BRCC3

General Information

Gene Name       : BRCC3
Gene ID             : ENSG00000185515.14
Essential Gene : No

Functions

Localization

Domains (AlphaFold: BRCC3)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878BRCC3ENSG00000185515.1431.6528.0029.82ENCSR000AEF
HepG2BRCC3ENSG00000185515.1418.0427.5422.79ENCSR985KAT
K562BRCC3ENSG00000185515.1418.1422.5120.33ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for BRCC3 is not avaliable on ENCORE database.



Proteins bound to RNA
  • BRCC3 RNA is bound by 10 proteins.  







eCLIP assay for BRCC3 is not avaliable on ENCORE database.





10 proteins are bound to BRCC3 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chrX154350088154350225+3'-UTR3.239963.50315HepG2UPF1
chrX154307151154307220+3'-UTR,intron-Distal,polyA_site3.927823.66668K562KHSRP
chrX154306869154306925+5'-UTR,CDS,intron-Proximal4.151573.35169HepG2U2AF2
chrX154306858154306916+5'-UTR,CDS,intron-Proximal4.861683.91589K562SF3B4
chrX154301633154301699+CDS,intron-Distal,intron-Proximal3.950388.55689HepG2U2AF2
chrX154300582154300648+CDS,intron-Distal,intron-Proximal5.893066.63358K562EFTUD2
chrX154300575154300657+CDS,intron-Distal,intron-Proximal4.4252315.12840K562AQR
chrX154299923154299975+CDS,intron-Proximal3.9496713.40055K562AQR
chrX154305388154305474+CDS,intron-Proximal5.8119111.49904K562SF3B4
chrX154313088154313171+intron-Distal4.471814.54503HepG2ILF3
chrX154341418154341484+intron-Distal3.308764.12241K562SAFB2
chrX154301934154302118+intron-Distal4.359754.75572K562MATR3
chrX154342692154342765+intron-Distal4.112754.56270K562SAFB2
chrX154299975154300033+intron-Distal,intron-Proximal4.0096912.56301K562AQR
chrX154300522154300548+intron-Distal,intron-Proximal3.906573.90026K562KHSRP
chrX154299961154300048+intron-Distal,intron-Proximal4.442174.22101K562PRPF8
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for BRCC3 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for BRCC3 is not available on ENCORE database.

  • 98 RBPs can affect the levels of BRCC3.  








The Knockdown/knockout RNA-Seq assay for BRCC3 is not available on ENCORE database.





98 RBPs can affect the gene expression of BRCC3 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
BRCC3ENSG00000185515.10980.35350750.489000.385402.355801.48440HepG2ABCF1
BRCC3ENSG00000185515.10387.32930698.12310-0.849904.031902.90230HepG2BCCIP
BRCC3ENSG00000185515.10473.98050889.71000-0.9085011.7414010.62270HepG2BOP1
BRCC3ENSG00000185515.10860.63470702.589700.292601.968601.30950HepG2CALR
BRCC3ENSG00000185515.10878.77420597.365600.556804.518803.54390HepG2CIRBP
BRCC3ENSG00000185515.10626.97330816.79580-0.381602.378201.73410HepG2CPSF6
BRCC3ENSG00000185515.101017.74690845.508300.267402.181301.60000HepG2CELF1
BRCC3ENSG00000185515.10713.84720909.19910-0.349004.151903.27220HepG2DAZAP1
BRCC3ENSG00000185515.10714.61170587.026300.283602.473301.68080HepG2DDX19B
BRCC3ENSG00000185515.10285.55180542.86040-0.9268011.077609.01000HepG2DDX1
BRCC3ENSG00000185515.10726.53620545.264500.414002.812802.13050HepG2DDX21
BRCC3ENSG00000185515.10434.91440727.93840-0.743106.439805.52620HepG2DDX3X
BRCC3ENSG00000185515.10406.59210625.30040-0.621004.139803.39570HepG2DDX6
BRCC3ENSG00000185515.10285.14500532.30600-0.9006011.283609.94250HepG2DNAJC21
BRCC3ENSG00000185515.10359.26590527.60330-0.554406.142005.22700HepG2DNAJC2
BRCC3ENSG00000185515.10738.17620514.693200.520204.668003.30990HepG2EIF3G
BRCC3ENSG00000185515.10974.51370664.326100.552704.107103.33200HepG2EIF4A3
BRCC3ENSG00000185515.101208.149701039.396300.217002.071801.53640HepG2ETF1
BRCC3ENSG00000185515.10466.47600757.85190-0.700105.026804.01710HepG2FIP1L1
BRCC3ENSG00000185515.10463.35360621.77230-0.424302.360401.74310HepG2G3BP1
BRCC3ENSG00000185515.10852.42690660.077200.368802.260801.45930HepG2G3BP2
BRCC3ENSG00000185515.10654.79360835.54620-0.351703.364802.34760HepG2HNRNPA2B1
BRCC3ENSG00000185515.10583.64890827.72250-0.504005.888504.89450HepG2HNRNPF
BRCC3ENSG00000185515.10622.13620828.23200-0.412805.073004.18280HepG2HNRNPL
BRCC3ENSG00000185515.10584.16050815.07330-0.480604.482703.57990HepG2IGF2BP1
BRCC3ENSG00000185515.10820.66370632.021700.376702.258601.64130HepG2IGF2BP2
BRCC3ENSG00000185515.10461.74130580.21540-0.329502.704401.69450HepG2KIF1C
BRCC3ENSG00000185515.10385.95020624.10290-0.693406.153004.37370HepG2LIN28B
BRCC3ENSG00000185515.10850.85490670.491000.343601.919601.36770HepG2MAGOH
BRCC3ENSG00000185515.10894.06220674.246900.407002.363501.77710HepG2MATR3
BRCC3ENSG00000185515.10465.20910613.52370-0.399202.401701.64510HepG2MSI2
BRCC3ENSG00000185515.10345.92360690.13190-0.9964010.046608.88410HepG2NCBP2
BRCC3ENSG00000185515.10692.63600901.55620-0.380303.230402.40870HepG2NOL12
BRCC3ENSG00000185515.10477.49810587.77280-0.299802.073501.33180HepG2PARN
BRCC3ENSG00000185515.10714.08250913.53660-0.355404.478203.76350HepG2PUM1
BRCC3ENSG00000185515.10534.35240912.88350-0.7726010.973209.68610HepG2PUM2
BRCC3ENSG00000185515.10645.56890821.29860-0.347302.777001.91920HepG2RBM15
BRCC3ENSG00000185515.10468.27420604.54290-0.368501.899001.33090HepG2RBM25
BRCC3ENSG00000185515.10925.91340684.474500.435804.401203.74710HepG2NELFE
BRCC3ENSG00000185515.10373.40050528.81590-0.502004.715803.91310HepG2SAFB2
BRCC3ENSG00000185515.10622.93500874.56900-0.489504.010103.17560HepG2SF3B1
BRCC3ENSG00000185515.10791.65930981.21810-0.309703.043802.52630HepG2SRFBP1
BRCC3ENSG00000185515.10944.13360668.380000.498205.884705.25950HepG2SRSF1
BRCC3ENSG00000185515.10564.30500813.19970-0.527106.331405.34860HepG2SRSF7
BRCC3ENSG00000185515.101199.42820851.934900.493407.682906.91130HepG2SSB
BRCC3ENSG00000185515.10735.69750600.681300.292401.958501.47270HepG2TAF15
BRCC3ENSG00000185515.10356.19100577.00170-0.695907.098706.36520HepG2TIAL1
BRCC3ENSG00000185515.10436.85390582.15670-0.414303.666303.03640HepG2TRIM56
BRCC3ENSG00000185515.10842.94560648.388700.378502.606901.99630HepG2U2AF1
BRCC3ENSG00000185515.10602.69800889.87230-0.562204.011202.99270HepG2UBE2L3
BRCC3ENSG00000185515.10544.30480399.544400.446002.915201.69810K562AARS
BRCC3ENSG00000185515.10167.93020357.21670-1.088903.146102.54720K562AGGF1
BRCC3ENSG00000185515.10166.83970371.67610-1.155603.292502.57800K562AKAP8L
BRCC3ENSG00000185515.10434.24080991.85180-1.191606.553405.71310K562AQR
BRCC3ENSG00000185515.10453.67060612.61150-0.433303.449201.94660K562BCCIP
BRCC3ENSG00000185515.10472.62180592.03900-0.325002.444301.54430K562BCLAF1
BRCC3ENSG00000185515.10291.67730727.62320-1.3188017.3322015.12440K562BOP1
BRCC3ENSG00000185515.10542.397001031.77180-0.927704.271502.90700K562CNOT7
BRCC3ENSG00000185515.10475.31260773.70600-0.702906.304305.12150K562CPSF6
BRCC3ENSG00000185515.10167.47190260.54810-0.637603.767501.64210K562DDX24
BRCC3ENSG00000185515.10119.68200245.90240-1.038907.662705.84120K562DDX3X
BRCC3ENSG00000185515.101535.24110963.215300.6724014.3770013.00570K562DDX47
BRCC3ENSG00000185515.10162.70510249.30530-0.615703.616502.06660K562DDX6
BRCC3ENSG00000185515.10782.44730977.72590-0.321402.856702.12760K562EIF2S2
BRCC3ENSG00000185515.10641.34320418.556700.615606.568905.35830K562EIF3G
BRCC3ENSG00000185515.10389.13770256.895800.599003.892202.92380K562EIF4A3
BRCC3ENSG00000185515.10150.89440231.33750-0.616503.560802.22360K562EIF4B
BRCC3ENSG00000185515.10151.19110224.23650-0.568602.605101.35620K562EWSR1
BRCC3ENSG00000185515.10463.93650923.24960-0.992806.704705.33710K562FIP1L1
BRCC3ENSG00000185515.10370.58800787.16220-1.0868012.4058010.51050K562FMR1
BRCC3ENSG00000185515.10670.36190267.158801.3271024.4432022.76550K562FXR1
BRCC3ENSG00000185515.10204.93920393.25750-0.940308.519605.91770K562G3BP1
BRCC3ENSG00000185515.10524.14500738.72590-0.495103.630802.72550K562GPKOW
BRCC3ENSG00000185515.10713.018401303.02350-0.8699013.1428011.47470K562GRSF1
BRCC3ENSG00000185515.10410.36810556.66560-0.439903.218402.05790K562HNRNPA1
BRCC3ENSG00000185515.10158.48340557.56730-1.814803.479002.06590K562HNRNPA2B1
BRCC3ENSG00000185515.10296.87630437.41180-0.559103.156102.52430K562HNRNPC
BRCC3ENSG00000185515.101016.76560759.316600.421102.538201.64860K562HNRNPM
BRCC3ENSG00000185515.10230.02390411.26650-0.838305.615003.93710K562IGF2BP2
BRCC3ENSG00000185515.10289.52880418.34290-0.531003.602002.20210K562IGF2BP3
BRCC3ENSG00000185515.10237.85100394.52560-0.730101.992601.30130K562KIF1C
BRCC3ENSG00000185515.10416.03220630.70900-0.600303.460702.40250K562KRR1
BRCC3ENSG00000185515.10300.36630443.41970-0.561903.427701.75820K562LIN28B
BRCC3ENSG00000185515.10259.78750389.80030-0.585403.461901.68920K562LSM11
BRCC3ENSG00000185515.10594.73950432.297100.460103.568302.60640K562MAGOH
BRCC3ENSG00000185515.10496.78050721.06750-0.537504.430603.30340K562METAP2
BRCC3ENSG00000185515.10148.46170309.77210-1.061102.673601.80880K562NAA15
BRCC3ENSG00000185515.10155.70850256.54170-0.720304.239102.70340K562NCBP2
BRCC3ENSG00000185515.10160.96620258.59580-0.683903.493301.44040K562PABPC4
BRCC3ENSG00000185515.10296.45820422.53510-0.511203.532801.99720K562PCBP1
BRCC3ENSG00000185515.101009.36720679.620300.570604.650703.57350K562PCBP3
BRCC3ENSG00000185515.10900.69720521.271400.788908.118806.76940K562POLR2G
BRCC3ENSG00000185515.10703.334601047.97080-0.575303.679502.71210K562PPIG
BRCC3ENSG00000185515.10186.90340580.76510-1.635702.887201.39610K562PPP1R8
BRCC3ENSG00000185515.10241.35600392.15730-0.700303.378202.36460K562PSIP1
BRCC3ENSG00000185515.10619.66790419.998300.561005.208204.32030K562PTBP1
BRCC3ENSG00000185515.10177.69160368.77290-1.053402.884402.33230K562PUS1
BRCC3ENSG00000185515.10159.64560359.17090-1.169803.349602.70680K562RBM15
BRCC3ENSG00000185515.10133.53520232.04870-0.797204.527802.76370K562RBM25
BRCC3ENSG00000185515.10237.61610357.65690-0.589903.383302.28800K562RCC2
BRCC3ENSG00000185515.10687.89590423.839300.698606.505604.74900K562NELFE
BRCC3ENSG00000185515.10694.74790511.755600.440902.688201.88460K562RPS19
BRCC3ENSG00000185515.10419.71230173.512201.2743010.688108.58540K562RPS3
BRCC3ENSG00000185515.10678.12420480.241300.497703.741502.04370K562SDAD1
BRCC3ENSG00000185515.10118.73130446.66330-1.911503.168701.85700K562SF1
BRCC3ENSG00000185515.10491.46120734.82100-0.580302.359501.60070K562SF3A3
BRCC3ENSG00000185515.10116.20780254.37850-1.130309.334107.71640K562SF3B4
BRCC3ENSG00000185515.10247.68310428.96910-0.792403.904801.53470K562SMNDC1
BRCC3ENSG00000185515.10227.05750339.06330-0.578503.061801.96940K562SRFBP1
BRCC3ENSG00000185515.10237.70850388.82810-0.709905.037103.54040K562SRSF5
BRCC3ENSG00000185515.101004.26410522.877200.9415016.1919014.23380K562SYNCRIP
BRCC3ENSG00000185515.10289.61270401.96440-0.472902.816401.99050K562TIA1
BRCC3ENSG00000185515.10256.25880394.40530-0.622103.934402.59800K562TRA2A
BRCC3ENSG00000185515.10284.73170400.58130-0.492502.670501.74460K562TRIM56
BRCC3ENSG00000185515.10346.49150244.893600.500603.056402.21150K562U2AF2
BRCC3ENSG00000185515.10396.94930675.83950-0.767702.645001.78650K562WDR3
BRCC3ENSG00000185515.10712.25860414.929800.779403.974701.99410K562XRCC6
BRCC3ENSG00000185515.10720.017401117.57430-0.634302.828301.95380K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for BRCC3 is not available on ENCORE database.





3 RBPs can affect the splicing of BRCC3 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEBRCC3ENSG00000185515.10chrX+154300601154300618154299705154299925154301651154301706-0.069000.002980.03045excludedK562AQR
SEBRCC3ENSG00000185515.10chrX+154327589154327664154319058154319114154344331154344463-0.231000.012340.09590excludedK562AQR
SEBRCC3ENSG00000185515.10chrX+154301651154301706154299773154299925154305444154305564-0.399000.001350.03851excludedHepG2SF3A3
SEBRCC3ENSG00000185515.10chrX+1543275891543276641543190581543191141543443311543444580.279000.001510.05137includedK562HNRNPU
A3SSBRCC3ENSG00000185515.10chrX+1543494611543495931543494971543495931543482731543484430.103000.000380.00293longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for BRCC3 is not avaliable on ENCORE database.