENSG00000198055.6739.57100430.963500.7790014.3684013.23860HepG2PUM1
GRK6ENSG00000198055.6709.61800565.046800.328602.225201.65460HepG2QKI
GRK6ENSG00000198055.6373.23480718.35410-0.9446014.1927013.20290HepG2RBM22
GRK6ENSG00000198055.6147.17750239.88740-0.704803.227102.38710HepG2RRP9
GRK6ENSG00000198055.6411.26020196.318401.0668013.5370012.27250HepG2SAFB2
GRK6ENSG00000198055.6352.27790228.938700.621703.891803.15020HepG2SMN1
GRK6ENSG00000198055.6451.44190811.34200-0.8458014.5988013.68810HepG2SRFBP1
GRK6ENSG00000198055.6366.74610566.95840-0.628506.236805.59700HepG2SRSF1
GRK6ENSG00000198055.6309.69990400.85070-0.372202.043601.49590HepG2SRSF5
GRK6ENSG00000198055.6308.43540461.24270-0.580605.459204.72870HepG2SRSF9
GRK6ENSG00000198055.6540.33770704.41520-0.382603.649603.07850HepG2SSB
GRK6ENSG00000198055.6581.71170455.852300.351603.081902.43230HepG2SUCLG1
GRK6ENSG00000198055.6170.25880313.13260-0.879004.459903.63210HepG2SUPV3L1
GRK6ENSG00000198055.6342.54170509.57810-0.573005.019504.30110HepG2TAF15
GRK6ENSG00000198055.6294.26480216.122600.445202.608802.05770HepG2TRIM56
GRK6ENSG00000198055.6544.98990396.640900.458303.366902.39480HepG2TUFM
GRK6ENSG00000198055.6272.63540492.07880-0.851906.650305.68960HepG2U2AF1
GRK6ENSG00000198055.6655.91300419.864800.643503.054902.17770HepG2UBE2L3
GRK6ENSG00000198055.6275.88840184.943700.576902.411801.70210HepG2UCHL5
GRK6ENSG00000198055.6341.65720226.093300.595502.637801.37750HepG2ZRANB2
GRK6ENSG00000198055.61044.555401451.84410-0.475004.467802.88350K562ABCF1
GRK6ENSG00000198055.61027.854501441.62730-0.488107.904607.01500K562AGGF1
GRK6ENSG00000198055.61017.411802219.84840-1.1256022.3560020.87040K562AQR
GRK6ENSG00000198055.6535.51750702.70110-0.392002.389501.58510K562BOP1
GRK6ENSG00000198055.61429.647301069.738300.418303.587402.38170K562DDX3X
GRK6ENSG00000198055.62250.116601864.129400.271403.515402.79300K562DDX47
GRK6ENSG00000198055.61556.664801837.10990-0.239002.449901.76590K562EIF2S2
GRK6ENSG00000198055.61428.58530980.623700.542703.012101.95610K562EIF3A
GRK6ENSG00000198055.6850.06390524.008700.697909.249907.80010K562EIF3G
GRK6ENSG00000198055.61338.580201006.392600.411404.860903.26330K562EIF4B
GRK6ENSG00000198055.61576.305201043.651800.594807.088505.67280K562FIP1L1
GRK6ENSG00000198055.6549.805901088.73610-0.9857012.6142010.01510K562FKBP4
GRK6ENSG00000198055.6329.18040463.26410-0.493003.313001.83090K562FUS
GRK6ENSG00000198055.61455.357501162.219000.324403.503202.83440K562FXR1
GRK6ENSG00000198055.664.69680342.01820-2.4023025.8916022.92310K562G3BP2
GRK6ENSG00000198055.61526.666802087.74190-0.451604.177002.85950K562HNRNPA1
GRK6ENSG00000198055.6618.102601252.97050-1.0194013.5641012.32700K562HNRNPC
GRK6ENSG00000198055.61356.48690697.753800.959003.227702.08910K562IGF2BP2
GRK6ENSG00000198055.6400.85040609.12310-0.603702.382401.52520K562KRR1
GRK6ENSG00000198055.61021.04480732.680100.478702.949302.08140K562MAGOH
GRK6ENSG00000198055.61088.49210731.097700.574103.636302.56550K562MATR3
GRK6ENSG00000198055.61432.631701727.02250-0.269603.392702.50150K562MTPAP
GRK6ENSG00000198055.61046.045501946.60110-0.896005.547904.36580K562PCBP3
GRK6ENSG00000198055.6905.380701493.01430-0.721605.688304.54220K562POLR2G
GRK6ENSG00000198055.61909.242001184.764200.688309.212207.48220K562PPIG
GRK6ENSG00000198055.61462.60780711.891801.0387013.1980011.80110K562PTBP1
GRK6ENSG00000198055.61703.733302748.05510-0.6897010.917209.28200K562PUF60
GRK6ENSG00000198055.61773.763201487.790300.253501.791101.33560K562PUS1
GRK6ENSG00000198055.61461.705401000.635300.546602.064401.36360K562RPS19
GRK6ENSG00000198055.6968.29260522.881100.888907.321005.59470K562RPS3
GRK6ENSG00000198055.6504.50780678.43100-0.427302.392901.49340K562SF3B1
GRK6ENSG00000198055.6285.25790481.17390-0.754306.307503.63340K562SND1
GRK6ENSG00000198055.61149.82000697.962200.720106.015304.98140K562SRSF1
GRK6ENSG00000198055.6749.48850504.731700.570305.004703.51540K562SRSF4
GRK6ENSG00000198055.61033.22710659.348300.647902.269401.33540K562SRSF5
GRK6ENSG00000198055.6139.35770335.72320-1.268504.789402.65550K562TAF15
GRK6ENSG00000198055.61293.72750706.230500.873207.806506.54230K562TARDBP
GRK6ENSG00000198055.6235.06410356.41510-0.600503.681601.83080K562TBRG4
GRK6ENSG00000198055.61139.02430681.279200.741408.535906.98580K562TIA1
GRK6ENSG00000198055.61139.24900668.899300.768106.871004.95760K562TRA2A
GRK6ENSG00000198055.6130.66720331.41860-1.342805.336203.71720K562U2AF1
GRK6ENSG00000198055.6127.59220342.31870-1.4238016.1516014.18030K562U2AF2
GRK6ENSG00000198055.61418.371401741.08570-0.295802.652001.79240K562WDR3
GRK6ENSG00000198055.62043.426402500.89300-0.291502.530301.71220K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for GRK6 is not available on ENCORE database.





1 RBPs can affect the splicing of GRK6 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEGRK6ENSG00000198055.6chr5+176860347176860411176860147176860240176860536176860677-0.079000.003680.04143excludedHepG2U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for GRK6 is not avaliable on ENCORE database.